Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies

Journal of Medicinal Chemistry

Volumn 56, Issue 24, 2013, Pages 10103-10117

  Wu, Jinhua ^a   Zhang, Yaohong ^a,b   Maida, Laura E ^a   Santos, Radleigh G ^a   Welmaker, Gregory S ^a   Lavoi, Travis M ^a   Nefzi, Adel ^a   Yu, Yongping ^a,b   Houghten, Richard A ^a   Toll, Lawrence ^a   Giulianotti, Marc A ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(4 TERT BUTYLCYCLOHEXYL)METHYL] 3 [4 [2 IMINO 3 [2 (PYRIDIN 3 YL)ETHYL]IMIDAZOLIDIN 4 YL]BUTYL]IMIDAZOLIDIN 2 IMINE; 3 [(4 TERT BUTYLCYCLOHEXYL)METHYL] 4 (CYCLOHEXYLMETHYL) 1 [4 [2 IMINO 3 [2 (PYRIDIN 3 YL)ETHYL]IMIDAZOLIDIN 4 YL]BUTYL]IMIDAZOLIDIN 2 IMINE; 3 [(4 TERT BUTYLCYCLOHEXYL)METHYL] 4 (CYCLOHEXYLMETHYL) 1 [4 [3 (3 FLUOROPHENETHYL) 2 IMINOIMIDAZOLIDIN 4 YL]BUTYL]IMIDAZOLIDIN 2 IMINE; 4 BENZYL 3 [(4 TERT BUTYLCYCLOHEXYL)METHYL] 1 [4 [2 IMINO 3 [2 (PYRIDIN 3 YL)ETHYL]IMIDAZOLIDIN 4 YL]BUTYL]IMIDAZOLIDIN 2 IMINE; 4 BENZYL 3 [(4 TERT BUTYLCYCLOHEXYL)METHYL] 1 [4 [3 (3 FLUOROPHENETHYL) 2 IMINOIMIDAZOLIDIN 4 YL]BUTYL]IMIDAZOLIDIN 2 IMINE; GUANIDINE DERIVATIVE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR ALPHA4BETA2; NICOTINIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DEPOLARIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

EID: 84891278912     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401543h     Document Type: Article

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