The role of gut microbiota in the pathogenesis of obesity and diabetes;Rola mikroflory jelitowej w patogenezie otyłości i cukrzycy

Postepy Higieny i Medycyny Doswiadczalnej

Volumn 67, Issue , 2013, Pages 288-303

  Stachowicz, Nina ^a   Kiersztan, Anna ^a  

^a UNIVERSITY OF WARSAW   (Poland)

Author keywords

"germ free" animals; Bacteroidetes; Firmicutes; Gut microbiota; Obesity; Prebiotics; Probiotics; Short chain fatty acids; Type 1 diabetes; Type 2 diabetes

Indexed keywords

PREBIOTIC AGENT; PROBIOTIC AGENT;

GASTROINTESTINAL TRACT; HUMAN; INSULIN RESISTANCE; LIPID METABOLISM; METABOLISM; METAGENOME; MICROBIOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; REVIEW;

DIABETES MELLITUS, TYPE 2; GASTROINTESTINAL TRACT; HUMANS; INSULIN RESISTANCE; LIPID METABOLISM; METAGENOME; OBESITY; PREBIOTICS; PROBIOTICS;

EID: 84883193357     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: 10.5604/17322693.1044746     Document Type: Article

References (97)

1. Agans R., Rigsbee L., Kenche H., Michail S., Khamis H. J., Paliy O.: Distal gut microbiota of adolescent children is different from that of adults. FEMS Microbiol. Ecol., 2011;77:404-412
2. Angelakis E., Armougom F., Million M., Raoult D.: The relationship between gut microbiota and weight gain in humans. Future Microbiol., 2012;7:91-109
3. Archer B. J., Johnson S. K., Devereux H. M., Baxter A. L.: Effect of fat replacement by inulin or lupin-kernel fibre on sausage patty acceptability, post-meal perceptions of satiety and food intake in men. Brit. J. Nutr., 2004;91:591-599
4. Arumugam M., Raes J., Pelletier E., Le Paslier D., Yamada T., Mende D. R., Fernandes G. R., Tap J., Bruls T., Batto J. M., Bertalan M., Borruel N., Casellas F., Fernandez L., Gautier L., Hansen T., Hattori M., Hayashi T., Kleerebezem M., Kurokawa K., Leclerc M., Levenez F., Manichanh C., Nielsen H. B., Nielsen T., Pons N., Poulain J., Qin J., Sicheritz-Ponten T., Tims S., Torrents D., Ugarte E., Zoetendal E. G., Wang J., Guarner F., Pedersen O., de Vos WM., Brunak S., Doré J.; MetaHIT Consortium, Antolín M., Artiguenave F., Blottiere H. M., Almeida M., Brechot C., Cara C., Chervaux C., Cultrone A., Delorme C., Denariaz G., Dervyn R., Foerstner K. U., Friss C., van de Guchte M., Guedon E., Haimet F., Huber W., van Hylckama-Vlieg J., Jamet A., Juste C., Kaci G., Knol J., Lakhdari O., Layec S., Le Roux K., Maguin E., Mérieux A., Melo Minardi R., M'rini C., Muller J., Oozeer R., Parkhill J., Renault P., Rescigno M., Sanchez N., Sunagawa S., Torrejon A., Turner K., Vandemeulebrouck G., Varela E., Winogradsky Y., Zeller G., Weissenbach Jw., Ehrlich S. D., Bork P.: Enterotypes of the human gut microbiome. Nature, 2011;473:174-180
5. Bäckhed F., Crawford P. A., O'Donnell D., Gordon J. I.: Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor. Proc. Natl. Acad. Sci. USA, 2007;104:606-611
6. Bäckhed F., Ding H., Wang T., Hooper L. V., Koh G. Y., Nagy A., Semenkovich C. F., Gordon J. I.: The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. USA, 2004;101:15718-15723
7. Barbara G., Stanghellini V., Brandi G., Cremon C., Di Nardo G., De Giorgio R., Corinaldesi R.: Interactions between commensal bacteria and gut sensorimotor function in health and disease. Am. J. Gastroenterol., 2005;100:2560-2568
8. Baxter J. D., Webb P.: Metabolism: bile acids heat things up. Nature, 2006;439:402-403
9. Benson A. K., Kelly S. A., Legge R., Ma F., Low S. J., Kim J., Zhang M., Oh P. L., Nehrenberg D., Hua K., Kachman S. D., Moriyama E. N., Walter J., Peterson D. A., Pomp D.: Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc. Natl. Acad. Sci. USA, 2010;107:18933-18938
10. Bjursell M., Admyre T., Göransson M., Marley A. E., Smith D. M., Oscarsson J., Bohlooly Y. M.: Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet. Am. J. Physiol. Endocrinol. Metab., 2011;300:E211-E220
11. Brown A. J., Goldsworthy S. M., Barnes A. A., Eilert M. M., Tcheang L., Daniels D., Muir A. I., Wigglesworth M. J., Kinghorn I., Fraser N. J., Pike N. B., Strum J. C., Steplewski K. M., Murdock P. R., Holder J. C., Marshall F. H., Szekeres P. G., Wilson S., Ignar D. M., Foord S. M., Wise A., Dowell S. J.: The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem., 2003;278:11312-11319
12. Brugman S., Klatter F. A., Visser J. T., Wildeboer-Veloo A. C., Harmsen H. J., Rozing J., Bos N. A.: Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia, 2006;49:2105-2108
13. Burcelin R., Serino M., Chabo C., Blasco-Baque V., Amar J.: Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. Acta Diabetol., 2011;48:257-273
14. Cani P. D., Amar J., Iglesias M. A., Poggi M., Knauf C., Bastelica D., Neyrinck A. M., Fava F., Tuohy K. M., Chabo C., Waget A., Delmée E., Cousin B., Sulpice T., Chamontin B., Ferrières J., Tanti J. F., Gibson G. R., Casteilla L., Delzenne N. M., Alessi M. C., Burcelin R.: Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 2007;56:1761-1772
15. Cani P. D., Bibiloni R., Knauf C., Waget A., Neyrinck A. M., Delzenne N. M., Burcelin R.: Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet induced obesity and diabetes in mice. Diabetes, 2008;57:1470-1481
16. Cani P. D., Delzenne N. M.: Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curr. Opin. Pharmacol., 2009;9:737-743
17. Cani P. D., Delzenne N. M.: The gut microbiome as therapeutic target. Pharmacol. Ther., 2011;130:202-212
18. Cani P. D., Joly E., Horsmans Y., Delzenne N. M.: Oligofructose promotes satiety in healthy human: a pilot study. Eur. J. Clin. Nutr., 2006;60:567-72
19. Cani P. D., Montoya M. L., Neyrinck A. M., Delzenne N. M., Lambert D. M.: Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide. Br. J. Nutr., 2004;92:757-761
20. Cani P. D., Neyrinck A. M., Fava F., Knauf C., Burcelin R. G., Tuohy K. M., Gibson G. R., Delzenne N. M.: Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia, 2007;50:2374-2383
21. Cani P. D., Neyrinck A. M., Maton N., Delzenne N. M.: Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1. Obes. Res., 2005;13:1000-1007
22. Chan R. S., Woo J.: Prevention of overweight and obesity: how effective is a current public health approach. Int. J. Environ. Res. Public Health, 2010;7:765-783
23. Claesson M. J., Cusack S., O'Sullivan O., Greene-Diniz R., de Weerd H., Flannery E., Marchesi J. R., Falush D., Dinan T., Fitzgerald G., Stanton C., van Sinderen D., O'Connor M., Harnedy N., O'Connor K., Henry C., O'Mahony D., Fitzgerald A. P., Shanahan F., Twomey C., Hill C., Ross R. P., O'Toole P. W.: Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc. Natl. Acad. Sci. USA, 2011;108(Suppl. 1):4586-4591
24. Creely S. J., McTernan P. G., Kusminski C. M., Fisher M., Da Silva N. F., Khanolkar M., Evans M., Harte A. L., Kumar S.: Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am. J. Physiol. Endocrinol. Metab., 2007;292:E740-E747
25. De Filippo C., Cavalieri D., Di Paola M., Ramazzotti M., Poullet J. B., Massart S., Collini S., Pieraccini G., Lionetti P.: Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc. Natl. Acad. Sci. USA, 2010;107:14691-14696
26. de La Serre C. B., Ellis C. L., Lee J., Hartman A. L., Rutledge J. C., Raybould H. E.: Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation. Am. J. Physiol. Gastrointest. Liver Physiol., 2010;299:G440-G448
27. Delzenne N. M., Cani P. D., Daubioul C., Neyrinck A. M.: Impact of inulin and oligofructose on gastrointestinal peptides. Br. J. Nutr., 2005;93(Suppl. 1):S157-S161
28. Denechaud P. D., Dentin R., Girard J., Postic C.: Role of ChREBP in hepatic steatosis and insulin resistance. FEBS Lett., 2008;582:68-73
29. Di Baise J. K., Zhang H., Crowell M. D., Krajmalnik-Brown R., Decker G. A., Rittmann B. E.: Gut microbiota and its possible relationship with obesity. Mayo Clin. Proc., 2008;83:460-469
30. Dumas M. E., Barton R. H., Toye A., Cloarec O., Blancher C., Rothwell A., Fearnside J., Tatoud R., Blanc V., Lindon J. C., Mitchell S. C., Holmes E., McCarthy M. I., Scott J., Gauguier D., Nicholson J. K.: Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc. Natl. Acad. Sci. USA, 2006;103:12511-12516
31. Duncan S. H., Belenguer A., Holtrop G., Johnstone A. M., Flint H. J., Lobley G. E.: Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl. Environ. Microbiol., 2007;73:1073-1078
32. Duncan S. H., Lobley G. E., Holtrop G., Ince J., Johnstone A. M., Louis P., Flint H. J.: Human colonic microbiota associated with diet, obesity and weight loss. Int. J. Obes., 2008;32:1720-1724
33. Eckburg P. B., Bik E. M., Bernstein C. N., Purdom E., Dethlefsen L., Sargent M., Gill S. R., Nelson K. E., Relman D. A.: Diversity of the human intestinal microbial flora. Science, 2005;308:1635-1638
34. Enck P., Zimmermann K., Rusch K., Schwiertz A., Klosterhalfen S., Frick J. S.: The effects of maturation on the colonic microflora in infancy and childhood. Gastroenterol. Res. Pract., 2009;2009:752401
35. Fallani M., Amarri S., Uusijarvi A., Adam R., Khanna S., Aguilera M., Gil A., Vieites J. M., Norin E., Young D., Scott J. A., Doré J., Edwards C. A.: INFABIO team: Determinants of the human infant intestinal microbiota after the introduction of first complementary foods in infant samples from five European centres. Microbiology, 2011;157:1385-1392
36. Farooqi I. S., Bullmore E., Keogh J., Gillard J., O'Rahilly S., Fletcher P. C.: Leptin regulates striatal regions and human eating behavior. Science, 2007;317:1355
37. Favier C. F., de Vos W. M., Akkermans A. D.: Development of bacterial and bifidobacterial communities in feces of newborn babies. Anaerobe, 2003;9:219-229
38. Favier C. F., Vaughan E. E., De Vos W. M., Akkermans A. D.: Molecular monitoring of succession of bacterial communities in human neonates. Appl. Environ. Microbiol., 2002;68:219-226
39. Flint H. J., Bayer E. A., Rincon M. T., Lamed R., White B. A.: Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis. Nat. Rev. Microbiol., 2008;6:121-131
40. Floch M. H., Montrose D. C.: Use of probiotics in humans: an analysis of the literature. Gastroenterol. Clin. North Am., 2005;34:547-570
41. Frank D. N., St Amand A. L., Feldman R. A., Boedeker E. C., Harpaz N., Pace N. R.: Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc. Natl. Acad. Sci. USA, 2007;104:13780-13785
42. Furet J. P., Kong L. C., Tap J., Poitou C., Basdevant A., Bouillot J. L., Mariat D., Corthier G., Doré J., Henegar C., Rizkalla S., Clément K.: Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes, 2010;59:3049-3057
43. Gao Z., Yin J., Zhang J., Ward R. E., Martin R. J., Lefevre M., Cefalu W. T., Ye J.: Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes, 2009;58:1509-1517
44. Greiner T., Bäckhed F.: Effects of the gut microbiota on obesity and glucose homeostasis. Trends Endocrinol. Metab., 2011;22:117-123
45. Grudell A. B., Camilleri M.: The role of peptide YY in integrative gut physiology and potential role in obesity. Curr. Opin. Endocrinol. Diabetes Obes., 2007;14:52-57
46. Harris K., Kassis A., Major G., Chou C. J.: Is the gut microbiota a new factor contributing to obesity and its metabolic disorders? J. Obes., 2012;2012:879151
47. Hildebrandt M. A., Hoffmann C., Sherrill-Mix S. A., Keilbaugh S. A., Hamady M., Chen Y. Y., Knight R., Ahima R. S., Bushman F., Wu G. D.: High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology, 2009;137:1716-1724
48. Kahn B. B., Alquier T., Carling D., Hardie D. G.: AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab., 2005;1:15-25
49. Kleessen B., Hartmann L., Blaut M.: Oligofructose and long-chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora. Br. J. Nutr., 2001;86:291-300
50. Kootte R. S., Vrieze A., Holleman F., Dallinga-Thie G. M., Zoetendal E. G., de Vos W. M., Groen A. K., Hoekstra J. B., Stroes E. S., Nieuwdorp M.: The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes Obes. Metab., 2012;14:112-120
51. Larsen N., Vogensen F. K., van den Berg F. W., Nielsen D. S., Andreasen A. S., Pedersen B. K., Al-Soud W. A., Sørensen S. J., Hansen L. H., Jakobsen M.: Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One, 2010;5:e9085
52. Larsen T. M., Toubro S., Gudmundsen O., Astrup A.: Conjugated linoleic acid supplementation for 1 y does not prevent weight or body fat regain. Am. J. Clin. Nutr.: 2006, 83:606-612
53. Lee H. Y., Park J. H., Seok S. H., Baek M. W., Kim D. J., Lee K. E., Paek K. S., Lee Y., Park J. H.: Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochim. Biophys. Acta, 2006;1761:736-744
54. Lefebvre P., Cariou B., Lien F., Kuipers F., Staels B.: Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev., 2009;89:147-191
55. Ley R. E., Bäckhed F., Turnbaugh P., Lozupone C. A., Knight R. D., Gordon J. I.: Obesity alters gut microbial ecology. Proc. Natl. Acad. Sci. USA, 2005;102:11070-11075
56. Ley R. E., Peterson D. A., Gordon J. I.: Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell, 2006;124:837-848
57. Ley R. E., Turnbaugh P. J., Klein S., Gordon J. I.: Microbial ecology: human gut microbes associated with obesity. Nature, 2006;444:1022-1023
58. Li M., Wang B., Zhang M., Rantalainen M., Wang S., Zhou H., Zhang Y., Shen J., Pang X., Zhang M., Wei H., Chen Y., Lu H., Zuo J., Su M., Qiu Y., Jia W., Xiao C., Smith L. M., Yang S., Holmes E., Tang H., Zhao G., Nicholson J. K., Li L., Zhao L.: Symbiotic gut microbes modulate human metabolic phenotypes. Proc. Natl. Acad. Sci. USA, 2008;105:2117-2122
59. Liszt K., Zwielehner J., Handschur M., Hippe B., Thaler R., Haslberger A. G.: Characterization of bacteria, clostridia and Bacteroides in faeces of vegetarians using qPCR and PCR-DGGE fingerprinting. Ann. Nutr. Metab., 2009;54:253-257
60. Ludwig W., Schleifer K. H.: Bacterial phylogeny based on 16S and 23S rRNA sequence analysis. FEMS Microbiol. Rev., 1994;15:155-173
61. Macfarlane S., Macfarlane G. T.: Bacterial diversity in the human gut. Adv. Appl. Microbiol., 2004;54:261-289
62. Marchesi J., Shanahan F.: The normal intestinal microbiota. Curr. Opin. Infect. Dis., 2007;20:508-513
63. Martin F. P., Wang Y., Sprenger N., Yap I. K., Lundstedt T., Lek P., Rezzi S., Ramadan Z., van Bladeren P., Fay L. B., Kochhar S., Lindon J. C., Holmes E., Nicholson J. K.: Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol. Syst. Biol., 2008;4:157
64. Maslowski K. M., Vieira A. T., Ng A., Kranich J., Sierro F., Yu D., Schilter H. C., Rolph M. S., Mackay F., Artis D., Xavier R. J., Teixeira M. M., Mackay C. R.: Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature, 2009;461:1282-1286
65. Membrez M., Blancher F., Jaquet M., Bibiloni R., Cani P. D., Burcelin R. G., Corthesy I., Macé K., Chou C. J.: Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. FASEB J., 2008;22:2416-2426
66. Murphy E. F., Cotter P. D., Healy S., Marques T. M., O'Sullivan O., Fouhy F., Clarke S. F., O'Toole P. W., Quigley E. M., Stanton C., Ross P. R., O'Doherty R. M., Shanahan F.: Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut, 2010;59:1635-1642
67. Neu J., Douglas-Escobar M., Lopez M.: Microbes and the developing gastrointestinal tract. Nutr. Clin. Pract., 2007;22:174-182
68. Nicholson J. K., Holmes E., Kinross J., Burcelin R., Gibson G., Jia W., Pettersson S.: Host-gut microbiota metabolic interactions. Science, 2012;336:1262-1267
69. Orrhage K., Nord C. E.: Factors controlling the bacterial colonization of the intestine in breastfed infants. Acta Paediatr. Suppl., 1999;88:47-57
70. Pai R., Kang G.: Microbes in the gut: a digestable account of host-symbiont interactions. Indian J. Med. Res., 2008;128:587-594
71. Palmer C., Bik E. M., Di Giulio D. B., Relman D. A., Brown P. O.: Development of the human infant intestinal microbiota. PLoS Biol., 2007;5:e177
72. Pappo I., Becovier H., Berry E. M., Freund H. R.: Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat. J. Surg. Res., 1991;51:106-112
73. Quigley E. M.: Gut microbiota and the role of probiotics in therapy. Curr. Opin. Pharmacol., 2011;11:593-603
74. Reinhardt C., Reigstad C. S., Bäckhed F.: Intestinal microbiota during infancy and its implications for obesity. J. Pediatr. Gastroenterol. Nutr., 2009;48:249-256
75. Roberfroid M. B.: Global view on functional foods: European perspectives. Brit. J. Nutr., 2002;88(Suppl. 2):S133-S138
76. Samuel B. S., Hansen E. E., Manchester J. K., Coutinho P. M., Henrissat B., Fulton R., Latreille P., Kim K., Wilson R. K., Gordon J. I.: Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut. Proc. Natl. Acad. Sci. USA, 2007;104:10643-10648
77. Schrezenmeir J., de Vrese M.: Probiotics, prebiotics, and synbiotics-approaching a definition. Am. J. Clin. Nutr., 2001;73(Suppl. 1):361s-364s
78. Schwiertz A., Taras D., Schäfer K., Beijer S., Bos N. A., Donus C., Hardt P. D.: Microbiota and SCFA in lean and overweight healthy subjects. Obesity, 2010;18:190-195
79. Shanahan F.: The host-microbe interface within the gut. Best Pract. Res. Clin. Gastroenterol., 2002;16:915-931
80. Shanahan F., Murphy E.: The hybrid science of diet, microbes, and metabolic health. Am. J. Clin. Nutr., 2011;94:1-2
81. Sonnenburg J. L., Chen C. T., Gordon J. I.: Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host. PLoS Biol., 2006;4:e413
82. Staiger H., Machicao F., Fritsche A., Häring H. U.: Pathomechanisms of type 2 diabetes genes. Endocr. Rev., 2009;30:557-585
83. Stappenbeck T. S., Hooper L. V., Gordon J. I.: Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc. Natl. Acad. Sci. USA, 2002;99:15451-15455
84. Stephani J., Radulovic K., Niess J. H.: Gut microbiota, probiotics and inflammatory bowel disease. Arch. Immunol. Ther. Exp., 2011;59:161-177
85. Swann J. R., Want E. J., Geier F. M., Spagou K., Wilson I. D., Sidaway J. E., Nicholson J. K., Holmes E.: Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc. Natl. Acad. Sci. USA, 2011;108(Suppl. 1):4523-4530
86. Thomas C., Gioiello A., Noriega L., Strehle A., Oury J., Rizzo G., Macchiarulo A., Yamamoto H., Mataki C., Pruzanski M., Pellicciari R., Auwerx J., Schoonjans K.: TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab., 2009;10:167-177
87. Turnbaugh P. J., Ley R. E., Mahowald M. A., Magrini V., Mardis E. R., Gordon J. I.: An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 2006;444:1027-1031
88. Turnbaugh P. J., Quince C., Faith J. J., McHardy A. C., Yatsunenko T., Niazi F., Affourtit J., Egholm M., Henrissat B., Knight R., Gordon J. I.: Organismal, genetic, and transcriptional variation in the deeply sequenced gut microbiomes of identical twins. Proc. Natl. Acad. Sci. USA, 2010;107:7503-7508
89. Turnbaugh P. J., Ridaura V. K., Faith J. J., Rey F. E., Knight R., Gordon J. I.: The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci. Transl. Med., 2009;1:6ra14
90. Vael C., Verhulst S. L., Nelen V., Goossens H., Desager K. N.: Intestinal microflora and body mass index during the first three years of life: an observational study. Gut Pathog., 2011;3:8
91. Venema K.: Role of gut microbiota in the control of energy and carbohydrate metabolism. Curr. Opin. Clin. Nutr. Metab. Care, 2010;13:432-438
92. Vijay-Kumar M., Aitken J. D., Carvalho F. A., Cullender T. C., Mwangi S., Srinivasan S., Sitaraman S. V., Knight R., Ley R. E., Gewirtz A. T.: Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science, 2010;328:228-231
93. Vilsbøll T., Krarup T., Madsbad S., Holst J. J.: Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects. Regul. Pept., 2003;114:115-121
94. Watanabe M., Houten S. M., Mataki C., Christoffolete M. A., Kim B. W., Sato H., Messaddeq N., Harney J. W., Ezaki O., Kodama T., Schoonjans K., Bianco A. C., Auwerx J.: Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature, 2006;439:484-489
95. Wen L., Ley R. E., Volchkov P. Y., Stranges P. B., Avanesyan L., Stonebraker A. C., Hu C., Wong F. S., Szot G. L., Bluestone J. A., Gordon J. I., Chervonsky A. V.: Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature, 2008;455:1109-1113
96. Wong J. M., de Souza R., Kendall C. W., Emam A., Jenkins D. J.: Colonic health: fermentation and short chain fatty acids. J. Clin. Gastroenterol., 2006;40:235-243
97. Zwielehner J., Liszt K., Handschur M., Lassl C., Lapin A., Haslberger A. G.: Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly. Exp. Gerontol., 2009;44:440-446