Mineralocorticoid and SGK1-sensitive inflammation and tissue fibrosis

Nephron - Physiology

Volumn 128, Issue 1-2, 2014, Pages 35-39

  Artunc, Ferruh ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Connective tissue growth factor; Mineralocorticoid receptor; SGK1; TH< inf>17 cells; TGF

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; EPLERENONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MINERALOCORTICOID; PHOSPHATIDYLINOSITOL 3 KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SMAD2 PROTEIN; SMAD3 PROTEIN; SPIRONOLACTONE; TRANSFORMING GROWTH FACTOR BETA; MINERALOCORTICOID RECEPTOR; PROTEIN SERINE THREONINE KINASE;

CELIAC DISEASE; CROHN DISEASE; DIABETIC NEPHROPATHY; FIBROSIS; GLOMERULONEPHRITIS; HEART MUSCLE FIBROSIS; INFLAMMATION; KIDNEY DISEASE; KIDNEY FIBROSIS; LIVER CIRRHOSIS; LUNG FIBROSIS; NEPHROTIC SYNDROME; PANCREATITIS; PERITONEAL FIBROSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVIEW; TH17 CELL; UPREGULATION; VASCULAR FIBROSIS; ANIMAL; MOUSE; PHYSIOLOGY; RAT;

ANIMALS; FIBROSIS; INFLAMMATION; MICE; MINERALOCORTICOIDS; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, MINERALOCORTICOID; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84928326296     PISSN: None     EISSN: 16602137     Source Type: Journal    
DOI: 10.1159/000368267     Document Type: Review

References (74)

1. Briet M, Schiffrin EL: Aldosterone: effects on the kidney and cardiovascular system. Nat Rev Nephrol 2010; 6: 261-273.
2. Pearce D, Bhargava A, Cole TJ: Aldosterone: its receptor, target genes, and actions. Vitam Horm 2003; 66: 29-76.
3. Tomaschitz A, Ritz E, Pieske B, Rus-Machan J, Kienreich K, Verheyen N, Gaksch M, Grubler M, Fahrleitner-Pammer A, Mrak P, Toplak H, Kraigher-Krainer E, Marz W, Pilz S: Aldosterone and parathyroid hormone interactions as mediators of metabolic and cardiovascular disease. Metabolism 2014; 63: 20-31.
4. Sakai RR, McEwen BS, Fluharty SJ, Ma LY: The amygdala: site of genomic and nongenomic arousal of aldosterone-induced sodium intake. Kidney Int 2000; 57: 1337-1345.
5. Vallon V, Huang DY, Grahammer F, Wyatt AW, Osswald H, Wulff P, Kuhl D, Lang F: SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess. Am J Physiol Regul Integr Comp Physiol 2005; 289:R395-R401.
6. Funder JW: Aldosterone, hypertension and heart failure: insights from clinical trials. Hypertens Res 2010; 33: 872-875.
7. Lang F, Stournaras C, Alesutan I: Regulation of transport across cell membranes by the serum-and glucocorticoid-inducible kinase SGK1. Mol Membr Biol 2014; 31: 29-36.
8. Azibani F, Fazal L, Chatziantoniou C, Samuel JL, Delcayre C: Aldosterone mediates cardiac fibrosis in the setting of hypertension. Curr Hypertens Rep 2013; 15: 395-400.
9. Bae EH, Kim IJ, Joo SY, Kim EY, Kim CS, Choi JS, Ma SK, Kim SH, Lee JU, Kim SW: Renoprotective effects of sildenafil in DOCAsalt hypertensive rats. Kidney Blood Press Res 2012; 36: 248-257.
10. Briet M, Schiffrin EL: Vascular actions of aldosterone. J Vasc Res 2013; 50: 89-99.
11. Chen H, Zhou Y, Chen KQ, An G, Ji SY, Chen QK: Anti-fibrotic effects via regulation of transcription factor Sp1 on hepatic stellate cells. Cell Physiol Biochem 2012; 29: 51-60.
12. Lahmer T, Hermans R, Schmaderer C, Chang J, Stock K, Lutz J, Heemann U, Baumann M: Mineralocorticoid receptor antagonism and aldosterone synthesis inhibition do not improve glomerulosclerosis and renal interstitial fibrosis in a model of chronic kidney allograft injury. Kidney Blood Press Res 2012; 35: 561-567.
13. Makowka A, Olejniczak-Fortak M, Nowicki M: A comparison of the antihypertensive and anti-inflammatory effects of aliskiren and ramipril add-on therapy in peritoneal dialysis patients-a pilot open label study. Kidney Blood Press Res 2012; 36: 18-25.
14. Okazaki A, Mori Y, Nakata M, Kimura T, Sonomura K, Sakoda C, Matsuoka E, Ishida M, Yamahara H, Kishimoto N, Nakagawa H, Matsubara H: Peritoneal mesothelial cells as a target of local aldosterone action: upregulation of connective tissue growth factor expression via serum-and glucocorticoid-inducible protein kinase 1. Kidney Blood Press Res 2009; 32: 151-160.
15. Schiffrin EL: Immune mechanisms in hypertension and vascular injury. Clin Sci (Lond) 2014; 126: 267-274.
16. Schiffrin EL: The immune system: role in hypertension. Can J Cardiol 2013; 29: 543-548.
17. Yamahara H, Kishimoto N, Nakata M, Okazaki A, Kimura T, Sonomura K, Matsuoka E, Shiotsu Y, Adachi T, Matsubara H, Iwasaka T, Mori Y: Direct aldosterone action as a profibrotic factor via ROS-mediated SGK1 in peritoneal fibroblasts. Kidney Blood Press Res 2009; 32: 185-193.
18. Amador CA, Barrientos V, Pena J, Herrada AA, Gonzalez M, Valdes S, Carrasco L, Alzamora R, Figueroa F, Kalergis AM, Michea L: Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T-helper 17 and the downregulation of regulatory T lymphocytes. Hypertension 2014; 63: 797-803.
19. Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA: Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013; 496: 518-522.
20. Liu G, Liu G, Alzoubi K, Umbach AT, Pelzl L, Borst O, Gawaz M, Lang F: Upregulation of store operated Ca channel Orai1, stimulation of Ca entry and triggering of cell membrane scrambling in platelets by mineralocorticoid DOCA. Kidney Blood Press Res 2014; 38: 21-30.
21. Langer HF, Bigalke B, Seizer P, Stellos K, Fateh-Moghadam S, Gawaz M: Interaction of platelets and inflammatory endothelium in the development and progression of coronary artery disease. Semin Thromb Hemost 2010; 36: 131-138.
22. Seizer P, Gawaz M, May AE: Platelet-monocyte interactions-a dangerous liaison linking thrombosis, inflammation and atherosclerosis. Curr Med Chem 2008; 15: 1976-1980.
23. Koenig JB, Jaffe IZ: Direct role for smooth muscle cell mineralocorticoid receptors in vascular remodeling: novel mechanisms and clinical implications. Curr Hypertens Rep 2014; 16: 427.
24. Brown NJ: Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Nat Rev Nephrol 2013; 9: 459-469.
25. Kiyomoto H, Rafiq K, Mostofa M, Nishiyama A: Possible underlying mechanisms responsible for aldosterone and mineralocorticoid receptor-dependent renal injury. J Pharmacol Sci 2008; 108: 399-405.
26. Lee TM, Chung TH, Lin SZ, Chang NC: Endothelin receptor blockade ameliorates renal injury by inhibition of RhoA/Rho-kinase signalling in deoxycorticosterone acetate-salt hypertensive rats. J Hypertens 2014; 32: 795-805.
27. Grossmann C, Gekle M: Non-classical actions of the mineralocorticoid receptor: misuse of EGF receptors? Mol Cell Endocrinol 2007; 277: 6-12.
28. Williams JS: Evolving research in nongenomic actions of aldosterone. Curr Opin Endocrinol Diabetes Obes 2013; 20: 198-203.
29. Bansal S, Lindenfeld J, Schrier RW: Sodium retention in heart failure and cirrhosis: potential role of natriuretic doses of mineralocorticoid antagonist? Circ Heart Fail 2009; 2: 370-376.
30. McCurley A, Jaffe IZ: Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol 2012; 350: 256-265.
31. McCurley A, McGraw A, Pruthi D, Jaffe IZ: Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease. Pflugers Arch 2013; 465: 1661-1670.
32. Bienvenu LA, Reichelt ME, Delbridge LM, Young MJ: Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: a focus on the cardiomyocyte. Clin Sci (Lond) 2013; 125: 409-421.
33. Dabrowski R, Szwed H: Antiarrhythmic potential of aldosterone antagonists in atrial fibrillation. Cardiol J 2012; 19: 223-229.
34. Essick EE, Sam F: Cardiac hypertrophy and fibrosis in the metabolic syndrome: a role for aldosterone and the mineralocorticoid receptor. Int J Hypertens 2011; 2011: 346985.
35. Galuppo P, Bauersachs J: Mineralocorticoid receptor activation in myocardial infarction and failure: recent advances. Eur J Clin Invest 2012; 42: 1112-1120.
36. Messaoudi S, Azibani F, Delcayre C, Jaisser F: Aldosterone, mineralocorticoid receptor, and heart failure. Mol Cell Endocrinol 2012; 350: 266-272.
37. Nguyen Dinh Cat A, Jaisser F: Extrarenal effects of aldosterone. Curr Opin Nephrol Hypertens 2012; 21: 147-156.
38. Young MJ, Lam EY, Rickard AJ: Mineralocorticoid receptor activation and cardiac fibrosis. Clin Sci (Lond) 2007; 112: 467-475.
39. Young MJ, Rickard AJ: Mechanisms of mineralocorticoid salt-induced hypertension and cardiac fibrosis. Mol Cell Endocrinol 2012; 350: 248-255.
40. Zannad F, Gattis Stough W, Rossignol P, Bauersachs J, McMurray JJ, Swedberg K, Struthers AD, Voors AA, Ruilope LM, Bakris GL, O'Connor CM, Gheorghiade M, Mentz RJ, Cohen-Solal A, Maggioni AP, Beygui F, Filippatos GS, Massy ZA, Pathak A, Pina IL, Sabbah HN, Sica DA, Tavazzi L, Pitt B: Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice. Eur Heart J 2012; 33: 2782-2795.
41. Artunc F, Amann K, Nasir O, Friedrich B, Sandulache D, Jahovic N, Risler T, Vallon V, Wulff P, Kuhl D, Lang F: Blunted DOCA/high salt induced albuminuria and renal tubulointerstitial damage in gene-targeted mice lacking SGK1. J Mol Med (Berl) 2006; 84: 737-746.
42. Nishiyama A, Hitomi H, Rahman A, Kiyomoto H: Drug discovery for overcoming chronic kidney disease: pharmacological effects of mineralocorticoid-receptor blockers. J Pharmacol Sci 2009; 109: 1-6.
43. Rafiq K, Hitomi H, Nakano D, Nishiyama A: Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney. J Pharmacol Sci 2011; 115: 1-7.
44. Ronconi V, Turchi F, Appolloni G, di Tizio V, Boscaro M, Giacchetti G: Aldosterone, mineralocorticoid receptor and the metabolic syndrome: role of the mineralocorticoid receptor antagonists. Curr Vasc Pharmacol 2012; 10: 238-246.
45. Lang F, Stournaras C: Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth. Hormones (Athens) 2013; 12: 160-171.
46. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V: (Patho)physiological significance of the serum-and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006; 86: 1151-1178.
47. Liu SL, Schmuck S, Chorazcyzewski JZ, Gros R, Feldman RD: Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation. Circulation 2003; 108: 2400-2406.
48. Mutoh A, Isshiki M, Fujita T: Aldosterone enhances ligand-stimulated nitric oxide production in endothelial cells. Hypertens Res 2008; 31: 1811-1820.
49. Pasham V, Rotte A, Gu S, Yang W, Bhandaru M, Rexhepaj R, Pathare G, Lang F: Upregulation of intestinal NHE3 following saline ingestion. Kidney Blood Press Res 2013; 37: 48-57.
50. Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK: Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 2013; 496: 513-517.
51. Vallon V, Wyatt AW, Klingel K, Huang DY, Hussain A, Berchtold S, Friedrich B, Grahammer F, Belaiba RS, Gorlach A, Wulff P, Daut J, Dalton ND, Ross J Jr, Flogel U, Schrader J, Osswald H, Kandolf R, Kuhl D, Lang F: SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment. J Mol Med (Berl) 2006; 84: 396-404.
52. Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J: Serum-and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int 2010; 78: 668-678.
53. Szebeni B, Vannay A, Sziksz E, Prokai A, Cseh A, Veres G, Dezsofi A, Gyorffy H, Szabo IR, Arato A: Increased expression of serum-and glucocorticoid-regulated kinase-1 in the duodenal mucosa of children with coeliac disease. J Pediatr Gastroenterol Nutr 2010; 50: 147-153.
54. Akhurst RJ, Hata A: Targeting the TGF-? signalling pathway in disease. Nat Rev Drug Discov 2012; 11: 790-811.
55. Li W, Cui M, Wei Y, Kong X, Tang L, Xu D: Inhibition of the expression of TGF-? 1 and CTGF in human mesangial cells by exendin-4, a glucagon-like peptide-1 receptor agonist. Cell Physiol Biochem 2012; 30: 749-757.
56. MacDonald EM, Cohn RD: TGF-? signaling: its role in fibrosis formation and myopathies. Curr Opin Rheumatol 2012; 24: 628-634.
57. Rassler B, Marx G, Schierle K, Zimmer HG: Catecholamines can induce pulmonary remodeling in rats. Cell Physiol Biochem 2012; 30: 1134-1147.
58. Roos M, Heinemann FM, Lindemann M, Horn PA, Lutz J, Stock K, Thurmel K, Baumann M, Witzke O, Heemann U: Fetuin-A pretransplant serum levels, kidney allograft function and rejection episodes: a 3-year posttransplantation follow-up. Kidney Blood Press Res 2011; 34: 328-333.
59. Wang HR, Chen DL, Zhao M, Shu SW, Xiong SX, Gan XD, Chao SP, Cao JL: C-reactive protein induces interleukin-6 and thrombospondin-1 protein and mRNA expression through activation of nuclear factor-?B in HK-2 cells. Kidney Blood Press Res 2012; 35: 211-219.
60. Shih VF, Tsui R, Caldwell A, Hoffmann A: A single NF?B system for both canonical and non-canonical signaling. Cell Res 2011; 21: 86-102.
61. Stone KP, Kastin AJ, Pan W: NF?B is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia. Cell Physiol Biochem 2011; 28: 115-124.
62. Tsai V, Parker WE, Orlova KA, Baybis M, Chi AW, Berg BD, Birnbaum JF, Estevez J, Okochi K, Sarnat HB, Flores-Sarnat L, Aronica E, Crino PB: Fetal brain mTOR signaling activation in tuberous sclerosis complex. Cereb Cortex 2014; 24: 315-327.
63. Chilukoti RK, Mostertz J, Bukowska A, Aderkast C, Felix SB, Busch M, Volker U, Goette A, Wolke C, Homuth G, Lendeckel U: Effects of irbesartan on gene expression revealed by transcriptome analysis of left atrial tissue in a porcine model of acute rapid pacing in vivo. Int J Cardiol 2013; 168: 2100-2108.
64. Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J: Serum-glucocorticoid regulated kinase-1 regulates alternatively activated macrophage polarization contributing to angiotensin IIinduced inflammation and cardiac fibrosis. Arterioscler Thromb Vasc Biol 2012; 32: 1675-1686.
65. Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Bostrom P, Morissette MR, Del Monte F, Begley MJ, Cantley LC, Ellinor PT, Tomaselli GF, Rosenzweig A: Pathological role of serum-and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation 2012; 126: 2208-2219.
66. Voelkl J, Lin Y, Alesutan I, Ahmed MS, Pasham V, Mia S, Gu S, Feger M, Saxena A, Metzler B, Kuhl D, Pichler BJ, Lang F: Sgk1 sensitivity of Na +/H + exchanger activity and cardiac remodeling following pressure overload. Basic Res Cardiol 2012; 107: 236.
67. Lucisano S, Buemi M, Passantino A, Aloisi C, Cernaro V, Santoro D: New insights on the role of vitamin D in the progression of renal damage. Kidney Blood Press Res 2013; 37: 667-678.
68. Ma TK, Szeto CC: Mineralocorticoid receptor antagonist for renal protection. Ren Fail 2012; 34: 810-817.
69. Markowitz M, Messineo F, Coplan NL: Aldosterone receptor antagonists in cardiovascular disease: a review of the recent literature and insight into potential future indications. Clin Cardiol 2012; 35: 605-609.
70. Nagata K: Mineralocorticoid antagonism and cardiac hypertrophy. Curr Hypertens Rep 2008; 10: 216-221.
71. Namsolleck P, Unger T: Aldosterone synthase inhibitors in cardiovascular and renal diseases. Nephrol Dial Transplant 2014; 29(suppl 1):i62-i68.
72. Tylicki L, Lizakowski S, Rutkowski P, Renke M, Sulikowska B, Heleniak Z, Donderski R, Bednarski R, Przybylska M, Manitius J, Rutkowski B: The enhanced renin-angiotensinaldosterone system pharmacological blockade-which is the best? Kidney Blood Press Res 2012; 36: 335-343.
73. Young MJ: Mechanisms of mineralocorticoid receptor-mediated cardiac fibrosis and vascular inflammation. Curr Opin Nephrol Hypertens 2008; 17: 174-180.
74. Lang F, Voelkl J: Therapeutic potential of serum and glucocorticoid inducible kinase inhibition. Expert Opin Investig Drugs 2013; 22: 701-714.