메뉴 건너뛰기




Volumn 50, Issue 2, 2013, Pages 89-99

Vascular actions of aldosterone

Author keywords

Arteries; Endothelial dysfunction; Genomic and nongenomic effects; Inflammation; Oxidative stress; Remodeling; Vascular stiffness; Vasoconstriction

Indexed keywords

ALDOSTERONE; ALDOSTERONE ANTAGONIST; ANGIOTENSIN II; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; EPLERENONE; G PROTEIN COUPLED RECEPTOR 30; LCI 699; MINERALOCORTICOID RECEPTOR; SODIUM CHLORIDE; SPIRONOLACTONE; UNCLASSIFIED DRUG;

EID: 84874229170     PISSN: 10181172     EISSN: 14230135     Source Type: Journal    
DOI: 10.1159/000345243     Document Type: Review
Times cited : (140)

References (87)
  • 1
    • 77951879058 scopus 로고    scopus 로고
    • Aldosterone: Effects on the kidney and cardiovascular system
    • Briet M, Schiffrin EL: Aldosterone: effects on the kidney and cardiovascular system. Nat Rev Nephrol 2010; 6: 261-273.
    • (2010) Nat Rev Nephrol , vol.6 , pp. 261-273
    • Briet, M.1    Schiffrin, E.L.2
  • 2
    • 2342642610 scopus 로고
    • Primary aldosteronism, a new clinical syndrome
    • Conn JW: Primary aldosteronism, a new clinical syndrome. J Lab Clin Med 1955; 45: 3-17.
    • (1955) J Lab Clin Med , vol.45 , pp. 3-17
    • Conn, J.W.1
  • 4
    • 0035569561 scopus 로고    scopus 로고
    • Schiffrin EL: ET(A) receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats
    • Park JB, Schiffrin EL: ET(A) receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats. Hypertension 2001; 37: 1444-1449.
    • (2001) Hypertension , vol.37 , pp. 1444-1449
    • Park, J.B.1
  • 5
    • 0036178760 scopus 로고    scopus 로고
    • Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: Role of endothelin-1
    • Park JB, Schiffrin EL: Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1. Am J Hypertens 2002; 15: 164-169.
    • (2002) Am J Hypertens , vol.15 , pp. 164-169
    • Park, J.B.1    Schiffrin, E.L.2
  • 6
    • 0030925069 scopus 로고    scopus 로고
    • Prevention of aortic fibrosis by spironolactone in spontaneously hypertensive rats
    • Benetos A, Lacolley P, Safar ME: Prevention of aortic fibrosis by spironolactone in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol 1997; 17: 1152-1156.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1152-1156
    • Benetos, A.1    Lacolley, P.2    Safar, M.E.3
  • 7
    • 0036791717 scopus 로고    scopus 로고
    • Spironolactone improves angiotensin-induced vascular changes and oxidative stress
    • Virdis A, Neves MF, Amiri F, Viel E, Touyz RM, Schiffrin EL: Spironolactone improves angiotensin-induced vascular changes and oxidative stress. Hypertension 2002; 40: 504-510.
    • (2002) Hypertension , vol.40 , pp. 504-510
    • Virdis, A.1    Neves, M.F.2    Amiri, F.3    Viel, E.4    Touyz, R.M.5    Schiffrin, E.L.6
  • 9
    • 33644645135 scopus 로고    scopus 로고
    • C-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats
    • Callera GE, Montezano AC, Yogi A, Tostes RC, He Y, Schiffrin EL, Touyz RM: c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension 2005; 46: 1032-1038.
    • (2005) Hypertension , vol.46 , pp. 1032-1038
    • Callera, G.E.1    Montezano, A.C.2    Yogi, A.3    Tostes, R.C.4    He, Y.5    Schiffrin, E.L.6    Touyz, R.M.7
  • 11
    • 0037180412 scopus 로고    scopus 로고
    • Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: Effects of eplerenone
    • Lacolley P, Labat C, Pujol A, Delcayre C, Benetos A, Safar M: Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone. Circulation 2002; 106: 2848-2853.
    • (2002) Circulation , vol.106 , pp. 2848-2853
    • Lacolley, P.1    Labat, C.2    Pujol, A.3    Delcayre, C.4    Benetos, A.5    Safar, M.6
  • 12
    • 0031406824 scopus 로고    scopus 로고
    • Association between increased plasma levels of aldosterone and decreased systemic arterial compliance in subjects with essential hypertension
    • Blacher J, Amah G, Girerd X, Kheder A, Ben Mais H, London GM, Safar ME: Association between increased plasma levels of aldosterone and decreased systemic arterial compliance in subjects with essential hypertension. Am J Hypertens 1997; 10: 1326-1334.
    • (1997) Am J Hypertens , vol.10 , pp. 1326-1334
    • Blacher, J.1    Amah, G.2    Girerd, X.3    Kheder, A.4    Ben Mais, H.5    London, G.M.6    Safar, M.E.7
  • 13
    • 20844447008 scopus 로고    scopus 로고
    • Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension
    • Safar ME, Cattan V, Lacolley P, Nzietchueng R, Labat C, Lajemi M, de Luca N, Benetos A: Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension. J Hypertens 2005; 23: 1159-1166.
    • (2005) J Hypertens , vol.23 , pp. 1159-1166
    • Safar, M.E.1    Cattan, V.2    Lacolley, P.3    Nzietchueng, R.4    Labat, C.5    Lajemi, M.6    De Luca, N.7    Benetos, A.8
  • 14
    • 0027081410 scopus 로고
    • Mineralocorticoid excess, dietary sodium, and myocardial fibrosis
    • Brilla CG, Weber KT: Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J Lab Clin Med 1992; 120: 893-901.
    • (1992) J Lab Clin Med , vol.120 , pp. 893-901
    • Brilla, C.G.1    Weber, K.T.2
  • 16
    • 31744433843 scopus 로고    scopus 로고
    • Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signalregulated kinases NAD(P)H oxidase/lectinlike oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats
    • Nakano S, Kobayashi N, Yoshida K, Ohno T, Matsuoka H: Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signalregulated kinases, NAD(P)H oxidase/lectinlike oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats. Hypertens Res 2005; 28: 925-936.
    • (2005) Hypertens Res , vol.28 , pp. 925-936
    • Nakano, S.1    Kobayashi, N.2    Yoshida, K.3    Ohno, T.4    Matsuoka, H.5
  • 17
    • 0036893647 scopus 로고    scopus 로고
    • Selective aldosterone blockade prevents angiotensin II/saltinduced vascular inflammation in the rat heart
    • Rocha R, Martin-Berger CL, Yang P, Scherrer R, Delyani J, McMahon E: Selective aldosterone blockade prevents angiotensin II/saltinduced vascular inflammation in the rat heart. Endocrinology 2002; 143: 4828-4836.
    • (2002) Endocrinology , vol.143 , pp. 4828-4836
    • Rocha, R.1    Martin-Berger, C.L.2    Yang, P.3    Scherrer, R.4    Delyani, J.5    McMahon, E.6
  • 18
    • 33845603497 scopus 로고    scopus 로고
    • Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase
    • Johar S, Cave AC, Narayanapanicker A, Grieve DJ, Shah AM: Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J 2006; 20: 1546-1548.
    • (2006) FASEB J , vol.20 , pp. 1546-1548
    • Johar, S.1    Cave, A.C.2    Narayanapanicker, A.3    Grieve, D.J.4    Shah, A.M.5
  • 20
    • 80051964047 scopus 로고    scopus 로고
    • Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: Role of PDGFR
    • Callera GE, Yogi A, Briones AM, Montezano AC, He Y, Tostes RC, Schiffrin EL, Touyz RM: Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR. Cardiovasc Res 2011; 91: 720-731.
    • (2011) Cardiovasc Res , vol.91 , pp. 720-731
    • Callera, G.E.1    Yogi, A.2    Briones, A.M.3    Montezano, A.C.4    He, Y.5    Tostes, R.C.6    Schiffrin, E.L.7    Touyz, R.M.8
  • 21
    • 40849083771 scopus 로고    scopus 로고
    • Aldosterone induces superoxide generation via Rac1 activation in endothelial cells
    • Iwashima F, Yoshimoto T, Minami I, Sakurada M, Hirono Y, Hirata Y: Aldosterone induces superoxide generation via Rac1 activation in endothelial cells. Endocrinology 2008; 149: 1009-1014.
    • (2008) Endocrinology , vol.149 , pp. 1009-1014
    • Iwashima, F.1    Yoshimoto, T.2    Minami, I.3    Sakurada, M.4    Hirono, Y.5    Hirata, Y.6
  • 23
    • 44949169677 scopus 로고    scopus 로고
    • Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion
    • Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ: Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res 2008; 102: 1359-1367.
    • (2008) Circ Res , vol.102 , pp. 1359-1367
    • Caprio, M.1    Newfell, B.G.2    La Sala, A.3    Baur, W.4    Fabbri, A.5    Rosano, G.6    Mendelsohn, M.E.7    Jaffe, I.Z.8
  • 24
    • 0036841807 scopus 로고    scopus 로고
    • Aldosterone-induced inflammation in the rat heart: Role of oxidative stress
    • Sun Y, Zhang J, Lu L, Chen SS, Quinn MT, Weber KT: Aldosterone-induced inflammation in the rat heart: role of oxidative stress. Am J Pathol 2002; 161: 1773-1781.
    • (2002) Am J Pathol , vol.161 , pp. 1773-1781
    • Sun, Y.1    Zhang, J.2    Lu, L.3    Chen, S.S.4    Quinn, M.T.5    Weber, K.T.6
  • 25
    • 2942685646 scopus 로고    scopus 로고
    • Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism
    • Nishizaka MK, Zaman MA, Green SA, Renfroe KY, Calhoun DA: Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism. Circulation 2004; 109: 2857-2861.
    • (2004) Circulation , vol.109 , pp. 2857-2861
    • Nishizaka, M.K.1    Zaman, M.A.2    Green, S.A.3    Renfroe, K.Y.4    Calhoun, D.A.5
  • 27
    • 0034651798 scopus 로고    scopus 로고
    • Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure
    • Farquharson CA, Struthers AD: Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure. Circulation 2000; 101: 594-597.
    • (2000) Circulation , vol.101 , pp. 594-597
    • Farquharson, C.A.1    Struthers, A.D.2
  • 31
    • 79551487567 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt
    • Griol-Charhbili V, Fassot C, Messaoudi S, Perret C, Agrapart V, Jaisser F: Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt. Hypertension 2011; 57: 238-244.
    • (2011) Hypertension , vol.57 , pp. 238-244
    • Griol-Charhbili, V.1    Fassot, C.2    Messaoudi, S.3    Perret, C.4    Agrapart, V.5    Jaisser, F.6
  • 39
    • 18844473100 scopus 로고
    • Effect of angiotensin II and deoxycorticosterone infusion on vascular angiotensin II receptors in rats
    • Schiffrin EL, Gutkowska J, Genest J: Effect of angiotensin II and deoxycorticosterone infusion on vascular angiotensin II receptors in rats. Am J Physiol 1984; 246:H608-H614.
    • (1984) Am J Physiol , vol.246
    • Schiffrin, E.L.1    Gutkowska, J.2    Genest, J.3
  • 40
    • 0022337756 scopus 로고
    • Effect of aldosterone on vascular angiotensin II receptors in the rat
    • Schiffrin EL, Franks DJ, Gutkowska J: Effect of aldosterone on vascular angiotensin II receptors in the rat. Can J Physiol Pharmacol 1985; 63: 1522-1527.
    • (1985) Can J Physiol Pharmacol , vol.63 , pp. 1522-1527
    • Schiffrin, E.L.1    Franks, D.J.2    Gutkowska, J.3
  • 41
    • 0027997406 scopus 로고
    • Vascular aldosterone: Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells
    • Hatakeyama H, Miyamori I, Fujita T, Takeda Y, Takeda R, Yamamoto H: Vascular aldosterone: biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells. J Biol Chem 1994; 269: 24316-24320.
    • (1994) J Biol Chem , vol.269 , pp. 24316-24320
    • Hatakeyama, H.1    Miyamori, I.2    Fujita, T.3    Takeda, Y.4    Takeda, R.5    Yamamoto, H.6
  • 45
    • 4444259683 scopus 로고    scopus 로고
    • Mechanism for aldosterone potentiation of angiotensin II-stimulated rat arterial smooth muscle cell proliferation
    • Xiao F, Puddefoot JR, Barker S, Vinson GP: Mechanism for aldosterone potentiation of angiotensin II-stimulated rat arterial smooth muscle cell proliferation. Hypertension 2004; 44: 340-345.
    • (2004) Hypertension , vol.44 , pp. 340-345
    • Xiao, F.1    Puddefoot, J.R.2    Barker, S.3    Vinson, G.P.4
  • 46
    • 24744471859 scopus 로고    scopus 로고
    • Aldosterone and angiotensin II synergistically induce mitogenic response in vascular smooth muscle cells
    • Min LJ, Mogi M, Li JM, Iwanami J, Iwai M, Horiuchi M: Aldosterone and angiotensin II synergistically induce mitogenic response in vascular smooth muscle cells. Circ Res 2005; 97: 434-442.
    • (2005) Circ Res , vol.97 , pp. 434-442
    • Min, L.J.1    Mogi, M.2    Li, J.M.3    Iwanami, J.4    Iwai, M.5    Horiuchi, M.6
  • 48
    • 52449122086 scopus 로고    scopus 로고
    • Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redoxsensitive RhoA pathways
    • Montezano AC, Callera GE, Yogi A, He Y, Tostes RC, He G, Schiffrin EL, Touyz RM: Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redoxsensitive RhoA pathways. Arterioscler Thromb Vasc Biol 2008; 28: 1511-1518.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1511-1518
    • Montezano, A.C.1    Callera, G.E.2    Yogi, A.3    He, Y.4    Tostes, R.C.5    He, G.6    Schiffrin, E.L.7    Touyz, R.M.8
  • 49
    • 84859050870 scopus 로고    scopus 로고
    • Angiotensin II-aldosterone interaction in human coronary microarteries involves GPR30 EGFR, and endothelial NO synthase
    • Batenburg WW, Jansen PM, van den Bogaerdt AJ, Danser AHJ: Angiotensin II-aldosterone interaction in human coronary microarteries involves GPR30, EGFR, and endothelial NO synthase. Cardiovasc Res 2012; 94: 136-143.
    • (2012) Cardiovasc Res , vol.94 , pp. 136-143
    • Batenburg, W.W.1    Jansen, P.M.2    Van Den Bogaerdt, A.J.3    Danser, A.H.J.4
  • 51
    • 0027396077 scopus 로고
    • Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats
    • Lariviere R, Thibault G, Schiffrin EL: Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats. Hypertension 1993; 21: 294-300.
    • (1993) Hypertension , vol.21 , pp. 294-300
    • Lariviere, R.1    Thibault, G.2    Schiffrin, E.L.3
  • 52
    • 0028934888 scopus 로고
    • Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats
    • Schiffrin EL, Lariviere R, Li JS, Sventek P, Touyz RM: Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats. Hypertension 1995; 25: 769-773.
    • (1995) Hypertension , vol.25 , pp. 769-773
    • Schiffrin, E.L.1    Lariviere, R.2    Li, J.S.3    Sventek, P.4    Touyz, R.M.5
  • 54
    • 0029092933 scopus 로고
    • Antihypertensive effect of an endothelin receptor antagonist in DOCAsalt spontaneously hypertensive rats
    • Schiffrin EL, Sventek P, Li JS, Turgeon A, Reudelhuber T: Antihypertensive effect of an endothelin receptor antagonist in DOCAsalt spontaneously hypertensive rats. Br J Pharmacol 1995; 115: 1377-1381.
    • (1995) Br J Pharmacol , vol.115 , pp. 1377-1381
    • Schiffrin, E.L.1    Sventek, P.2    Li, J.S.3    Turgeon, A.4    Reudelhuber, T.5
  • 55
    • 0031865858 scopus 로고    scopus 로고
    • Effect of chronic treatment with two different ET(A) selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats
    • Li JS, Turgeon A, Schiffrin EL: Effect of chronic treatment with two different ET(A) selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Am J Hypertens 1998; 11: 554-562.
    • (1998) Am J Hypertens , vol.11 , pp. 554-562
    • Li, J.S.1    Turgeon, A.2    Schiffrin, E.L.3
  • 56
    • 0038141826 scopus 로고    scopus 로고
    • Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling
    • Pu Q, Neves MF, Virdis A, Touyz RM, Schiffrin EL: Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension 2003; 42: 49-55.
    • (2003) Hypertension , vol.42 , pp. 49-55
    • Pu, Q.1    Neves, M.F.2    Virdis, A.3    Touyz, R.M.4    Schiffrin, E.L.5
  • 63
    • 0242525727 scopus 로고    scopus 로고
    • Aldosterone regulates vascular reactivity: Short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation
    • Liu SL, Schmuck S, Chorazcyzewski JZ, Gros R, Feldman RD: Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation. Circulation 2003; 108: 2400-2406.
    • (2003) Circulation , vol.108 , pp. 2400-2406
    • Liu, S.L.1    Schmuck, S.2    Chorazcyzewski, J.Z.3    Gros, R.4    Feldman, R.D.5
  • 64
    • 14244263221 scopus 로고    scopus 로고
    • Eplerenone blocks nongenomic effects of aldosterone on the Na +/H + exchanger, intracellular Ca 2+ levels, and vasoconstriction in mesenteric resistance vessels
    • Michea L, Delpiano AM, Hitschfeld C, Lobos L, Lavandero S, Marusic ET: Eplerenone blocks nongenomic effects of aldosterone on the Na +/H + exchanger, intracellular Ca 2+ levels, and vasoconstriction in mesenteric resistance vessels. Endocrinology 2005; 146: 973-980.
    • (2005) Endocrinology , vol.146 , pp. 973-980
    • Michea, L.1    Delpiano, A.M.2    Hitschfeld, C.3    Lobos, L.4    Lavandero, S.5    Marusic, E.T.6
  • 65
    • 45849093226 scopus 로고    scopus 로고
    • Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: Possible role of AT1 receptor dimerization
    • Yamada M, Kushibiki M, Osanai T, Tomita H, Okumura K: Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization. Cardiovasc Res 2008; 79: 169-178.
    • (2008) Cardiovasc Res , vol.79 , pp. 169-178
    • Yamada, M.1    Kushibiki, M.2    Osanai, T.3    Tomita, H.4    Okumura, K.5
  • 67
    • 0028928768 scopus 로고
    • Rapid effects of aldosterone on sodium transport in vascular smooth muscle cells
    • Christ M, Douwes K, Eisen C, Bechtner G, Theisen K, Wehling M: Rapid effects of aldosterone on sodium transport in vascular smooth muscle cells. Hypertension 1995; 25: 117-123.
    • (1995) Hypertension , vol.25 , pp. 117-123
    • Christ, M.1    Douwes, K.2    Eisen, C.3    Bechtner, G.4    Theisen, K.5    Wehling, M.6
  • 68
    • 0029046443 scopus 로고
    • Nongenomic effects of aldosterone on intracellular Ca 2+ in vascular smooth muscle cells
    • Wehling M, Neylon CB, Fullerton M, Bobik A, Funder JW: Nongenomic effects of aldosterone on intracellular Ca 2+ in vascular smooth muscle cells. Circ Res 1995; 76: 973-979.
    • (1995) Circ Res , vol.76 , pp. 973-979
    • Wehling, M.1    Neylon, C.B.2    Fullerton, M.3    Bobik, A.4    Funder, J.W.5
  • 71
    • 34548207763 scopus 로고    scopus 로고
    • Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: The Framingham Offspring Study
    • Ingelsson E, Pencina MJ, Tofler GH, Benjamin EJ, Lanier KJ, Jacques PF, Fox CS, Meigs JB, Levy D, Larson MG, et al: Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation 2007; 116: 984-992.
    • (2007) Circulation , vol.116 , pp. 984-992
    • Ingelsson, E.1    Pencina, M.J.2    Tofler, G.H.3    Benjamin, E.J.4    Lanier, K.J.5    Jacques, P.F.6    Fox, C.S.7    Meigs, J.B.8    Levy, D.9    Larson, M.G.10
  • 74
    • 0033158374 scopus 로고    scopus 로고
    • Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women
    • Goodfriend TL, Kelley DE, Goodpaster BH, Winters SJ: Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. Obes Res 1999; 7: 355-362.
    • (1999) Obes Res , vol.7 , pp. 355-362
    • Goodfriend, T.L.1    Kelley, D.E.2    Goodpaster, B.H.3    Winters, S.J.4
  • 75
    • 0026506195 scopus 로고
    • In vitro effects of insulin on aldosterone production in rat zona glomerulosa cells
    • Petrasek D, Jensen G, Tuck M, Stern N: In vitro effects of insulin on aldosterone production in rat zona glomerulosa cells. Life Sci 1992; 50: 1781-1787.
    • (1992) Life Sci , vol.50 , pp. 1781-1787
    • Petrasek, D.1    Jensen, G.2    Tuck, M.3    Stern, N.4
  • 80
    • 80051931949 scopus 로고    scopus 로고
    • Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors
    • Nguyen Dinh Cat A, Briones AM, Callera GE, Yogi A, He Y, Montezano AC, Touyz RM: Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension 2011; 58: 479-488.
    • (2011) Hypertension , vol.58 , pp. 479-488
    • Nguyen Dinh Cat, A.1    Briones, A.M.2    Callera, G.E.3    Yogi, A.4    He, Y.5    Montezano, A.C.6    Touyz, R.M.7
  • 84
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure-Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J, Wittes J: The effect of spironolactone on morbidity and mortality in patients with severe heart failure-Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7    Wittes, J.8
  • 85
    • 38549140081 scopus 로고    scopus 로고
    • Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients
    • Savoia C, Touyz RM, Amiri F, Schiffrin EL: Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients. Hypertension 2008; 51: 432-439.
    • (2008) Hypertension , vol.51 , pp. 432-439
    • Savoia, C.1    Touyz, R.M.2    Amiri, F.3    Schiffrin, E.L.4
  • 86
    • 78149238346 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition with LCI699: A proof-of-concept study in patients with primary aldosteronism
    • Amar L, Azizi M, Menard J, Peyrard S, Watson C, Plouin PF: Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension 2010; 56: 831-838.
    • (2010) Hypertension , vol.56 , pp. 831-838
    • Amar, L.1    Azizi, M.2    Menard, J.3    Peyrard, S.4    Watson, C.5    Plouin, P.F.6
  • 87
    • 80255141746 scopus 로고    scopus 로고
    • Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: Results of a randomized, doubleblind, placebo-and active-controlled phase 2 trial
    • Calhoun DA, White WB, Krum H, Guo W, Bermann G, Trapani A, Lefkowitz MP, Menard J: Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, doubleblind, placebo-and active-controlled phase 2 trial. Circulation 2011; 124: 1945-1955.
    • (2011) Circulation , vol.124 , pp. 1945-1955
    • Calhoun, D.A.1    White, W.B.2    Krum, H.3    Guo, W.4    Bermann, G.5    Trapani, A.6    Lefkowitz, M.P.7    Menard, J.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.