Direct aldosterone action as a profibrotic factor via ROS-mediated SGK1 in peritoneal fibroblasts

Kidney and Blood Pressure Research

Volumn 32, Issue 3, 2009, Pages 185-193

  Yamahara, Hideki ^a   Kishimoto, Noriko ^b   Nakata, Midori ^b   Okazaki, Akiko ^b   Kimura, Taikou ^b   Sonomura, Kazuhiro ^b   Matsuoka, Eiko ^b   Shiotsu, Yayoi ^b   Adachi, Takaomi ^b   Matsubara, Hiroaki ^b   Iwasaka, Toshiji ^a   Mori, Yasukiyo ^b  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Aldosterone; Connective tissue growth factor; Fibroblasts; Peritoneal fibrosis; Reactive oxygen species; Serum and glucocorticoid inducible protein kinase 1

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 2; ALDOSTERONE; ALDOSTERONE SYNTHASE; APOCYNIN; CONNECTIVE TISSUE GROWTH FACTOR; LIPOFECTAMINE; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; OXYGEN; REACTIVE OXYGEN METABOLITE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SMALL INTERFERING RNA; SPIRONOLACTONE; TEMPOL;

ALDOSTERONE RELEASE; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; GENE SILENCING; GENETIC TRANSFECTION; IMMUNOCYTOCHEMISTRY; MALE; NONHUMAN; PERITONEAL DISEASE; PERITONEAL FIBROBLAST; PERITONEAL FIBROSIS; PERITONEUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; UPREGULATION;

ALDOSTERONE; ANIMALS; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; GENE EXPRESSION REGULATION; IMMEDIATE-EARLY PROTEINS; PERITONEAL FIBROSIS; PROTEIN-SERINE-THREONINE KINASES; RATS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 66749154806     PISSN: 14204096     EISSN: None     Source Type: Journal    
DOI: 10.1159/000225379     Document Type: Article

References (39)

1. Rombouts K, Wielant A, Hellemans K, Schuppan D, Geerts A: Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts. Br J Pharmacol 2001;134:224-232. (Pubitemid 32835486)
2. Nishiyama A, Yao L, Fan Y, Kyaw M, Kataoka N, Hashimoto K, Nagai Y, Nakamura E, Yoshizumi M, Shokoji T, Kimura S, Kiyomoto H, Tsujioka K, Kohno M, Tamaki T, Kajiya F, Abe Y: Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability. Hypertension 2005;45:710-716. (Pubitemid 40418370)
3. Fejes-Toth G, Pearce D, Naray-Fejes-Toth A: Subcellular localization of mineralocorticoid receptors in living cells: effects of receptor agonists and antagonists. Proc Natl Acad Sci USA 1998;95:2973-2978. (Pubitemid 28135839)
4. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DW, Evans RM: Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 1987;237:268-275. (Pubitemid 17095145)
5. Miyata K, Rahman M, Shokoji T, Nagai Y, Zhang GX, Sun GP, Kimura S, Yukimura T, Kiyomoto H, Kohno M, Abe Y, Nishiyama A: Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells. J Am Soc Nephrol 2005;16:2906-2912. (Pubitemid 44743488)
6. Nagai Y, Miyata K, Sun GP, Rahman M, Kimura S, Miyatake A, Kiyomoto H, Kohno M, Abe Y, Yoshizumi M, Nishiyama A: Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts. Hypertension 2005;46:1039-1045.
7. Ersoy R, Celik A, Yilmaz O, Sarioglu S, Sis B, Akan P, Yenicerioglu Y, Ormen M, Camsari T: The effects of irbesartan and spironolactone in prevention of peritoneal fibrosis in rat. Perit Dial Int 2007;27:424-431. (Pubitemid 47202195)
8. Nishimura H, Ito Y, Mizuno M, Tanaka A, Morita Y, Murayama S, Yuzawa Y, Matsuo S: Mineralocorticoid receptor blockade ameliorates peritoneal fibrosis in new rat peritonitis model. Am J Physiol Renal Physiol 2008;294:1084-1093.
9. Shibata S, Nagase M, Yoshida S, Kawachi H, Fujita T: Podocyte as the target for aldosterone: roles of oxidative stress and sgk1. Hypertension 2007;49:355-364. (Pubitemid 46143013)
10. Terada Y, Kuwana H, Kobayashi T, Okada T, Suzuki N, Yoshimoto T, Hirata Y, Sasaki S: Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium. J Am Soc Nephrol 2008;19:298-309. (Pubitemid 351240652)
11. BelAiba RS, Djordjevic T, Bonello S, Artunc F, Lang F, Hess J, Görlach A: The serum- and glucocorticoid-inducible kinase Sgk1 is involved in pulmonary vascular remodeling. Circ Research 2006;98:828-836.
12. Friedrich B, Wärntges S, Klingel K, Sauter M, Kandolf R, Risler T, Müller GA, Witzgall R, Kriz W, Gröne HJ, Lang F: Upregulation of the human serum and glucocorticoid-dependent kinase 1 in glomerulonephritis. Kidney Blood Press Res 2002;25:303-307. (Pubitemid 35356751)
13. Wärntges S, Klingel K, Weigert C, Fillon S, Buck M, Schleicher E, Rondemann HP, Knabbe C, Kandolf R, Lang F: Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis. Cell Physiol Biochem 2002;12:135-142. (Pubitemid 34665137)
14. Fillon S, Klingel K, Wärntges S, Sauter M, Gabrysch S, Pestel S, Tanneur V, Waldegger S, Zipfel A, Viebahn R, Häussinger D, Bröer S, Kandolf R, Lang F: Expression of the serine/threonine kinase hSGK1 in chronic viral hepatitis. Cell Physiol Biochem 2002;12:47-54. (Pubitemid 34253032)
15. Sirker A, Zhang M, Murdoch C, Shah AM: Involvement of NADPH oxidase in cardiac remodeling and heart failure. Am J Nephrol 2007;27:649-660. (Pubitemid 350014953)
16. Nishiyama A, Yao L, Nagai Y, Miyata K, Yoshizumi M, Kagami S, Kondo S, Kiyomoto H, Kimura S, Kohno M, Abe Y: Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension 2004;24:841-848. (Pubitemid 38405598)
17. Noh H, Kim JS, Han KH, Lee GT, Song JS, Chung SH, Jeon JS, Ha H, Lee HB: Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane. Kidney Int 2006;69:2022-2028. (Pubitemid 43924266)
18. Iglarz M, Touyz RM, Viel EC, Amiri F, Schiffrin EL: Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction with the renin-angiotensin system. Am J Hypertens 2004;17:597-603.
19. Hayashi H, Kobara M, Abe M, Tanaka N, Gouda E, Toba H, Yamada H, Tatsumi T, Nakata T, Matsubara H: Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis. Hypertens Res 2008;31:363-375.
20. Higuchi C, Tanihata T, Nishimura H, Naito T, Sanaka T: Effects of glucose and plasminogen activator inhibitor-1 on collagen metabolism in the peritoneum. Ther Apher Dial 2005;9:173-181. (Pubitemid 40734781)
21. Ogata S, Naito T, Yorioka N, Kiribayashi K, Kuratsune M, Kohno N: Effect of lactate and bicarbonate on human peritoneal mesothelial cells, fibroblasts and vascular endothelial cells, and the role of basic fibroblast growth factor. Nephrol Dial Transplant 2004;19:2831-2837. (Pubitemid 39480980)
22. Terada Y, Kobayashi T, Kuwana H, Tanaka H, Inoshita S, Kuwahara M, Sasaki S: Aldosterone stimulates proliferation of mesangial cells by activating mitogen-activated protein kinase 1/2, cyclin D1, and cyclin A. J Am Soc Nephrol 2005;16:2296-2305. (Pubitemid 41725047)
23. Luu-The V, Paquet N, Calvo E, Cumps J: Improved real-time RT-PCR method for highthroughput measurements using second derivative calculation and double correction. Biotechniques 2005;38:287-293. (Pubitemid 40216386)
24. Jiménez-Heffernan JA, Aguilera A, Aroeira LS, Lara-Pezzi E, Bajo MA, del Peso G, Ramírez M, Gamallo C, Sánchez-Tomero JA, Alvarez V, López-Cabrera M, Selgas R: Immunohistochemical characterization of fibroblast subpopulations in normal peritoneal tissue and in peritoneal dialysis-induced fibrosis. Virchows Arch 2004;443:247-256. (Pubitemid 38446437)
25. Sakai N, Wada T, Matsushima K, Bucala R, Iwai M, Horiuchi M, Kaneko S: The renin-angiotensin system contributes to renal fibrosis through regulation of fibrocytes. J Hypertens 2008;26:780-790. (Pubitemid 351354927)
26. Takeda M, Tatsumi T, Matsunaga S, Hayashi H, Kimata M, Honsho S, Nishikawa S, Mano A, Shiraishi J, Yamada H, Takahashi T, Matoba S, Kobara M, Matsubara H: Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts. Hypertens Res 2007;30:427-437. (Pubitemid 46958893)
27. +-dependent 11β-hydroxysteroid dehydrogenase in the human heart. J Mol Cell Cardiol 1996;28:781-787.
28. Takeda Y, Yoneda T, Demura M, Miyamori I, Mabuchi H: Cardiac aldosterone production in genetically hypertensive rats. Hypertension 2000;36:495-500. (Pubitemid 30778225)
29. Lai L, Chen J, Hao CM, Lin S, Gu Y: Aldosterone promotes fibronectin production through a Smad2-dependent TGF-β1 pathway in mesangial cells. Biochem Biophys Res Commun 2006;348:70-75. (Pubitemid 44163483)
30. Callera GE, Touyz RM, Tostes RC, Yogi A, He Y, Malkinson S, Schiffrin EL: Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension 2005;45:773-779. (Pubitemid 40418380)
31. Leong ML, Maiyar AC, Kim B, O'Keeffe BA, Firestone GL: Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem 2003;278:5871-5882. (Pubitemid 36800834)
32. Tanabe A, Naruse M, Hara Y, Sato A, Tsuchiya K, Nishikawa T, Imaki T, Takano K: Aldosterone antagonist facilitates the cardioprotective effects of angiotensin receptor blockers in hypertensive rats. J Hypertens 2004;22:1017-1023. (Pubitemid 38680478)
33. Gupta S, Clarkson MR, Duggan J, Brady HR: Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int 2000;58:1389-1399. (Pubitemid 30739645)
34. Yokoi H, Mukoyama M, Sugawara A, Mori K, Nagae T, Makino H, Suhanami T, Yahata K, Fujinaga Y, Tanaka I, Nakao K: Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis. Am J Physiol Renal Physiol 2002;282:F933-F942. (Pubitemid 34654499)
35. Hussain A, Wyatt AW, Wang K, Bhandaru M, Biswas R, Avram D, Föller M, Rexhepaj R, Friedrich B, Ullrich S, Müller G, Kuhl D, Risler T, Lang F: SGK1-dependent upregulation of connective tissue growth factor by angiotensin II. Kidney Blood Press Res 2008;31:80-86. (Pubitemid 351630064)
36. Vallon V, Wyatt AW, Klingel K, Huang DY, Hussain A, Berchtold S, Friedrich B, Grahammer F, Belaiba RS, Görlach A, Wulff P, Daut J, Dalton ND, Ross J Jr, Flögel U, Schrader J, Osswald H, Kandolf R, Kuhl D, Lang F: SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment. J Mol Med 2006;84:396-404. (Pubitemid 43673614)
37. Zarrinkalam KH, Stanley JM, Gray J, Oliver N, Faull RJ: Connective tissue growth factor and its regulation in the peritoneal cavity of peritoneal dialysis patients. Kidney Int 2003;64:331-338. (Pubitemid 36714188)
38. Oh KH, Margetts PJ: Cytokines and growth factors involved in peritoneal fibrosis of peritoneal dialysis patients. Int J Artif Organs 2005;28:129-134. (Pubitemid 40485211)
39. Van Westrhenen R, Aten J, Hajji N, de Boer OJ, Kunne C, de Waart DR, Krediet RT: Cyclosporin A induces peritoneal fibrosis and angiogenesis during chronic peritoneal exposure to a glucose-based, lactate-buffered dialysis solution in the rat. Blood Purif 2007;25:466-472. (Pubitemid 351194890)