메뉴 건너뛰기




Volumn 21, Issue 2, 2012, Pages 147-156

Extrarenal effects of aldosterone

Author keywords

aldosterone; fibrogenic and proinflammatory effects; metabolic syndrome; mineralocorticoid receptor; receptor tyrosine kinases

Indexed keywords

ALDOSTERONE; MINERALOCORTICOID RECEPTOR; REACTIVE OXYGEN METABOLITE; SPIRONOLACTONE;

EID: 84857041383     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32834fb25b     Document Type: Review
Times cited : (88)

References (140)
  • 1
    • 38749154752 scopus 로고    scopus 로고
    • The mineralocorticoid receptor: Insights into its molecular and (patho)physiological biology
    • Viengchareun S, Le Menuet D, Martinerie L, et al. The mineralocorticoid receptor: Insights into its molecular and (patho)physiological biology. Nucl Recept Signal 2007; 5:e012.
    • (2007) Nucl Recept Signal , vol.5
    • Viengchareun, S.1    Le Menuet, D.2    Martinerie, L.3
  • 2
    • 0041883742 scopus 로고    scopus 로고
    • Non-genomic actions of aldosterone: Mechanisms and consequences in kidney cells
    • DOI 10.1093/ndt/gfg265
    • Boldyreff B, Wehling M. Nongenomic actions of aldosterone: Mechanisms and consequences in kidney cells. Nephrol Dial Transplant 2003; 18:1693-1695. (Pubitemid 37098534)
    • (2003) Nephrology Dialysis Transplantation , vol.18 , Issue.9 , pp. 1693-1695
    • Boldyreff, B.1    Wehling, M.2
  • 4
    • 33645412965 scopus 로고    scopus 로고
    • Nongenomic actions of aldosterone: Physiological or pathophysiological role?
    • Mihailidou AS. Nongenomic actions of aldosterone: Physiological or pathophysiological role? Steroids 2006; 71:277-280.
    • (2006) Steroids , vol.71 , pp. 277-280
    • Mihailidou, A.S.1
  • 5
    • 84855642277 scopus 로고    scopus 로고
    • Nongenomic actions of aldosterone: From receptors and signals to membrane targets
    • doi:10.1016/j.mce.2011.07.019. [Epub ahead of print]
    • Dooley R, Harvey BJ, Thomas W. Nongenomic actions of aldosterone: From receptors and signals to membrane targets. Mol Cell Endocrinol 2011. doi:10.1016/j.mce.2011.07.019. [Epub ahead of print]
    • (2011) Mol Cell Endocrinol
    • Dooley, R.1    Harvey, B.J.2    Thomas, W.3
  • 6
    • 81155155589 scopus 로고    scopus 로고
    • Diverse immunostaining patterns of mineralocorticoid receptor monoclonal antibodies
    • Gomez-Sanchez CE, Warden M, Gomez-Sanchez MT, et al. Diverse immunostaining patterns of mineralocorticoid receptor monoclonal antibodies. Steroids 2011; 76:1541-1545.
    • (2011) Steroids , vol.76 , pp. 1541-1545
    • Gomez-Sanchez, C.E.1    Warden, M.2    Gomez-Sanchez, M.T.3
  • 7
    • 0026689952 scopus 로고
    • Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor
    • Lombés M, Oblin ME, Gasc JM, et al. Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor. Circ Res 1992; 71:503-510.
    • (1992) Circ Res , vol.71 , pp. 503-510
    • Lombés, M.1    Oblin, M.E.2    Gasc, J.M.3
  • 8
    • 77954942414 scopus 로고    scopus 로고
    • The mineralocorticoid receptor is a constitutive nuclear factor in cardiomyocytes due to hyperactive nuclear localization signals
    • Hernández-Díaz I, Giraldez T, ArnauMR, et al. The mineralocorticoid receptor is a constitutive nuclear factor in cardiomyocytes due to hyperactive nuclear localization signals. Endocrinology 2010; 151:3888-3899.
    • (2010) Endocrinology , vol.151 , pp. 3888-3899
    • Hernández-Díaz, I.1    Giraldez, T.2    Arnau, M.R.3
  • 9
    • 77954434421 scopus 로고    scopus 로고
    • The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure
    • Nguyen Dinh Cat A, Griol-Charhbili V, Loufrani L, et al. The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure. FASEB J 2010; 24:2454-2463.
    • (2010) FASEB J. , vol.24 , pp. 2454-2463
    • Nguyen Dinh Cat, A.1    Griol-Charhbili, V.2    Loufrani, L.3
  • 10
    • 80051931949 scopus 로고    scopus 로고
    • Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors
    • This study demonstrates that adipocyte-derived factors impact on proinflammatory mediators expression in vascular smooth muscle cells. This is mediated in part through aldosterone/mineralocorticoid receptor-dependent pathways, but also through aldosterone-independent mineralocorticoid receptor pathways
    • Nguyen Dinh Cat A, Briones AM, Callera GE, et al. Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension 2011; 58:479-488. This study demonstrates that adipocyte-derived factors impact on proinflammatory mediators expression in vascular smooth muscle cells. This is mediated in part through aldosterone/mineralocorticoid receptor-dependent pathways, but also through aldosterone-independent mineralocorticoid receptor pathways.
    • (2011) Hypertension , vol.58 , pp. 479-488
    • Nguyen Dinh Cat, A.1    Briones, A.M.2    Callera, G.E.3
  • 11
    • 34347406538 scopus 로고    scopus 로고
    • Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis
    • DOI 10.1096/fj.06-7970com
    • Caprio M, Fé ve B, Claës A, et al. Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis. FASEB J 2007; 21:2185-2194. (Pubitemid 47026453)
    • (2007) FASEB Journal , vol.21 , Issue.9 , pp. 2185-2194
    • Caprio, M.1    Feve, B.2    Claes, A.3    Viengchareun, S.4    Lombes, M.5    Zennaro, M.-C.6
  • 12
    • 78650805849 scopus 로고    scopus 로고
    • Antiadipogenic effects of the mineralocorticoid receptor antagonist drospirenone: Potential implications for the treatment of metabolic syndrome
    • This study demonstrates that a specific mineralocorticoid receptor antagonist, drospirenone, inhibits adipogenesis at the level of differentiation and proliferation of adipocytes, suggesting a direct role of aldosterone/mineralocorticoid receptor activation in these processes
    • Caprio M, Antelmi A, Chetrite G, et al. Antiadipogenic effects of the mineralocorticoid receptor antagonist drospirenone: Potential implications for the treatment of metabolic syndrome. Endocrinology 2011; 152:113-125. This study demonstrates that a specific mineralocorticoid receptor antagonist, drospirenone, inhibits adipogenesis at the level of differentiation and proliferation of adipocytes, suggesting a direct role of aldosterone/ mineralocorticoid receptor activation in these processes.
    • (2011) Endocrinology , vol.152 , pp. 113-125
    • Caprio, M.1    Antelmi, A.2    Chetrite, G.3
  • 13
    • 70349257487 scopus 로고    scopus 로고
    • Deletion of mineralocorticoid receptors from macrophages protects against DOC/salt-induced cardiac fibrosis and increased blood pressure
    • Rickard AJ, Morgan J, Tesch G, et al. Deletion of mineralocorticoid receptors from macrophages protects against DOC/salt-induced cardiac fibrosis and increased blood pressure. Hypertension 2009; 54:537-543.
    • (2009) Hypertension , vol.54 , pp. 537-543
    • Rickard, A.J.1    Morgan, J.2    Tesch, G.3
  • 14
    • 77956388193 scopus 로고    scopus 로고
    • Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice
    • doi: 10.1172/ JCI41080. This work demonstrates the contribution of myeloid cells to cardiovascular damage and hypertension and determined the role of mineralocorticoid receptor in modulating macrophage phenotype
    • Usher MG, Duan SZ, Ivaschenko CY, et al. Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice. J Clin Invest 2010; 120:3350-3364; doi: 10.1172/ JCI41080. This work demonstrates the contribution of myeloid cells to cardiovascular damage and hypertension and determined the role of mineralocorticoid receptor in modulating macrophage phenotype.
    • (2010) J Clin Invest , vol.120 , pp. 3350-3364
    • Usher, M.G.1    Duan, S.Z.2    Ivaschenko, C.Y.3
  • 15
    • 74949094864 scopus 로고    scopus 로고
    • The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon?
    • Farman N, Maubec E, Poeggeler B, et al. The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon? Exp Dermatol 2010; 19:100-107.
    • (2010) Exp Dermatol , vol.19 , pp. 100-107
    • Farman, N.1    Maubec, E.2    Poeggeler, B.3
  • 16
    • 59649109530 scopus 로고    scopus 로고
    • A new look at the eye: Aldosterone and mineralocorticoid receptors as novel targets in retinal vasculopathy
    • Touyz RM, Callera GE. A new look at the eye: Aldosterone and mineralocorticoid receptors as novel targets in retinal vasculopathy. Circ Res 2009; 104:9-11.
    • (2009) Circ Res , vol.104 , pp. 9-11
    • Touyz, R.M.1    Callera, G.E.2
  • 17
    • 77956628297 scopus 로고    scopus 로고
    • The neuroretina is a novel mineralocorticoid target: Aldosterone up-regulates ion and water channels in Müller glial cells
    • Zhao M, Valamanesh F, Celerier I, et al. The neuroretina is a novel mineralocorticoid target: Aldosterone up-regulates ion and water channels in Müller glial cells. FASEB J 2010; 24:3405-3415.
    • (2010) FASEB J. , vol.24 , pp. 3405-3415
    • Zhao, M.1    Valamanesh, F.2    Celerier, I.3
  • 18
    • 79955480850 scopus 로고    scopus 로고
    • Mineralocorticoid receptors in the brain and cardiovascular regulation: Minority rule?
    • Gomez-Sanchez EP. Mineralocorticoid receptors in the brain and cardiovascular regulation: Minority rule? Trends Endocrinol Metab 2011; 22:179-187.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 179-187
    • Gomez-Sanchez, E.P.1
  • 19
    • 79955622277 scopus 로고    scopus 로고
    • Mineralocorticoid receptor activation and blockade: An emerging paradigm in chronic kidney disease
    • Bertocchio JP, Warnock DG, Jaisser F. Mineralocorticoid receptor activation and blockade: An emerging paradigm in chronic kidney disease. Kidney Int 2011; 79:1051-1060.
    • (2011) Kidney Int , vol.79 , pp. 1051-1060
    • Bertocchio, J.P.1    Warnock, D.G.2    Jaisser, F.3
  • 21
    • 84856339877 scopus 로고    scopus 로고
    • Aldosterone, mineralocorticoid receptor, and heart failure
    • doi:10.1016/ j.mce.2011.06.038. [Epub ahead of print] This review summarizes the deleterious effects of aldosterone in the heart. The authors discuss interesting points related to the critical role of mineralocorticoid receptor antagonists in heart diseases, the importance of interaction between aldosterone and salt, angiotensin II and oxidative stress to induce fibrosis and elucidate the question of the ligand that is involved in mineralocorticoid receptor activation effects
    • Messaoudi S, Azibani F, Delcayre C, Jaisser F. Aldosterone, mineralocorticoid receptor, and heart failure. Mol Cell Endocrinol 2011. doi:10.1016/ j.mce.2011.06.038. [Epub ahead of print] This review summarizes the deleterious effects of aldosterone in the heart. The authors discuss interesting points related to the critical role of mineralocorticoid receptor antagonists in heart diseases, the importance of interaction between aldosterone and salt, angiotensin II and oxidative stress to induce fibrosis and elucidate the question of the ligand that is involved in mineralocorticoid receptor activation effects.
    • (2011) Mol Cell Endocrinol
    • Messaoudi, S.1    Azibani, F.2    Delcayre, C.3    Jaisser, F.4
  • 22
    • 84856346254 scopus 로고    scopus 로고
    • Mechanisms of mineralocorticoid salt-induced hypertension and cardiac fibrosis
    • doi:10. 1016/j.mce.2011.09.008. [Epub ahead of print] This review raises the question of the role of mineralocorticoid receptor activation in macrophages. Mineralocorticoid receptor may be important for the activation of tissue macrophages and the onset of fibrosis whereas vascular mineralocorticoid receptor (endothelial cell and vascular smooth muscle cell) and macrophage mineralocorticoid receptor contribute to the increased systolic blood pressure response
    • Young MJ, Rickard AJ. Mechanisms of mineralocorticoid salt-induced hypertension and cardiac fibrosis. Mol Cell Endocrinol 2011. doi:10. 1016/j.mce.2011.09.008. [Epub ahead of print] This review raises the question of the role of mineralocorticoid receptor activation in macrophages. Mineralocorticoid receptor may be important for the activation of tissue macrophages and the onset of fibrosis whereas vascular mineralocorticoid receptor (endothelial cell and vascular smooth muscle cell) and macrophage mineralocorticoid receptor contribute to the increased systolic blood pressure response.
    • (2011) Mol Cell Endocrinol
    • Young, M.J.1    Rickard, A.J.2
  • 24
    • 0035887191 scopus 로고    scopus 로고
    • Effect of successful electrical cardioversion on serum aldosterone in patients with persistent atrial fibrillation
    • DOI 10.1016/S0002-9149(01)01905-1, PII S0002914901019051
    • Goette A, Hoffmanns P, Enayati W, et al. Effect of successful electrical cardioversion on serum aldosterone in patients with persistent atrial fibrillation. Am J Cardiol 2001; 88:906-909. (Pubitemid 32995932)
    • (2001) American Journal of Cardiology , vol.88 , Issue.8 , pp. 906-909
    • Goette, A.1    Hoffmanns, P.2    Enayati, W.3    Meltendorf, U.4    Geller J.Christoph5    Klein, H.U.6
  • 25
    • 76449091669 scopus 로고    scopus 로고
    • Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation
    • Tsai CT, Chiang FT, Tseng CD, et al. Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation. J Am Coll Cardiol 2010; 55:758-770.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 758-770
    • Tsai, C.T.1    Chiang, F.T.2    Tseng, C.D.3
  • 26
    • 77950228107 scopus 로고    scopus 로고
    • Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing
    • Zhao J, Li J, Li W, et al. Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing. Br J Pharmacol 2010; 159:1584-1594.
    • (2010) Br J Pharmacol , vol.159 , pp. 1584-1594
    • Zhao, J.1    Li, J.2    Li, W.3
  • 27
    • 84865259929 scopus 로고    scopus 로고
    • Aldosterone promotes atrial fibrillation
    • doi:10.1093/eurheartj/ehr266. [Epub ahead of print] This study demonstrates that chronic aldosterone treatment disturbs atrial conduction without compromised ventricular haemodynamic function and electrical remodeling, suggesting a direct role of aldosterone in the pathogenesis of atrial fibrillation
    • Reil JC, Hohl M, Selejan S, et al. Aldosterone promotes atrial fibrillation. Eur Heart J 2011. doi:10.1093/eurheartj/ehr266. [Epub ahead of print] This study demonstrates that chronic aldosterone treatment disturbs atrial conduction without compromised ventricular haemodynamic function and electrical remodeling, suggesting a direct role of aldosterone in the pathogenesis of atrial fibrillation.
    • (2011) Eur Heart J.
    • Reil, J.C.1    Hohl, M.2    Selejan, S.3
  • 31
    • 66549118329 scopus 로고    scopus 로고
    • Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins
    • Gomez AM, Rueda A, Sainte-Marie Y, et al. Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins. Circulation 2009; 119:2179-2187.
    • (2009) Circulation , vol.119 , pp. 2179-2187
    • Gomez, A.M.1    Rueda, A.2    Sainte-Marie, Y.3
  • 32
    • 84875228346 scopus 로고    scopus 로고
    • Aldosterone induces electrical remodeling independent of hypertension
    • doi:10.1016/ j.ijcard.2011.06.100. [Epub ahead of print]
    • Dartsch T, Fischer R, Gapelyuk A, et al. Aldosterone induces electrical remodeling independent of hypertension. Int J Cardiol 2011. doi:10.1016/ j.ijcard.2011.06.100. [Epub ahead of print]
    • (2011) Int J Cardiol
    • Dartsch, T.1    Fischer, R.2    Gapelyuk, A.3
  • 33
    • 33745172144 scopus 로고    scopus 로고
    • Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart
    • De Mello WC. Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart. J Renin Angiotensin Aldosterone Syst 2006; 7:40-46. (Pubitemid 43891244)
    • (2006) JRAAS - Journal of the Renin-Angiotensin-Aldosterone System , vol.7 , Issue.1 , pp. 40-46
    • De Mello, W.C.1
  • 34
    • 61949425807 scopus 로고    scopus 로고
    • Gap junction remodeling and spironolactone-dependent reverse remodeling in the hypertrophied heart
    • Qu J, Volpicelli FM, Garcia LI, et al. Gap junction remodeling and spironolactone-dependent reverse remodeling in the hypertrophied heart. Circ Res 2009; 104:365-371.
    • (2009) Circ Res , vol.104 , pp. 365-371
    • Qu, J.1    Volpicelli, F.M.2    Garcia, L.I.3
  • 38
    • 34548500119 scopus 로고    scopus 로고
    • Aldosterone and end-organ damage
    • DOI 10.1042/CS20070123
    • Marney AM, Brown NJ. Aldosterone and end-organ damage. Clin Sci (Lond) 2007; 113:267-278. (Pubitemid 47372685)
    • (2007) Clinical Science , vol.113 , Issue.5-6 , pp. 267-278
    • Marney, A.M.1    Brown, N.J.2
  • 39
    • 0033710929 scopus 로고    scopus 로고
    • PKCepsilon modulates NF-kappaB and AP-1 via mitogen-Activated protein kinases in adult rabbit cardiomyocytes
    • Li RC, Ping P, Zhang J, et al. PKCepsilon modulates NF-kappaB and AP-1 via mitogen-Activated protein kinases in adult rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol 2000; 279:H1679-H1689.
    • (2000) Am J Physiol Heart Circ Physiol , vol.279
    • Li, R.C.1    Ping, P.2    Zhang, J.3
  • 40
    • 82955201853 scopus 로고    scopus 로고
    • Aldosterone-induced osteopontin gene transcription in vascular smooth muscle cells involves glucocorticoid response element
    • doi: 10.1038/hr.2011.119. [Epub ahead of print]
    • Kiyosue A, Nagata D, Myojo M, et al. Aldosterone-induced osteopontin gene transcription in vascular smooth muscle cells involves glucocorticoid response element. Hypertens Res 2011. doi: 10.1038/hr.2011.119. [Epub ahead of print]
    • (2011) Hypertens Res
    • Kiyosue, A.1    Nagata, D.2    Myojo, M.3
  • 41
    • 80051552165 scopus 로고    scopus 로고
    • Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways
    • Newfell BG, Iyer LK, Mohammad NN, et al. Aldosterone regulates vascular gene transcription via oxidative stress-dependent and -independent pathways. Arterioscler Thromb Vasc Biol 2011; 31:1871-1880.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1871-1880
    • Newfell, B.G.1    Iyer, L.K.2    Mohammad, N.N.3
  • 42
    • 78049438298 scopus 로고    scopus 로고
    • Placental growth factor mediates aldosterone-dependent vascular injury in mice
    • This study demonstrates the implication of vascular mineralocorticoid receptor activation directly through PGF synthesis in arterial remodeling after vascular injury
    • Jaffe IZ, Newfell BG, Aronovitz M, et al. Placental growth factor mediates aldosterone-dependent vascular injury in mice. J Clin Invest 2010; 120:3891-3900. This study demonstrates the implication of vascular mineralocorticoid receptor activation directly through PGF synthesis in arterial remodeling after vascular injury.
    • (2010) J Clin Invest , vol.120 , pp. 3891-3900
    • Jaffe, I.Z.1    Newfell, B.G.2    Aronovitz, M.3
  • 44
    • 33845603497 scopus 로고    scopus 로고
    • Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase
    • Johar S, Cave AC, Narayanapanicker A, et al. Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase. FASEB J 2006; 20:1546-1548.
    • (2006) FASEB J. , vol.20 , pp. 1546-1548
    • Johar, S.1    Cave, A.C.2    Narayanapanicker, A.3
  • 45
    • 33846963787 scopus 로고    scopus 로고
    • Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
    • Leopold JA, Dam A, Maron BA, et al. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med 2007; 13:189-197;
    • (2007) Nat Med , vol.13 , pp. 189-197
    • Leopold, J.A.1    Dam, A.2    Maron, B.A.3
  • 46
    • 69949174384 scopus 로고    scopus 로고
    • Erratum in
    • Erratum in: Nat Med 2009; 15:1093.
    • (2009) Nat Med , vol.15 , pp. 1093
  • 47
    • 0036791717 scopus 로고    scopus 로고
    • Spironolactone improves angiotensin induced vascular changes and oxidative stress
    • Virdis A, Neves MF, Amiri F, et al. Spironolactone improves angiotensin induced vascular changes and oxidative stress. Hypertension 2002; 40:504-510.
    • (2002) Hypertension , vol.40 , pp. 504-510
    • Virdis, A.1    Neves, M.F.2    Amiri, F.3
  • 49
    • 43449086995 scopus 로고    scopus 로고
    • New insights on signaling cascades induced by crosstalk between angiotensin II and aldosterone
    • Lemarié CA, Paradis P, Schiffrin EL. New insights on signaling cascades induced by crosstalk between angiotensin II and aldosterone. J Mol Med 2008; 86:673-678.
    • (2008) J Mol Med , vol.86 , pp. 673-678
    • Lemarié, C.A.1    Paradis, P.2    Schiffrin, E.L.3
  • 50
    • 57449102566 scopus 로고    scopus 로고
    • Crosstalk between mineralocorticoid and angiotensin II signaling for cardiac remodeling
    • Di Zhang A, Nguyen Dinh Cat A, Soukaseum C, et al. Crosstalk between mineralocorticoid and angiotensin II signaling for cardiac remodeling. Hypertension 2008; 52:1060-1067.
    • (2008) Hypertension , vol.52 , pp. 1060-1067
    • Di Zhang, A.1    Nguyen Dinh Cat, A.2    Soukaseum, C.3
  • 51
    • 67651131121 scopus 로고    scopus 로고
    • Actions of aldosterone in the cardiovascular system: The good, the bad, and the ugly?
    • Gekle M, Grossmann C. Actions of aldosterone in the cardiovascular system: The good, the bad, and the ugly? Pflugers Arch 2009; 458:231-246.
    • (2009) Pflugers Arch , vol.458 , pp. 231-246
    • Gekle, M.1    Grossmann, C.2
  • 52
    • 0024319420 scopus 로고
    • Cardiac interstitium in health and disease: The fibrillar collagen network
    • Weber KT. Cardiac interstitium in health and disease: The fibrillar collagen network. J Am Coll Cardiol 1989; 13:1637-1652. (Pubitemid 19145564)
    • (1989) Journal of the American College of Cardiology , vol.13 , Issue.7 , pp. 1637-1652
    • Weber, K.T.1
  • 53
    • 0025675680 scopus 로고
    • Remodeling of the rat right and left ventricles in experimental hypertension
    • Brilla CG, Pick R, Tan LB, et al. Remodeling of the rat right and left ventricles in experimental hypertension. Circ Res 1990; 67:1355-1364.
    • (1990) Circ Res , vol.67 , pp. 1355-1364
    • Brilla, C.G.1    Pick, R.2    Tan, L.B.3
  • 54
    • 85047680324 scopus 로고
    • Myocardial fibrosis: Functional significance and regulatory factors
    • Weber KT, Brilla CG, Janicki JS. Myocardial fibrosis: Functional significance and regulatory factors. Cardiovasc Res 1993; 27:341-348. (Pubitemid 23116130)
    • (1993) Cardiovascular Research , vol.27 , Issue.3 , pp. 341-348
    • Weber, K.T.1    Brilla, C.G.2    Janicki, J.S.3
  • 56
    • 0028840698 scopus 로고
    • Biological determinants of aldosterone-induced cardiac fibrosis in rats
    • Robert V, Silvestre JS, Charlemagne D, et al. Biological determinants of aldosterone-induced cardiac fibrosis in rats. Hypertension 1995; 26:971-978.
    • (1995) Hypertension , vol.26 , pp. 971-978
    • Robert, V.1    Silvestre, J.S.2    Charlemagne, D.3
  • 57
    • 0032949682 scopus 로고    scopus 로고
    • Molecular mechanisms of myocardial remodeling
    • Swynghedauw B. Molecular mechanisms of myocardial remodeling. Physiol Rev 1999; 79:215-262. (Pubitemid 29056953)
    • (1999) Physiological Reviews , vol.79 , Issue.1 , pp. 215-262
    • Swynghedauw, B.1
  • 58
    • 3042647297 scopus 로고    scopus 로고
    • Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone/salt-treated rats
    • DOI 10.1210/en.2004-0005
    • Young M, Funder JW. Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone/salt-treated rats. Endocrinology 2004; 145:3153-3157. (Pubitemid 38829985)
    • (2004) Endocrinology , vol.145 , Issue.7 , pp. 3153-3157
    • Young, M.1    Funder, J.W.2
  • 59
    • 0027227646 scopus 로고
    • Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism
    • DOI 10.1006/jmcc.1993.1066
    • Brilla CG, Matsubara LS, Weber KT. Antialdosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism. J Mol Cell Cardiol 1993; 25:563-575. (Pubitemid 23208145)
    • (1993) Journal of Molecular and Cellular Cardiology , vol.25 , Issue.5 , pp. 563-575
    • Brilla, C.G.1    Matsubara, L.S.2    Weber, K.T.3
  • 60
    • 0036893647 scopus 로고    scopus 로고
    • Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart
    • DOI 10.1210/en.2002-220120
    • Rocha R, Martin-Berger CL, Yang P, et al. Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology 2002; 143:4828-4836. (Pubitemid 35397623)
    • (2002) Endocrinology , vol.143 , Issue.12 , pp. 4828-4836
    • Rocha, R.1    Martin-Berger, C.L.2    Yang, P.3    Scherrer, R.4    Delyani, J.5    McMahon, E.6
  • 62
    • 79953199333 scopus 로고    scopus 로고
    • The mineralocorticoid receptor in heart: Different effects in different cells
    • Jaisser F, Swynghedauw B, Delcayre C. The mineralocorticoid receptor in heart: Different effects in different cells. Hypertension 2011; 57:679-680.
    • (2011) Hypertension , vol.57 , pp. 679-680
    • Jaisser, F.1    Swynghedauw, B.2    Delcayre, C.3
  • 63
    • 79751529118 scopus 로고    scopus 로고
    • Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction
    • The authors studied the effects of cardiomyocyte-specific mineralocorticoid receptor deficiency in transgenic mice. Mineralocorticoid receptor deletion in the heart leads to infarct healing and prevents progressive adverse cardiac remodeling, contractile dysfunction, and molecular alterations in ischemic heart failure
    • Fraccarollo D, Berger S, Galuppo P, et al. Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation 2011; 123:400-408. The authors studied the effects of cardiomyocyte-specific mineralocorticoid receptor deficiency in transgenic mice. Mineralocorticoid receptor deletion in the heart leads to infarct healing and prevents progressive adverse cardiac remodeling, contractile dysfunction, and molecular alterations in ischemic heart failure.
    • (2011) Circulation , vol.123 , pp. 400-408
    • Fraccarollo, D.1    Berger, S.2    Galuppo, P.3
  • 64
    • 79953224745 scopus 로고    scopus 로고
    • Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function after chronic pressure overload
    • The authors compared the response to a chronic severe pressure overload in two mouse models with cell-specific deletion of mineralocorticoid receptor in cardiomyocytes or in fibroblasts. Cardiac-mineralocorticoid receptor deletion, but not in fibroblasts, prevents from ventricular dilatation and failure, after chronic pressure overload
    • Lother A, Berger S, Gilsbach R, et al. Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function after chronic pressure overload. Hypertension 2011; 57:746-754. The authors compared the response to a chronic severe pressure overload in two mouse models with cell-specific deletion of mineralocorticoid receptor in cardiomyocytes or in fibroblasts. Cardiac-mineralocorticoid receptor deletion, but not in fibroblasts, prevents from ventricular dilatation and failure, after chronic pressure overload.
    • (2011) Hypertension , vol.57 , pp. 746-754
    • Lother, A.1    Berger, S.2    Gilsbach, R.3
  • 65
    • 36349024715 scopus 로고    scopus 로고
    • Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells
    • DOI 10.1161/CIRCULATIONAHA.107.722009
    • Ambroisine ML, Favre J, Oliviero P, et al. Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-Activated potassium (BKCa) channels of vascular smooth muscle cells. Circulation 2007; 116: 2435-2443. (Pubitemid 350145078)
    • (2007) Circulation , vol.116 , Issue.21 , pp. 2435-2443
    • Ambroisine, M.-L.1    Favre, J.2    Oliviero, P.3    Rodriguez, C.4    Gao, J.5    Thuillez, C.6    Samuel, J.-L.7    Richard, V.8    Delcayre, C.9
  • 66
    • 79958030363 scopus 로고    scopus 로고
    • Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression
    • This study shows that mineralocorticoid receptor activation only in the cardiomyocytes is sufficient to induce a NOX-dependent, reactive oxygen species-mediated coronary endothelial dysfunction
    • Favre J, Gao J, Zhang AD, et al. Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression. Am J Physiol Heart Circ Physiol 2011; 300:H2035-H2043. This study shows that mineralocorticoid receptor activation only in the cardiomyocytes is sufficient to induce a NOX-dependent, reactive oxygen species-mediated coronary endothelial dysfunction.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300
    • Favre, J.1    Gao, J.2    Zhang, A.D.3
  • 67
    • 77649161839 scopus 로고    scopus 로고
    • Heart failure: Aldosterone antagonists are underused by clinicians
    • Samuel JL, Delcayre C. Heart failure: Aldosterone antagonists are underused by clinicians. Nat Rev Cardiol 2010; 7:125-127.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 125-127
    • Samuel, J.L.1    Delcayre, C.2
  • 68
    • 70349248001 scopus 로고    scopus 로고
    • Are macrophages the foot soldiers in the war waged by aldosterone against the heart?
    • Dorrance AM. Are macrophages the foot soldiers in the war waged by aldosterone against the heart? Hypertension 2009; 54:451-453.
    • (2009) Hypertension , vol.54 , pp. 451-453
    • Dorrance, A.M.1
  • 69
    • 0028831049 scopus 로고
    • Production of aldosterone in isolated blood vessels
    • Takeda Y, Miyamori I, Yoneda T, et al. Production of aldosterone in isolated blood vessels. Hypertension 1995; 25:170-173.
    • (1995) Hypertension , vol.25 , pp. 170-173
    • Takeda, Y.1    Miyamori, I.2    Yoneda, T.3
  • 70
    • 3142776828 scopus 로고    scopus 로고
    • Enhancement of glucocorticoid and mineralocorticoid receptor density in the microcirculation of the spontaneously hypertensive rat
    • DOI 10.1080/10739680490266207
    • DeLano FA, Schmid-Schonbein GW. Enhancement of glucocorticoid and mineralocorticoid receptor density in the microcirculation of the spontaneously hypertensive rat. Microcirculation 2004; 11:69-78. (Pubitemid 39618607)
    • (2004) Microcirculation , vol.11 , Issue.1 , pp. 69-78
    • Delano, F.A.1    Schmid-Schonbein, G.W.2
  • 71
    • 84856325649 scopus 로고    scopus 로고
    • Mineralocorticoid receptors in vascular function and disease
    • doi:10.1016/j.mce.2011.06.014. [Epub ahead of print] This review explains the nongenomic and genomic effects of aldosterone in the vascular endothelial and smooth muscle cells and highlights the recent findings regarding the role of aldosterone and the mineralocorticoid receptor in vitro and in vivo
    • McCurley A, Jaffe IZ. Mineralocorticoid receptors in vascular function and disease. Mol Cell Endocrinol 2011. doi:10.1016/j.mce.2011.06.014. [Epub ahead of print] This review explains the nongenomic and genomic effects of aldosterone in the vascular endothelial and smooth muscle cells and highlights the recent findings regarding the role of aldosterone and the mineralocorticoid receptor in vitro and in vivo.
    • (2011) Mol Cell Endocrinol
    • McCurley, A.1    Jaffe, I.Z.2
  • 73
    • 77954242394 scopus 로고    scopus 로고
    • The epithelial sodium channel (ENaC) mediator of the aldosterone response in the vascular endothelium?
    • Kusche-Vihrog K, Callies C, Fels J, Oberleithner H. The epithelial sodium channel (ENaC): Mediator of the aldosterone response in the vascular endothelium? Steroids 2010; 75:544-549.
    • (2010) Steroids , vol.75 , pp. 544-549
    • Kusche-Vihrog, K.1    Callies, C.2    Fels, J.3    Oberleithner, H.4
  • 74
    • 77957921063 scopus 로고    scopus 로고
    • Nitric oxide release follows endothelial nanomechanics and not vice versa
    • Fels J, Callies C, Kusche-Vihrog K, Oberleithner H. Nitric oxide release follows endothelial nanomechanics and not vice versa. Pflugers Arch 2010; 460:915-923.
    • (2010) Pflugers Arch , vol.460 , pp. 915-923
    • Fels, J.1    Callies, C.2    Kusche-Vihrog, K.3    Oberleithner, H.4
  • 75
    • 77957894160 scopus 로고    scopus 로고
    • Menage a trois: Aldosterone sodium and nitric oxide in vascular endothelium
    • Fels J,Oberleithner H, Kusche-Vihrog K.Menage a trois: Aldosterone, sodium and nitric oxide in vascular endothelium. Biochim Biophys Acta 2010; 1802:1193-1212.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 1193-1212
    • Fels, J.1    Oberleithner, H.2    Kusche-Vihrog, K.3
  • 76
    • 79551486467 scopus 로고    scopus 로고
    • C-reactive protein makes human endothelium stiff and tight
    • This study unravels the role of endothelial cell stiffness in inflammatory and vascular disease and present a novel mechanism involving aldosterone/mineralocorticoid receptor, C-reactive protein, nitric oxide and PI3K/Akt signaling in the pathophysiology of endothelial dysfunction
    • Kusche-Vihrog K, Urbanova K, Blanqué A, et al. C-reactive protein makes human endothelium stiff and tight. Hypertension 2011; 57:231-237. This study unravels the role of endothelial cell stiffness in inflammatory and vascular disease and present a novel mechanism involving aldosterone/ mineralocorticoid receptor, C-reactive protein, nitric oxide and PI3K/Akt signaling in the pathophysiology of endothelial dysfunction.
    • (2011) Hypertension , vol.57 , pp. 231-237
    • Kusche-Vihrog, K.1    Urbanova, K.2    Blanqué, A.3
  • 78
    • 54049129652 scopus 로고    scopus 로고
    • Nitric oxide and vascular reactivity in sepsis
    • Fernandes D, Assreuy J. Nitric oxide and vascular reactivity in sepsis. Shock 2008; 30:10-13.
    • (2008) Shock , vol.30 , pp. 10-13
    • Fernandes, D.1    Assreuy, J.2
  • 79
    • 67049155914 scopus 로고    scopus 로고
    • Endothelial epithelial sodium channel inhibition activates endothelial nitric oxide synthase via phosphoinositide 3-kinase/Akt in small-diameter mesenteric arteries
    • Perez FR, Venegas F, Gonzalez M, et al. Endothelial epithelial sodium channel inhibition activates endothelial nitric oxide synthase via phosphoinositide 3-kinase/Akt in small-diameter mesenteric arteries. Hypertension 2009; 53:1000-1007.
    • (2009) Hypertension , vol.53 , pp. 1000-1007
    • Perez, F.R.1    Venegas, F.2    Gonzalez, M.3
  • 80
    • 33644987045 scopus 로고    scopus 로고
    • Effects of aldosterone on the vasculature
    • DOI 10.1161/01.HYP.0000201443.63240.a7, PII 0000426820060300000002
    • Schiffrin EL. Effects of aldosterone on the vasculature. Hypertension 2006; 47:312-318. (Pubitemid 43740260)
    • (2006) Hypertension , vol.47 , Issue.3 , pp. 312-318
    • Schiffrin, E.L.1
  • 81
    • 0038141826 scopus 로고    scopus 로고
    • Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling
    • DOI 10.1161/01.HYP.0000078357.92682.EC
    • Pu Q, Neves MF, Virdis A, et al. Endothelin antagonism on aldosteroneinduced oxidative stress and vascular remodeling. Hypertension 2003; 42:49-55. (Pubitemid 36849598)
    • (2003) Hypertension , vol.42 , Issue.1 , pp. 49-55
    • Pu, Q.1    Neves, M.F.2    Virdis, A.3    Touyz, R.M.4    Schiffrin, E.L.5
  • 82
    • 69849102868 scopus 로고    scopus 로고
    • Aldosterone-induced endothelial dysfunction of rat aorta: Role of poly(ADP-ribose) activation
    • Tasatargil A, Tekcan M, Celik-Ozenci C, et al. Aldosterone-induced endothelial dysfunction of rat aorta: Role of poly(ADP-ribose) activation. J Renin Angiotensin Aldosterone Syst 2009; 10:127-137.
    • (2009) J Renin Angiotensin Aldosterone Syst , vol.10 , pp. 127-137
    • Tasatargil, A.1    Tekcan, M.2    Celik-Ozenci, C.3
  • 83
    • 43849104699 scopus 로고    scopus 로고
    • Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity
    • Nagata D, Takahashi M, Sawai K, et al. Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity. Hypertension 2006; 476:1-7.
    • (2006) Hypertension , vol.476 , pp. 1-7
    • Nagata, D.1    Takahashi, M.2    Sawai, K.3
  • 85
    • 33645822083 scopus 로고    scopus 로고
    • Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts
    • DOI 10.1161/01.HYP.0000203148.42892.7a, PII 0000426820060400000014
    • Kobayashi N, Yoshid K, Nakano S, et al. Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts. Hypertension 2006; 47:671-679. (Pubitemid 43740237)
    • (2006) Hypertension , vol.47 , Issue.4 , pp. 671-679
    • Kobayashi, N.1    Yoshida, K.2    Nakano, S.3    Ohno, T.4    Honda, T.5    Tsubokou, Y.6    Matsuoka, H.7
  • 86
    • 33646488692 scopus 로고    scopus 로고
    • Aldosterone antagonism improves endothelial-dependent vasorelaxation in heart failure via upregulation of endothelial nitric oxide synthase production
    • Thai HM, Do BQ, Tran TD, et al. Aldosterone antagonism improves endothelial-dependent vasorelaxation in heart failure via upregulation of endothelial nitric oxide synthase production. J Card Fail 2006; 3:240-245.
    • (2006) J Card Fail , vol.3 , pp. 240-245
    • Thai, H.M.1    Do, B.Q.2    Tran, T.D.3
  • 87
    • 74949109381 scopus 로고    scopus 로고
    • Rapid aldosterone signaling and vascular reactivity: Relax or don't do it
    • Leopold JA. Rapid aldosterone signaling and vascular reactivity: Relax or don't do it. J Cardiovasc Pharmacol 2009; 54:465-467.
    • (2009) J Cardiovasc Pharmacol , vol.54 , pp. 465-467
    • Leopold, J.A.1
  • 88
    • 0027396077 scopus 로고
    • Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats
    • Lariviere R, Thibault G, Schiffrin EL. Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats. Hypertension 1993; 21:294-300. (Pubitemid 23065167)
    • (1993) Hypertension , vol.21 , Issue.3 , pp. 294-300
    • Lariviere, R.1    Thibault, G.2    Schiffrin, E.L.3
  • 89
    • 0035569561 scopus 로고    scopus 로고
    • a receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats
    • Park JB, Schiffrin EL. ETA receptor antagonist prevents blood pressure elevation and vascular remodeling in aldosterone-infused rats. Hypertension 2001; 37:1444-1449. (Pubitemid 34225390)
    • (2001) Hypertension , vol.37 , Issue.6 , pp. 1444-1449
    • Park, J.B.1    Schiffrin, E.L.2
  • 92
    • 0242525727 scopus 로고    scopus 로고
    • Aldosterone Regulates Vascular Reactivity: Short-Term Effects Mediated by Phosphatidylinositol 3-Kinase-Dependent Nitric Oxide Synthase Activation
    • DOI 10.1161/01.CIR.0000093188.53554.44
    • Liu SL, Schmuck S, Chorazcyzewski JZ, et al. Aldosterone regulates vascular reactivity: Short-term effects mediated by phosphatidylinositol 3-kinasedependent nitric oxide synthase activation. Circulation 2003; 108:2400-2406. (Pubitemid 37413549)
    • (2003) Circulation , vol.108 , Issue.19 , pp. 2400-2406
    • Liu, S.L.1    Schmuck, S.2    Chorazcyzewski, J.Z.3    Gros, R.4    Feldman, R.D.5
  • 93
  • 95
    • 77952752549 scopus 로고    scopus 로고
    • Rapid vascular effects of steroids a question of balance?
    • Feldman RD, Gros R. Rapid vascular effects of steroids: A question of balance? Can J Cardiol 2010; 26 (Suppl. A):22A-26A.
    • (2010) Can J Cardiol , vol.26 , Issue.SUPPL. A.
    • Feldman, R.D.1    Gros, R.2
  • 97
    • 79953235261 scopus 로고    scopus 로고
    • GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone
    • This study brings the new concept of a unique aldosterone plasma membrane receptor, which is different from the classic cytosolic mineralocorticoid receptor protein and exclusively mediates rapid aldosterone signaling. However, this is still a matter of debate
    • Gros R, Ding Q, Sklar LA, et al. GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension 2011; 57:442-451. This study brings the new concept of a unique aldosterone plasma membrane receptor, which is different from the classic cytosolic mineralocorticoid receptor protein and exclusively mediates rapid aldosterone signaling. However, this is still a matter of debate.
    • (2011) Hypertension , vol.57 , pp. 442-451
    • Gros, R.1    Ding, Q.2    Sklar, L.A.3
  • 98
    • 0027960069 scopus 로고
    • Rapid effects of aldosterone on free intracellular calcium in vascular smooth muscle and endothelial cells: Subcellular localization of calcium elevations by single cell imaging
    • Wehling M, Ulsenheimer A, Schneider M, et al. Rapid effects of aldosterone on free intracellular calcium in vascular smooth muscle and endothelial cells: Subcellular localization of calcium elevations by single cell imaging. Biochem Biophys Res Commun 1994; 204:475-481.
    • (1994) Biochem Biophys Res Commun , vol.204 , pp. 475-481
    • Wehling, M.1    Ulsenheimer, A.2    Schneider, M.3
  • 99
    • 0344959523 scopus 로고    scopus 로고
    • Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells
    • Christ M, Gunther A, Heck M, et al. Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. Circulation 1999; 99:1485-1491. (Pubitemid 29140916)
    • (1999) Circulation , vol.99 , Issue.11 , pp. 1485-1491
    • Christ, M.1    Gunther2    , A.3    Heck, M.4    Schmidt, B.M.W.5    Falkenstein, E.6    Wehling, M.7
  • 101
    • 0029166430 scopus 로고
    • Rapid aldosterone signaling in vascular smooth muscle cells: Involvement of phospholipase C, diacylglycerol and protein kinase C alpha
    • Christ M, Meyer C, Sippel K, et al. Rapid aldosterone signaling in vascular smooth muscle cells: Involvement of phospholipase C, diacylglycerol and protein kinase C alpha. Biochem Biophys Res Commun 1995; 213:123-129.
    • (1995) Biochem Biophys Res Commun , vol.213 , pp. 123-129
    • Christ, M.1    Meyer, C.2    Sippel, K.3
  • 102
    • 0033183230 scopus 로고    scopus 로고
    • Rapid aldosterone effects on tyrosine phosphorylation in vascular smooth muscle cells
    • Manegold JC, Falkenstein E, Wehling M, et al. Rapid aldosterone effects on tyrosine phosphorylation in vascular smooth muscle cells. Cell Mol Biol 1999; 45:805-813.
    • (1999) Cell Mol Biol , vol.45 , pp. 805-813
    • Manegold, J.C.1    Falkenstein, E.2    Wehling, M.3
  • 107
    • 34848842134 scopus 로고    scopus 로고
    • Non-classical actions of the mineralocorticoid receptor: Misuse of EGF receptors?
    • DOI 10.1016/j.mce.2007.07.001, PII S0303720707002560
    • Grossmann C, Gekle M. Nonclassical actions of the mineralocorticoid receptor: Misuses of EGF receptors? Mol Cell Endocrinol 2007; 277:6-12. (Pubitemid 47496192)
    • (2007) Molecular and Cellular Endocrinology , vol.277 , Issue.1-2 , pp. 6-12
    • Grossmann, C.1    Gekle, M.2
  • 108
    • 33644645135 scopus 로고    scopus 로고
    • C-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats
    • Callera GE, Montezano AC, Yogi A, et al. c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension 2005; 46:1032-1038.
    • (2005) Hypertension , vol.46 , pp. 1032-1038
    • Callera, G.E.1    Montezano, A.C.2    Yogi, A.3
  • 109
    • 79551487567 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt
    • This study provides the first demonstration that EGFR activity is a key component in the functional consequences of aldosterone in the vessel but is not involved in the structural remodeling of the vascular wall induced by aldosterone
    • Griol-Charhbili V, Fassot C, Messaoudi S, et al. Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt. Hypertension 2011; 57:238-244. This study provides the first demonstration that EGFR activity is a key component in the functional consequences of aldosterone in the vessel but is not involved in the structural remodeling of the vascular wall induced by aldosterone.
    • (2011) Hypertension , vol.57 , pp. 238-244
    • Griol-Charhbili, V.1    Fassot, C.2    Messaoudi, S.3
  • 110
    • 67449152446 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling in the vascular system
    • Morello F, Perino A, Hirsch E. Phosphoinositide 3-kinase signalling in the vascular system. Cardiovasc Res 2009; 82:261-271.
    • (2009) Cardiovasc Res , vol.82 , pp. 261-271
    • Morello, F.1    Perino, A.2    Hirsch, E.3
  • 111
    • 22544485647 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor inhibits cytokine-induced NF-κB activation and nitric oxide production via activation of the phosphatidylinositol 3-kinase pathway
    • Mehta VB, Besner GE. Heparin-binding epidermal growth factor-like growth factor inhibits cytokine-induced NF-kappa b activation and nitric oxide production via activation of the phosphatidylinositol 3-kinase pathway. J Immunol 2005; 175:1911-1918. (Pubitemid 41023098)
    • (2005) Journal of Immunology , vol.175 , Issue.3 , pp. 1911-1918
    • Mehta, V.B.1    Besner, G.E.2
  • 112
    • 33845588970 scopus 로고    scopus 로고
    • Heparin binding EGF is necessary for vasospastic response to endothelin
    • Chansel D, Ciroldi M, Vandermeersch S, et al. Heparin binding EGF is necessary for vasospastic response to endothelin. FASEB J 2006; 20:1936-1938.
    • (2006) FASEB J. , vol.20 , pp. 1936-1938
    • Chansel, D.1    Ciroldi, M.2    Vandermeersch, S.3
  • 113
    • 80051964047 scopus 로고    scopus 로고
    • Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: Role of PDGFR
    • This study demonstrates that proinflammatory effects of aldosterone in VSMCs involve c-Src activation and trafficking to cholesterol-rich domains via PDGFR. These novel findings identify lipid rafts/caveolae as dynamic scaffolding systems for aldosterone/mineralocorticoid receptor in VSMCs and suggest important crosstalk between PDGFR and c-Src, processes that may be important in nongenomic events of aldosterone proinflammatory vascular signaling
    • Callera GE, Yogi A, Briones AM, et al. Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: Role of PDGFR. Cardiovasc Res 2011; 91:720-731. This study demonstrates that proinflammatory effects of aldosterone in VSMCs involve c-Src activation and trafficking to cholesterol-rich domains via PDGFR. These novel findings identify lipid rafts/caveolae as dynamic scaffolding systems for aldosterone/mineralocorticoid receptor in VSMCs and suggest important crosstalk between PDGFR and c-Src, processes that may be important in nongenomic events of aldosterone proinflammatory vascular signaling.
    • (2011) Cardiovasc Res , vol.91 , pp. 720-731
    • Callera, G.E.1    Yogi, A.2    Briones, A.M.3
  • 114
    • 72149099639 scopus 로고    scopus 로고
    • Mineralocorticoid receptors in the metabolic syndrome
    • Zennaro MC, Caprio M, Fé ve B. Mineralocorticoid receptors in the metabolic syndrome. Trends Endocrinol Metab 2009; 20:444-451.
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 444-451
    • Zennaro, M.C.1    Caprio, M.2    Féve, B.3
  • 115
    • 79955974994 scopus 로고    scopus 로고
    • The role of aldosterone in the metabolic syndrome
    • Briet M, Schiffrin EL. The role of aldosterone in the metabolic syndrome. Curr Hypertens Rep 2011; 3:163-172.
    • (2011) Curr Hypertens Rep , vol.3 , pp. 163-172
    • Briet, M.1    Schiffrin, E.L.2
  • 116
    • 84856330068 scopus 로고    scopus 로고
    • The role of the mineralocorticoid receptor in adipocyte biology and fat metabolism
    • doi:10.1016/j.mce.2011.09.011. [Epub ahead of print] This review summarizes the latest concepts on the role of the mineralocorticoid receptor in white and brown adipocytes, and highlights the potential benefits of tissue-selective mineralocorticoid receptor blockade in the treatment of obesity and metabolic syndrome
    • Marzolla V, Armani A, Zennaro MC, et al. The role of the mineralocorticoid receptor in adipocyte biology and fat metabolism. Mol Cell Endocrinol 2011. doi:10.1016/j.mce.2011.09.011. [Epub ahead of print] This review summarizes the latest concepts on the role of the mineralocorticoid receptor in white and brown adipocytes, and highlights the potential benefits of tissue-selective mineralocorticoid receptor blockade in the treatment of obesity and metabolic syndrome.
    • (2011) Mol Cell Endocrinol
    • Marzolla, V.1    Armani, A.2    Zennaro, M.C.3
  • 117
    • 77957311044 scopus 로고    scopus 로고
    • Salt, aldosterone, and insulin resistance: Impact on the cardiovascular system
    • Lastra G, Dhuper S, Johnson MS, et al. Salt, aldosterone, and insulin resistance: Impact on the cardiovascular system. Nat Rev Cardiol 2010; 7:577-584.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 577-584
    • Lastra, G.1    Dhuper, S.2    Johnson, M.S.3
  • 118
    • 77649291571 scopus 로고    scopus 로고
    • Aldosterone: Role in the cardiometabolic syndrome and resistant hypertension
    • Whaley-Connell A, Johnson MS, Sowers JR. Aldosterone: Role in the cardiometabolic syndrome and resistant hypertension. Prog Cardiovasc Dis 2010; 52:401-409.
    • (2010) Prog Cardiovasc Dis , vol.52 , pp. 401-409
    • Whaley-Connell, A.1    Johnson, M.S.2    Sowers, J.R.3
  • 119
    • 81755177460 scopus 로고    scopus 로고
    • The renin-Angiotensin-Aldosterone system and glucose homeostasis
    • Luther JM, Brown NJ. The renin-Angiotensin-Aldosterone system and glucose homeostasis. Trends Pharmacol Sci 2011; 32:734-739.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 734-739
    • Luther, J.M.1    Brown, N.J.2
  • 120
    • 11244311897 scopus 로고    scopus 로고
    • Fat cells may be the obesity-hypertension link: Human adipogenic factors stimulate aldosterone secretion from adrenocortical cells
    • DOI 10.1081/ERC-200044122
    • Ehrhart-Bornstein M, Arakelyan K, Krug AW, et al. Fat cells may be the obesity-hypertension link: Human adipogenic factors stimulate aldosterone secretion from adrenocortical cells. Endocr Res 2004; 30:865-870. (Pubitemid 40070185)
    • (2004) Endocrine Research , vol.30 , Issue.4 , pp. 865-870
    • Ehrhart-Bornstein, M.1    Arakelyan, K.2    Krug, A.W.3    Scherbaum, W.A.4    Bornstein, S.R.5
  • 121
    • 23144456873 scopus 로고    scopus 로고
    • Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes
    • DOI 10.1055/s-2005-870240
    • Kraus D, Jäger J, Meier B, et al. Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes. Horm Metab Res 2005; 37:455-459. (Pubitemid 41081228)
    • (2005) Hormone and Metabolic Research , vol.37 , Issue.7 , pp. 455-459
    • Kraus, D.1    Jager, J.2    Meier, B.3    Fasshauer, M.4    Klein, J.5
  • 122
    • 66549130863 scopus 로고    scopus 로고
    • Narrative review: The emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension
    • Sowers JR, Whaley-Connell A, Epstein M. Narrative review: The emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med 2009; 150:776-783.
    • (2009) Ann Intern Med , vol.150 , pp. 776-783
    • Sowers, J.R.1    Whaley-Connell, A.2    Epstein, M.3
  • 123
    • 63849107748 scopus 로고    scopus 로고
    • Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes
    • Wada T, Ohshima S, Fujisawa E, et al. Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes. Endocrinology 2009; 150:1662-1669.
    • (2009) Endocrinology , vol.150 , pp. 1662-1669
    • Wada, T.1    Ohshima, S.2    Fujisawa, E.3
  • 124
    • 34247264495 scopus 로고    scopus 로고
    • Metabolic risk factors and renal disease
    • DOI 10.1038/sj.ki.5002006, PII 5002006
    • Sowers JR. Metabolic risk factors and renal disease. Kidney Int 2007; 71:719-720. (Pubitemid 46624014)
    • (2007) Kidney International , vol.71 , Issue.8 , pp. 719-720
    • Sowers, J.R.1
  • 125
    • 84857052216 scopus 로고    scopus 로고
    • Role of the renin-Angiotensin system and aldosterone on cardiometabolic syndrome
    • Stiefel P, Vallejo-Vaz AJ, García Morillo S, et al. Role of the renin-Angiotensin system and aldosterone on cardiometabolic syndrome. Int J Hypertens 2011; 2011:685238.
    • (2011) Int J Hypertens , vol.2011 , pp. 685238
    • Stiefel, P.1    Vallejo-Vaz, A.J.2    García Morillo, S.3
  • 126
    • 79960916860 scopus 로고    scopus 로고
    • Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets
    • This study demonstrates for the first time that endogenous aldosterone regulates insulin secretion and that perturbation of aldosterone directly alters insulin secretion within beta cells. Indeed, aldosterone deficiency enhances glucosestimulated insulin secretion in vivo and that this effect is independent of electrolyte disturbance, insulin sensitivity or renin activity in an aldosterone synthase deficiency mouse model
    • Luther JM, Luo P, Kreger MT, et al. Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets. Diabetologia 2011; 54:2152-2163. This study demonstrates for the first time that endogenous aldosterone regulates insulin secretion and that perturbation of aldosterone directly alters insulin secretion within beta cells. Indeed, aldosterone deficiency enhances glucosestimulated insulin secretion in vivo and that this effect is independent of electrolyte disturbance, insulin sensitivity or renin activity in an aldosterone synthase deficiency mouse model.
    • (2011) Diabetologia , vol.54 , pp. 2152-2163
    • Luther, J.M.1    Luo, P.2    Kreger, M.T.3
  • 127
    • 0036563232 scopus 로고    scopus 로고
    • Hormonal regulation of the human adipose-tissue renin-angiotensin system: Relationship to obesity and hypertension
    • DOI 10.1097/00004872-200205000-00032
    • Gorzelniak K, Engeli S, Janke J, et al. Hormonal regulation of the human adipose-tissue renin-Angiotensin system: Relationship to obesity and hypertension. J Hypertens 2002; 20:965-973. (Pubitemid 34913678)
    • (2002) Journal of Hypertension , vol.20 , Issue.5 , pp. 965-973
    • Gorzelniak, K.1    Engeli, S.2    Janke, J.3    Luft, F.C.4    Sharma, A.M.5
  • 129
    • 33745845825 scopus 로고    scopus 로고
    • Physiology of local renin-angiotensin systems
    • DOI 10.1152/physrev.00036.2005
    • Paul M, Mehr AP, Kreutz R. Physiology of local renin-Angiotensin systems. Physiol Rev 2006; 86:747-803. (Pubitemid 44033382)
    • (2006) Physiological Reviews , vol.86 , Issue.3 , pp. 747-803
    • Paul, M.1    Mehr, A.P.2    Kreutz, R.3
  • 133
    • 34547940635 scopus 로고    scopus 로고
    • Larger anti-adipogenic effect of angiotensin II on omental preadipose cells of obese humans
    • Brucher R, Cifuentes M, Acuna MJ, et al. Larger antiadipogenic effect of angiotensin II on omental preadipose cells of obese humans. Obesity (Silver Spring) 2007; 15:1643-1646. (Pubitemid 47264942)
    • (2007) Obesity , vol.15 , Issue.7 , pp. 1643-1646
    • Brucher, R.1    Cifuentes, M.2    Acuna, M.J.3    Albala, C.4    Rojas, C.V.5
  • 134
    • 79953697675 scopus 로고    scopus 로고
    • Renin-Angiotensin-Aldosterone system in diabetes and hypertension
    • Hsueh WA, Wyne K. Renin-Angiotensin-Aldosterone system in diabetes and hypertension. J Clin Hypertens 2011; 13:224-237.
    • (2011) J Clin Hypertens , vol.13 , pp. 224-237
    • Hsueh, W.A.1    Wyne, K.2
  • 136
    • 34447324638 scopus 로고    scopus 로고
    • Regulation of vascular function and insulin sensitivity by adipose tissue: Focus on perivascular adipose tissue
    • DOI 10.1080/10739680701303584, PII 779873905
    • Eringa EC, Bakker W, Smulders YM, et al. Regulation of vascular function and insulin sensitivity by adipose tissue: Focus on perivascular adipose tissue. Microcirculation 2007; 14:389-402. (Pubitemid 47050030)
    • (2007) Microcirculation , vol.14 , Issue.4-5 , pp. 389-402
    • Eringa, E.C.1    Bakker, W.2    Smulders, Y.M.3    Serne, E.H.4    Yudkin, J.S.5    Stehouwer, C.D.A.6
  • 137
    • 34249729448 scopus 로고    scopus 로고
    • The fatter the better? Perivascular adipose tissue attenuates vascular contraction through different mechanisms
    • DOI 10.1038/sj.bjp.0707229, PII 0707229
    • Brandes RP. The fatter the better? Perivascular adipose tissue attenuates vascular contraction through different mechanisms. Br J Pharmacol 2007; 151:303-304. (Pubitemid 46842670)
    • (2007) British Journal of Pharmacology , vol.151 , Issue.3 , pp. 303-304
    • Brandes, R.P.1
  • 139
    • 0025855222 scopus 로고
    • Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness
    • Soltis EE, Cassis LA. Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Clin Exp Hypertens A 1991; 13:277-296.
    • (1991) Clin Exp Hypertens A. , vol.13 , pp. 277-296
    • Soltis, E.E.1    Cassis, L.A.2
  • 140
    • 79953731321 scopus 로고    scopus 로고
    • Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat
    • Withers SB, Agabiti-Rosei C, Livingstone DM, et al. Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat. Arterioscler Thromb Vasc Biol 2011; 31:908-913.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 908-913
    • Withers, S.B.1    Agabiti-Rosei, C.2    Livingstone, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.