Endothelin receptor blockade ameliorates renal injury by inhibition of RhoA/Rho-kinase signalling in deoxycorticosterone acetate-salt hypertensive rats

Journal of Hypertension

Volumn 32, Issue 4, 2014, Pages 795-805

  Lee, Tsung Ming ^a,b   Chung, Tun Hui ^c   Lin, Shinn Zong ^a,d   Chang, Nen Chung ^e,f  

^a Cardiology Section   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Connective tissue growth factor; Deoxycorticosterone acetate salt hypertensive rats; Endothelin; RhoA ROCK

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (1,3 BENZODIOXOL 5 YL) 1 [(2,6 DIETHYLPHENYL)CARBAMOYLMETHYL] 2 (4 PROPOXYPHENYL) 3 PYRROLIDINECARBOXYLIC ACID; ATRASENTAN; BOSENTAN; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; EPLERENONE; EXOENZYME C3; FASUDIL; MESSENGER RNA; MINERALOCORTICOID RECEPTOR; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; DEOXYCORTICOSTERONE ACETATE; ENDOTHELIN RECEPTOR ANTAGONIST; PYRROLIDINE DERIVATIVE; SALT INTAKE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DEOXYCORTICOSTERONE-SALT INDUCED HYPERTENSION; DRUG EFFECT; DRUG EFFICACY; ELEVATED BLOOD PRESSURE; ENZYME ACTIVITY; ENZYME INHIBITION; GLOMERULOSCLEROSIS; HISTOPATHOLOGY; ISOLATED KIDNEY; KIDNEY DYSFUNCTION; KIDNEY FIBROSIS; KIDNEY INJURY; MALE; MYOFIBROBLAST; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; RENAL PROTECTION; KIDNEY FUNCTION; ANIMAL; BLOOD PRESSURE; CHEMICALLY INDUCED; CHEMISTRY; FIBROSIS; GENE EXPRESSION REGULATION; HYPERTENSION; KIDNEY; METABOLISM; RANDOMIZATION; SALT INTAKE; WISTAR RAT;

ANIMALS; BLOOD PRESSURE; DESOXYCORTICOSTERONE ACETATE; ENDOTHELIN RECEPTOR ANTAGONISTS; ENDOTHELIN-1; FIBROSIS; GENE EXPRESSION REGULATION; HYPERTENSION; KIDNEY; MALE; PROTEINURIA; PYRROLIDINES; RANDOM ALLOCATION; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SODIUM CHLORIDE, DIETARY;

EID: 84896319078     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0000000000000092     Document Type: Article

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