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Volumn 12, Issue 5, 2015, Pages 763-777

Differences in physicochemical properties to consider in the design, evaluation and choice between microparticles and nanoparticles for drug delivery

Author keywords

Delivery; Drug; Micrometer; Nanometer

Indexed keywords

DENDRIMER; NANOMATERIAL; NANOPARTICLE; DRUG;

EID: 84928321828     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2015.988135     Document Type: Review
Times cited : (35)

References (86)
  • 1
    • 84896388835 scopus 로고    scopus 로고
    • Why is the nanoscale special (or not)? Fundamental properties and how it relates to the design of nano-enabled drug delivery systems
    • Otto DP, de Villiers MM. Why is the nanoscale special (or not)? Fundamental properties and how it relates to the design of nano-enabled drug delivery systems. Nanotechnol Rev 2013;2:171-99
    • (2013) Nanotechnol Rev , vol.2 , pp. 171-199
    • Otto, D.P.1    De Villiers, M.M.2
  • 2
    • 84860570762 scopus 로고    scopus 로고
    • Physicochemical principles of nanosized drug delivery systems
    • De Villiers MM, Aramwit P, Kwon GS, editors. Springer; New York
    • Otto DP, de Villiers MM. Physicochemical principles of nanosized drug delivery systems. In: De Villiers MM, Aramwit P, Kwon GS, editors. Nanotechnology in drug delivery. Springer; New York: 2009. p. 3-33
    • (2009) Nanotechnology in Drug Delivery , pp. 3-33
    • Otto, D.P.1    De Villiers, M.M.2
  • 3
    • 84928313663 scopus 로고    scopus 로고
    • The physics of macro-, micro-and nanomaterials
    • Guisbiers G, Shirinyan AS, Wautelet M. The physics of macro-, micro-and nanomaterials. Phys Mag 2005;27:131-41
    • (2005) Phys Mag , vol.27 , pp. 131-141
    • Guisbiers, G.1    Shirinyan, A.S.2    Wautelet, M.3
  • 4
    • 33745452651 scopus 로고    scopus 로고
    • Size matters: Why nanomaterials are different
    • Roduner E. Size matters: why nanomaterials are different. Chem Soc Rev 2006;35:583-92
    • (2006) Chem Soc Rev , vol.35 , pp. 583-592
    • Roduner, E.1
  • 5
    • 0036398815 scopus 로고    scopus 로고
    • Thermal characteristics in a nanometer scale
    • Hatta I. Thermal characteristics in a nanometer scale. J Therm Anal Calorim 2002;69:717-25
    • (2002) J Therm Anal Calorim , vol.69 , pp. 717-725
    • Hatta, I.1
  • 6
    • 0034562665 scopus 로고    scopus 로고
    • Particularities of heat conduction in nanostructures
    • Chen G. Particularities of heat conduction in nanostructures. J Nanopart Res 2000;2:199-204
    • (2000) J Nanopart Res , vol.2 , pp. 199-204
    • Chen, G.1
  • 7
    • 1642306501 scopus 로고    scopus 로고
    • Polymorph selectivity under nanoscopic confinement
    • Ha JM, Wolf JH, Hillmyer MA, et al. Polymorph selectivity under nanoscopic confinement. J Am Chem Soc 2004;126:3382-3
    • (2004) J Am Chem Soc , vol.126 , pp. 3382-3383
    • Ha, J.M.1    Wolf, J.H.2    Hillmyer, M.A.3
  • 8
    • 79952744343 scopus 로고    scopus 로고
    • Controlled nucleation from solution using polymer microgels
    • Diao Y, Helgeson ME, Myerson AS, et al. Controlled nucleation from solution using polymer microgels. J Am Chem Soc 2011;133:3756-9
    • (2011) J Am Chem Soc , vol.133 , pp. 3756-3759
    • Diao, Y.1    Helgeson, M.E.2    Myerson, A.S.3
  • 9
    • 6444239981 scopus 로고    scopus 로고
    • Melting of nanostructured drugs embedded into a polymer matrix
    • Bergese P, Colombo I, Gervasoni D, et al. Melting of nanostructured drugs embedded into a polymer matrix. J Phys Chem B 2004;108:15488-93
    • (2004) J Phys Chem B , vol.108 , pp. 15488-15493
    • Bergese, P.1    Colombo, I.2    Gervasoni, D.3
  • 10
    • 33846072457 scopus 로고    scopus 로고
    • Solubility of fractal nanoparticles
    • Mihranyan A, Strømme M. Solubility of fractal nanoparticles. Surf Sci 2007;601:315-19
    • (2007) Surf Sci , vol.601 , pp. 315-319
    • Mihranyan, A.1    Strømme, M.2
  • 11
    • 33748890137 scopus 로고    scopus 로고
    • Solid solubility limit in alloying nanoparticles
    • Ouyang G, Tan X, Wang CX, et al. Solid solubility limit in alloying nanoparticles. Nanotechnology 2006;17:4257-62
    • (2006) Nanotechnology , vol.17 , pp. 4257-4262
    • Ouyang, G.1    Tan, X.2    Wang, C.X.3
  • 12
    • 0142089127 scopus 로고    scopus 로고
    • Higher surface energy of free nanoparticles
    • Nanda KK, Maisels A, Kruis FE, et al. Higher surface energy of free nanoparticles. Phys Rev Lett 2003;91:106102
    • (2003) Phys Rev Lett , vol.91 , pp. 106102
    • Nanda, K.K.1    Maisels, A.2    Kruis, F.E.3
  • 13
    • 5344234787 scopus 로고    scopus 로고
    • The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs
    • Kipp JE. The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. Int J Pharm 2004;284:109-22
    • (2004) Int J Pharm , vol.284 , pp. 109-122
    • Kipp, J.E.1
  • 14
    • 0023709168 scopus 로고
    • Physicochemical aspects of drug release. VIII. The relation between particle size and surface specific dissolution rate in agitated suspensions
    • Bisrat M, Nystrom C. Physicochemical aspects of drug release. VIII. The relation between particle size and surface specific dissolution rate in agitated suspensions. Int J Pharm 1988;47:223-31
    • (1988) Int J Pharm , vol.47 , pp. 223-231
    • Bisrat, M.1    Nystrom, C.2
  • 15
    • 33645276807 scopus 로고    scopus 로고
    • Experimental determination of the diffusion boundary layer width of micro and submicron particles
    • Galli C. Experimental determination of the diffusion boundary layer width of micro and submicron particles. Int J Pharm 2006;313:114-22
    • (2006) Int J Pharm , vol.313 , pp. 114-122
    • Galli, C.1
  • 16
    • 0023815359 scopus 로고
    • Physicochemical aspects of drug release. VII. The effect of surfactant concentration and drug particle size on solubility and dissolution rate of felodipine, a sparingly soluble drug
    • Anderberg EK, Bisrat M, Nystrom C. Physicochemical aspects of drug release. VII. The effect of surfactant concentration and drug particle size on solubility and dissolution rate of felodipine, a sparingly soluble drug. Int J Pharm 1988;47:67-77
    • (1988) Int J Pharm , vol.47 , pp. 67-77
    • Anderberg, E.K.1    Bisrat, M.2    Nystrom, C.3
  • 17
    • 84862833470 scopus 로고    scopus 로고
    • Optimizing particle size for targeting diseased microvasculature: From experiments to artificial neural networks
    • Boso DP, Lee SY, Ferrari M, et al. Optimizing particle size for targeting diseased microvasculature: from experiments to artificial neural networks. Int J Nanomedicine 2011;6:1517-26
    • (2011) Int J Nanomedicine , vol.6 , pp. 1517-1526
    • Boso, D.P.1    Lee, S.Y.2    Ferrari, M.3
  • 18
    • 83855162774 scopus 로고    scopus 로고
    • Numerical analysis of micro-and nano-particle deposition in a realistic human upper airway
    • Farhadi Ghalati P, Keshavarzian E, Abouali O, et al. Numerical analysis of micro-and nano-particle deposition in a realistic human upper airway. Comput Biol Med 2012;42:39-49
    • (2012) Comput Biol Med , vol.42 , pp. 39-49
    • Farhadi Ghalati, P.1    Keshavarzian, E.2    Abouali, O.3
  • 19
    • 84861710006 scopus 로고    scopus 로고
    • Micro and nanoparticle deposition in human nasal passage pre and port virtual maxillary sinus endoscopic surgery
    • Abouali O, Keshavarzian E, Farhadi Ghalati P, et al. Micro and nanoparticle deposition in human nasal passage pre and port virtual maxillary sinus endoscopic surgery. Respir Physiol Neurobiol 2012;181:335-45
    • (2012) Respir Physiol Neurobiol , vol.181 , pp. 335-345
    • Abouali, O.1    Keshavarzian, E.2    Farhadi Ghalati, P.3
  • 20
    • 79954824167 scopus 로고    scopus 로고
    • Numerical investigation of septal deviation effect on deposition of nano/microparticles in human nasal passage
    • Moghadas H, Abouali O, Faramarzi A, et al. Numerical investigation of septal deviation effect on deposition of nano/microparticles in human nasal passage. Respir Physiol Neurobiol 2011;177:9-18
    • (2011) Respir Physiol Neurobiol , vol.177 , pp. 9-18
    • Moghadas, H.1    Abouali, O.2    Faramarzi, A.3
  • 21
    • 77957348594 scopus 로고    scopus 로고
    • Airflow and nanoparticle deposition in rat nose under various breathing and sniffing conditions-a computational evaluation of the unsteady and turbulent effect
    • Jiang JB, Zhao K. Airflow and nanoparticle deposition in rat nose under various breathing and sniffing conditions-a computational evaluation of the unsteady and turbulent effect. J Aerosol Sci 2010;41:1030-43
    • (2010) J Aerosol Sci , vol.41 , pp. 1030-1043
    • Jiang, J.B.1    Zhao, K.2
  • 22
    • 80053649704 scopus 로고    scopus 로고
    • Computational fluid dynamics simulations of submicrometer and micrometer particle deposition in the nasal passages of a Sprague-Dawley rat
    • Schroeter JD, Kimbell JS, Asgharian B, et al. Computational fluid dynamics simulations of submicrometer and micrometer particle deposition in the nasal passages of a Sprague-Dawley rat. J Aerosol Sci 2012;43:31-44
    • (2012) J Aerosol Sci , vol.43 , pp. 31-44
    • Schroeter, J.D.1    Kimbell, J.S.2    Asgharian, B.3
  • 23
    • 84884536594 scopus 로고    scopus 로고
    • Numerical simulations on aerodynamic focusing of particles in a wide size range of 30 nm-10 μ m
    • Lee KS, Hwang TH, Kim SH, et al. Numerical simulations on aerodynamic focusing of particles in a wide size range of 30 nm-10 μ m. Aerosol Sci Technol 2013;47:1001-8
    • (2013) Aerosol Sci Technol , vol.47 , pp. 1001-1008
    • Lee, K.S.1    Hwang, T.H.2    Kim, S.H.3
  • 24
    • 84884163202 scopus 로고    scopus 로고
    • In-silico simulations of advanced drug delivery systems: What will the future offer?
    • Siepmann J. In-silico simulations of advanced drug delivery systems: what will the future offer? Int J Pharm 2013;454:512-16
    • (2013) Int J Pharm , vol.454 , pp. 512-516
    • Siepmann, J.1
  • 25
    • 33845537609 scopus 로고    scopus 로고
    • Modeling the release of nanoparticles from mobile microcapsules
    • Verberg R, Alexeev A, Balazs AC. Modeling the release of nanoparticles from mobile microcapsules. J Chem Phys 2006;125:224712
    • (2006) J Chem Phys , vol.125 , pp. 224712
    • Verberg, R.1    Alexeev, A.2    Balazs, A.C.3
  • 26
    • 84899862179 scopus 로고    scopus 로고
    • Margination of micro-and nano-particles in blood flow and its effect on drug delivery
    • Müller K, Fedosov DA, Gompper G. Margination of micro-and nano-particles in blood flow and its effect on drug delivery. Sci Rep 2014;4:4871
    • (2014) Sci Rep , vol.4 , pp. 4871
    • Müller, K.1    Fedosov, D.A.2    Gompper, G.3
  • 27
    • 84894457968 scopus 로고    scopus 로고
    • Micellar drug nanocarriers and biomembranes: How do they interact?
    • De Nicola A, Hezaveh S, Zhao Y, et al. Micellar drug nanocarriers and biomembranes: how do they interact? Phys Chem Chem Phys 2014;16:5093-105
    • (2014) Phys Chem Chem Phys , vol.16 , pp. 5093-5105
    • De Nicola, A.1    Hezaveh, S.2    Zhao, Y.3
  • 28
    • 84859495714 scopus 로고    scopus 로고
    • Mucociliary clearance of micro-and nanoparticles is independent of size, shape and charge-an ex vivo and in silico approach
    • Kirch J, Guenther M, Doshi N, et al. Mucociliary clearance of micro-and nanoparticles is independent of size, shape and charge-an ex vivo and in silico approach. J Control Release 2012;159:128-34
    • (2012) J Control Release , vol.159 , pp. 128-134
    • Kirch, J.1    Guenther, M.2    Doshi, N.3
  • 29
    • 84855679759 scopus 로고    scopus 로고
    • Spontaneous vesicle self-assembly: A mesoscopic view of membrane dynamics
    • Shillcock JC. Spontaneous vesicle self-assembly: a mesoscopic view of membrane dynamics. Langmuir 2012;28:541-7
    • (2012) Langmuir , vol.28 , pp. 541-547
    • Shillcock, J.C.1
  • 30
    • 84864809993 scopus 로고    scopus 로고
    • Solubilization of saikosaponin a by ginsenoside Ro biosurfactant in aqueous solution: Mesoscopic simulation
    • Dai X, Shi X, Wang Y, et al. Solubilization of saikosaponin a by ginsenoside Ro biosurfactant in aqueous solution: mesoscopic simulation. J Colloid Interface Sci 2012;384:73-80
    • (2012) J Colloid Interface Sci , vol.384 , pp. 73-80
    • Dai, X.1    Shi, X.2    Wang, Y.3
  • 31
    • 84864678599 scopus 로고    scopus 로고
    • PH-sensitive drug loading/releasing in amphiphilic copolymer PAE-PEG: Integrating molecular dynamics and dissipative particle dynamics simulations
    • Luo Z, Jiang J. pH-sensitive drug loading/releasing in amphiphilic copolymer PAE-PEG: integrating molecular dynamics and dissipative particle dynamics simulations. J Control Release 2012;162:185-93
    • (2012) J Control Release , vol.162 , pp. 185-193
    • Luo, Z.1    Jiang, J.2
  • 32
    • 78651333634 scopus 로고    scopus 로고
    • Dissipative particle dynamics studies on microstructure of pH-sensitive micelles for sustained drug delivery
    • Guo XD, Zhang LJ, Wu ZM, et al. Dissipative particle dynamics studies on microstructure of pH-sensitive micelles for sustained drug delivery. Macromolecules 2010;43:7839-44
    • (2010) Macromolecules , vol.43 , pp. 7839-7844
    • Guo, X.D.1    Zhang, L.J.2    Wu, Z.M.3
  • 33
    • 84857777395 scopus 로고    scopus 로고
    • Designing nanoparticle translocation through membranes by computer simulations
    • Ding HM, Tian WD, Ma YQ. Designing nanoparticle translocation through membranes by computer simulations. ACS Nano 2012;6:1230-8
    • (2012) ACS Nano , vol.6 , pp. 1230-1238
    • Ding, H.M.1    Tian, W.D.2    Ma, Y.Q.3
  • 34
    • 70449527465 scopus 로고    scopus 로고
    • Comparison of antitumor efficacy of paclitaxel delivered in nano-and microparticles
    • Chakravarthi SS, De S, Miller DW, Robinson DH. Comparison of antitumor efficacy of paclitaxel delivered in nano-and microparticles. Int J Pharm 2010;383:37-44
    • (2010) Int J Pharm , vol.383 , pp. 37-44
    • Chakravarthi, S.S.1    De, S.2    Miller, D.W.3    Robinson, D.H.4
  • 35
    • 20044382269 scopus 로고    scopus 로고
    • Effect of particle size of nanospheres and microspheres on the cellular-association and cytotoxicity of paclitaxel in 4T1 cells
    • De S, Miller DW, Robinson DH. Effect of particle size of nanospheres and microspheres on the cellular-association and cytotoxicity of paclitaxel in 4T1 cells. Pharm Res 2005;22:766-75
    • (2005) Pharm Res , vol.22 , pp. 766-775
    • De S1    Miller, D.W.2    Robinson, D.H.3
  • 36
    • 84855761355 scopus 로고    scopus 로고
    • Activation of invariant Natural Killer T lymphocytes in response to the alpha-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles
    • Macho Fernandez E, Chang J, Fontaine J, et al. Activation of invariant Natural Killer T lymphocytes in response to the alpha-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles. Int J Pharm 2012;423:45-54
    • (2012) Int J Pharm , vol.423 , pp. 45-54
    • MacHo Fernandez, E.1    Chang, J.2    Fontaine, J.3
  • 37
    • 28644432836 scopus 로고    scopus 로고
    • Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration
    • Amrite AC, Kompella UB. Size-dependent disposition of nanoparticles and microparticles following subconjunctival administration. J Pharm Pharmacol 2005;57:1555-63
    • (2005) J Pharm Pharmacol , vol.57 , pp. 1555-1563
    • Amrite, A.C.1    Kompella, U.B.2
  • 38
    • 0034872426 scopus 로고    scopus 로고
    • Size-dependent bioadhesion of microand nanoparticulate carriers to the inflamed colonic mucosa
    • Lamprecht A, Schäfer U, Lehr CM. Size-dependent bioadhesion of microand nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res 2001;18:788-93
    • (2001) Pharm Res , vol.18 , pp. 788-793
    • Lamprecht, A.1    Schäfer, U.2    Lehr, C.M.3
  • 39
    • 84870685434 scopus 로고    scopus 로고
    • A. Nano-and microscaled particles for drug targeting to inflamed intestinal mucosa-a first in vivo study in human patients
    • Schmidt C, Lautenschlaeger C, Collnot EM, et al. A. Nano-and microscaled particles for drug targeting to inflamed intestinal mucosa-a first in vivo study in human patients. J Control Release 2013;165:139-45
    • (2013) J Control Release , vol.165 , pp. 139-145
    • Schmidt, C.1    Lautenschlaeger, C.2    Collnot, E.M.3
  • 40
    • 84875348429 scopus 로고    scopus 로고
    • Differences in the biokinetics of inhaled nano-versus micrometer-sized particles
    • Kreyling WG, Semmler-Behnke M, Takenaka S, et al. Differences in the biokinetics of inhaled nano-versus micrometer-sized particles. Acc Chem Res 2013;46:714-22
    • (2013) Acc Chem Res , vol.46 , pp. 714-722
    • Kreyling, W.G.1    Semmler-Behnke, M.2    Takenaka, S.3
  • 41
    • 77952674646 scopus 로고    scopus 로고
    • Targeted PLGA nano-but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro
    • Cruz LJ, Tacken PJ, Fokkink R, et al. Targeted PLGA nano-but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro. J Control Release 2010;144:118-26
    • (2010) J Control Release , vol.144 , pp. 118-126
    • Cruz, L.J.1    Tacken, P.J.2    Fokkink, R.3
  • 42
    • 84875294819 scopus 로고    scopus 로고
    • Vivo detection of lipid-based nano-and microparticles in the outermost human stratum corneum by EDX analysis
    • Iannuccelli V, Coppi G, Romagnoli M, et al. In vivo detection of lipid-based nano-and microparticles in the outermost human stratum corneum by EDX analysis. Int J Pharm 2013;447:204-12
    • (2013) Int J Pharm , vol.447 , pp. 204-212
    • Iannuccelli, V.1    Coppi, G.2    Romagnoli, M.3
  • 43
    • 79953198946 scopus 로고    scopus 로고
    • Nanoparticles and microparticles for skin drug delivery
    • Prow TW, Grice JE, Lin LL, et al. Nanoparticles and microparticles for skin drug delivery. Adv Drug Deliv Rev 2011;63:470-91
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 470-491
    • Prow, T.W.1    Grice, J.E.2    Lin, L.L.3
  • 44
    • 84883507197 scopus 로고    scopus 로고
    • Elongated microparticles for enhanced drug delivery to ex vivo and in vivo pig skin
    • Raphael AP, Primiero CA, Ansaldo AB, et al. Elongated microparticles for enhanced drug delivery to ex vivo and in vivo pig skin. J Control Release 2013;172:96-104
    • (2013) J Control Release , vol.172 , pp. 96-104
    • Raphael, A.P.1    Primiero, C.A.2    Ansaldo, A.B.3
  • 45
    • 84928340194 scopus 로고    scopus 로고
    • Comparison of MnO2 nanoparticles and microparticles distribution in CNS and muscle and effect on acute pain threshold in rats
    • Nosrati N, Hassanpour-Ezzati M, Mousavi SZ, et al. Comparison of MnO2 nanoparticles and microparticles distribution in CNS and muscle and effect on acute pain threshold in rats. Nanomedicine J 2014;1:180-90
    • (2014) Nanomedicine J , vol.1 , pp. 180-190
    • Nosrati, N.1    Hassanpour-Ezzati, M.2    Mousavi, S.Z.3
  • 46
    • 0037426692 scopus 로고    scopus 로고
    • Nano-encapsulation of furosemide microcrystals for controlled drug release
    • Ai H, Jones SA, De Villiers MM, et al. Nano-encapsulation of furosemide microcrystals for controlled drug release. J Cont Release 2003;86:59-68
    • (2003) J Cont Release , vol.86 , pp. 59-68
    • Ai, H.1    Jones, S.A.2    De Villiers, M.M.3
  • 47
    • 20144380664 scopus 로고    scopus 로고
    • Controlled release of dexamethasone from microcapsules produced by polyelectrolyte layer-by-layer nanoassembly
    • Pargaonkar N, Lvov YM, Li N, et al. Controlled release of dexamethasone from microcapsules produced by polyelectrolyte layer-by-layer nanoassembly. Pharm Res 2005;22(5):826-35
    • (2005) Pharm Res , vol.22 , Issue.5 , pp. 826-835
    • Pargaonkar, N.1    Lvov, Y.M.2    Li, N.3
  • 48
    • 84896397695 scopus 로고    scopus 로고
    • Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles
    • Strydom SJ, Otto DP, Stieger N, et al. Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles. Powder Technol 2014;256:470-6
    • (2014) Powder Technol , vol.256 , pp. 470-476
    • Strydom, S.J.1    Otto, D.P.2    Stieger, N.3
  • 49
    • 12144268816 scopus 로고    scopus 로고
    • Encapsulation of drug nanoparticles in self-assembled macromolecular nanoshells
    • Zahr AS, De Villiers MM, Pishko MV. Encapsulation of drug nanoparticles in self-assembled macromolecular nanoshells. Langmuir 2005;21(1):403-10
    • (2005) Langmuir , vol.21 , Issue.1 , pp. 403-410
    • Zahr, A.S.1    De Villiers, M.M.2    Pishko, M.V.3
  • 50
    • 15244341414 scopus 로고    scopus 로고
    • Effect of viscosity and concentration of wall former, emulsifier and pore-inducer on the properties of amoxicillin microcapsules prepared by emulsion solvent evaporation
    • Song M, Li N, Sun S, et al. Effect of viscosity and concentration of wall former, emulsifier and pore-inducer on the properties of amoxicillin microcapsules prepared by emulsion solvent evaporation. Farmaco 2005;60(3):61-267
    • (2005) Farmaco , vol.60 , Issue.3 , pp. 61-267
    • Song, M.1    Li, N.2    Sun, S.3
  • 51
    • 34648843305 scopus 로고    scopus 로고
    • Effect of the microencapsulation of nanoparticles on the reduction of burst release
    • Hasan AS, Socha M, Lamprecht A, et al. Effect of the microencapsulation of nanoparticles on the reduction of burst release. Int J Pharm 2007;344:53-61
    • (2007) Int J Pharm , vol.344 , pp. 53-61
    • Hasan, A.S.1    Socha, M.2    Lamprecht, A.3
  • 52
    • 84874931115 scopus 로고    scopus 로고
    • Spherical agglomerates of pure drug nanoparticles for improved pulmonary delivery in dry powder inhalers
    • Hu J, Dong Y, Pastorin G, et al. Spherical agglomerates of pure drug nanoparticles for improved pulmonary delivery in dry powder inhalers. J Nanopart Res 2013;15:1560
    • (2013) J Nanopart Res , vol.15 , pp. 1560
    • Hu, J.1    Dong, Y.2    Pastorin, G.3
  • 53
    • 84888378566 scopus 로고    scopus 로고
    • Preparation and characterization of novel magnetic nano-in-microparticles for site-specific pulmonary drug delivery
    • McBride AA, Price DN, Lamoureux LR, et al. Preparation and characterization of novel magnetic nano-in-microparticles for site-specific pulmonary drug delivery. Mol Pharm 2013;10:3574-81
    • (2013) Mol Pharm , vol.10 , pp. 3574-3581
    • McBride, A.A.1    Price, D.N.2    Lamoureux, L.R.3
  • 54
    • 69849113836 scopus 로고    scopus 로고
    • Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization
    • Pouponneau P, Leroux JC, Martel S. Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization. Biomaterials 2009;30:6327-32
    • (2009) Biomaterials , vol.30 , pp. 6327-6332
    • Pouponneau, P.1    Leroux, J.C.2    Martel, S.3
  • 55
    • 84892615858 scopus 로고    scopus 로고
    • Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery
    • Pinkerton NM, Zhang SW, Youngblood RL, et al. Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery. Biomacromolecules 2014;15:252-61
    • (2014) Biomacromolecules , vol.15 , pp. 252-261
    • Pinkerton, N.M.1    Zhang, S.W.2    Youngblood, R.L.3
  • 56
    • 84865309834 scopus 로고    scopus 로고
    • Nano-inside-micro: Disease-responsive microgels with encapsulated nanoparticles for intracellular drug delivery to the deep lung
    • Wanakule P, Liu GW, Fleury AT, et al. Nano-inside-micro: disease-responsive microgels with encapsulated nanoparticles for intracellular drug delivery to the deep lung. J Control Release 2012;162:429-37
    • (2012) J Control Release , vol.162 , pp. 429-437
    • Wanakule, P.1    Liu, G.W.2    Fleury, A.T.3
  • 57
    • 84879781237 scopus 로고    scopus 로고
    • Modeling of highly efficient drug delivery system induced by self-assembly of nanocarriers: A density functional study
    • Jiang J, Cao D. Modeling of highly efficient drug delivery system induced by self-assembly of nanocarriers: a density functional study. Sci China Chem 2013;56:249-55
    • (2013) Sci China Chem , vol.56 , pp. 249-255
    • Jiang, J.1    Cao, D.2
  • 58
    • 77949898500 scopus 로고    scopus 로고
    • Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems
    • Yao F, Kao WJ. Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems. Expert Opin Drug Deliv 2010;7:429-44
    • (2010) Expert Opin Drug Deliv , vol.7 , pp. 429-444
    • Yao, F.1    Kao, W.J.2
  • 59
    • 36949034965 scopus 로고    scopus 로고
    • Inhalation toxicity and lung toxicokinetics of C60 fullerene nanoparticles and microparticles
    • Baker GL, Gupta A, Clark ML, et al. Inhalation toxicity and lung toxicokinetics of C60 fullerene nanoparticles and microparticles. Toxicol Sci 2008;101:122-31
    • (2008) Toxicol Sci , vol.101 , pp. 122-131
    • Baker, G.L.1    Gupta, A.2    Clark, M.L.3
  • 62
    • 84863516257 scopus 로고    scopus 로고
    • Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic responses of micro-and nano-particles of dolomite on human lung epithelial cells A549
    • Patil G, Khan MI, Patel DK, et al. Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic responses of micro-and nano-particles of dolomite on human lung epithelial cells A549. Environ Toxicol Pharmacol 2012;34:436-45
    • (2012) Environ Toxicol Pharmacol , vol.34 , pp. 436-445
    • Patil, G.1    Khan, M.I.2    Patel, D.K.3
  • 63
    • 83455220587 scopus 로고    scopus 로고
    • Evaluation of cytotoxic, genotoxic and inflammatory responses of micro-and nano-particles of granite on human lung fibroblast cell IMR-90
    • Ahmad I, Khan MI, Patil G, et al. Evaluation of cytotoxic, genotoxic and inflammatory responses of micro-and nano-particles of granite on human lung fibroblast cell IMR-90. Toxicol Lett 2012;208:300-7
    • (2012) Toxicol Lett , vol.208 , pp. 300-307
    • Ahmad, I.1    Khan, M.I.2    Patil, G.3
  • 64
    • 84870174971 scopus 로고    scopus 로고
    • Comparative study of genotoxicity and tissue distribution of nano and micro sized iron oxide in rats after acute oral treatment
    • Singh SP, Rahman MF, Murty US, et al. Comparative study of genotoxicity and tissue distribution of nano and micro sized iron oxide in rats after acute oral treatment. Toxicol Appl Pharmacol 2013;266:56-66
    • (2013) Toxicol Appl Pharmacol , vol.266 , pp. 56-66
    • Singh, S.P.1    Rahman, M.F.2    Murty, U.S.3
  • 65
    • 84878516059 scopus 로고    scopus 로고
    • Genotoxicity of nano-and micro-sized manganese oxide in rats after acute oral treatment
    • Singh SP, Kumari M, Kumari SI, et al. Genotoxicity of nano-and micro-sized manganese oxide in rats after acute oral treatment. Mutat Res 2013;754:39-50
    • (2013) Mutat Res , vol.754 , pp. 39-50
    • Singh, S.P.1    Kumari, M.2    Kumari, S.I.3
  • 66
    • 52449097520 scopus 로고    scopus 로고
    • Comparison of acute responses of mice livers to short-term exposure to nano-sized or micro-sized silver particles
    • Cha K, Hong HW, Choi YG, et al. Comparison of acute responses of mice livers to short-term exposure to nano-sized or micro-sized silver particles. Biotechnol Lett 2008;30:1893-9
    • (2008) Biotechnol Lett , vol.30 , pp. 1893-1899
    • Cha, K.1    Hong, H.W.2    Choi, Y.G.3
  • 67
    • 79957557933 scopus 로고    scopus 로고
    • Evaluation of magnetic micro-and nano-particle toxicity to ocular tissues
    • Raju HB, Hu Y, Vedula A, et al. Evaluation of magnetic micro-and nano-particle toxicity to ocular tissues. PLoS One 2011;6:e17452
    • (2011) PLoS One , vol.6 , pp. e17452
    • Raju, H.B.1    Hu, Y.2    Vedula, A.3
  • 68
    • 33947322486 scopus 로고    scopus 로고
    • Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety
    • Nohynek GJ, Lademann J, Ribaud C, et al. Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety. Crit Rev Toxicol 2007;37:251-77
    • (2007) Crit Rev Toxicol , vol.37 , pp. 251-277
    • Nohynek, G.J.1    Lademann, J.2    Ribaud, C.3
  • 69
    • 36048929111 scopus 로고    scopus 로고
    • Effect of pH on the solubility and release of furosemide from polyamidoamine (PAMAM) dendrimer complexes
    • Devarakonda B, Otto DP, Judefeind A, et al. Effect of pH on the solubility and release of furosemide from polyamidoamine (PAMAM) dendrimer complexes. Int J Pharm 2007;345:142-53
    • (2007) Int J Pharm , vol.345 , pp. 142-153
    • Devarakonda, B.1    Otto, D.P.2    Judefeind, A.3
  • 70
    • 5344265361 scopus 로고    scopus 로고
    • The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine
    • Devarakonda B, Hill RA, de Villiers MM. The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine. Int J Pharm 2004;284:133-40
    • (2004) Int J Pharm , vol.284 , pp. 133-140
    • Devarakonda, B.1    Hill, R.A.2    De Villiers, M.M.3
  • 71
    • 45849135648 scopus 로고    scopus 로고
    • The effect of polyamidoamine dendrimers on the in vitro cytotoxicity of paclitaxel in cultured prostate cancer (PC-3M) cells
    • Devarakonda B, Judefeind A, Chigurupati S, et al. The effect of polyamidoamine dendrimers on the in vitro cytotoxicity of paclitaxel in cultured prostate cancer (PC-3M) cells. J Biomed Nanotechnol 2007;3:384-93
    • (2007) J Biomed Nanotechnol , vol.3 , pp. 384-393
    • Devarakonda, B.1    Judefeind, A.2    Chigurupati, S.3
  • 72
    • 84871405125 scopus 로고    scopus 로고
    • Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity
    • Strydom SJ, Rose WE, Otto DP, et al. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine 2013;9:85-93
    • (2013) Nanomedicine , vol.9 , pp. 85-93
    • Strydom, S.J.1    Rose, W.E.2    Otto, D.P.3
  • 73
    • 77953702051 scopus 로고    scopus 로고
    • Dendrimer toxicity: Let's meet the challenge
    • Jain K, Kesharwani P, Gupta U, et al. Dendrimer toxicity: let's meet the challenge. Int J Pharm 2010;394:122-42
    • (2010) Int J Pharm , vol.394 , pp. 122-142
    • Jain, K.1    Kesharwani, P.2    Gupta, U.3
  • 74
    • 4043103282 scopus 로고    scopus 로고
    • Cytotoxicity, haemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery
    • Chen HT, Neerman MF, Parrish AR, et al. Cytotoxicity, haemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery. J Am Chem Soc 2004;126:10044-8
    • (2004) J Am Chem Soc , vol.126 , pp. 10044-10048
    • Chen, H.T.1    Neerman, M.F.2    Parrish, A.R.3
  • 75
    • 84884915152 scopus 로고    scopus 로고
    • Facing the truth about nanotechnology in drug delivery
    • Park K. Facing the truth about nanotechnology in drug delivery. ACS Nano 2013;7:7442-7
    • (2013) ACS Nano , vol.7 , pp. 7442-7447
    • Park, K.1
  • 76
    • 84866517033 scopus 로고    scopus 로고
    • Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells
    • Varela JA, Bexiga MG, Aberg C, et al. Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells. J Nanobiotechnology 2012;10:39
    • (2012) J Nanobiotechnology , vol.10 , pp. 39
    • Varela, J.A.1    Bexiga, M.G.2    Aberg, C.3
  • 77
    • 84879459400 scopus 로고    scopus 로고
    • Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft
    • Chu KS, Hasan W, Rawal S, et al. Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft. Nanomedicine 2013;9:686-93
    • (2013) Nanomedicine , vol.9 , pp. 686-693
    • Chu, K.S.1    Hasan, W.2    Rawal, S.3
  • 78
    • 68549095935 scopus 로고    scopus 로고
    • Tissue distribution of 20 nm, 100 nm and 1000 nm fluorescent polystyrene latex nanospheres following acute systemic or acute and repeat airway exposure in the rat
    • Sarlo K, Blackburn KL, Clark ED, et al. Tissue distribution of 20 nm, 100 nm and 1000 nm fluorescent polystyrene latex nanospheres following acute systemic or acute and repeat airway exposure in the rat. Toxicology 2009;263:117-26
    • (2009) Toxicology , vol.263 , pp. 117-126
    • Sarlo, K.1    Blackburn, K.L.2    Clark, E.D.3
  • 79
    • 84861463132 scopus 로고    scopus 로고
    • Tissue distribution of inhaled micro-and nano-sized Cerium oxide particles in rats: Results from a 28-day exposure study
    • Geraets L, Oomen AG, Schroeter JD, et al. Tissue distribution of inhaled micro-and nano-sized Cerium oxide particles in rats: results from a 28-day exposure study. Toxicol Sci 2012;127:463-73
    • (2012) Toxicol Sci , vol.127 , pp. 463-473
    • Geraets, L.1    Oomen, A.G.2    Schroeter, J.D.3
  • 80
    • 67650229580 scopus 로고    scopus 로고
    • The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
    • Cho M, Cho WS, Choi M, et al. The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles. Toxicol Lett 2009;189:177-83
    • (2009) Toxicol Lett , vol.189 , pp. 177-183
    • Cho, M.1    Cho, W.S.2    Choi, M.3
  • 81
    • 75549087322 scopus 로고    scopus 로고
    • Size and shape effects in the biodistribution of intravascularly injected particles
    • Decuzzi P, Godin B, Tanaka T, et al. Size and shape effects in the biodistribution of intravascularly injected particles. J Control Release 2010;141:320-7
    • (2010) J Control Release , vol.141 , pp. 320-327
    • Decuzzi, P.1    Godin, B.2    Tanaka, T.3
  • 82
    • 84869155482 scopus 로고    scopus 로고
    • Biocompatibility of Si-based nano-and micro-particles
    • Jaganathan H, Godin B. Biocompatibility of Si-based nano-and micro-particles. Adv Drug Deliv Rev 2012;64:1800-19
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 1800-1819
    • Jaganathan, H.1    Godin, B.2
  • 83
    • 84858719145 scopus 로고    scopus 로고
    • Modeling nanoparticle uptake and intracellular distribution using stochastic process algebras
    • Dobay MPD, Alberola AP, Mendoza ER, et al. Modeling nanoparticle uptake and intracellular distribution using stochastic process algebras. J Nanopart Res 2012;14:821
    • (2012) J Nanopart Res , vol.14 , pp. 821
    • Dobay, M.P.D.1    Alberola, A.P.2    Mendoza, E.R.3
  • 84
    • 77955293577 scopus 로고    scopus 로고
    • Peculiarities of live cells' interaction with micro-and nanoparticles
    • Dukhin AS, Ulberg ZR, Karamushka VI, et al. Peculiarities of live cells' interaction with micro-and nanoparticles. Adv Colloid Interface Sci 2010;159:60-71
    • (2010) Adv Colloid Interface Sci , vol.159 , pp. 60-71
    • Dukhin, A.S.1    Ulberg, Z.R.2    Karamushka, V.I.3
  • 85
    • 44449169014 scopus 로고    scopus 로고
    • Polystyrene nanoparticle trafficking across alveolar epithelium
    • Yacobi NR, DeMaio L, Xie J, et al. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine 2008;4:139-45
    • (2008) Nanomedicine , vol.4 , pp. 139-145
    • Yacobi, N.R.1    Demaio, L.2    Xie, J.3
  • 86
    • 70349232194 scopus 로고    scopus 로고
    • Biodegradable poly(Epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery systems
    • Wei X, Gong C, Gou M, et al. Biodegradable poly(Epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery systems. Int J Pharm 2009;381:1-18
    • (2009) Int J Pharm , vol.381 , pp. 1-18
    • Wei, X.1    Gong, C.2    Gou, M.3


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