Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge-an ex vivo and in silico approach

Journal of Controlled Release

Volumn 159, Issue 1, 2012, Pages 128-134

  Kirch, Julian ^a   Guenther, Marco ^b   Doshi, Nishit ^c   Schaefer, Ulrich F ^a   Schneider, Marc ^a   Mitragotri, Samir ^c   Lehr, Claus Michael ^a,d  

^a SAARLAND UNIVERSITY   (Germany)

^b Saarland University of Applied Sciences   (Germany)

^c University of California   (United States)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

Mucociliary clearance; Mucus penetration; Nanoparticles; Particle uptake; Pulmonary delivery

Indexed keywords

AEROSOL PARTICLES; COMPUTATIONAL MODELING; CONTROLLED RELEASE FORMULATIONS; EX-VIVO; IN-SILICO; INHALED PARTICLES; MUCOCILIARY CLEARANCE; MUCUS PENETRATION; MUCUS-GEL; PARTICLE PENETRATION; PARTICLE UPTAKE; PULMONARY DELIVERY; RESIDENCE TIME; SUBMICROMETERS; TIME FRAME;

BIOCHEMISTRY; NANOPARTICLES; SURFACE CHEMISTRY;

BODY FLUIDS;

CHEMICAL COMPOUND; MICROPARTICLE; NANOPARTICLE; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; DRUG DELIVERY SYSTEM; EX VIVO STUDY; HUMAN; MUCOCILIARY CLEARANCE; MUCUS; PARAMETERS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE CHARGE; SURFACE CHEMISTRY; SURFACE SHAPE; SURFACE SIZE;

ANIMALS; CHICK EMBRYO; COMPUTER SIMULATION; LUNG; MODELS, BIOLOGICAL; MUCOCILIARY CLEARANCE; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENEIMINE; POLYSTYRENES; SURFACE PROPERTIES;

EID: 84859495714     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.12.015     Document Type: Article

References (44)

1. N. Sanders, C. Rudolph, K. Braeckmans, S.C. De Smedt, and J. Demeester Extracellular barriers in respiratory gene therapy Adv. Drug Deliv. Rev. 61 2009 115 127
2. K. Khanvilkar, M.D. Donovan, and D.R. Flanagan Drug transfer through mucus Adv. Drug Deliv. Rev. 48 2001 173 193
3. R.A. Cone Barrier properties of mucus Adv. Drug Deliv. Rev. 61 2009 75 85
4. R. Sturm, and W. Hofmann A theoretical approach to the deposition and clearance of fibers with variable size in the human respiratory tract J. Hazard. Mater. 170 2009 210 218
5. S.H. Randell, and R.C. Boucher Effective mucus clearance is essential for respiratory health Am. J. Respir. Cell Mol. Biol. 35 2006 20 28
6. G.R. Fulford, and J.R. Blake Muco-ciliary transport in the lung J. Theor. Biol. 121 1986 381 402
7. J. Iravani, and G.N. Melville Mucociliary function in the respiratory tract as influenced by physicochemical factors Pharmacol. Ther. B 2 1976 471 492
8. M.B. Antunes, and N.A. Cohen Mucociliary clearance-a critical upper airway host defense mechanism and methods of assessment Curr. Opin. Allergy Clin. Immunol. 7 2007 5 10
9. M. Geiser, and W.G. Kreyling Deposition and biokinetics of inhaled nanoparticles Part. Fibre Toxicol. 7 2010 2
10. M. Geiser, L.M. Cruz-Orive, V. Im Hof, and P. Gehr Assessment of particle retention and clearance in the intrapulmonary conducting airways of hamster lungs with the fractionator J. Microsc. 160 1990 75 88
11. M. Geiser, P. Gerber, I. Maye, V. Im Hof, and P. Gehr Retention of Teflon particles in hamster lungs: a stereological study J. Aerosol Med. 13 2000 43 55
12. M. Geiser, V. Im Hof, W. Siegenthaler, R. Grunder, and P. Gehr Ultrastructure of the aqueous lining layer in hamster airways: is there a two-phase system? Microsc. Res. Tech. 36 1997 428 437
13. M. Geiser, A.L. Serra, L.M. Cruz-Orive, M. Baumann, V. Im Hof, and P. Gehr Efficiency of airway macrophage recovery by bronchoalveolar lavage in hamsters: a stereological approach Eur. Respir. J. 8 1995 1712 1718
14. R.C. Boucher Airway surface dehydration in cystic fibrosis: pathogenesis and therapy Annu. Rev. Med. 58 2007 157 170
15. M. King Physiology of mucus clearance Paediatr. Respir. Rev. 7 Suppl. 1 2006 S212 S214
16. S.H. Donaldson, T.E. Corcoran, B.L. Laube, and W.D. Bennett Mucociliary clearance as an outcome measure for cystic fibrosis clinical research Proc. Am. Thorac. Soc. 4 2007 399 405
17. A. Livraghi, and S.H. Randell Cystic fibrosis and other respiratory diseases of impaired mucus clearance Toxicol. Pathol. 35 2007 116 129
18. W.D. Bennett Effect of beta-adrenergic agonists on mucociliary clearance J. Allergy Clin. Immunol. 110 2002 S291 S297
19. A. Henning, M. Schneider, M. Bur, F. Blank, P. Gehr, and C.M. Lehr Embryonic chicken trachea as a new in vitro model for the investigation of mucociliary particle clearance in the airways AAPS PharmSciTech 9 2008 521 527
20. A. Henning, M. Schneider, N. Nafee, L. Muijs, E. Rytting, X. Wang, T. Kissel, D. Grafahrend, D. Klee, and C.-M. Lehr Influence of particle size and material properties on mucociliary clearance from the airways J. Aerosol Med. Pulm. Drug Deliv. 23 2010 233 241
21. J.A. Champion, Y.K. Katare, and S. Mitragotri Making polymeric micro- and nanoparticles of complex shapes Proc. Natl. Acad. Sci. U. S. A. 104 2007 11901 11904
22. P. Tseng, D. Di Carlo, and J.W. Judy Rapid and dynamic intracellular patterning of cell-internalized magnetic fluorescent nanoparticles Nano Lett. 9 2009 3053 3059
23. C. Cinti, M. Taranta, I. Naldi, and S. Grimaldi Newly engineered magnetic erythrocytes for sustained and targeted delivery of anti-cancer therapeutic compounds PLoS One 6 2011 e17132
24. R.L. Powell, E.F. Aharonson, W.H. Schwarz, D.F. Proctor, G.K. Adams, and M. Reasor Rheological behavior of normal tracheobronchial mucus of canines J. Appl. Physiol. 37 1974 447 451
25. W. Hofmann, and B. Asgharian The effect of lung structure on mucociliary clearance and particle retention in human and rat lungs Toxicol. Sci. 73 2003 448 456
26. P. Gehr, V. Im Hof, M. Geiser, and S. Schurch The mucociliary system of the lung-role of surfactants Schweiz. Med. Wochenschr. 130 2000 691 698
27. B.K. Rubin, O. Ramirez, J.G. Zayas, B. Finegan, and M. King Collection and analysis of respiratory mucus from subjects without lung disease Am. Rev. Respir. Dis. 141 1990 1040 1043
28. A. Jeanneret-Grosjean, M. King, M.C. Michoud, H. Liote, and R. Amyot Sampling technique and rheology of human tracheobronchial mucus Am. Rev. Respir. Dis. 137 1988 707 710
29. H. Matsui, S.H. Randell, S.W. Peretti, C.W. Davis, and R.C. Boucher Coordinated clearance of periciliary liquid and mucus from airway surfaces J. Clin. Invest. 102 1998 1125 1131
30. D.J. Smith, E.A. Gaffney, and J.R. Blake A viscoelastic traction layer model of muco-ciliary transport Bull. Math. Biol. 69 2007 289 327
31. D.J. Smith, E.A. Gaffney, and J.R. Blake Modelling mucociliary clearance Respir. Physiol. Neurobiol. 163 2008 178 188
32. P. Gehr, F.H. Green, M. Geiser, V. Im Hof, M.M. Lee, and S. Schurch Airway surfactant, a primary defense barrier: mechanical and immunological aspects J. Aerosol Med. 9 1996 163 181
33. J. Fiegel, F. Jin, J. Hanes, and K. Stebe Wetting of a particle in a thin film J. Colloid Interface Sci. 291 2005 507 514
34. S. Schurch, P. Gehr, V. Im Hof, M. Geiser, and F. Green Surfactant displaces particles toward the epithelium in airways and alveoli Respir. Physiol. 80 1990 17 32
35. S.K. Lai, D.E. O'Hanlon, S. Harrold, S.T. Man, Y.Y. Wang, R. Cone, and J. Hanes Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus Proc. Natl. Acad. Sci. U. S. A. 104 2007 1482 1487
36. S.K. Lai, Y.Y. Wang, D. Wirtz, and J. Hanes Micro- and macrorheology of mucus Adv. Drug Deliv. Rev. 61 2009 86 100
37. N.N. Sanders, S.C. De Smedt, and J. Demeester Mobility and stability of gene complexes in biogels J. Control. Release 87 2003 117 129
38. A. van As, and I. Webster The organization of ciliary activity and mucus transport in pulmonary airways S. Afr. Med. J. 46 1972 347 350
39. D.E. Sims, and M.M. Horne Heterogeneity of the composition and thickness of tracheal mucus in rats Am. J. Physiol. 273 1997 L1036 L1041
40. W. Moller, K. Felten, K. Sommerer, G. Scheuch, G. Meyer, P. Meyer, K. Haussinger, and W.G. Kreyling Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery Am. J. Respir. Crit. Care Med. 177 2008 426 432
41. V. Im Hof, P. Gehr, V. Gerber, M.M. Lee, and S. Schurch In vivo determination of surface tension in the horse trachea and in vitro model studies Respir. Physiol. 109 1997 81 93
42. K.E. Fischer, B.J. Aleman, S.L. Tao, R. Hugh Daniels, E.M. Li, M.D. Bunger, G. Nagaraj, P. Singh, A. Zettl, and T.A. Desai Biomimetic nanowire coatings for next generation adhesive drug delivery systems Nano Lett. 9 2009 716 720
43. J.S. Crater, and R.L. Carrier Barrier properties of gastrointestinal mucus to nanoparticle transport Macromol. Biosci. 10 2010 1473 1483
44. M.T. Valentine, Z.E. Perlman, M.L. Gardel, J.H. Shin, P. Matsudaira, T.J. Mitchison, and D.A. Weitz Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials Biophys. J. 86 2004 4004 4014