Nano-inside-micro: Disease-responsive microgels with encapsulated nanoparticles for intracellular drug delivery to the deep lung

Journal of Controlled Release

Volumn 162, Issue 2, 2012, Pages 429-437

  Wanakule, Prinda ^a   Liu, Gary W ^a   Fleury, Asha T ^a   Roy, Krishnendu ^a  

^a The University of Texas at Austin   (United States)

Author keywords

Enzyme responsive; Hydrogel; Microgels; Microparticles; Pulmonary

Indexed keywords

AERODYNAMIC DIAMETERS; AERODYNAMIC PROPERTIES; ALVEOLAR MACROPHAGES; BIOLOGIC DRUGS; CARRIER SYSTEMS; CELLULAR UPTAKE; DELIVERY SYSTEMS; ENCAPSULATED NANOPARTICLES; INHALABLE DRUG; INTERNAL STRUCTURE; INTRACELLULAR DRUG DELIVERY; MICHAEL ADDITIONS; MICRO-GELS; MICRO-PARTICLES; MULTI-TIERED; NON-SPECIFICITY; PATIENT COMPLIANCE; PHYSIOLOGICAL LEVELS; PULMONARY; RESIDENCE TIME; RESPIRABLE FRACTIONS; SIDE EFFECT; THERAPEUTIC AGENTS; TRIGGERED RELEASE; WATER-IN-OIL;

ADDITION REACTIONS; AERODYNAMICS; BIOLOGICAL ORGANS; DRUG DELIVERY; DRUG INTERACTIONS; EMULSIFICATION; ENZYMES; HYDROGELS; MACROPHAGES; NANOPARTICLES; STRUCTURAL OPTIMIZATION; TOXICITY;

GELS;

BIOLOGICAL PRODUCT; NANOPARTICLE; WATER OIL CREAM;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENZYME RELEASE; HUMAN; HUMAN CELL; HYDROGEL; LUNG ALVEOLUS MACROPHAGE; MEAN RESIDENCE TIME; MICHAEL ADDITION; MICROGEL; NANOENCAPSULATION; NANOFABRICATION; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SCANNING ELECTRON MICROSCOPY;

ADMINISTRATION, INHALATION; ANIMALS; CELL LINE; CELL LINE, TUMOR; DNA; DRUG CARRIERS; DRUG COMPOUNDING; GELS; HEK293 CELLS; HUMANS; HYDROLYSIS; IMMUNOGLOBULIN G; LUNG; MICE; NANOPARTICLES; OLIGOPEPTIDES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; TRYPSIN;

EID: 84865309834     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.026     Document Type: Article

References (43)

1. D.A. Edwards, and C. Dunbar Bioengineering of therapeutic aerosols Annu. Rev. Biomed. Eng. 4 2002 93 107
2. Y. Son, and J. McConville Advancements in dry powder delivery to the lung Drug Dev. Ind. Pharm. 34 2008 948 959
3. G. Pilcer, and K. Amighi Formulation strategy and use of excipients in pulmonary drug delivery Int. J. Pharm. 392 2010 1 19
4. I.M. El-Sherbiny, S. McGill, and H.D.C. Smyth Swellable microparticles as carriers for sustained pulmonary drug delivery J. Pharm. Sci. 99 2010 2343 2356
5. F. Ahsan, I.P. Rivas, M.A. Khan, and A.I. Torres Suarez Targeting to macrophages: role of physicochemical properties of particulate carriers - liposomes and microspheres - on the phagocytosis by macrophages J. Control. Release 79 2002 29 40
6. J.A. Champion, A. Walker, and S. Mitragotri Role of particle size in phagocytosis of polymeric microspheres Pharm. Res. 25 2008 1815 1821
7. K. Makino, N. Yamamoto, K. Higuchi, N. Harada, H. Ohshima, and H. Terada Phagocytic uptake of polystyrene microspheres by alveolar macrophages: effects of the size and surface properties of the microspheres Colloids Surf. B Biointerfaces 27 2003 33 39
8. S.K. Lai, Y.-Y. Wang, and J. Hanes Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues Adv. Drug Deliv. Rev. 61 2009 158 171
9. J.C. Sung, B.L. Pulliam, and D.A. Edwards Nanoparticles for drug delivery to the lungs Trends Biotechnol. 25 2007 563 570
10. E. Rytting, J. Nguyen, and X. Wang Biodegradable polymeric nanocarriers for pulmonary drug delivery Expert Opin. Drug Deliv. 5 2008 629 639
11. P. Wanakule, and K. Roy Disease-responsive drug delivery: the next generation of smart delivery devices Curr. Drug Metab. 13 2012 42 49
12. M. Caldorera-Moore, N. Guimard, L. Shi, and K. Roy Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers Expert Opin. Drug Deliv. 7 2010 479 495
13. D.L. Elbert, A.B. Pratt, M.P. Lutolf, S. Halstenberg, and J.A. Hubbell Protein delivery from materials formed by self-selective conjugate addition reactions J. Control. Release 76 2001 11 25
14. M.D. Bhavsar, and M.M. Amiji Development of novel biodegradable polymeric nanoparticles-in-microsphere formulation for local plasmid DNA delivery in the gastrointestinal tract AAPS PharmSciTech 9 2008 288 294
15. N. Tsapis, D. Bennett, B. Jackson, D.A. Weitz, and D.A. Edwards Trojan particles: large porous carriers of nanoparticles for drug delivery Proc. Natl. Acad. Sci. U. S. A. 99 2002 12001 12005
16. C. Wong, T. Stylianopoulos, J. Cui, J. Martin, V.P. Chauhan, W. Jiang, Z. Popović, R.K. Jain, M.G. Bawendi, and D. Fukumura Multistage nanoparticle delivery system for deep penetration into tumor tissue Proc. Natl. Acad. Sci. U. S. A. 108 2011 2426 2431
17. S. Kim, E.H. Chung, M. Gilbert, and K.E. Healy Synthetic MMP-13 degradable ECMs based on poly(N-isopropylacrylamide-co-acrylic acid) semi-interpenetrating polymer networks. I. Degradation and cell migration J. Biomed. Mater. Res. A 75 2005 73 88
18. A. Metters, and J.A. Hubbell Network formation and degradation behavior of hydrogels formed by Michael-type addition reactions Biomacromolecules 6 2005 290 301
19. Y. Qiu, and K. Park Environment-sensitive hydrogels for drug delivery Adv. Drug Deliv. Rev. 53 2001 321 339
20. A.A. Aimetti, A.J. Machen, and K.S. Anseth Poly(ethylene glycol) hydrogels formed by thiol-ene photopolymerization for enzyme-responsive protein delivery Biomaterials 30 2009 6048 6054
21. A. Chang, M. Scheer, A. Grote, I. Schomburg, and D. Schomburg BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009 Nucleic Acids Res. 37 2009 D588 D592
22. E. Gasteiger, A. Gattiker, C. Hoogland, I. Ivanyi, R.D. Appel, and A. Bairoch ExPASy: the proteomics server for in-depth protein knowledge and analysis Nucleic Acids Res. 31 2003 3784 3788
23. Y.-S. Chen, R.G. Alany, S.A. Young, C.R. Green, and I.D. Rupenthal In vitro release characteristics and cellular uptake of poly(d,l-lactic-co-glycolic acid) nanoparticles for topical delivery of antisense oligodeoxynucleotides Drug Deliv. 18 2011 493 501
24. S.P. Kasturi, I. Skountzou, R.A. Albrecht, D. Koutsonanos, T. Hua, H.I. Nakaya, R. Ravindran, S. Stewart, M. Alam, M. Kwissa, F. Villinger, N. Murthy, J. Steel, J. Jacob, R.J. Hogan, A. Garciía-Sastre, R. Compans, and B. Pulendran Programming the magnitude and persistence of antibody responses with innate immunity Nature 470 2011 543 547
25. S.K. Sahoo, W. Ma, and V. Labhasetwar Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer Int. J. Cancer 112 2004 335 340
26. A. Singh, H. Nie, B. Ghosn, H. Qin, L.W. Kwak, and K. Roy Efficient modulation of T-cell response by dual-mode, single-carrier delivery of cytokine-targeted siRNA and DNA vaccine to antigen-presenting cells Mol. Ther. 16 2008 2011 2021
27. A. Singh, S. Suri, and K. Roy In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA-DNA carrying microparticles to dendritic cells Biomaterials 30 2009 5187 5200
28. A. Pusztai, G. Grant, S. Bardocz, K. Baintner, E. Gelencsér, and S.W. Ewen Both free and complexed trypsin inhibitors stimulate pancreatic secretion and change duodenal enzyme levels Am. J. Physiol. 272 1997 G340 G350
29. O.Z. Fisher, and N.A. Peppas Polybasic nanomatrices prepared by UV-initiated photopolymerization Macromolecules 42 2009 3391 3398
30. M. Ehrbar, S.C. Rizzi, R.G. Schoenmakers, B.S. Miguel, J.A. Hubbell, F.E. Weber, and M.P. Lutolf Biomolecular hydrogels formed and degraded via site-specific enzymatic reactions Biomacromolecules 8 2007 3000 3007
31. M.P. Lutolf, F.E. Weber, H.G. Schmoekel, J.C. Schense, T. Kohler, R. Müller, and J.A. Hubbell Repair of bone defects using synthetic mimetics of collagenous extracellular matrices Nat. Biotechnol. 21 2003 513 518
32. B. Mather, K. Viswanathan, K. Miller, and T. Long Michael addition reactions in macromolecular design for emerging technologies Prog. Polym. Sci. 31 2006 487 531
33. K. Hadinoto, P. Phanapavudhikul, Z. Kewu, and R.B.H. Tan Dry powder aerosol delivery of large hollow nanoparticulate aggregates as prospective carriers of nanoparticulate drugs: effects of phospholipids Int. J. Pharm. 333 2007 187 198
34. K. Hadinoto, K. Zhu, and R.B.H. Tan Drug release study of large hollow nanoparticulate aggregates carrier particles for pulmonary delivery Int. J. Pharm. 341 2007 195 206
35. Y. Liu, and P. Daum The effect of refractive index on size distributions and light scattering coefficients derived from optical particle counters J. Aerosol Sci. 31 2000 945 957
36. C. Vauthier, C. Schmidt, and P. Couvreur Measurement of the density of polymeric nanoparticulate drug carriers by isopycnic centrifugation J. Nanopart. Res. 1999
37. D.G. Grier A revolution in optical manipulation Nature 424 2003 810 816
38. J.K. Armstrong, R.B. Wenby, H.J. Meiselman, and T.C. Fisher The hydrodynamic radii of macromolecules and their effect on red blood cell aggregation Biophys. J. 87 2004 4259 4270
39. R.S. Dias, J. Innerlohinger, O. Glatter, M.G. Miguel, and B. Lindman Coil-globule transition of DNA molecules induced by cationic surfactants: a dynamic light scattering study J. Phys. Chem. B 109 2005 10458 10463
40. H. Oana, K. Tsumoto, Y. Yoshikawa, and K. Yoshikawa Folding transition of large DNA completely inhibits the action of a restriction endonuclease as revealed by single-chain observation FEBS Lett. 530 2002 143 146
41. J. Patterson, and J.A. Hubbell Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2 Biomaterials 31 2010 7836 7845
42. J. Patterson, and J.A. Hubbell SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels Biomaterials 32 2011 1301 1310
43. M.P. Lutolf, J.L. Lauer-Fields, H.G. Schmoekel, A.T. Metters, F.E. Weber, G.B. Fields, and J.A. Hubbell Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics Proc. Natl. Acad. Sci. U. S. A. 100 2003 5413 5418