A rationally designed six-residue swap generates comparability in the aggregation behavior of α-synuclein and β-synuclein

Biochemistry

Volumn 51, Issue 44, 2012, Pages 8771-8778

  Roodveldt, Cintia ^a   Andersson, August ^b   De Genst, Erwin J ^b   Labrador Garrido, Adahir ^a   Buell, Alexander K ^b   Dobson, Christopher M ^b   Tartaglia, Gian Gaetano ^c   Vendruscolo, Michele ^b  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION BEHAVIOR; AGGREGATION PROCESS; AGGREGATION PROPENSITY; AGGREGATION RATE; CELLULAR ENVIRONMENT; CELLULAR TOXICITIES; CONTROL EXPERIMENTS; PARKINSON'S DISEASE; RATIONAL DESIGN; SEQUENCE VARIATIONS; SYNUCLEIN;

AGGLOMERATION; OLIGOMERS; TOXICITY;

PROTEINS;

ALPHA SYNUCLEIN; ALPHA2BETA SYNUCLEIN; BETA SYNUCLEIN; BETA2ALPHA PROTEIN; MUTANT PROTEIN; OLIGOMER; PROTEIN VARIANT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; SITE DIRECTED MUTAGENESIS;

ALPHA-SYNUCLEIN; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BETA-SYNUCLEIN; CELL SURVIVAL; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE ALIGNMENT; TUMOR CELLS, CULTURED;

EID: 84868523449     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300558q     Document Type: Article

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