Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity

ACS Chemical Biology

Volumn 9, Issue 10, 2014, Pages 2309-2317

  Mannini, Benedetta ^a   Mulvihill, Estefania ^a   Sgromo, Caterina ^a   Cascella, Roberta ^a   Khodarahmi, Reza ^b   Ramazzotti, Matteo ^a   Dobson, Christopher M ^c   Cecchi, Cristina ^a   Chiti, Fabrizio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 ANILINO 1 NAPHTHALENESULFONIC ACID; AMINO ACID; ARGININE; ESCHERICHIA COLI PROTEIN; GLUTAMIC ACID; HOE 33342; LEUCINE; OLIGOMER; PROTEIN; HYPF PROTEIN, E COLI; TRANSFERASE;

APOPTOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; CELL VIABILITY; CIRCULAR DICHROISM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIGHT SCATTERING; MTT ASSAY; PROTEIN SECONDARY STRUCTURE; REDUCTION; SITE DIRECTED MUTAGENESIS; SURFACE PROPERTY; TOXICITY; TURBIDIMETRY; CELL PROLIFERATION; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI; GENETICS; METABOLISM; MUTATION; PH; PROTEIN MULTIMERIZATION;

CARBOXYL AND CARBAMOYL TRANSFERASES; CELL PROLIFERATION; CIRCULAR DICHROISM; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MUTATION; PROTEIN MULTIMERIZATION;

EID: 84908211476     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500505m     Document Type: Article

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