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Volumn 14, Issue 6, 2015, Pages 867-879

Activation of autophagy via ca2+-dependent ampk/ mtor pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress

Author keywords

Adaptation; Apoptosis; Autophagy; Hyperosmotic stress; Notochordal cells

Indexed keywords

ADENYLATE KINASE; AUTOPHAGY PROTEIN 5; CALCIUM; MAMMALIAN TARGET OF RAPAMYCIN; SMALL INTERFERING RNA; ATG5 PROTEIN, RAT; HEAT SHOCK PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN; SQSTM1 PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE;

EID: 84928109445     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1004946     Document Type: Article
Times cited : (77)

References (55)
  • 2
    • 84908610175 scopus 로고    scopus 로고
    • The responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: Implications for disc degeneration
    • PMID:25277442
    • Chen JW, Ni BB, Li B, Yang YH, Jiang SD, Jiang LS. The responses of autophagy and apoptosis to oxidative stress in nucleus pulposus cells: implications for disc degeneration. Cell Physiol Biochem 2014; 34:1175-89; PMID:25277442; http://dx.doi.org/10.1159/ 000366330
    • (2014) Cell Physiol Biochem , vol.34 , pp. 1175-1189
    • Chen, J.W.1    Ni, B.B.2    Li, B.3    Yang, Y.H.4    Jiang, S.D.5    Jiang, L.S.6
  • 3
    • 84872133973 scopus 로고    scopus 로고
    • Increased macroautophagy in the pathological process of intervertebral disc degeneration in rats
    • PMID:22835012
    • Ye W, Zhu W, Xu K, Liang A, Peng Y, Huang D, Li C. Increased macroautophagy in the pathological process of intervertebral disc degeneration in rats. Connect Tissue Res 2012; 54:22-8; PMID:22835012; http://dx.doi.org/10.3109/03008207.2012.715702
    • (2012) Connect Tissue Res , vol.54 , pp. 22-28
    • Ye, W.1    Zhu, W.2    Xu, K.3    Liang, A.4    Peng, Y.5    Huang, D.6    Li, C.7
  • 4
    • 80755188000 scopus 로고    scopus 로고
    • Age-related increases of macroautophagy and chaperone-mediated autophagy in rat nucleus pulposus
    • PMID:21591930
    • Ye W, Xu K, Huang D, Liang A, Peng Y, Zhu W, Li C. Age-related increases of macroautophagy and chaperone-mediated autophagy in rat nucleus pulposus. Connect Tissue Res 2011; 52:472-8; PMID:21591930; http://dx.doi.org/10.3109/03008207.2011.564336
    • (2011) Connect Tissue Res , vol.52 , pp. 472-478
    • Ye, W.1    Xu, K.2    Huang, D.3    Liang, A.4    Peng, Y.5    Zhu, W.6    Li, C.7
  • 6
    • 80051642761 scopus 로고    scopus 로고
    • Autophagy in rat annulus fibrosus cells: Evidence and possible implications
    • PMID:21846367
    • Shen C, Yan J, Jiang LS, Dai LY. Autophagy in rat annulus fibrosus cells: evidence and possible implications. Arthritis Res Ther 2011; 13:R132; PMID:21846367; http://dx.doi.org/10.1186/ar3443
    • (2011) Arthritis Res Ther , vol.13 , Issue.R132
    • Shen, C.1    Yan, J.2    Jiang, L.S.3    Dai, L.Y.4
  • 7
    • 84911162804 scopus 로고    scopus 로고
    • Responses and adaptations of intervertebral disc cells to microenvironmental stress: A possible central role of autophagy in the adaptive mechanism
    • PMID:25000273
    • Jiang L, Yuan F, Yin X, Dong J. Responses and adaptations of intervertebral disc cells to microenvironmental stress: a possible central role of autophagy in the adaptive mechanism. Connect Tissue Res 2014; 55:311-21; PMID:25000273; http://dx.doi.org/10.3109/ 03008207.2014.942419
    • (2014) Connect Tissue Res , vol.55 , pp. 311-321
    • Jiang, L.1    Yuan, F.2    Yin, X.3    Dong, J.4
  • 8
    • 0036865353 scopus 로고    scopus 로고
    • The role of the physicochemical environment in determining disc cell behaviour
    • PMID:12440933
    • Urban JP. The role of the physicochemical environment in determining disc cell behaviour. Biochem Soc Trans 2002; 30:858-64; PMID:12440933; http://dx.doi.org/10.1042/BST0300858
    • (2002) Biochem Soc Trans , vol.30 , pp. 858-864
    • Urban, J.P.1
  • 9
    • 84876098330 scopus 로고    scopus 로고
    • Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regeneration
    • PMID:23259403
    • Shoukry M, Li J, Pei M. Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regeneration. Stem Cells Dev 2013; 22:1162-76; PMID:23259403; http://dx.doi.org/10.1089/scd.2012.0597
    • (2013) Stem Cells Dev , vol.22 , pp. 1162-1176
    • Shoukry, M.1    Li, J.2    Pei, M.3
  • 10
    • 44249119586 scopus 로고    scopus 로고
    • The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: Implications for degenerative disc disease
    • PMID:18433481
    • Johnson WE, Stephan S, Roberts S. The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease. Arthritis Res Ther 2008; 10:R46; PMID:18433481; http://dx.doi.org/10.1186/ar2405
    • (2008) Res Ther , vol.10 , Issue.R46
    • Johnson, W.E.1    Stephan, S.2    Roberts, S.3
  • 11
    • 84880994042 scopus 로고    scopus 로고
    • Intermittent cyclic mechanical tensioninduced down-regulation of ectonucleotide pyrophosphatase phosphodiesterase 1 gene expression is mainly dependent on TGF-beta1 in end-plate chondrocytes
    • PMID:23420746
    • Xu HG, Li ZR, Wang H, Liu P, Xiang SN, Wang CD, Zhang XL. Intermittent cyclic mechanical tensioninduced down-regulation of ectonucleotide pyrophosphatase phosphodiesterase 1 gene expression is mainly dependent on TGF-beta1 in end-plate chondrocytes. Orthopaedic Surgery 2013; 5:40-5; PMID:23420746; http://dx.doi.org/10.1111/os.12028
    • (2013) Orthopaedic Surgery , vol.5 , pp. 40-45
    • Xu, H.G.1    Li, Z.R.2    Wang, H.3    Liu, P.4    Xiang, S.N.5    Wang, C.D.6    Zhang, X.L.7
  • 12
    • 0030952489 scopus 로고    scopus 로고
    • Proteoglycan synthesis in the intervertebral disk nucleus: The role of extracellular osmolality
    • C1499-506PMID:9176140
    • Ishihara H, Warensjo K, Roberts S, Urban JP. Proteoglycan synthesis in the intervertebral disk nucleus: the role of extracellular osmolality. Am J Physiol 1997; 272:C1499-506; PMID:9176140
    • (1997) Am J Physiol , vol.272
    • Ishihara, H.1    Warensjo, K.2    Roberts, S.3    Urban, J.P.4
  • 13
    • 0012037395 scopus 로고
    • Swelling of the intervertebral disc in vitro
    • PMID:6456121
    • Urban JP, Maroudas A. Swelling of the intervertebral disc in vitro. Connect Tissue Res 1981; 9:1-10; PMID:6456121; http://dx.doi.org/10.3109/ 03008208109160234
    • (1981) Connect Tissue Res , vol.9 , pp. 1-10
    • Urban, J.P.1    Maroudas, A.2
  • 15
    • 37349012152 scopus 로고    scopus 로고
    • Physical limitations to tissue engineering of intervertebral disc cells: Effect of extracellular osmotic change on glycosaminoglycan production and cell metabolism
    • PMID:18074689
    • Takeno K, Kobayashi S, Negoro K, Uchida K, Miyazaki T, Yayama T, Shimada S, Baba H. Physical limitations to tissue engineering of intervertebral disc cells: effect of extracellular osmotic change on glycosaminoglycan production and cell metabolism. Laboratory investigation. J Neurosurg Spine 2007; 7:637-44; PMID:18074689; http://dx.doi.org/10.3171/SPI-07/ 12/637
    • (2007) Laboratory Investigation. J Neurosurg Spine , vol.7 , pp. 637-644
    • Takeno, K.1    Kobayashi, S.2    Negoro, K.3    Uchida, K.4    Miyazaki, T.5    Yayama, T.6    Shimada, S.7    Baba, H.8
  • 16
    • 34248663510 scopus 로고    scopus 로고
    • Hyperosmotic stressinduced apoptotic signaling pathways in chondrocytes
    • PMID:17392049
    • Racz B, Reglodi D, Fodor B, Gasz B, Lubics A, Gallyas F, Jr., Roth E, Borsiczky B. Hyperosmotic stressinduced apoptotic signaling pathways in chondrocytes. Bone 2007; 40:1536-43; PMID:17392049; http://dx.doi.org/10.1016/j.bone.2007.02.011
    • (2007) Bone , vol.40 , pp. 1536-1543
    • Racz, B.1    Reglodi, D.2    Fodor, B.3    Gasz, B.4    Lubics, A.5    Gallyas, F.6    Roth, E.7    Borsiczky, B.8
  • 17
    • 84874138680 scopus 로고    scopus 로고
    • Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes
    • PMID:23442954
    • Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA. Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J 2013; 104:759-69; PMID:23442954; http://dx.doi.org/10.1016/j.bpj.2013.01.006
    • (2013) Biophys J , vol.104 , pp. 759-769
    • Irianto, J.1    Swift, J.2    Martins, R.P.3    McPhail, G.D.4    Knight, M.M.5    Discher, D.E.6    Lee, D.A.7
  • 18
    • 84894463673 scopus 로고    scopus 로고
    • Boning up on autophagy: The role of autophagy in skeletal biology
    • PMID:24225636
    • Shapiro IM, Layfield R, Lotz M, Settembre C, Whitehouse C. Boning up on autophagy: the role of autophagy in skeletal biology. Autophagy 2014; 10:7-19; PMID:24225636; http://dx.doi.org/10.4161/auto. 26679
    • (2014) Autophagy , vol.10 , pp. 7-19
    • Shapiro, I.M.1    Layfield, R.2    Lotz, M.3    Settembre, C.4    Whitehouse, C.5
  • 19
    • 84893675756 scopus 로고    scopus 로고
    • Autophagy: A critical regulator of cellular metabolism and homeostasis
    • PMID:23708729
    • Ryter SW, Cloonan SM, Choi AM. Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol cells 2013; 36:7-16; PMID:23708729; http://dx.doi.org/10.1007/s10059-013-0140-8
    • (2013) Mol Cells , vol.36 , pp. 7-16
    • Ryter, S.W.1    Cloonan, S.M.2    Choi, A.M.3
  • 21
    • 84896106296 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates p62- dependent autophagy-like aggregate clearance in hepatocytes
    • 2014, PMID:24683544
    • Chen C, Deng M, Sun Q, Loughran P, Billiar TR, Scott MJ. Lipopolysaccharide stimulates p62- dependent autophagy-like aggregate clearance in hepatocytes. Biomed Res Int 2014; 2014:267350; PMID:24683544
    • (2014) Biomed Res Int
    • Chen, C.1    Deng, M.2    Sun, Q.3    Loughran, P.4    Billiar, T.R.5    Scott, M.J.6
  • 22
    • 84890549211 scopus 로고    scopus 로고
    • High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells
    • PMID:23907350
    • Park EY, Park JB. High glucose-induced oxidative stress promotes autophagy through mitochondrial damage in rat notochordal cells. Int Orthop 2013; 37:2507-14; PMID:23907350; http://dx.doi.org/10.1007/ s00264-013-2037-8
    • (2013) Int Orthop , vol.37 , pp. 2507-2514
    • Park, E.Y.1    Park, J.B.2
  • 23
    • 84888857607 scopus 로고    scopus 로고
    • Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression
    • PMID:24120490
    • Ma KG, Shao ZW, Yang SH, Wang J, Wang BC, Xiong LM, Wu Q, Chen SF. Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression. Osteoarthritis Cartilage 2013; 21:2030-8; PMID:24120490; http://dx.doi.org/10.1016/j.joca.2013.10.002
    • (2013) Osteoarthritis Cartilage , vol.21 , pp. 2030-2038
    • Ma, K.G.1    Shao, Z.W.2    Yang, S.H.3    Wang, J.4    Wang, B.C.5    Xiong, L.M.6    Wu, Q.7    Chen, S.F.8
  • 24
    • 80052638037 scopus 로고    scopus 로고
    • A dual role for Ca (2C) in autophagy regulation
    • PMID:21571367
    • Decuypere JP, Bultynck G, Parys JB. A dual role for Ca (2C) in autophagy regulation. Cell Calcium 2011; 50:242-50; PMID:21571367; http://dx.doi.org/10.1016/j.ceca.2011.04.001
    • (2011) Cell Calcium , vol.50 , pp. 242-250
    • Decuypere, J.P.1    Bultynck, G.2    Parys, J.B.3
  • 26
    • 56549125810 scopus 로고    scopus 로고
    • Cadmium- induced autophagy and apoptosis are mediated by a calcium signaling pathway
    • PMID:18850067
    • Wang SH, Shih YL, Ko WC, Wei YH, Shih CM. Cadmium- induced autophagy and apoptosis are mediated by a calcium signaling pathway. Cell Mol Life Sci 2008; 65:3640-52; PMID:18850067; http://dx.doi. org/10.1007/s00018-008-8383-9
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3640-3652
    • Wang, S.H.1    Shih, Y.L.2    Ko, W.C.3    Wei, Y.H.4    Shih, C.M.5
  • 27
    • 77950575506 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-b peptide metabolism
    • PMID:20080969
    • Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, et al. AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-b peptide metabolism. J Biol Chem 2010; 285:9100-13; PMID:20080969; http://dx.doi.org/10.1074/jbc.M109. 060061
    • (2010) J Biol Chem , vol.285 , pp. 9100-9113
    • Vingtdeux, V.1    Giliberto, L.2    Zhao, H.3    Chandakkar, P.4    Wu, Q.5    Simon, J.E.6    Janle, E.M.7    Lobo, J.8    Ferruzzi, M.G.9    Davies, P.10
  • 28
    • 77949736802 scopus 로고    scopus 로고
    • Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2C) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis
    • PMID:20197400
    • Law BY, Wang M, Ma DL, Al-Mousa F, Michelangeli F, Cheng SH, Ng MH, To KF, Mok AY, Ko RY, et al. Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2C) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol Cancer Ther 2010; 9:718-30; PMID:20197400; http://dx.doi.org/10.1158/1535- 7163.MCT-09-0700
    • (2010) Mol Cancer Ther , vol.9 , pp. 718-730
    • Law, B.Y.1    Wang, M.2    Ma, D.L.3    Al-Mousa, F.4    Michelangeli, F.5    Cheng, S.H.6    Ng, M.H.7    To, K.F.8    Mok, A.Y.9    Ko, R.Y.10
  • 29
    • 84884903357 scopus 로고    scopus 로고
    • Autophagic cell death induced by resveratrol depends on the Ca(2C)/AMPK/mTOR pathway in A549 cells
    • PMID:23680031
    • Zhang J, Chiu J, Zhang H, Qi T, Tang Q, Ma K, Lu H, Li G. Autophagic cell death induced by resveratrol depends on the Ca(2C)/AMPK/mTOR pathway in A549 cells. Biochem Pharmacol 2013; 86:317-28; PMID:23680031; http://dx.doi.org/10.1016/j.bcp. 2013.05.003
    • (2013) Biochem Pharmacol , vol.86 , pp. 317-328
    • Zhang, J.1    Chiu, J.2    Zhang, H.3    Qi, T.4    Tang, Q.5    Ma, K.6    Lu, H.7    Li, G.8
  • 30
    • 77956916659 scopus 로고    scopus 로고
    • Parallel activation of Ca(2C)-induced survival and death pathways in cardiomyocytes by sorbitol- induced hyperosmotic stress
    • PMID:20454859
    • Chiong M, Parra V, Eisner V, Ibarra C, Maldonado C, Criollo A, Bravo R, Quiroga C, Contreras A, Vicencio JM, et al. Parallel activation of Ca(2C)-induced survival and death pathways in cardiomyocytes by sorbitol- induced hyperosmotic stress. Apoptosis 2010; 15:887-903; PMID:20454859; http://dx.doi.org/10.1007/s10495-010-0505-9
    • (2010) Apoptosis , vol.15 , pp. 887-903
    • Chiong, M.1    Parra, V.2    Eisner, V.3    Ibarra, C.4    Maldonado, C.5    Criollo, A.6    Bravo, R.7    Quiroga, C.8    Contreras, A.9    Vicencio, J.M.10
  • 31
    • 0034753575 scopus 로고    scopus 로고
    • Hyperosmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways
    • PMID:11716854
    • Erickson GR, Alexopoulos LG, Guilak F. Hyperosmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways. J Biomech 2001; 34:1527-35; PMID:11716854; http://dx.doi.org/10.1016/S0021-9290(01)00156-7
    • (2001) J Biomech , vol.34 , pp. 1527-1535
    • Erickson, G.R.1    Alexopoulos, L.G.2    Guilak, F.3
  • 32
    • 33847644213 scopus 로고    scopus 로고
    • The role of CaC2 on rhein-induced apoptosis in human cervical cancer Ca Ski cells
    • PMID:17352257
    • Ip SW, Weng YS, Lin SY, Mei D, Tang NY, Su CC, Chung JG. The role of CaC2 on rhein-induced apoptosis in human cervical cancer Ca Ski cells. Anticancer Res 2007; 27:379-89; PMID:17352257
    • (2007) Anticancer Res , vol.27 , pp. 379-389
    • Ip, S.W.1    Weng, Y.S.2    Lin, S.Y.3    Mei, D.4    Tang, N.Y.5    Su, C.C.6    Chung, J.G.7
  • 34
    • 84859829726 scopus 로고    scopus 로고
    • Autophagy and selfdefense
    • PMID:22399380
    • Martinez-Borra J, Lopez-Larrea C. Autophagy and selfdefense. Adv Exp Med Biol 2012; 738:169-84; PMID:22399380; http://dx.doi.org/10.1007/978-1- 4614-1680-7_11
    • (2012) Adv Exp Med Biol , vol.738 , pp. 169-184
    • Martinez-Borra, J.1    Lopez-Larrea, C.2
  • 35
    • 80053900670 scopus 로고    scopus 로고
    • Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA
    • PMID:21808292
    • Lotz MK, Carames B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Nat Rev Rheumatol 2011; 7:579-87; PMID:21808292
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 579-587
    • Lotz, M.K.1    Carames, B.2
  • 36
    • 84892187515 scopus 로고    scopus 로고
    • The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis
    • PMID:24126970
    • Chang J, Wang W, Zhang H, Hu Y, Wang M, Yin Z. The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis. Int J Mol Med 2013; 32:1311-8; PMID:24126970
    • (2013) Int J Mol Med , vol.32 , pp. 1311-1318
    • Chang, J.1    Wang, W.2    Zhang, H.3    Hu, Y.4    Wang, M.5    Yin, Z.6
  • 37
    • 84857910484 scopus 로고    scopus 로고
    • Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
    • PMID:22084394
    • Carames B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Ann Rheum Dis 2011; 71:575-81; PMID:22084394; http://dx.doi.org/10.1136/annrheumdis-2011-200557
    • (2011) Ann Rheum Dis , vol.71 , pp. 575-581
    • Carames, B.1    Hasegawa, A.2    Taniguchi, N.3    Miyaki, S.4    Blanco, F.J.5    Lotz, M.6
  • 38
    • 75349112375 scopus 로고    scopus 로고
    • Mitochondrial turnover and aging of long-lived postmitotic cells: The mitochondrial-lysosomal axis theory of aging
    • PMID:19650712
    • Terman A, Kurz T, Navratil M, Arriaga EA, Brunk UT. Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal 2010; 12:503-35; PMID:19650712; http://dx.doi.org/10.1089/ars.2009. 2598
    • (2010) Antioxid Redox Signal , vol.12 , pp. 503-535
    • Terman, A.1    Kurz, T.2    Navratil, M.3    Arriaga, E.A.4    Brunk, U.T.5
  • 42
    • 84890404446 scopus 로고    scopus 로고
    • Ovarian cancer G protein-coupled receptor 1 is involved in acid-induced apoptosis of endplate chondrocytes in intervertebral discs
    • PMID:23821474
    • Yuan FL, Wang HR, Yuan W, Zhao MD, Cao L, Duan PG, Jiang YQ, Li XL, Dong J. Ovarian cancer G protein-coupled receptor 1 is involved in acid-induced apoptosis of endplate chondrocytes in intervertebral discs. J Bone Miner Res 2014; 29:67-77; PMID:23821474; http://dx.doi.org/10.1002/jbmr. 2030
    • (2014) J Bone Miner Res , vol.29 , pp. 67-77
    • Yuan, F.L.1    Wang, H.R.2    Yuan, W.3    Zhao, M.D.4    Cao, L.5    Duan, P.G.6    Jiang, Y.Q.7    Li, X.L.8    Dong, J.9
  • 43
    • 0027495705 scopus 로고
    • Dependence of hepatocytic autophagy on intracellularly sequestered calcium
    • PMID:8253727
    • Gordon PB, Holen I, Fosse M, Rotnes JS, Seglen PO. Dependence of hepatocytic autophagy on intracellularly sequestered calcium. J Biol Chem 1993; 268:26107-12; PMID:8253727
    • (1993) J Biol Chem , vol.268 , pp. 26107-26112
    • Gordon, P.B.1    Holen, I.2    Fosse, M.3    Rotnes, J.S.4    Seglen, P.O.5
  • 44
    • 77952759763 scopus 로고    scopus 로고
    • Role of inositol trisphosphate receptors in autophagy in DT40 cells
    • PMID:20308071
    • Khan MT, Joseph SK. Role of inositol trisphosphate receptors in autophagy in DT40 cells. J Biol Chem 2010; 285:16912-20; PMID:20308071; http://dx.doi. org/10.1074/jbc.M110.114207
    • (2010) J Biol Chem , vol.285 , pp. 16912-16920
    • Khan, M.T.1    Joseph, S.K.2
  • 47
    • 77951518297 scopus 로고    scopus 로고
    • Hyperosmotic stress induces autophagy and apoptosis in recombinant Chinese hamster ovary cell culture
    • PMID:20014438
    • Han YK, Kim YG, Kim JY, Lee GM. Hyperosmotic stress induces autophagy and apoptosis in recombinant Chinese hamster ovary cell culture. Biotechnol Bioeng 2010; 105:1187-92; PMID:20014438
    • (2010) Biotechnol Bioeng , vol.105 , pp. 1187-1192
    • Han, Y.K.1    Kim, Y.G.2    Kim, J.Y.3    Lee, G.M.4
  • 48
    • 33845360165 scopus 로고    scopus 로고
    • Programmed cell death in intervertebral disc degeneration
    • PMID:17051327
    • Zhao CQ, Jiang LS, Dai LY. Programmed cell death in intervertebral disc degeneration. Apoptosis 2006; 11:2079-88; PMID:17051327; http://dx.doi.org/10.1007/s10495-006-0290-7
    • (2006) Apoptosis , vol.11 , pp. 2079-2088
    • Zhao, C.Q.1    Jiang, L.S.2    Dai, L.Y.3
  • 49
    • 79951576783 scopus 로고    scopus 로고
    • Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism
    • PMID:21082355
    • Ravindran J, Gupta N, Agrawal M, Bala Bhaskar AS, Lakshmana Rao PV. Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism. Apoptosis 2011; 16:145-61; PMID:21082355; http://dx.doi.org/10.1007/s10495-010-0554-0
    • (2011) Apoptosis , vol.16 , pp. 145-161
    • Ravindran, J.1    Gupta, N.2    Agrawal, M.3    Bala Bhaskar, A.S.4    Lakshmana Rao, P.V.5
  • 50
    • 84876697580 scopus 로고    scopus 로고
    • Regulation of autophagy in oxygen- dependent cellular stress
    • PMID:23092322
    • Ryter SW, Choi AM. Regulation of autophagy in oxygen- dependent cellular stress. Curr Pharm Des 2013; 19:2747-56; PMID:23092322; http://dx.doi.org/10.2174/1381612811319150010
    • (2013) Curr Pharm Des , vol.19 , pp. 2747-2756
    • Ryter, S.W.1    Choi, A.M.2
  • 51
    • 70349771967 scopus 로고    scopus 로고
    • Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes
    • PMID:19790068
    • Phan MN, Leddy HA, Votta BJ, Kumar S, Levy DS, Lipshutz DB, Lee SH, Liedtke W, Guilak F. Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis Rheum 2009; 60:3028-37; PMID:19790068; http:// dx.doi.org/10.1002/art.24799
    • (2009) Arthritis Rheum , vol.60 , pp. 3028-3037
    • Phan, M.N.1    Leddy, H.A.2    Votta, B.J.3    Kumar, S.4    Levy, D.S.5    Lipshutz, D.B.6    Lee, S.H.7    Liedtke, W.8    Guilak, F.9
  • 52
    • 77957683080 scopus 로고    scopus 로고
    • Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: Ageand sex-dependent progression of osteoarthritis in Trpv4-deficient mice
    • PMID:20583100
    • Clark AL, Votta BJ, Kumar S, Liedtke W, Guilak F. Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: ageand sex-dependent progression of osteoarthritis in Trpv4-deficient mice. Arthritis Rheum 2010; 62:2973-83; PMID:20583100; http://dx.doi.org/10.1002/ art.27624
    • (2010) Arthritis Rheum , vol.62 , pp. 2973-2983
    • Clark, A.L.1    Votta, B.J.2    Kumar, S.3    Liedtke, W.4    Guilak, F.5
  • 53
    • 84890553057 scopus 로고    scopus 로고
    • Lactate down-regulates matrix systhesis and promotes apoptosis and autophagy in rat nucleus pulposus cells
    • PMID:24307209
    • Wu W, Zhang X, Hu X, Wang X, Sun L, Zheng X, Jiang L, Ni X, Xu C, Tian N, et al. Lactate down-regulates matrix systhesis and promotes apoptosis and autophagy in rat nucleus pulposus cells. J Orthop Res 2013; 32:253-61; PMID:24307209; http://dx.doi.org/10.1002/jor.22503
    • (2013) J Orthop Res , vol.32 , pp. 253-261
    • Wu, W.1    Zhang, X.2    Hu, X.3    Wang, X.4    Sun, L.5    Zheng, X.6    Jiang, L.7    Ni, X.8    Xu, C.9    Tian, N.10
  • 54
    • 84901311762 scopus 로고    scopus 로고
    • Mitochondrial KATP channel involvement in angiotensin II-induced autophagy in vascular smooth muscle cells
    • PMID:24847907
    • Yu KY, Wang YP, Wang LH, Jian Y, Zhao XD, Chen JW, Murao K, Zhu W, Dong L, Wang GQ, et al. Mitochondrial KATP channel involvement in angiotensin II-induced autophagy in vascular smooth muscle cells. Basic Res Cardiol 2014; 109:416; PMID:24847907; http://dx.doi.org/10.1007/s00395- 014-0416-y
    • (2014) Basic Res Cardiol , vol.109 , Issue.416
    • Yu, K.Y.1    Wang, Y.P.2    Wang, L.H.3    Jian, Y.4    Zhao, X.D.5    Chen, J.W.6    Murao, K.7    Zhu, W.8    Dong, L.9    Wang, G.Q.10
  • 55
    • 77749296078 scopus 로고    scopus 로고
    • Autophagy is involved in starvation response and cell death in Blastocystis
    • PMID:19910412
    • Yin J, Ye AJ, Tan KS. Autophagy is involved in starvation response and cell death in Blastocystis. Microbiology 2010; 156:665-77; PMID:19910412; http://dx.doi.org/10.1099/mic.0.033944-0
    • (2010) Microbiology , vol.156 , pp. 665-677
    • Yin, J.1    Ye, A.J.2    Tan, K.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.