Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism

Apoptosis

Volumn 16, Issue 2, 2011, Pages 145-161

  Ravindran, Jayaraj ^a   Gupta, Nimesh ^a   Agrawal, Mona ^a   Bala Bhaskar, A S ^a   Lakshmana Rao, P V ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Apoptosis; Apoptosis inhibition; MAP kinases; Mitochondrial membrane potential; Okadaic acid; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 7; CASPASE 8 INHIBITOR; CASPASE 9; CYCLOSPORIN A; CYTOCHROME C; ESTERASE; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; REACTIVE OXYGEN METABOLITE; SYNAPTOPHYSIN;

ARTICLE; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION;

ACETYLCYSTEINE; AMINO ACID CHLOROMETHYL KETONES; ANTHRACENES; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BLOTTING, WESTERN; CASPASE 3; CASPASE 7; CASPASE 9; CELL LINE, TUMOR; CYCLOSPORINS; CYTOCHROMES C; DNA DAMAGE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GLUTATHIONE; HUMANS; IMIDAZOLES; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OKADAIC ACID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; PYRIDINES; REACTIVE OXYGEN SPECIES; U937 CELLS;

EID: 79951576783     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0554-0     Document Type: Article

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