Design of a Highly Selective Quenched Activity-Based Probe and Its Application in Dual Color Imaging Studies of Cathepsin S Activity Localization

Journal of the American Chemical Society

Volumn 137, Issue 14, 2015, Pages 4771-4777

  Oresic Bender, Kristina ^a   Ofori, Leslie ^a   Van Der Linden, Wouter A ^a   Mock, Elliot D ^a   Datta, Gopal K ^b   Chowdhury, Somenath ^b   Li, Hao ^a   Segal, Ehud ^a   Sanchez Lopez, Mateo ^a   Ellman, Jonathan A ^b,d   Figdor, Carl G ^c   Bogyo, Matthew ^a   Verdoes, Martijn ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; INFRARED DEVICES;

ACTIVITY-BASED PROBE; BIOLOGICAL FUNCTIONS; CHEMICAL EQUATIONS; DENDRITIC CELLS; IMMUNE CELLS; ITS APPLICATIONS; NEAR INFRARED; REACTIVE CYSTEINE;

PROBES;

CATHEPSIN S; CYSTEINE; GREEN FLUORESCENT PROTEIN; CATHEPSIN; FLUORESCENT DYE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BREAST TUMOR; CELL VACUOLE; COLOR; DENDRITIC CELL; ENZYME ACTIVITY; ENZYME LOCALIZATION; FLUORESCENCE IMAGING; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR PROBE; MOUSE; NONHUMAN; QUENCHED ACTIVITY BASED PROBE; SYNTHESIS; ANIMAL; CHEMISTRY; DRUG DESIGN; ENZYME SPECIFICITY; ENZYMOLOGY; EXPERIMENTAL MAMMARY NEOPLASM; HUMAN; INFRARED RADIATION; METABOLISM; PROCEDURES; RAW 264.7 CELL LINE;

ANIMALS; CATHEPSINS; COLOR; DENDRITIC CELLS; DRUG DESIGN; FLUORESCENT DYES; HUMANS; INFRARED RAYS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; OPTICAL IMAGING; RAW 264.7 CELLS; SUBSTRATE SPECIFICITY;

EID: 84927941287     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b00315     Document Type: Article

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