Hedgehog signaling activates a positive feedback mechanism involving insulin-like growth factors to induce osteoblast differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 15, 2015, Pages 4678-4683

  Shi, Yu ^a   Chen, Jianquan ^a,b   Karner, Courtney M ^a   Long, Fanxin ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Akt; Gli2; Hedgehog; Igf; Osteoblast

Indexed keywords

ALKALINE PHOSPHATASE; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MESSENGER RNA; PROTEIN KINASE B; SERINE; SOMATOMEDIN B; SOMATOMEDIN C RECEPTOR; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; GLI PROTEIN, MOUSE; IGF2 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; MORPHOLINE DERIVATIVE; MULTIPROTEIN COMPLEX; PURINE DERIVATIVE; PURMORPHAMINE; RECOMBINANT PROTEIN; SOMATOMEDIN RECEPTOR; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW STROMA CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE DELETION; MOUSE; MOUSE EMBRYO; NONHUMAN; OSSIFICATION; OSTEOBLAST; POSITIVE FEEDBACK; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECTS; FEEDBACK SYSTEM; GENETICS; IN SITU HYBRIDIZATION; KNOCKOUT MOUSE; MESENCHYMAL STROMA CELL; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSGENIC MOUSE; WESTERN BLOTTING;

ERINACEIDAE;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; FEEDBACK, PHYSIOLOGICAL; FEMALE; HEDGEHOG PROTEINS; IN SITU HYBRIDIZATION; INSULIN-LIKE GROWTH FACTOR II; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MESENCHYMAL STROMAL CELLS; MICE, KNOCKOUT; MICE, TRANSGENIC; MORPHOLINES; MULTIPROTEIN COMPLEXES; OSTEOBLASTS; PROTO-ONCOGENE PROTEINS C-AKT; PURINES; RECEPTORS, SOMATOMEDIN; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84927925164     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1502301112     Document Type: Article

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