Gli1 protein participates in hedgehog-mediated specification of osteoblast lineage during endochondral ossification

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17860-17869

  Hojo, Hironori ^a   Ohba, Shinsuke ^a   Yano, Fumiko ^a   Saito, Taku ^a   Ikeda, Toshiyuki ^a   Nakajima, Keiji ^a   Komiyama, Yuske ^a   Nakagata, Naomi ^b   Suzuki, Kentaro ^b   Takato, Tsuyoshi ^a   Kawaguchi, Hiroshi ^a   Chung, Ung Il ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE FORMATION; ENDOCHONDRAL OSSIFICATION; HEDGEHOG SIGNALING; HISTOLOGICAL ANALYSIS; IN-VITRO; IN-VITRO ANALYSIS; MASTER REGULATORS; OSTEOBLAST DIFFERENTIATION; OSTEOGENESIS; OSTERIX; OVER-EXPRESSION; REGULATORY REGIONS;

BONE; CELLS; GENES; MAMMALS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

CYTOLOGY;

ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; MESSENGER RNA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR GLI3; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ANIMAL EXPERIMENT; ARTICLE; CELL LINEAGE; CELL SPECIFICITY; CONTROLLED STUDY; EMBRYO; ENCHONDRAL OSSIFICATION; FETUS; GENETIC ASSOCIATION; HISTOLOGY; IN VITRO STUDY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PERICHONDRIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WILD TYPE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; OSTEOBLASTS; OSTEOGENESIS; SPINE; UP-REGULATION;

ERINACEIDAE; MAMMALIA; MUS;

EID: 84861212387     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.347716     Document Type: Article

References (33)

1. Jiang, J., and Hui, C. (2008) Hedgehog signaling in development and cancer. Dev. Cell 15, 801-812
2. Jacob, J., and Briscoe, J. (2003) Gli proteins and the control of spinal cord patterning. EMBO Rep. 4, 761-765
3. Stecca, B., and Ruiz, I Altaba, A. (2010) Context-dependent regulation of the Gli code in cancer by Hedgehog and non-Hedgehog signals. J. Mol. Cell. Biol. 2, 84-95
4. Park, H. L., Bai, C., Platt, K. A., Matise, M. P., Beeghly, A., Hui, C. C., Nakashima, M., and Joyner, A. L. (2000) Mouse Gli1 mutants are viable but have defects in Shh signaling in combination with a Gli2 mutation. Development 127, 1593-1605
5. Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D., and Joyner, A. L. (2002) Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 129, 4753-4761
6. - mice. Oncogene 24, 4026-4036
7. St-Jacques, B., Hammerschmidt, M., and McMahon, A. P. (1999) Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 13, 2072-2086 (Pubitemid 29407348)
8. Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R., and de Crombrugghe, B. (2002) The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29 (Pubitemid 34137009)
9. Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y. H., Inada, M., Sato, M., Okamoto, R., Kitamura, Y., Yoshiki, S., and Kishimoto, T. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764 (Pubitemid 27516178)
10. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., and Karsenty, G. (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89, 747-754 (Pubitemid 27516177)
11. Long, F., Chung, U. I., Ohba, S., McMahon, J., Kronenberg, H. M., and McMahon, A. P. (2004) Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131, 1309-1318 (Pubitemid 38443885)
12. Ohba, S., Kawaguchi, H., Kugimiya, F., Ogasawara, T., Kawamura, N., Saito, T., Ikeda, T., Fujii, K., Miyajima, T., Kuramochi, A., Miyashita, T., Oda, H., Nakamura, K., Takato, T., and Chung, U. I. (2008) Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev. Cell 14, 689-699 (Pubitemid 351622616)
13. Hilton, M. J., Tu, X., Cook, J., Hu, H., and Long, F. (2005) Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. Development 132, 4339-4351 (Pubitemid 41576695)
14. Joeng, K. S., and Long, F. (2009) The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development 136, 4177-4185
15. Mo, R., Freer, A. M., Zinyk, D. L., Crackower, M. A., Michaud, J., Heng, H. H., Chik, K. W., Shi, X. M., Tsui, L. C., Cheng, S. H., Joyner, A. L., and Hui, C. (1997) Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 124, 113-123 (Pubitemid 27053011)
16. Saito, T., Fukai, A., Mabuchi, A., Ikeda, T., Yano, F., Ohba, S., Nishida, N., Akune, T., Yoshimura, N., Nakagawa, T., Nakamura, K., Tokunaga, K., Chung, U. I., and Kawaguchi, H. (2010) Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development. Nat. Med. 16, 678-686
17. Arai, F., Ohneda, O., Miyamoto, T., Zhang, X. Q., and Suda, T. (2002) Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J. Exp. Med. 195, 1549-1563 (Pubitemid 34666069)
18. Hojo, H., Yano, F., Ohba, S., Igawa, K., Nakajima, K., Komiyama, Y., Kan, A., Ikeda, T., Yonezawa, T., Woo, J. T., Takato, T., Nakamura, K., Kawaguchi, H., and Chung, U. I. (2010) Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. J. Bone Miner. Metab. 28, 627-633
19. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. (1983) Accurate transcription initiation byRNApolymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489
20. Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., and Long, F. (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132, 49-60 (Pubitemid 40207966)
21. Vokes, S. A., Ji, H., Wong, W. H., and McMahon, A. P. (2008) A genomescale analysis of the cis-regulatory circuitry underlying Sonic hedgehogmediated patterning of the mammalian limb. Genes Dev. 22, 2651-2663
22. Ingham, P. W., and McMahon, A. P. (2001) Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15, 3059-3087 (Pubitemid 33115673)
23. Bai, C. B., and Joyner, A. L. (2001) Gli1 can rescue the in vivo function of Gli2. Development 128, 5161-5172 (Pubitemid 34083041)
24. Kronenberg, H. M. (2003) Developmental regulation of the growth plate. Nature 423, 332-336
25. Chung, U. I., Schipani, E., McMahon, A. P., and Kronenberg, H. M. (2001) Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J. Clin. Invest. 107, 295-304 (Pubitemid 32157961)
26. Drakopoulou, E., Outram, S. V., Rowbotham, N. J., Ross, S. E., Furmanski, A. L., Saldana, J. I., Hager-Theodorides, A. L., and Crompton, T. (2010) Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development. Cell Cycle 9, 4144-4152
27. Merchant, A., Joseph, G., Wang, Q., Brennan, S., and Matsui, W. (2010) Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood 115, 2391-2396
28. Karlstrom, R. O., Tyurina, O. V., Kawakami, A., Nishioka, N., Talbot, W. S., Sasaki, H., and Schier, A. F. (2003) Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development 130, 1549-1564 (Pubitemid 36527516)
29. Long, F. (2012) Building strong bones: molecular regulation of the osteoblast lineage. Nat. Rev. Mol. Cell Biol. 13, 27-38
30. Tu, X., Joeng, K. S., and Long, F. (2012) Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation. Dev. Biol. 362, 76-82
31. Mak, K. K., Bi, Y., Wan, C., Chuang, P. T., Clemens, T., Young, M., and Yang, Y. (2008) Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev. Cell 14, 674-688 (Pubitemid 351622607)
32. Koziel, L., Wuelling, M., Schneider, S., and Vortkamp, A. (2005) Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132, 5249-5260 (Pubitemid 43020179)
33. Shimoyama, A., Wada, M., Ikeda, F., Hata, K., Matsubara, T., Nifuji, A., Noda, M., Amano, K., Yamaguchi, A., Nishimura, R., and Yoneda, T. (2007) Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol. Biol. Cell 18, 2411- 2418