메뉴 건너뛰기




Volumn 132, Issue 19, 2005, Pages 4339-4351

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development

Author keywords

Catenin; Cartilage bone; Gli3; Ihh; Mouse; PTHrP (Pthlh); Vascularization; Wnt

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI3; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 27644467931     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.02025     Document Type: Article
Times cited : (165)

References (36)
  • 1
    • 1842839986 scopus 로고    scopus 로고
    • Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site
    • Agren, M., Kogerman, P., Kleman, M. I., Wessling, M. and Toftgard, R. (2004). Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene 330, 101-114.
    • (2004) Gene , vol.330 , pp. 101-114
    • Agren, M.1    Kogerman, P.2    Kleman, M.I.3    Wessling, M.4    Toftgard, R.5
  • 2
    • 0036801765 scopus 로고    scopus 로고
    • Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
    • Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D. and Joyner, A. L. (2002). Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 129, 4753-4761.
    • (2002) Development , vol.129 , pp. 4753-4761
    • Bai, C.B.1    Auerbach, W.2    Lee, J.S.3    Stephen, D.4    Joyner, A.L.5
  • 3
    • 0347764480 scopus 로고    scopus 로고
    • All mouse ventral spinal cord patterning by hedgehog is gli dependent and involves an activator function of gli3
    • Bai, C. B., Stephen, D. and Joyner, A. L. (2004). All mouse ventral spinal cord patterning by hedgehog is gli dependent and involves an activator function of gli3. Dev. Cell 6, 103-115.
    • (2004) Dev. Cell , vol.6 , pp. 103-115
    • Bai, C.B.1    Stephen, D.2    Joyner, A.L.3
  • 4
    • 0031595311 scopus 로고    scopus 로고
    • The XtJ allele generates a Gli3 fusion transcript
    • Buscher, D., Grotewold, L. and Ruther, U. (1998). The XtJ allele generates a Gli3 fusion transcript. Mamm. Genome 9, 676-678.
    • (1998) Mamm. Genome , vol.9 , pp. 676-678
    • Buscher, D.1    Grotewold, L.2    Ruther, U.3
  • 5
    • 0346888543 scopus 로고    scopus 로고
    • Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction
    • Buttitta, L., Mo, R., Hui, C. C. and Fan, C. M. (2003). Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130, 6233-6243.
    • (2003) Development , vol.130 , pp. 6233-6243
    • Buttitta, L.1    Mo, R.2    Hui, C.C.3    Fan, C.M.4
  • 6
    • 13244299109 scopus 로고    scopus 로고
    • FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development
    • Chamorro, M. N., Schwartz, D. R., Vonica, A., Brivanlou, A. H., Cho, K. R. and Varmus, H. E. (2005). FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development. EMBO J. 24, 73-84.
    • (2005) EMBO J. , vol.24 , pp. 73-84
    • Chamorro, M.N.1    Schwartz, D.R.2    Vonica, A.3    Brivanlou, A.H.4    Cho, K.R.5    Varmus, H.E.6
  • 7
    • 16844370419 scopus 로고    scopus 로고
    • Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development
    • Colnot, C., de la Fuente, L., Huang, S., Hu, D., Lu, C., St-Jacques, B. and Helms, J. A. (2005). Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development 132, 1057-1067.
    • (2005) Development , vol.132 , pp. 1057-1067
    • Colnot, C.1    de la Fuente, L.2    Huang, S.3    Hu, D.4    Lu, C.5    St-Jacques, B.6    Helms, J.A.7
  • 8
    • 0031855859 scopus 로고    scopus 로고
    • Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    • Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J. and Hui, C. C. (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 125, 2533-2543.
    • (1998) Development , vol.125 , pp. 2533-2543
    • Ding, Q.1    Motoyama, J.2    Gasca, S.3    Mo, R.4    Sasaki, H.5    Rossant, J.6    Hui, C.C.7
  • 10
    • 13444302715 scopus 로고    scopus 로고
    • Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    • Hu, U., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M. and Long, F. (2005). Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132, 49-60.
    • (2005) Development , vol.132 , pp. 49-60
    • Hu, U.1    Hilton, M.J.2    Tu, X.3    Yu, K.4    Ornitz, D.M.5    Long, F.6
  • 11
    • 0033950445 scopus 로고    scopus 로고
    • Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways
    • Karp, S. J., Schipani, E., St-Jacques, B., Hunzelman, J., Kronenberg, H. and McMahon, A. P. (2000). Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. Development 127, 543-548.
    • (2000) Development , vol.127 , pp. 543-548
    • Karp, S.J.1    Schipani, E.2    St-Jacques, B.3    Hunzelman, J.4    Kronenberg, H.5    McMahon, A.P.6
  • 12
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y. H., Inada, M. et al. (1997). Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6    Shimizu, Y.7    Bronson, R.T.8    Gao, Y.H.9    Inada, M.10
  • 13
    • 0035913986 scopus 로고    scopus 로고
    • Induction of pancreatic differentiation by signals from blood vessels
    • Lammert, E., Cleaver, O. and Melton, D. (2001). Induction of pancreatic differentiation by signals from blood vessels. Science 294, 564-567.
    • (2001) Science , vol.294 , pp. 564-567
    • Lammert, E.1    Cleaver, O.2    Melton, D.3
  • 15
    • 2342481730 scopus 로고    scopus 로고
    • Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis
    • Li, Y., Zhang, H., Choi, S. C., Litingtung, Y. and Chiang, C. (2004). Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev. Biol. 270, 214-231.
    • (2004) Dev. Biol. , vol.270 , pp. 214-231
    • Li, Y.1    Zhang, H.2    Choi, S.C.3    Litingtung, Y.4    Chiang, C.5
  • 16
    • 0033808256 scopus 로고    scopus 로고
    • Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
    • Litingtung, Y. and Chiang, C. (2000). Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3. Nat. Neurosci. 3, 979-985.
    • (2000) Nat. Neurosci. , vol.3 , pp. 979-985
    • Litingtung, Y.1    Chiang, C.2
  • 17
    • 0037194765 scopus 로고    scopus 로고
    • Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
    • Litingtung, Y., Dahn, R. D., Li, Y., Fallon, J. F. and Chiang, C. (2002). Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418, 979-983.
    • (2002) Nature , vol.418 , pp. 979-983
    • Litingtung, Y.1    Dahn, R.D.2    Li, Y.3    Fallon, J.F.4    Chiang, C.5
  • 18
    • 0035691559 scopus 로고    scopus 로고
    • Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation
    • Long, F., Zhang, X. M., Karp, S., Yang, Y. and McMahon, A. P. (2001). Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development 128, 5099-5108.
    • (2001) Development , vol.128 , pp. 5099-5108
    • Long, F.1    Zhang, X.M.2    Karp, S.3    Yang, Y.4    McMahon, A.P.5
  • 19
    • 1842611651 scopus 로고    scopus 로고
    • Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
    • Long, F., Chung, U. I., Ohba, S., McMahon, J., Kronenberg, H. M. and McMahon, A. P. (2004). Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 131, 1309-1318.
    • (2004) Development , vol.131 , pp. 1309-1318
    • Long, F.1    Chung, U.I.2    Ohba, S.3    McMahon, J.4    Kronenberg, H.M.5    McMahon, A.P.6
  • 20
    • 0031679850 scopus 로고    scopus 로고
    • Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    • Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A. and Joyner, A. L. (1998). Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770.
    • (1998) Development , vol.125 , pp. 2759-2770
    • Matise, M.P.1    Epstein, D.J.2    Park, H.L.3    Platt, K.A.4    Joyner, A.L.5
  • 21
    • 0035914069 scopus 로고    scopus 로고
    • Liver organogenesis promoted by endothelial cells prior to vascular function
    • Matsumoto, K., Yoshitomi, H., Rossant, J. and Zaret, K. S. (2001). Liver organogenesis promoted by endothelial cells prior to vascular function. Science 294, 559-563.
    • (2001) Science , vol.294 , pp. 559-563
    • Matsumoto, K.1    Yoshitomi, H.2    Rossant, J.3    Zaret, K.S.4
  • 22
    • 0036134643 scopus 로고    scopus 로고
    • High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion
    • Maynard, T. M., Jain, M. D., Balmer, C. W. and LaMantia, A. S. (2002). High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion. Mamm. Genome 13, 58-61.
    • (2002) Mamm. Genome , vol.13 , pp. 58-61
    • Maynard, T.M.1    Jain, M.D.2    Balmer, C.W.3    LaMantia, A.S.4
  • 23
    • 0019126423 scopus 로고
    • Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S
    • McLeod, M. J. (1980). Differential staining of cartilage and bone in whole mouse fetuses by alcian blue and alizarin red S. Teratology 22, 299-301.
    • (1980) Teratology , vol.22 , pp. 299-301
    • McLeod, M.J.1
  • 24
    • 1242331822 scopus 로고    scopus 로고
    • Impaired endochondral bone development and osteopenia in Gli2-deficient mice
    • Miao, D., Liu, H., Plut, P., Niu, M., Huo, R., Goltzman, D. and Henderson, J. E. (2004). Impaired endochondral bone development and osteopenia in Gli2-deficient mice. Exp. Cell. Res. 294, 210-222.
    • (2004) Exp. Cell. Res. , vol.294 , pp. 210-222
    • Miao, D.1    Liu, H.2    Plut, P.3    Niu, M.4    Huo, R.5    Goltzman, D.6    Henderson, J.E.7
  • 25
    • 0037439152 scopus 로고    scopus 로고
    • Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development
    • Mill, P., Mo, R., Fu, H., Grachtchouk, M., Kim, P. C., Dlugosz, A. A. and Hui, C. C. (2003). Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev. 17, 282-294.
    • (2003) Genes Dev. , vol.17 , pp. 282-294
    • Mill, P.1    Mo, R.2    Fu, H.3    Grachtchouk, M.4    Kim, P.C.5    Dlugosz, A.A.6    Hui, C.C.7
  • 27
    • 0031683165 scopus 로고    scopus 로고
    • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    • Motoyama, J., Liu, J., Mo, R., Ding, Q., Post, M. and Hui, C. C. (1998). Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20, 54-57.
    • (1998) Nat. Genet. , vol.20 , pp. 54-57
    • Motoyama, J.1    Liu, J.2    Mo, R.3    Ding, Q.4    Post, M.5    Hui, C.C.6
  • 28
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J. M., Behringer, R. R. and de Crombrugghe, B. (2002). The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    de Crombrugghe, B.7
  • 29
    • 9144240010 scopus 로고    scopus 로고
    • DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway
    • Niida, A., Hiroko, T., Kasai, M., Furukawa, Y., Nakamura, Y., Suzuki, Y., Sugano, S. and Akiyama, T. (2004). DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway. Oncogene 23, 8520-8526.
    • (2004) Oncogene , vol.23 , pp. 8520-8526
    • Niida, A.1    Hiroko, T.2    Kasai, M.3    Furukawa, Y.4    Nakamura, Y.5    Suzuki, Y.6    Sugano, S.7    Akiyama, T.8
  • 31
    • 0034055649 scopus 로고    scopus 로고
    • Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
    • Park, H. L., Bai, C., Platt, K. A., Matise, M. P., Beeghly, A., Hui, C. C., Nakashima, M. and Joyner, A. L. (2000). Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127, 1593-1605.
    • (2000) Development , vol.127 , pp. 1593-1605
    • Park, H.L.1    Bai, C.2    Platt, K.A.3    Matise, M.P.4    Beeghly, A.5    Hui, C.C.6    Nakashima, M.7    Joyner, A.L.8
  • 33
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: Implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki, H., Nishizaki, Y., Hui, C., Nakafuku, M. and Kondoh, H. (1999). Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915-3924.
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.3    Nakafuku, M.4    Kondoh, H.5
  • 34
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques, B., Hammerschmidt, M. and McMahon, A. P. (1999). Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 13, 2072-2086.
    • (1999) Genes Dev. , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 35
    • 0029750190 scopus 로고    scopus 로고
    • Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
    • Vortkamp, A., Lee, K., Lanske, B., Segre, G. V., Kronenberg, H. M. and Tabin, C. J. (1996). Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273, 613-622.
    • (1996) Science , vol.273 , pp. 613-622
    • Vortkamp, A.1    Lee, K.2    Lanske, B.3    Segre, G.V.4    Kronenberg, H.M.5    Tabin, C.J.6
  • 36
    • 0346963598 scopus 로고    scopus 로고
    • MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    • Vu, T. H., Shipley, J. M., Bergers, G., Berger, J. E., Helms, J. A., Hanahan, D., Shapiro, S. D., Senior, R. M. and Werb, Z. (1998). MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 93, 411-422.
    • (1998) Cell , vol.93 , pp. 411-422
    • Vu, T.H.1    Shipley, J.M.2    Bergers, G.3    Berger, J.E.4    Helms, J.A.5    Hanahan, D.6    Shapiro, S.D.7    Senior, R.M.8    Werb, Z.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.