Suppression of neurite outgrowth of primary cultured hippocampal neurons is involved in impairment of glutamate metabolism and NMDA receptor function caused by nanoparticulate TiO2

Biomaterials

Volumn 53, Issue , 2015, Pages 76-85

  Hong, Fashui ^a   Sheng, Lei ^b   Ze, Yuguan ^b   Hong, Jie ^b   Zhou, Yingjun ^a   Wang, Ling ^c   Liu, Dong ^b   Yu, Xiaohong ^b   Xu, Bingqing ^b   Zhao, Xiaoyang ^b   Ze, Xiao ^b  

^a HUAIYIN NORMAL UNIVERSITY   (China)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

Glutamate metabolism; Neurite outgrowth; NMDA receptor function; Primary hippocampal neurons; Titanium dioxide nanoparticles

Indexed keywords

AMINO ACIDS; CALCIUM; CYTOLOGY; ENZYME ACTIVITY; METABOLISM; NITRIC OXIDE; PLANTS (BOTANY); SODIUM COMPOUNDS; TITANIUM DIOXIDE;

CONCENTRATION-DEPENDENT MANNERS; DOWN-REGULATED PROTEINS; INTRACELLULAR CALCIUM; NANO-TITANIUM DIOXIDE; NEURITE OUTGROWTH; NMDA RECEPTOR; PRIMARY HIPPOCAMPAL NEURONS; TITANIUM DIOXIDE NANOPARTICLES;

NEURONS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; CALCIUM; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM; SODIUM; TITANIUM DIOXIDE NANOPARTICLE; NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL NUCLEUS; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVITY; HIPPOCAMPAL NEURONAL CULTURE; IN VITRO STUDY; NERVE FIBER GROWTH; NEUROTOXICITY; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM CURRENT; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; HIPPOCAMPUS; METABOLISM; NEURITE; RAT; SPRAGUE DAWLEY RAT;

RATTUS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; GLUTAMIC ACID; HIPPOCAMPUS; NANOPARTICLES; NEURITES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TITANIUM;

EID: 84927920575     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.02.067     Document Type: Article

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