메뉴 건너뛰기




Volumn 19, Issue 6, 2014, Pages 558-565

The potential role for regulatory T-cell therapy in vascularized composite allograft transplantation

Author keywords

Immune regulation; Regulatory T cells; Skin transplantation; Vascularized composite allotransplantation

Indexed keywords

ACUTE GRAFT REJECTION; CD4+ T LYMPHOCYTE; GRAFT SURVIVAL; HUMAN; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; PLASTIC SURGERY; REGULATORY T LYMPHOCYTE; REVIEW; SKIN TRANSPLANTATION; VASCULARIZED COMPOSITE ALLOTRANSPLANTATION; ALLOTRANSPLANTATION; ANIMAL; COMPOSITE GRAFT; GRAFT REJECTION; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY;

EID: 84927693581     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0000000000000139     Document Type: Review
Times cited : (15)

References (96)
  • 1
    • 0030042679 scopus 로고    scopus 로고
    • Rejection of the component tissues of limb allografts in rats immunosuppressed with FK-506 and cyclosporine
    • Buttemeyer R, Jones NF, Min Z, Rao U. Rejection of the component tissues of limb allografts in rats immunosuppressed with FK-506 and cyclosporine. Plast Reconstr Surg 1996; 97:139-148.
    • (1996) Plast Reconstr Surg , vol.97 , pp. 139-148
    • Buttemeyer, R.1    Jones, N.F.2    Min, Z.3    Rao, U.4
  • 2
    • 0035865216 scopus 로고    scopus 로고
    • Differential susceptibility of heart, skin and islet allografts to T cell-mediated rejection
    • Jones ND, Morris PJ, Wood KJ. Differential susceptibility of heart, skin and islet allografts to T cell-mediated rejection. J Immunol 2001; 166:2824-2830.
    • (2001) J Immunol , vol.166 , pp. 2824-2830
    • Jones, N.D.1    Morris, P.J.2    Wood, K.J.3
  • 3
    • 0025971311 scopus 로고
    • Relative antigenicity of components of a vascularised limb allograft
    • Lee WP, Yaremchuk MJ, Pan YC, et al. Relative antigenicity of components of a vascularised limb allograft. Plast Reconstr Surg 1991; 87:401-411.
    • (1991) Plast Reconstr Surg , vol.87 , pp. 401-411
    • Lee, W.P.1    Yaremchuk, M.J.2    Pan, Y.C.3
  • 4
    • 73349140870 scopus 로고    scopus 로고
    • Prolonged survival of composite facial allografts in nonhuman primates associated with posttransplant lymphopro-liferative disorder
    • Barth RN, Nam AJ, Stanwix MG, et al. Prolonged survival of composite facial allografts in nonhuman primates associated with posttransplant lymphopro-liferative disorder. Transplantation 2009; 88:1242-1250.
    • (2009) Transplantation , vol.88 , pp. 1242-1250
    • Barth, R.N.1    Nam, A.J.2    Stanwix, M.G.3
  • 6
    • 84890350335 scopus 로고    scopus 로고
    • A critical analysis of rejection in vascularized composite allotransplantation: Clinical, cellular and molecular aspects, current challenges, and novel concepts
    • Sarhane KA, Tuffaha SH, Broyles JM, et al. A critical analysis of rejection in vascularized composite allotransplantation: clinical, cellular and molecular aspects, current challenges, and novel concepts. Front Immunol 2013; 4:406.
    • (2013) Front Immunol , vol.4 , pp. 406
    • Sarhane, K.A.1    Tuffaha, S.H.2    Broyles, J.M.3
  • 7
    • 84888302137 scopus 로고    scopus 로고
    • Monitoring and long-term outcomes in vascularized composite allotransplantation
    • Kaufman CL, Ouseph R, Marvin MR, et al. Monitoring and long-term outcomes in vascularized composite allotransplantation. Curr Opin Organ Transplant 2013; 18:652-658.
    • (2013) Curr Opin Organ Transplant , vol.18 , pp. 652-658
    • Kaufman, C.L.1    Ouseph, R.2    Marvin, M.R.3
  • 8
    • 84859431038 scopus 로고    scopus 로고
    • Graft vasculopathy in clinical hand transplantation
    • Kaufman CL, Ouseph R, Blair B, et al. Graft vasculopathy in clinical hand transplantation. Am J Transplant 2012; 12:1004-1016.
    • (2012) Am J Transplant , vol.12 , pp. 1004-1016
    • Kaufman, C.L.1    Ouseph, R.2    Blair, B.3
  • 9
    • 84892368973 scopus 로고    scopus 로고
    • Antibody-mediated rejection in hand transplantation
    • Weissenbacher A, Hautz T, Zelger B, et al. Antibody-mediated rejection in hand transplantation. Transpl Int 2014; 27:e13-e17.
    • (2014) Transpl Int , vol.27 , pp. e13-e17
    • Weissenbacher, A.1    Hautz, T.2    Zelger, B.3
  • 10
    • 84906830441 scopus 로고    scopus 로고
    • Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts
    • Hautz T, Zelger BG, Nasr IW, et al. Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts. Transpl Int 2014; 27:966-976.
    • (2014) Transpl Int , vol.27 , pp. 966-976
    • Hautz, T.1    Zelger, B.G.2    Nasr, I.W.3
  • 11
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008; 133:775-787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 12
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001; 27:68-73.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3
  • 13
    • 13144261691 scopus 로고    scopus 로고
    • FOXP3 acts as a rheostat of the immune response
    • Ochs HD, Ziegler SF, Torgerson TR. FOXP3 acts as a rheostat of the immune response. Immunol Rev 2005; 203:156-164.
    • (2005) Immunol Rev , vol.203 , pp. 156-164
    • Ochs, H.D.1    Ziegler, S.F.2    Torgerson, T.R.3
  • 14
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007; 8:191-197.
    • (2007) Nat Immunol , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 15
    • 33846423147 scopus 로고    scopus 로고
    • Selective depletion of foxp3+ regulatory T cells induces a scurfy-like disease
    • Lahl K, Loddenkemper C, Drouin C, et al. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 2007; 204:57-63.
    • (2007) J Exp Med , vol.204 , pp. 57-63
    • Lahl, K.1    Loddenkemper, C.2    Drouin, C.3
  • 16
    • 55849107041 scopus 로고    scopus 로고
    • +Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo
    • +Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo. J Clin Invest 2008; 118:3639-3650.
    • (2008) J Clin Invest , vol.118 , pp. 3639-3650
    • Vukmanovic-Stejic, M.1    Agius, E.2    Booth, N.3
  • 17
    • 28244444532 scopus 로고    scopus 로고
    • Messenger RNA for FOXP3 in the urine of renal-allograft recipients
    • Muthukumar T, Dadhania D, Ding R, et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005; 353:2342-2351.
    • (2005) N Engl J Med , vol.353 , pp. 2342-2351
    • Muthukumar, T.1    Dadhania, D.2    Ding, R.3
  • 18
    • 34250829022 scopus 로고    scopus 로고
    • Hyperexpression of foxp3 and IDO during acute rejection of islet allografts
    • Yang H, Ding R, Sharma VK, et al. Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts. Transplantation 2007; 83:1643-1647.
    • (2007) Transplantation , vol.83 , pp. 1643-1647
    • Yang, H.1    Ding, R.2    Sharma, V.K.3
  • 19
    • 47249084696 scopus 로고    scopus 로고
    • FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes
    • Bunnag S, Allanach K, Jhangri GS, et al. FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes. Am J Transplant 2008; 8:1423-1433.
    • (2008) Am J Transplant , vol.8 , pp. 1423-1433
    • Bunnag, S.1    Allanach, K.2    Jhangri, G.S.3
  • 20
    • 34250617034 scopus 로고    scopus 로고
    • Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients
    • Dijke IE, Velthuis JH, Caliskan K, et al. Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients. Transplantation 2007; 83:1477-1484.
    • (2007) Transplantation , vol.83 , pp. 1477-1484
    • Dijke, I.E.1    Velthuis, J.H.2    Caliskan, K.3
  • 21
    • 62849086405 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and foxp3 expression in skin rejection of human hand allografts
    • Hautz T, Brandacher G, Zelger B, et al. Indoleamine 2,3-dioxygenase and foxp3 expression in skin rejection of human hand allografts. Transplant Proc 2009; 41:509-512.
    • (2009) Transplant Proc , vol.41 , pp. 509-512
    • Hautz, T.1    Brandacher, G.2    Zelger, B.3
  • 22
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 23
    • 1642454708 scopus 로고    scopus 로고
    • Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent process
    • Karim M, Kingsley CI, Bushell AR, et al. Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent process. J Immunol 2004; 172:923-928.
    • (2004) J Immunol , vol.172 , pp. 923-928
    • Karim, M.1    Kingsley, C.I.2    Bushell, A.R.3
  • 24
    • 0036467522 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells prevent graft rejection: Ctla-4- and IL-10-dependent immunoregulation of alloresponses
    • Kingsley CI, Karim M, Bushell AR, Wood KJ. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J Immunol 2002; 168:1080-1086.
    • (2002) J Immunol , vol.168 , pp. 1080-1086
    • Kingsley, C.I.1    Karim, M.2    Bushell, A.R.3    Wood, K.J.4
  • 25
    • 14844352743 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: Antigen-specific reactivation in vivo is critical for bystander regulation
    • Karim M, Feng G, Wood KJ, Bushell AR. CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulation. Blood 2005; 105:4871-4877.
    • (2005) Blood , vol.105 , pp. 4871-4877
    • Karim, M.1    Feng, G.2    Wood, K.J.3    Bushell, A.R.4
  • 26
    • 84875458605 scopus 로고    scopus 로고
    • Active demethylation of the foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    • Toker A, Engelbert D, Garg G, et al. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J Immunol 2013; 190:3180-3188.
    • (2013) J Immunol , vol.190 , pp. 3180-3188
    • Toker, A.1    Engelbert, D.2    Garg, G.3
  • 27
    • 49649107703 scopus 로고    scopus 로고
    • DNA methylation controls foxp3 gene expression
    • Polansky JK, Kretschmer K, Freyer J, et al. DNA methylation controls Foxp3 gene expression. Eur J Immunol 2008; 38:1654-1663.
    • (2008) Eur J Immunol , vol.38 , pp. 1654-1663
    • Polansky, J.K.1    Kretschmer, K.2    Freyer, J.3
  • 28
    • 80955181118 scopus 로고    scopus 로고
    • Moving to tolerance: Clinical application of T regulatory cells
    • McMurchy AN, Bushell A, Levings MK, Wood KJ. Moving to tolerance: clinical application of T regulatory cells. Semin Immunol 2011; 23:304-313.
    • (2011) Semin Immunol , vol.23 , pp. 304-313
    • McMurchy, A.N.1    Bushell, A.2    Levings, M.K.3    Wood, K.J.4
  • 29
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
    • Mottet C, Uhlig HH, Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003; 170:3939-3943.
    • (2003) J Immunol , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 30
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3
  • 31
    • 34548558737 scopus 로고    scopus 로고
    • Transplantation tolerance: Lessons from experimental rodent models
    • Kingsley CI, Nadig SN, Wood KJ. Transplantation tolerance: lessons from experimental rodent models. Transpl Int 2007; 20:828-841.
    • (2007) Transpl Int , vol.20 , pp. 828-841
    • Kingsley, C.I.1    Nadig, S.N.2    Wood, K.J.3
  • 32
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4:330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 33
    • 84883505814 scopus 로고    scopus 로고
    • Modulation of treg cells/T effector function by GITR signaling is context-dependent
    • Ephrem A, Epstein AL, Stephens GL, et al. Modulation of Treg cells/T effector function by GITR signaling is context-dependent. Eur J Immunol 2013; 43:2421-2429.
    • (2013) Eur J Immunol , vol.43 , pp. 2421-2429
    • Ephrem, A.1    Epstein, A.L.2    Stephens, G.L.3
  • 34
    • 47249119632 scopus 로고    scopus 로고
    • Latency-associated peptide identifies a novel CD4+CD25+ regulatoryT cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis
    • Chen ML, Yan BS, Bando Y, et al. Latency-associated peptide identifies a novel CD4+CD25+ regulatoryT cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol 2008; 180:7327-7337.
    • (2008) J Immunol , vol.180 , pp. 7327-7337
    • Chen, M.L.1    Yan, B.S.2    Bando, Y.3
  • 35
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over foxp3+ regulatory T cell function
    • Wing K, Onishi Y, Prieto-Martin P, et al. CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008; 322:271-275.
    • (2008) Science , vol.322 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 36
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • Marson A, Kretschmer K, Frampton GM, et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 2007; 445:931-935.
    • (2007) Nature , vol.445 , pp. 931-935
    • Marson, A.1    Kretschmer, K.2    Frampton, G.M.3
  • 37
    • 78649639989 scopus 로고    scopus 로고
    • CD4+ regulatory T cells in solid organ transplantation
    • Issa F, Wood KJ. CD4+ regulatory T cells in solid organ transplantation. Curr Opin Organ Transplant 2010; 15:757-764.
    • (2010) Curr Opin Organ Transplant , vol.15 , pp. 757-764
    • Issa, F.1    Wood, K.J.2
  • 38
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated foxp3 expression
    • Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007; 445:766-770.
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 39
    • 79951802928 scopus 로고    scopus 로고
    • Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells
    • Francis RS, Feng G, Tha-In T, et al. Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells. Eur J Immunol 2011; 41:726-738.
    • (2011) Eur J Immunol , vol.41 , pp. 726-738
    • Francis, R.S.1    Feng, G.2    Tha-In, T.3
  • 40
    • 79956272192 scopus 로고    scopus 로고
    • Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection
    • Feng G, Nadig SN, Backdahl L, et al. Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection. Sci Transl Med 2011; 3:83ra40.
    • (2011) Sci Transl Med , vol.3 , pp. 83ra40
    • Feng, G.1    Nadig, S.N.2    Backdahl, L.3
  • 41
    • 79952200110 scopus 로고    scopus 로고
    • Regulatory T cell enrichment by IFN-gamma conditioning
    • Feng G, Wood KJ, Bushell A. Regulatory T cell enrichment by IFN-gamma conditioning. Methods Mol Biol 2011; 677:281-301.
    • (2011) Methods Mol Biol , vol.677 , pp. 281-301
    • Feng, G.1    Wood, K.J.2    Bushell, A.3
  • 42
    • 56649102190 scopus 로고    scopus 로고
    • Peripherally induced treg: Mode, stability, and role in specific tolerance
    • Apostolou I, Verginis P, Kretschmer K, et al. Peripherally induced Treg: mode, stability, and role in specific tolerance. J Clin Immunol 2008; 28:619-624.
    • (2008) J Clin Immunol , vol.28 , pp. 619-624
    • Apostolou, I.1    Verginis, P.2    Kretschmer, K.3
  • 43
    • 33646240855 scopus 로고    scopus 로고
    • Single-cell analysis of normal and FOXP3-mutant human T cells: Foxp3 expression without regulatory T cell development
    • Gavin MA, Torgerson TR, Houston E, et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A 2006; 103:6659-6664.
    • (2006) Proc Natl Acad SciUSA , vol.103 , pp. 6659-6664
    • Gavin, M.A.1    Torgerson, T.R.2    Houston, E.3
  • 44
    • 34247271308 scopus 로고    scopus 로고
    • Maintenance of the foxp3-dependent developmental program in mature regulatory T cells requires continued expression of foxp3
    • Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 2007; 8:277-284.
    • (2007) Nat Immunol , vol.8 , pp. 277-284
    • Williams, L.M.1    Rudensky, A.Y.2
  • 45
    • 84874206502 scopus 로고    scopus 로고
    • Translating tolerogenic therapies to the clinic: Where do we stand?
    • Issa F, Wood KJ. Translating tolerogenic therapies to the clinic: where do we stand? Front Immunol 2012; 3:254.
    • (2012) Front Immunol , vol.3 , pp. 254
    • Issa, F.1    Wood, K.J.2
  • 46
    • 33845379986 scopus 로고    scopus 로고
    • Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
    • Battaglia M, Stabilini A, Migliavacca B, et al. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients. J Immunol 2006; 177:8338-8347.
    • (2006) J Immunol , vol.177 , pp. 8338-8347
    • Battaglia, M.1    Stabilini, A.2    Migliavacca, B.3
  • 47
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005; 105:4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 48
    • 84872072150 scopus 로고    scopus 로고
    • Multiple unit pooled umbilical cord blood is a viable source of therapeutic regulatory T cells
    • Milward K, Issa F, Hester J, et al. Multiple unit pooled umbilical cord blood is a viable source of therapeutic regulatory T cells. Transplantation 2013; 95:85-93.
    • (2013) Transplantation , vol.95 , pp. 85-93
    • Milward, K.1    Issa, F.2    Hester, J.3
  • 49
    • 84896697076 scopus 로고    scopus 로고
    • Novel GMP-compatible protocol employing an allogeneic B cell bank for clonal expansion of allospecific natural regulatory T cells
    • Landwehr-Kenzel S, Issa F, Luu SH, et al. Novel GMP-compatible protocol employing an allogeneic B cell bank for clonal expansion of allospecific natural regulatory T cells. Am J Transplant 2014; 14:594-606.
    • (2014) Am J Transplant , vol.14 , pp. 594-606
    • Landwehr-Kenzel, S.1    Issa, F.2    Luu, S.H.3
  • 50
    • 84886786872 scopus 로고    scopus 로고
    • Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation
    • Putnam AL, Safinia N, Medvec A, et al. Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation. Am J Transplant 2013; 13:3010-3020.
    • (2013) Am J Transplant , vol.13 , pp. 3010-3020
    • Putnam, A.L.1    Safinia, N.2    Medvec, A.3
  • 51
    • 84861568296 scopus 로고    scopus 로고
    • Regulatory immune cells in transplantation
    • Wood KJ, Bushell A, Hester J. Regulatory immune cells in transplantation. Nat Rev Immunol 2012; 12:417-430.
    • (2012) Nat Rev Immunol , vol.12 , pp. 417-430
    • Wood, K.J.1    Bushell, A.2    Hester, J.3
  • 52
    • 0037439805 scopus 로고    scopus 로고
    • Split tolerance to a composite tissue allograft in a swine model
    • Mathes DW, Randolph MA, Solari MG, et al. Split tolerance to a composite tissue allograft in a swine model. Transplantation 2003; 75:25-31.
    • (2003) Transplantation , vol.75 , pp. 25-31
    • Mathes, D.W.1    Randolph, M.A.2    Solari, M.G.3
  • 53
    • 84889882988 scopus 로고    scopus 로고
    • Vascularized composite allograft transplant survival in miniature swine: Is MHC tolerance sufficient for acceptance of epidermis?
    • Cetrulo CL Jr, Torabi R, Scalea JR, et al. Vascularized composite allograft transplant survival in miniature swine: is MHC tolerance sufficient for acceptance of epidermis? Transplantation 2013; 96:966-974.
    • (2013) Transplantation , vol.96 , pp. 966-974
    • Cetrulo, C.L.1    Torabi, R.2    Scalea, J.R.3
  • 54
    • 78650835204 scopus 로고    scopus 로고
    • Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model
    • Issa F, Hester J, Goto R, et al. Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model. Transplantation 2010; 90:1321-1327.
    • (2010) Transplantation , vol.90 , pp. 1321-1327
    • Issa, F.1    Hester, J.2    Goto, R.3
  • 55
    • 79956288367 scopus 로고    scopus 로고
    • Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells
    • Sagoo P, Ali N, Garg G, et al. Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci Transl Med 2011; 3:83ra42.
    • (2011) Sci Transl Med , vol.3 , pp. 83ra42
    • Sagoo, P.1    Ali, N.2    Garg, G.3
  • 56
    • 84871731716 scopus 로고    scopus 로고
    • Homing of regulatory T cells to human skin is important for the prevention of alloimmune-mediated pathology in an in vivo cellular therapy model
    • Issa F, Hester J, Milward K, Wood KJ. Homing of regulatory T cells to human skin is important for the prevention of alloimmune-mediated pathology in an in vivo cellular therapy model. PLoS One 2012; 7:e53331.
    • (2012) PLoS One , vol.7
    • Issa, F.1    Hester, J.2    Milward, K.3    Wood, K.J.4
  • 57
    • 33646046528 scopus 로고    scopus 로고
    • The vast majority of CLA+ tcells are resident in normal skin
    • Clark RA, Chong B, Mirchandani N, et al. The vast majority of CLA+ Tcells are resident in normal skin. J Immunol 2006; 176:4431-4439.
    • (2006) J Immunol , vol.176 , pp. 4431-4439
    • Clark, R.A.1    Chong, B.2    Mirchandani, N.3
  • 58
    • 34250336452 scopus 로고    scopus 로고
    • Altering the distribution of foxp3(+) regulatory T cells results in tissue-specific inflammatory disease
    • Sather BD, Treuting P, Perdue N, et al. Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med 2007; 204:1335-1347.
    • (2007) J Exp Med , vol.204 , pp. 1335-1347
    • Sather, B.D.1    Treuting, P.2    Perdue, N.3
  • 59
    • 17144393320 scopus 로고    scopus 로고
    • Recruitment of foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor
    • Lee I, Wang L, Wells AD, et al. Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med 2005; 201:1037-1044.
    • (2005) J Exp Med , vol.201 , pp. 1037-1044
    • Lee, I.1    Wang, L.2    Wells, A.D.3
  • 60
    • 0041835978 scopus 로고    scopus 로고
    • Clinicopathologic features of graft rejection of the first human hand allograft
    • Kanitakis J, Jullien D, Petruzzo P, et al. Clinicopathologic features of graft rejection of the first human hand allograft. Transplantation 2003; 76:688-693.
    • (2003) Transplantation , vol.76 , pp. 688-693
    • Kanitakis, J.1    Jullien, D.2    Petruzzo, P.3
  • 61
    • 0033611066 scopus 로고    scopus 로고
    • Immunologic factors: The major risk for decreased long-term renal allograft survival
    • Humar A, Hassoun A, Kandaswamy R, et al. Immunologic factors: the major risk for decreased long-term renal allograft survival. Transplantation 1999; 68:1842-1846.
    • (1999) Transplantation , vol.68 , pp. 1842-1846
    • Humar, A.1    Hassoun, A.2    Kandaswamy, R.3
  • 62
    • 80053612507 scopus 로고    scopus 로고
    • Regulatory T cells as modulators of chronic allograft dysfunction
    • Issa F, Chandrasekharan D, Wood KJ. Regulatory T cells as modulators of chronic allograft dysfunction. Curr Opin Immunol 2011; 23:648-654.
    • (2011) Curr Opin Immunol , vol.23 , pp. 648-654
    • Issa, F.1    Chandrasekharan, D.2    Wood, K.J.3
  • 63
    • 77954539326 scopus 로고    scopus 로고
    • In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells
    • Nadig SN, Wieckiewicz J, Wu DC, et al. In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat Med 2010; 16:809-813.
    • (2010) Nat Med , vol.16 , pp. 809-813
    • Nadig, S.N.1    Wieckiewicz, J.2    Wu, D.C.3
  • 64
    • 77954614267 scopus 로고    scopus 로고
    • CD4+ regulatory T cells generated in vitro with IFN-{gamma} and allogeneic APC inhibit transplant arteriosclerosis
    • Warnecke G, Feng G, Goto R, et al. CD4+ regulatory T cells generated in vitro with IFN-{gamma} and allogeneic APC inhibit transplant arteriosclerosis. Am J Pathol 2010; 177:464-472.
    • (2010) Am J Pathol , vol.177 , pp. 464-472
    • Warnecke, G.1    Feng, G.2    Goto, R.3
  • 65
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012; 30:531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 66
    • 77949269609 scopus 로고    scopus 로고
    • In vivo observations of cell trafficking in allotransplanted vascularized skin flaps and conventional skin grafts
    • Horner BM, Ferguson KK, Randolph MA, et al. In vivo observations of cell trafficking in allotransplanted vascularized skin flaps and conventional skin grafts. J Plast Reconstr Aesthet Surg 2010; 63:711-719.
    • (2010) J Plast Reconstr Aesthet Surg , vol.63 , pp. 711-719
    • Horner, B.M.1    Ferguson, K.K.2    Randolph, M.A.3
  • 67
    • 65949105474 scopus 로고    scopus 로고
    • Correlation of chimerism with graft size and revascularization in vascularized and nonvascularized skin allografts
    • Nasir S, Bozkurt M, Krokowicz L, et al. Correlation of chimerism with graft size and revascularization in vascularized and nonvascularized skin allografts. Ann Plast Surg 2009; 62:430-438.
    • (2009) Ann Plast Surg , vol.62 , pp. 430-438
    • Nasir, S.1    Bozkurt, M.2    Krokowicz, L.3
  • 68
    • 84878593698 scopus 로고    scopus 로고
    • Cognate antigen directs CD8+ T cell migration to vascularized transplants
    • Walch JM, Zeng Q, Li Q, et al. Cognate antigen directs CD8+ T cell migration to vascularized transplants. J Clin Invest 2013; 123:2663-2671.
    • (2013) J Clin Invest , vol.123 , pp. 2663-2671
    • Walch, J.M.1    Zeng, Q.2    Li, Q.3
  • 69
    • 0018649589 scopus 로고
    • The immediately vascularized skin allograft
    • Perloff LJ, Barker CF. The immediately vascularized skin allograft. Transplantation 1979; 28:125-130.
    • (1979) Transplantation , vol.28 , pp. 125-130
    • Perloff, L.J.1    Barker, C.F.2
  • 70
    • 84881369551 scopus 로고    scopus 로고
    • Vascularized osteomyocutaneous allografts are permissive to tolerance by induction-based immunomodulatory therapy
    • Lin CH, Zhang W, Ng TW, et al. Vascularized osteomyocutaneous allografts are permissive to tolerance by induction-based immunomodulatory therapy. Am J Transplant 2013; 13:2161-2168.
    • (2013) Am J Transplant , vol.13 , pp. 2161-2168
    • Lin, C.H.1    Zhang, W.2    Ng, T.W.3
  • 71
    • 37349068519 scopus 로고    scopus 로고
    • Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion
    • Horibe EK, Sacks J, Unadkat J, et al. Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion. Transpl Immunol 2008; 18:307-318.
    • (2008) Transpl Immunol , vol.18 , pp. 307-318
    • Horibe, E.K.1    Sacks, J.2    Unadkat, J.3
  • 72
    • 67649586583 scopus 로고    scopus 로고
    • Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model
    • Kuo YR, Goto S, Shih HS, et al. Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model. Transplantation 2009; 87:1769-1777.
    • (2009) Transplantation , vol.87 , pp. 1769-1777
    • Kuo, Y.R.1    Goto, S.2    Shih, H.S.3
  • 73
    • 20544457031 scopus 로고    scopus 로고
    • The role of nondeletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade
    • Bigenzahn S, Blaha P, Koporc Z, et al. The role of nondeletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade. Am J Transplant 2005; 5:1237-1247.
    • (2005) Am J Transplant , vol.5 , pp. 1237-1247
    • Bigenzahn, S.1    Blaha, P.2    Koporc, Z.3
  • 74
    • 84927697750 scopus 로고    scopus 로고
    • Poster sessions: Basic
    • San Francisco, USA 2014
    • World Transplant Congress 2014, San Francisco, USA. Poster Sessions: Basic. Am J Transplant 2014; 14:278-419.
    • (2014) Am J Transplant , vol.14 , pp. 278-419
  • 75
    • 84872968851 scopus 로고    scopus 로고
    • Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance
    • Xu H, Ramsey DM, Wu S, et al. Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance. Transplantation 2013; 95:301-308.
    • (2013) Transplantation , vol.95 , pp. 301-308
    • Xu, H.1    Ramsey, D.M.2    Wu, S.3
  • 76
    • 84895062978 scopus 로고    scopus 로고
    • Vascularized composite allograft tolerance across MHC barriers in a large animal model
    • Leonard DA, Kurtz JM, Mallard C, et al. Vascularized composite allograft tolerance across MHC barriers in a large animal model. AmJ Transplant 2014; 14:343-355.
    • (2014) AmJ Transplant , vol.14 , pp. 343-355
    • Leonard, D.A.1    Kurtz, J.M.2    Mallard, C.3
  • 77
    • 84904617608 scopus 로고    scopus 로고
    • Simultaneous transplantation of hematopoietic stem cells and a vascularized composite allograft leads to tolerance
    • Mathes DW, Chang J, Hwang B, et al. Simultaneous transplantation of hematopoietic stem cells and a vascularized composite allograft leads to tolerance. Transplantation 2014; 98:131-138.
    • (2014) Transplantation , vol.98 , pp. 131-138
    • Mathes, D.W.1    Chang, J.2    Hwang, B.3
  • 78
    • 79954746812 scopus 로고    scopus 로고
    • Evidence that FoxP3+ regulatory T cells may play a role in promoting long-term acceptance of composite tissue allotransplants
    • Bozulic LD, Wen Y, Xu H, Ildstad ST. Evidence that FoxP3+ regulatory T cells may play a role in promoting long-term acceptance of composite tissue allotransplants. Transplantation 2011; 91:908-915.
    • (2011) Transplantation , vol.91 , pp. 908-915
    • Bozulic, L.D.1    Wen, Y.2    Xu, H.3    Ildstad, S.T.4
  • 79
    • 0025674112 scopus 로고
    • Induction of tolerance in peripheral T cells with monoclonal antibodies
    • Qin SX, Wise M, Cobbold SP, et al. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur J Immunol 1990; 20:2737-2745.
    • (1990) Eur J Immunol , vol.20 , pp. 2737-2745
    • Qin, S.X.1    Wise, M.2    Cobbold, S.P.3
  • 80
    • 0034071426 scopus 로고    scopus 로고
    • Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
    • Wekerle T, Kurtz J, Ito H, et al. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat Med 2000; 6:464-469.
    • (2000) Nat Med , vol.6 , pp. 464-469
    • Wekerle, T.1    Kurtz, J.2    Ito, H.3
  • 81
    • 0033571542 scopus 로고    scopus 로고
    • Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a nonmyeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance
    • Wekerle T, Sayegh MH, Ito H, et al. Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a nonmyeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance. Transplantation 1999; 68:1348-1355.
    • (1999) Transplantation , vol.68 , pp. 1348-1355
    • Wekerle, T.1    Sayegh, M.H.2    Ito, H.3
  • 82
    • 0034235458 scopus 로고    scopus 로고
    • Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning
    • Durham MM, Bingaman AW, Adams AB, et al. Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J Immunol 2000; 165:1-4.
    • (2000) J Immunol , vol.165 , pp. 1-4
    • Durham, M.M.1    Bingaman, A.W.2    Adams, A.B.3
  • 83
    • 85047692674 scopus 로고    scopus 로고
    • Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloa-blative conditioning
    • Seung E, Mordes JP, Rossini AA, Greiner DL. Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloa-blative conditioning. J Clin Invest 2003; 112:795-808.
    • (2003) J Clin Invest , vol.112 , pp. 795-808
    • Seung, E.1    Mordes, J.P.2    Rossini, A.A.3    Greiner, D.L.4
  • 84
    • 84872928015 scopus 로고    scopus 로고
    • Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning
    • Lin JY, Tsai FC, Wallace CG, et al. Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning. Chimerism 2013; 4:20-22.
    • (2013) Chimerism , vol.4 , pp. 20-22
    • Lin, J.Y.1    Tsai, F.C.2    Wallace, C.G.3
  • 85
    • 33745804056 scopus 로고    scopus 로고
    • An appraisal of tolerance in liver transplantation
    • Lerut J, Sanchez-Fueyo A. An appraisal of tolerance in liver transplantation. Am J Transplant 2006; 6:1774-1780.
    • (2006) Am J Transplant , vol.6 , pp. 1774-1780
    • Lerut, J.1    Sanchez-Fueyo, A.2
  • 86
    • 78650179150 scopus 로고    scopus 로고
    • Clinical operational tolerance after renal transplantation: Current status and future challenges
    • Orlando G, Hematti P, Stratta RJ, et al. Clinical operational tolerance after renal transplantation: current status and future challenges. Ann Surg 2010; 252:915-928.
    • (2010) Ann Surg , vol.252 , pp. 915-928
    • Orlando, G.1    Hematti, P.2    Stratta, R.J.3
  • 87
    • 33846910502 scopus 로고    scopus 로고
    • Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation
    • Koshiba T, Li Y, Takemura M, et al. Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transpl Immunol 2007; 17:94-97.
    • (2007) Transpl Immunol , vol.17 , pp. 94-97
    • Koshiba, T.1    Li, Y.2    Takemura, M.3
  • 88
    • 10044262162 scopus 로고    scopus 로고
    • Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation
    • Li Y, Koshiba T, Yoshizawa A, et al. Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. Am J Transplant 2004; 4:2118-2125.
    • (2004) Am J Transplant , vol.4 , pp. 2118-2125
    • Li, Y.1    Koshiba, T.2    Yoshizawa, A.3
  • 89
    • 58849121453 scopus 로고    scopus 로고
    • The presence of foxp3 expressing T cells within grafts of tolerance human liver transplant recipients
    • Li Y, Zhao X, Cheng D, et al. The presence of Foxp3 expressing T cells within grafts of tolerance human liver transplant recipients. Transplantation 2008; 86:1837-1843.
    • (2008) Transplantation , vol.86 , pp. 1837-1843
    • Li, Y.1    Zhao, X.2    Cheng, D.3
  • 90
    • 33846252277 scopus 로고    scopus 로고
    • Multiparameter immune profiling of operational tolerance in liver transplantation
    • Martinez-Llordella M, Puig-Pey I, Orlando G, et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant 2007; 7:309-319.
    • (2007) Am J Transplant , vol.7 , pp. 309-319
    • Martinez-Llordella, M.1    Puig-Pey, I.2    Orlando, G.3
  • 91
    • 77953209236 scopus 로고    scopus 로고
    • Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans
    • Sagoo P, Perucha E, Sawitzki B, et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010; 120:1848-1861.
    • (2010) J Clin Invest , vol.120 , pp. 1848-1861
    • Sagoo, P.1    Perucha, E.2    Sawitzki, B.3
  • 92
    • 77951939323 scopus 로고    scopus 로고
    • Differential monocyte STAT6 activation and CD4(+)CD25(+)Foxp3(+) T cells in kidney operational tolerance transplanted individuals
    • Moraes-Vieira PM, Silva HM, Takenaka MC, et al. Differential monocyte STAT6 activation and CD4(+)CD25(+)Foxp3(+) T cells in kidney operational tolerance transplanted individuals. Hum Immunol 2010; 71:442-450.
    • (2010) Hum Immunol , vol.71 , pp. 442-450
    • Moraes-Vieira, P.M.1    Silva, H.M.2    Takenaka, M.C.3
  • 93
    • 33845941704 scopus 로고    scopus 로고
    • Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation
    • Eljaafari A, Badet L, Kanitakis J, et al. Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation. Transplantation 2006; 82:1764-1768.
    • (2006) Transplantation , vol.82 , pp. 1764-1768
    • Eljaafari, A.1    Badet, L.2    Kanitakis, J.3
  • 94
    • 84881612661 scopus 로고    scopus 로고
    • Regulatory T cells are not predictive of outcomes in a nonhuman primate model of vascu-larized composite allotransplantation
    • Brazio PS, Munivenkatappa RB, Bojovic B, et al. Regulatory T cells are not predictive of outcomes in a nonhuman primate model of vascu-larized composite allotransplantation. Transplantation 2013; 96:267-273.
    • (2013) Transplantation , vol.96 , pp. 267-273
    • Brazio, P.S.1    Munivenkatappa, R.B.2    Bojovic, B.3
  • 95
    • 84864463754 scopus 로고    scopus 로고
    • Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo
    • Hester J, Schiopu A, Nadig SN, Wood KJ. Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo. Am J Transplant 2012; 12:2008-2016.
    • (2012) Am J Transplant , vol.12 , pp. 2008-2016
    • Hester, J.1    Schiopu, A.2    Nadig, S.N.3    Wood, K.J.4
  • 96
    • 84927694152 scopus 로고    scopus 로고
    • A GMP treg expansion protocol restores treg suppressor function in end-stage liver disease: Implications for adoptive transfer therapy
    • Safinia N, Vaikunthanathan T, Fraser H, et al. A GMP Treg expansion protocol restores Treg suppressor function in end-stage liver disease: implications for adoptive transfer therapy. Gut 2014; 63:A92-A93.
    • (2014) Gut , vol.63 , pp. A92-A93
    • Safinia, N.1    Vaikunthanathan, T.2    Fraser, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.