Evidence that foxP3+ regulatory T cells may play a role in promoting long-term acceptance of composite tissue allotransplants

Transplantation

Volumn 91, Issue 8, 2011, Pages 908-915

  Bozulic, Larry D ^a,b   Wen, Yujie ^b   Xu, Hong ^b   Ildstad, Suzanne T ^b  

^a Regenerex LLC   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Bone marrow transplantation; Composite tissue allotransplant; T regulatory cells; Tolerance

Indexed keywords

LYMPHOCYTE ANTIBODY; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3;

ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE GRAFT; BONE MARROW CELL; CD4+ CD25+ T LYMPHOCYTE; CHIMERA; COMPOSITE GRAFT; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; ISOGRAFT; LIMB; LYMPHOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; MALE; MIXED LYMPHOCYTE REACTION; MYOCUTANEOUS FLAP; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; SKIN BIOPSY; SPLEEN CELL;

ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; GRAFT SURVIVAL; HINDLIMB; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MICROSCOPY, CONFOCAL; RATS; RATS, INBRED F344; RATS, INBRED WF; SKIN TRANSPLANTATION; SPLEEN; SURGICAL FLAPS; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS; WHOLE-BODY IRRADIATION;

EID: 79954746812     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31820fafb4     Document Type: Article

References (36)

1. Ravindra KV, Wu S-L, Bozulic L, et al. Composite tissue transplantation: A rapidly advancing field. Transplant Proc 2008; 40: 1237.
2. Ildstad ST, Wren SM, Bluestone JA, et al. Characterization of mixed allogeneic chimeras: Immunocompetence, in vitro reactivity and genetic specificity of tolerance. J Exp Med 1985; 162: 231.
3. Colson YL, Zadach K, Nalesnik M, et al. Mixed allogeneic chimerism in the rat. Donor-specific transplantation tolerance without chronic rejection for primarily vascularized cardiac allografts. Transplantation 1995; 60: 971.
4. Luo B, Nanji SA, Schur CD, et al. Robust tolerance to fully allogeneic islet transplants achieved by chimerism with minimal conditioning. Transplantation 2005; 80: 370.
5. Wekerle T, Sayegh MH, Ito H, et al. Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance. Transplantation 1999; 68: 1348.
6. Tomita Y, Sachs DH, Khan A, et al. Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-GY whole body irradiation. Transplantation 1996; 61: 469.
7. Sakaguchi S, Wing K, Onishi Y, et al. Regulatory T cells: How do they suppress immune responses? Int Immunol 2009; 21: 1105.
8. Sakaguchi S, Yamaguchi T, Nomura T, et al. Regulatory T cells and immune tolerance. Cell 2008; 133: 775.
9. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057.
10. Bashuda H, Kimikawa M, Seino K, et al. Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest 2005; 115: 1896.
11. Eljaafari A, Badet L, Kanitakis J, et al. Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation. Transplantation 2006; 82: 1764.
12. Barao I, Hanash AM, Hallett W, et al. Suppression of natural killer cell-mediated bone marrow cell rejection by CD4-CD25 regulatory T cells. Proc Natl Acad Sci USA 2006; 103: 5460.
13. Hanash AM, Levy RB. Donor CD4-CD25 T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation. Blood 2005; 105: 1828.
14. Weng L, Dyson J, Dazzi F. Low-intensity transplant regimens facilitate recruitment of donor-specific regulatory T cells that promote hematopoietic engraftment. Proc Natl Acad Sci USA 2007; 104: 8415.
15. Fehr T, Takeuchi Y, Kurtz J, et al. Early regulation of CD8 T cell alloreactivity by CD4-. Eur J Immunol 2005; 35: 2679.
16. Cendales LC, Kirk AD, Moresi JM, et al. Composite tissue allotransplantation: Classification of clinical acute skin rejection. Transplantation 2006; 81: 418.
17. Adamson LA, Huang W, Breidenbach WC, et al. A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allotransplantation. Microsurgery 2007; 27: 630.
18. Ildstad ST, Sachs DH. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 1984; 307: 168.
19. Colson YL, Xu H, Huang Y, et al. Mixed xenogeneic chimerism induces donor-specific humoral and cellular immune tolerance for cardiac xenografts. J Immunol 2004; 173: 5827.
20. Foster RD, Ascher NL, McCalmont TH, et al. Mixed allogeneic chimerism as a reliable model for composite tissue allograft tolerance induction across major and minor histocompatibility barriers. Transplantation 2001; 72: 791.
21. Pham SM, Mitruka SN, Youm W, et al. Mixed hematopoietic chimerism induces donor-specific tolerance for lung allografts in rodents. Am J Respir Crit Care Med 1999; 159: 199.
22. Foster RD, Fan L, Neipp M, et al. Donor-specific tolerance induction in composite tissue allografts. Am J Surg 1998; 176: 418; erratum in: Am J Surg 1999; 177: 529.
23. Nasir S, Bozkurt M, Krokowicz L, et al. Correlation of chimerism with graft size and revascularization in vascularized and nonvascularized skin allografts. Ann Plast Surg 2009; 62: 430.
24. Wells AD, Li XC, Li Y, et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 1999; 5: 1303.
25. Lechler RI, Garden OA, Turka LA. The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol 2003; 3: 147.
26. Walsh PT, Taylor DK, Turka LA. Tregs and transplantation tolerance. J Clin Invest 2004; 114: 1398.
27. Kurtz J, Wekerle T, Sykes M. Tolerance in mixed chimerism -A role for regulatory cells? Trends Immunol 2004; 25: 518.
28. Jonuleit H, Schmitt E, Kakirman H, et al. Infectious tolerance: Human CD25(-) regulatory T cells convey suppressor activity to conventional CD4(-) T helper cells. J Exp Med 2002; 196: 255.
29. Dieckmann D, Bruett CH, Ploettner H, et al. Human CD4(-)CD25(-) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected]. J Exp Med 2002; 196: 247.
30. ChenW,JinW,Hardegen N, et al. Conversion of peripheralCD4-CD25 naive T cells to CD4-CD25 regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875.
31. Yamagiwa S, Gray JD, Hashimoto S, et al. A role for TGF-beta in the generation and expansion of CD4-CD25 regulatory T cells from human peripheral blood. J Immunol 2001; 166: 7282.
32. Karim M, Kingsley CL, Bushell AR, et al. Alloantigen-induced CD25-CD4- regulatory T cell can develop in vivo from CD25-CD4- precursors in a thymus-independent process. J Immunol 2004;172:923-928. (Pubitemid 38113750)
33. Bunnag S, Allanach K, Jhangri GS, et al. FOXP3 expression in human kidney transplant biopsies is associated with rejection and time post transplant but not with favorable outcomes. Am J Transplant 2008; 8: 1423.
34. Louis S, Braudeau C, Giral M, et al. Contrasting CD25hiCD4-T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance. Transplantation 2006; 81: 398.
35. Kaufman CL, Colson YL, Wren SM, et al. Phenotypic characterization of a novel bone-marrow derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 1994; 84: 2436.
36. Huang Y, Rezzoug F, Chilton PM, et al. Matching at the MHC class I K locus is essential for long-term engraftment of purified hematopoietic stem cells: A role for host NK cells in regulating HSC engraftment. Blood 2004; 104: 873.