Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning

Chimerism

Volumn 4, Issue 1, 2013, Pages 20-22

  Lin, Jeng Yee ^a,b   Tsai, Feng Chou ^b   Wallace, Christopher Glenn ^a,c   Huang, Wei Chao ^a,c   Wei, Fu Chan ^a,c   Liao, Shuen Kuei ^a,b,d  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d Former Employee of Astellas Pharma Taiwan   (Taiwan)

Author keywords

Composite tissue allograft; Graftversus host disease; Mixed chimerism; Transplantation; Vascularized bone marrow transplantation; Vascularized composite allograft

Indexed keywords

RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TRANSPLANTATION; CD4+ T LYMPHOCYTE; DOWN REGULATION; EFFECTOR CELL; FEASIBILITY STUDY; GRAFT REJECTION; IMMUNOLOGICAL PARAMETERS; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTIC INFILTRATION; MIXED CHIMERISM; NONHUMAN; RAT; REGULATORY T LYMPHOCYTE; VASCULARIZED BONE MARROW TRANSPLANTATION; VASCULARIZED COMPOSITE ALLOGRAFT;

EID: 84872928015     PISSN: 19381956     EISSN: 19381964     Source Type: Journal    
DOI: 10.4161/chim.23349     Document Type: Article

References (10)

1. Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature 1953; 172:603-6; PMID:13099277; http://dx.doi. org/10.1038/172603a0.
2. Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 1989; 169:493-502; PMID:2562984; http://dx.doi. org/10.1084/jem.169.2.493.
3. Colson YL, Zadach K, Nalesnik M, Ildstad ST. Mixed allogeneic chimerism in the rat. Donorspecific transplantation tolerance without chronic rejection for primarily vascularized cardiac allografts. Transplantation 1995; 60:971-80; PMID:7491703.
4. Pilat N, Baranyi U, Klaus C, Jaeckel E, Mpofu N, Wrba F, et al. Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning. Am J Transplant 2010; 10:751-62; PMID:20148810; http://dx.doi.org/10.1111/j.1600-6143.2010.03018.x.
5. Lin JY, Tsai FC, Wallace CG, Huang WC, Wei FC, Liao SK. Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning. J Surg Res 2012; 178:974-81; PMID:22819314; http:// dx.doi.org/10.1016/j.jss.2012.06.061.
6. Lin JY, Tsai FC, Wallace CG, Huang WC, Wei FC, Liao SK. Optimizing chimerism level through bone marrow transplantation and irradiation to induce long-term tolerance to composite tissue allotransplantation. J Surg Res 2012; 178:487-93; PMID:22484382; http://dx.doi.org/10.1016/j. jss.2012.02.064.
7. Kawai T, Cosimi AB, Spitzer TR, Tolkoff-Rubin N, Suthanthiran M, Saidman SL, et al. HLAmismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358:353-61; PMID:18216355; http://dx.doi. org/10.1056/NEJMoa071074.
8. Bozulic LD, Wen Y, Xu H, Ildstad ST. Evidence that FoxP3+ regulatory T cells may play a role in promoting long-term acceptance of composite tissue allotransplants. Transplantation 2011; 91:908-15; PMID:21304439; http://dx.doi.org/10.1097/ TP.0b013e31820fafb4.
9. Eljaafari A, Badet L, Kanitakis J, Ferrand C, Farre A, Petruzzo P, et al. Isolation of regulatory T cells in the skin of a human hand-allograft, up to six years posttransplantation. Transplantation 2006; 82:1764-8; PMID:17198273; http://dx.doi.org/10.1097/01. tp.0000250937.46187.ca.
10. Hautz T, Brandacher G, Zelger B, Müller HG, Lee AW, Fuchs D, et al. Indoleamine 2,3-dioxygenase and foxp3 expression in skin rejection of human hand allografts. Transplant Proc 2009; 41:509-12; PMID:19328914; http://dx.doi.org/10.1016/j. transproceed.2009.01.008.