메뉴 건너뛰기




Volumn 6, Issue FEB, 2015, Pages

Identification of essential amino acid residues in the nisin dehydratase NisB

Author keywords

Dehydratase; Lanthionine; Lantibiotics; Mechanism; NisB; NisC; Nisin; Posttranslational modifications

Indexed keywords

ESSENTIAL AMINO ACID; HYDROLYASE; NISB HYDROLYASE; NISIN; UNCLASSIFIED DRUG;

EID: 84927522174     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2015.00102     Document Type: Article
Times cited : (11)

References (40)
  • 1
    • 84870918230 scopus 로고    scopus 로고
    • Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
    • Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., et al. (2013). Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat. Prod. Rep. 30, 108-160. doi: 10.1039/c2np20085f.
    • (2013) Nat. Prod. Rep , vol.30 , pp. 108-160
    • Arnison, P.G.1    Bibb, M.J.2    Bierbaum, G.3    Bowers, A.A.4    Bugni, T.S.5    Bulaj, G.6
  • 2
    • 0033579207 scopus 로고    scopus 로고
    • Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic
    • Breukink, E., Wiedemann, I., van Kraaij, C., Kuipers, O. P., Sahl, H. G., and de Kruijff, B. (1999). Use of the cell wall precursor lipid II by a pore-forming peptide antibiotic. Science 286, 2361-2364. doi: 10.1126/science.286.5448.2361.
    • (1999) Science , vol.286 , pp. 2361-2364
    • Breukink, E.1    Wiedemann, I.2    van Kraaij, C.3    Kuipers, O.P.4    Sahl, H.G.5    de Kruijff, B.6
  • 3
    • 0030597972 scopus 로고    scopus 로고
    • Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin
    • Chan, W. C., Leyland, M., Clark, J., Dodd, H. M., Lian, L. Y., Gasson, M. J., et al. (1996). Structure-activity relationships in the peptide antibiotic nisin: antibacterial activity of fragments of nisin. FEBS Lett. 390, 129-132. doi: 10.1016/0014-5793(96)00638-2.
    • (1996) FEBS Lett , vol.390 , pp. 129-132
    • Chan, W.C.1    Leyland, M.2    Clark, J.3    Dodd, H.M.4    Lian, L.Y.5    Gasson, M.J.6
  • 4
    • 27644492521 scopus 로고    scopus 로고
    • Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production
    • Chatterjee, C., Miller, L. M., Leung, Y. L., Xie, L. L., Yi, M. S., Kelleher, N. L., et al. (2005). Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J. Am. Chem. Soc. 127, 15332-15333. doi: 10.1021/ja0543043.
    • (2005) J. Am. Chem. Soc , vol.127 , pp. 15332-15333
    • Chatterjee, C.1    Miller, L.M.2    Leung, Y.L.3    Xie, L.L.4    Yi, M.S.5    Kelleher, N.L.6
  • 5
    • 0029757175 scopus 로고    scopus 로고
    • Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin
    • de Ruyter, P. G., Kuipers, O. P., and de Vos, W. M. (1996). Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin. Appl. Environ. Microbiol. 62, 3662-3667.
    • (1996) Appl. Environ. Microbiol , vol.62 , pp. 3662-3667
    • de Ruyter, P.G.1    Kuipers, O.P.2    de Vos, W.M.3
  • 6
    • 77951254784 scopus 로고    scopus 로고
    • Oral and pulmonary delivery of thioether-bridged angiotensin-(1-7)
    • de Vries, L., Reitzema-Klein, C. E., Meter-Arkema, A., van Dam, A., Rink, R., Moll, G. N., et al. (2010). Oral and pulmonary delivery of thioether-bridged angiotensin-(1-7) Peptides 31, 893-898. doi: 10.1016/j.peptides.2010.02.015.
    • (2010) Peptides , vol.31 , pp. 893-898
    • de Vries, L.1    Reitzema-Klein, C.E.2    Meter-Arkema, A.3    van Dam, A.4    Rink, R.5    Moll, G.N.6
  • 8
    • 77950563372 scopus 로고    scopus 로고
    • Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights
    • Goto, Y., Li, B., Claesen, J., Shi, Y., Bibb, M. J., and van der Donk, W. A. (2010). Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. PLoS Biol. 8:e1000339. doi: 10.1371/journal.pbio.1000339.
    • (2010) PLoS Biol , vol.8
    • Goto, Y.1    Li, B.2    Claesen, J.3    Shi, Y.4    Bibb, M.J.5    van der Donk, W.A.6
  • 9
    • 0034954509 scopus 로고    scopus 로고
    • Spontaneous nisin-resistant listeria monocytogenes mutants with increased expression of a putative penicillin-binding protein and their sensitivity to various antibiotics
    • Gravesen, A., Sorensen, K., Aarestrup, F. M., and Knochel, S. (2001). Spontaneous nisin-resistant listeria monocytogenes mutants with increased expression of a putative penicillin-binding protein and their sensitivity to various antibiotics. Microb. Drug. Resist. 7, 127-135. doi: 10.1089/10766290152045002.
    • (2001) Microb. Drug. Resist , vol.7 , pp. 127-135
    • Gravesen, A.1    Sorensen, K.2    Aarestrup, F.M.3    Knochel, S.4
  • 10
    • 33748766086 scopus 로고    scopus 로고
    • An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II
    • Hasper, H. E., Kramer, N. E., Smith, J. L., Hillman, J. D., Zachariah, C., Kuipers, O. P., et al. (2006). An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II. Science 313, 1636-1637. doi: 10.1126/science.1129818.
    • (2006) Science , vol.313 , pp. 1636-1637
    • Hasper, H.E.1    Kramer, N.E.2    Smith, J.L.3    Hillman, J.D.4    Zachariah, C.5    Kuipers, O.P.6
  • 11
    • 80054845759 scopus 로고    scopus 로고
    • Determining sites of interaction between prenisin and its modification enzymes NisB and NisC
    • Khusainov, R., Heils, R., Lubelski, J., Moll, G. N., and Kuipers, O. P. (2011). Determining sites of interaction between prenisin and its modification enzymes NisB and NisC. Mol. Microbiol. 82, 706-718. doi: 10.1111/j.1365-2958.2011.07846.x.
    • (2011) Mol. Microbiol , vol.82 , pp. 706-718
    • Khusainov, R.1    Heils, R.2    Lubelski, J.3    Moll, G.N.4    Kuipers, O.P.5
  • 12
    • 84868120939 scopus 로고    scopus 로고
    • When the leader gets loose: in vivo biosynthesis of a leaderless prenisin is stimulated by a trans-acting leader peptide
    • Khusainov, R., and Kuipers, O. P. (2012). When the leader gets loose: in vivo biosynthesis of a leaderless prenisin is stimulated by a trans-acting leader peptide. Chembiochem 13, 2433-2438. doi: 10.1002/cbic.201200437.
    • (2012) Chembiochem , vol.13 , pp. 2433-2438
    • Khusainov, R.1    Kuipers, O.P.2
  • 13
    • 84883634798 scopus 로고    scopus 로고
    • The presence of modifiable residues in the core peptide part of precursor nisin is not crucial for precursor nisin interactions with NisB-and NisC
    • Khusainov, R., and Kuipers, O. P. (2013b). The presence of modifiable residues in the core peptide part of precursor nisin is not crucial for precursor nisin interactions with NisB-and NisC. PLoS ONE 8:e74890. doi: 10.1371/journal.pone.0074890.
    • (2013) PLoS ONE , vol.8
    • Khusainov, R.1    Kuipers, O.P.2
  • 14
    • 84878791111 scopus 로고    scopus 로고
    • Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC
    • Khusainov, R., Moll, G. N., and Kuipers, O. P. (2013a). Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC. FEBS Open Bio. 3, 237-242. doi: 10.1016/j.fob.2013.05.001.
    • (2013) FEBS Open Bio , vol.3 , pp. 237-242
    • Khusainov, R.1    Moll, G.N.2    Kuipers, O.P.3
  • 15
    • 25444499680 scopus 로고    scopus 로고
    • Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin
    • Kluskens, L. D., Kuipers, A., Rink, R., de Boef, E., Fekken, S., Driessen, A. J., et al. (2005). Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin. Biochemistry 44, 12827-12834. doi: 10.1021/bi050805p.
    • (2005) Biochemistry , vol.44 , pp. 12827-12834
    • Kluskens, L.D.1    Kuipers, A.2    Rink, R.3    de Boef, E.4    Fekken, S.5    Driessen, A.J.6
  • 16
    • 62449281004 scopus 로고    scopus 로고
    • Angiotensin-(1-7) with thioether bridge: An angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog
    • Kluskens, L. D., Nelemans, S. A., Rink, R., de Vries, L., Meter-Arkema, A., Wang, Y., et al. (2009). Angiotensin-(1-7) with thioether bridge: An angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog. J. Pharmacol. Exp. Ther. 328, 849-854. doi: 10.1124/jpet.108.146431.
    • (2009) J. Pharmacol. Exp. Ther , vol.328 , pp. 849-854
    • Kluskens, L.D.1    Nelemans, S.A.2    Rink, R.3    de Vries, L.4    Meter-Arkema, A.5    Wang, Y.6
  • 17
    • 48449091725 scopus 로고    scopus 로고
    • Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of lactococcus lactis
    • Kramer, N. E., Hasper, H. E., van den Bogaard, P. T. C., Morath, S., de Kruijff, B., Hartung, T., et al. (2008). Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of lactococcus lactis. Microbiology 154, 1755-1762. doi: 10.1099/mic.0.2007/015412-0.
    • (2008) Microbiology , vol.154 , pp. 1755-1762
    • Kramer, N.E.1    Hasper, H.E.2    van den Bogaard, P.T.C.3    Morath, S.4    de Kruijff, B.5    Hartung, T.6
  • 18
    • 2542432896 scopus 로고    scopus 로고
    • NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides
    • Kuipers, A., de Boef, E., Rink, R., Fekken, S., Kluskens, L. D., Driessen, A. J. M., et al. (2004). NisT, the transporter of the lantibiotic nisin, can transport fully modified, dehydrated, and unmodified prenisin and fusions of the leader peptide with non-lantibiotic peptides. J. Biol. Chem. 279, 22176-22182. doi: 10.1074/jbc.M312789200.
    • (2004) J. Biol. Chem , vol.279 , pp. 22176-22182
    • Kuipers, A.1    de Boef, E.2    Rink, R.3    Fekken, S.4    Kluskens, L.D.5    Driessen, A.J.M.6
  • 19
    • 55049131364 scopus 로고    scopus 로고
    • Mechanistic dissection of the enzyme complexes involved in biosynthesis of lacticin 3147 and nisin
    • Kuipers, A., Meijer-Wierenga, J., Rink, R., Kluskens, L. D., and Moll, G. N. (2008). Mechanistic dissection of the enzyme complexes involved in biosynthesis of lacticin 3147 and nisin. Appl. Environ. Microbiol. 74, 6591-6597. doi: 10.1128/AEM.01334-08.
    • (2008) Appl. Environ. Microbiol , vol.74 , pp. 6591-6597
    • Kuipers, A.1    Meijer-Wierenga, J.2    Rink, R.3    Kluskens, L.D.4    Moll, G.N.5
  • 20
    • 0027162304 scopus 로고
    • Characterization of the nisin gene cluster nisABTCIPR of lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity
    • Kuipers, O. P., Beerthuyzen, M. M., Siezen, R. J., and de Vos, W. M. (1993b). Characterization of the nisin gene cluster nisABTCIPR of lactococcus lactis. Requirement of expression of the nisA and nisI genes for development of immunity. Eur. J. Biochem. 216, 281-291 doi: 10.1111/j.1432-1033.1993.tb18143.x.
    • (1993) Eur. J. Biochem , vol.216 , pp. 281-291
    • Kuipers, O.P.1    Beerthuyzen, M.M.2    Siezen, R.J.3    de Vos, W.M.4
  • 21
    • 0027205659 scopus 로고
    • Biosynthesis and secretion of a precursor of nisin-Z by lactococcus-lactis, directed by the leader peptide of the homologous lantibiotic subtilin from bacillus-subtilis
    • Kuipers, O. P., Rollema, H. S., Devos, W. M., and Siezen, R. J. (1993a). Biosynthesis and secretion of a precursor of nisin-Z by lactococcus-lactis, directed by the leader peptide of the homologous lantibiotic subtilin from bacillus-subtilis. FEBS Lett. 330, 23-27. doi: 10.1016/0014-5793(93)80911-D.
    • (1993) FEBS Lett , vol.330 , pp. 23-27
    • Kuipers, O.P.1    Rollema, H.S.2    Devos, W.M.3    Siezen, R.J.4
  • 22
    • 69349105507 scopus 로고    scopus 로고
    • Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry
    • Lee, M. V., Ihnken, L. A. F., You, Y. O., McClerren, A. L., van der Donk, W. A., and Kelleher, N. L. (2009). Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. J. Am. Chem. Soc. 131, 12258-12264. doi: 10.1021/ja9033507.
    • (2009) J. Am. Chem. Soc , vol.131 , pp. 12258-12264
    • Lee, M.V.1    Ihnken, L.A.F.2    You, Y.O.3    McClerren, A.L.4    van der Donk, W.A.5    Kelleher, N.L.6
  • 23
    • 34547137156 scopus 로고    scopus 로고
    • Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin
    • Li, B., and van der Donk, W. A. (2007). Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. J. Biol. Chem. 282, 21169-21175. doi: 10.1074/jbc.M701802200.
    • (2007) J. Biol. Chem , vol.282 , pp. 21169-21175
    • Li, B.1    van der Donk, W.A.2
  • 24
    • 70350031573 scopus 로고    scopus 로고
    • Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin
    • Lubelski, J., Khusainov, R., and Kuipers, O. P. (2009). Directionality and coordination of dehydration and ring formation during biosynthesis of the lantibiotic nisin. J. Biol. Chem. 284, 25962-25972. doi: 10.1074/jbc.M109.026690.
    • (2009) J. Biol. Chem , vol.284 , pp. 25962-25972
    • Lubelski, J.1    Khusainov, R.2    Kuipers, O.P.3
  • 25
    • 38949166717 scopus 로고    scopus 로고
    • Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin
    • Lubelski, J., Rink, R., Khusainov, R., Moll, G. N., and Kuipers, O. P. (2008). Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin. Cell. Mol. Life. Sci. 65, 455-476. doi: 10.1007/s00018-007-7171-2.
    • (2008) Cell. Mol. Life. Sci , vol.65 , pp. 455-476
    • Lubelski, J.1    Rink, R.2    Khusainov, R.3    Moll, G.N.4    Kuipers, O.P.5
  • 26
    • 77950113113 scopus 로고    scopus 로고
    • Production of a class II two-component lantibiotic of streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence
    • Majchrzykiewicz, J. A., Lubelski, J., Moll, G. N., Kuipers, A., Bijlsma, J. J. E., Kuipers, O. P., et al. (2010). Production of a class II two-component lantibiotic of streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence. Antimicrob. Agents. Chemother. 54, 1498-1505. doi: 10.1128/AAC.00883-09.
    • (2010) Antimicrob. Agents. Chemother , vol.54 , pp. 1498-1505
    • Majchrzykiewicz, J.A.1    Lubelski, J.2    Moll, G.N.3    Kuipers, A.4    Bijlsma, J.J.E.5    Kuipers, O.P.6
  • 27
    • 80052238993 scopus 로고    scopus 로고
    • Substrate recognition and specificity of the NisB protein, the lantibiotic dehydratase involved in nisin biosynthesis
    • Mavaro, A., Abts, A., Bakkes, P. J., Moll, G. N., Driessen, A. J. M., Smits, S. H. J., et al. (2011). Substrate recognition and specificity of the NisB protein, the lantibiotic dehydratase involved in nisin biosynthesis. J. Biol. Chem. 286, 30552-30560. doi: 10.1074/jbc.M111.263210.
    • (2011) J. Biol. Chem , vol.286 , pp. 30552-30560
    • Mavaro, A.1    Abts, A.2    Bakkes, P.J.3    Moll, G.N.4    Driessen, A.J.M.5    Smits, S.H.J.6
  • 28
    • 77953528770 scopus 로고    scopus 로고
    • In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C-C bond as a post-translational modification
    • Mueller, W. M., Schmiederer, T., Ensle, P., and Suessmuth, R. D. (2010). In vitro biosynthesis of the prepeptide of type-III lantibiotic labyrinthopeptin A2 including formation of a C-C bond as a post-translational modification. Angew. Chem. Int. Ed. Engl. 49, 2436-2440. doi: 10.1002/anie.200905909.
    • (2010) Angew. Chem. Int. Ed. Engl , vol.49 , pp. 2436-2440
    • Mueller, W.M.1    Schmiederer, T.2    Ensle, P.3    Suessmuth, R.D.4
  • 29
    • 84925460979 scopus 로고    scopus 로고
    • Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB
    • Ortega, M. A., Hao, Y., Zhang, Q., Walker, M. C., van der Donk, W. A., and Nair, S. K. (2015). Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB. Nature 517, 509-512. doi: 10.1038/nature13888.
    • (2015) Nature , vol.517 , pp. 509-512
    • Ortega, M.A.1    Hao, Y.2    Zhang, Q.3    Walker, M.C.4    van der Donk, W.A.5    Nair, S.K.6
  • 30
  • 32
    • 36048994654 scopus 로고    scopus 로고
    • NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides
    • Rink, R., Kluskens, L. D., Kuipers, A., Driessen, A. J. M., Kuipers, O. P., and Moll, G. N. (2007). NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides. Biochemistry 46, 13179-13189. doi: 10.1021/bi700106z.
    • (2007) Biochemistry , vol.46 , pp. 13179-13189
    • Rink, R.1    Kluskens, L.D.2    Kuipers, A.3    Driessen, A.J.M.4    Kuipers, O.P.5    Moll, G.N.6
  • 33
    • 20544436705 scopus 로고    scopus 로고
    • Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes
    • Rink, R., Kuipers, A., de Boef, E., Leenhouts, K. J., Driessen, A. J., Moll, G. N., et al. (2005). Lantibiotic structures as guidelines for the design of peptides that can be modified by lantibiotic enzymes. Biochemistry 44, 8873-8882. doi: 10.1021/bi050081h.
    • (2005) Biochemistry , vol.44 , pp. 8873-8882
    • Rink, R.1    Kuipers, A.2    de Boef, E.3    Leenhouts, K.J.4    Driessen, A.J.5    Moll, G.N.6
  • 35
    • 2442525077 scopus 로고    scopus 로고
    • HMM Logos for visualization of protein families
    • Schuster-Bockler, B., Schultz, J., and Rahmann, S. (2004). HMM Logos for visualization of protein families. BMC Bioinformatics 5:7. doi: 10.1186/1471-2105-5-7.
    • (2004) BMC Bioinformatics , vol.5 , pp. 7
    • Schuster-Bockler, B.1    Schultz, J.2    Rahmann, S.3
  • 36
    • 50949089673 scopus 로고    scopus 로고
    • Distinct contributions of the nisin biosynthesis enzymes NisB and NisC and transporter NisT to prenisin production by Lactococcus lactis
    • van den Berg van Saparoea, H. B., Bakkes, P. J., Moll, G. N., and Driessen, A. J. M. (2008). Distinct contributions of the nisin biosynthesis enzymes NisB and NisC and transporter NisT to prenisin production by Lactococcus lactis. Appl. Environ. Microbiol. 74, 5541-5548. doi: 10.1128/AEM.00342-08.
    • (2008) Appl. Environ. Microbiol , vol.74 , pp. 5541-5548
    • van den Berg van Saparoea, H.B.1    Bakkes, P.J.2    Moll, G.N.3    Driessen, A.J.M.4
  • 37
    • 0028017962 scopus 로고
    • Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by lactococcus lactis
    • van der Meer, J., Rollema, H., Siezen, R., Beerthuyzen, M., Kuipers, O., and De Vos, W. (1994). Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by lactococcus lactis. J. Biol. Chem. 269, 3555-3562.
    • (1994) J. Biol. Chem , vol.269 , pp. 3555-3562
    • van der Meer, J.1    Rollema, H.2    Siezen, R.3    Beerthuyzen, M.4    Kuipers, O.5    De Vos, W.6
  • 38
    • 79956161039 scopus 로고    scopus 로고
    • Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans
    • van Heel, A. J., Montalban-Lopez, M., and Kuipers, O. P. (2011). Evaluating the feasibility of lantibiotics as an alternative therapy against bacterial infections in humans. Expert. Opin. Drug. Metab. Toxicol. 7, 675-680. doi: 10.1517/17425255.2011.573478.
    • (2011) Expert. Opin. Drug. Metab. Toxicol , vol.7 , pp. 675-680
    • van Heel, A.J.1    Montalban-Lopez, M.2    Kuipers, O.P.3
  • 39
    • 84879828226 scopus 로고    scopus 로고
    • Designing and producing modified, new-to-nature peptides with antimicrobial activity by use of a combination of various lantibiotic modification enzymes
    • van Heel, A. J., Mu, D., Montalban-Lopez, M., Hendriks, D., and Kuipers, O. P. (2013). Designing and producing modified, new-to-nature peptides with antimicrobial activity by use of a combination of various lantibiotic modification enzymes. ACS Synth. Biol. 2, 397-404. doi: 10.1021/sb3001084.
    • (2013) ACS Synth. Biol , vol.2 , pp. 397-404
    • van Heel, A.J.1    Mu, D.2    Montalban-Lopez, M.3    Hendriks, D.4    Kuipers, O.P.5
  • 40
    • 0942268866 scopus 로고    scopus 로고
    • Lacticin 481, in vitro reconstitution of lantibiotic synthetase activity
    • Xie, L., Miller, L. M., Chatterjee, C., Averin, O., Kelleher, N. L., and van der Donk, W. A. (2004). Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science 303, 679-681. doi: 10.1126/science.1092600.
    • (2004) Science , vol.303 , pp. 679-681
    • Xie, L.1    Miller, L.M.2    Chatterjee, C.3    Averin, O.4    Kelleher, N.L.5    van der Donk, W.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.