An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II

Science

Volumn 313, Issue 5793, 2006, Pages 1636-1637

  Hasper, Hester E ^a   Kramer, Naomi E ^a,b   Smith, James L ^c   Hillman, J D ^d   Zachariah, Cherian ^e   Kuipers, Oscar P ^b   De Kruijff, Ben ^a   Breukink, Eefjan ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c MISSISSIPPI STATE UNIVERSITY   (United States)

^d Oragenics Inc   (United States)

^e Banyon Biomarkers Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMICAL ENGINEERING; BIOLOGICAL ORGANS; CELLS; LIPIDS; POLYPEPTIDES;

BINDING SPECIFICITY; BLOCK CELL WALL SYNTHESIS; GRAM-POSITIVE BACTERIA; LANTIBIOTICS;

BACTERIA;

AMINO ACID DERIVATIVE; LANTIBIOTIC;

AMINO ACID; ANTIMICROBIAL ACTIVITY; BACTERIUM; CELL ORGANELLE; LIPID; PEPTIDE;

ARTICLE; BACTERIAL CELL WALL; BACTERICIDAL ACTIVITY; BINDING AFFINITY; CELL DIVISION; CYTOLYSIS; GRAM POSITIVE BACTERIUM; LIPID BILAYER; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN TARGETING;

ANTI-BACTERIAL AGENTS; BACILLUS; BACILLUS MEGATERIUM; BACILLUS SUBTILIS; BACTERIOCINS; CELL DIVISION; CELL WALL; LIPID BILAYERS; MEMBRANES, ARTIFICIAL; NISIN; PEPTIDES; PEPTIDOGLYCAN; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID; VANCOMYCIN;

BACTERIA (MICROORGANISMS); POSIBACTERIA;

EID: 33748766086     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1129818     Document Type: Article

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21. H.E.H. and N.E.K. were supported by the Nederlandse Organisatie voor Wetenschappelijk and the Onderzoek Stichting voor de Technische Wetenschappen (grant 349-5257). We thank P. van den Bogaard and D. Sakharov for their help with the confocal fluorescence experiments.