NisC, the cyclase of the lantibiotic nisin, can catalyze cyclization of designed nonlantibiotic peptides

Biochemistry

Volumn 46, Issue 45, 2007, Pages 13179-13189

  Rink, Rick ^a   Kluskens, Leon D ^a   Kuipers, Anneke ^a   Driessen, Arnold J M ^b   Kuipers, Oscar P ^b   Moll, Gert N ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYZE CYCLIZATION; DEHYDRORESIDUES; NISIN CYCLASE (NISC); NONLANTIBIOTIC PEPTIDES;

ANTIBIOTICS; BACTERIA; CATALYST ACTIVITY; DEHYDRATION; ENZYME ACTIVITY; SYNTHESIS (CHEMICAL);

PEPTIDES;

ALANYLSERYLVALYLGLUTAMYLCYSTEINYLLYSINE; ALANYLSERYLVALYLTRYPTOPHYLCYSTEINYLGLUTAMIC ACID; ALANYLTHREONYLVALYLALANYLTHREONYLCYSTEINYLLYSYLGLYCYLCYSTEINYLLYSINE; ALANYLTHREONYLVALYLGLUTAMYLCYSTEINYLLYSINE; ALANYLTHREONYLVALYLTRYPTOPHYLCYSTEINYLGLUTAMIC ACID; ANTIBIOTIC AGENT; BUTYRIC ACID DERIVATIVE; CYSTEINE; CYSTEINYLARGINYLTYROSYLTHREONYLASPARTYLPROLYLLYSYLPROLYLHISTIDYL ISOLEUCYLARGINYLLEUCYLARGINYLISOLEUCYLLYSINE; DEHYDROALANINE; ENZYME; HEXAPEPTIDE; ISOLEUCYLTHREONYLARGINYLISOLEUCYLCYSTEINYLLYSINE; ISOLEUCYLTHREONYLPROLYLGLYCYLCYSTEINYLLYSINE; ISOLEUCYLTHREONYLPROLYLGLYCYLCYSTEINYLLYSYLALANYLTHREONYLVALYL GLUTAMYLCYSTEINYLLYSYLISOLEUCYLTHREONYLPROLYLGLYCYLCYSTEINYLLYSYL ALANYLTHREONYLVALYLGLUTAMYLCYSTEINYLLYSINE; ISOLEUCYLTHREONYLSERYLISOLEUCYLSERYLLEUCYLCYSTEINYLTHREONYLPROLYL GLYCYLCYSTEINYLLYSYLTHREONYLGLYCYLALANYLLEUCYLMETHIONYLGLYCYLCYSTEINYL ASPARAGINYLMETHIONYLLYSYLTHREONYLALANYLTHREONYLCYSTEINYLHISTIDYLCYSTEINYL SERYLISOLEUCYLHISTIDYLVALYLSERYLLYSINE; LANTIBIOTIC; LYSYLTHREONYLALANYLTHREONYLCYSTEINYLHISTIDYLCYSTEINYLSERYLLYSINE; METHIONYLSERYLTHREONYLLYSYLASPARTIC ACID; METHIONYLSERYLTHREONYLLYSYLASPARTYLPHENYLALANYLASPARAGINYLLEUCYL ASPARTYLLEUCYLVALYLSERYLVALYLSERYLLYSYLLYSYLASPARTYLSERYLGLYCYL ALANYLSERYLPROLYLARGININE; NISIN; NISIN CYCLASE; NISIN DEHYDRATASE; SULFIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; COMPUTER MODEL; CYCLIZATION; ENZYME MECHANISM; IN VIVO STUDY; LACTOCOCCUS LACTIS; MOLECULAR INTERACTION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN STABILITY;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; ESCHERICHIA COLI PROTEINS; INTRAMOLECULAR LYASES; LACTOCOCCUS LACTIS; MEMBRANE PROTEINS; NISIN; OLIGOPEPTIDES; PEPTIDES, CYCLIC;

LACTOCOCCUS LACTIS; POSIBACTERIA;

EID: 36048994654     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700106z     Document Type: Article

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