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Volumn 303, Issue 5658, 2004, Pages 679-681

Lacticin 481: In Vitro Reconstitution of Lantibiotic Synthetase Activity

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; CATALYSIS; CHEMICAL BONDS; DEHYDRATION;

EID: 0942268866     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092600     Document Type: Article
Times cited : (213)

References (29)
  • 1
    • 0033579207 scopus 로고    scopus 로고
    • E. Breukink et al., Science 286, 2361 (1999).
    • (1999) Science , vol.286 , pp. 2361
    • Breukink, E.1
  • 10
    • 0942298426 scopus 로고    scopus 로고
    • note
    • Lack of lantibiotic production may be due to disruption of the posttranslational modification process, degradation of the non-native peptide product or intermediates, breakdown of self-immunity resulting in shutdown of production, or perturbation of signaling pathways in cases in which the bacteriocin acts as a quorum sensor controlling its own expression. See references (25-28).
  • 11
    • 0023912839 scopus 로고
    • N. Schnell et al., Nature 333, 276 (1988).
    • (1988) Nature , vol.333 , pp. 276
    • Schnell, N.1
  • 14
  • 16
    • 0942265849 scopus 로고    scopus 로고
    • note
    • Materials and methods are available as supporting material on Science Online.
  • 17
    • 0942287505 scopus 로고    scopus 로고
    • note
    • 6-tag linker is GSSHHHHHHSSGLVPRGSH. The DNA sequences of all constructs were verified and the masses of the expressed gene products were determined by mass spectrometry.
  • 24
    • 0942298425 scopus 로고    scopus 로고
    • thesis, University of Illinois, Urbana-Champaign
    • L. Xie, thesis, University of Illinois, Urbana-Champaign (2003).
    • (2003)
    • Xie, L.1
  • 29
    • 0942298423 scopus 로고    scopus 로고
    • note
    • This work was supported by grants from the National Institutes of Health to W.A.V. (GM58822) and N.L.K. (GM 067725), the Beckman Foundation, and the Burroughs Wellcome Fund (APP 1920 to W.A.V.).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.