Use of the cell wail precursor lipid II by a pore-forming peptide antibiotic

Science

Volumn 286, Issue 5448, 1999, Pages 2361-2364

  Breukink, E ^a   Wiedemann, I ^a   Van Kraaij, C ^a   Kuipers, O P ^a   Sahl, H G ^a   De Kruijff, B ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

MAGAININ DERIVATIVE; MEMBRANE LIPID; NISIN; POLYPEPTIDE ANTIBIOTIC AGENT; VANCOMYCIN; ANTIINFECTIVE AGENT; DRUG DERIVATIVE; ISOPRENOID PHOSPHATE SUGAR; NISIN Z; PEPTIDE; PEPTIDOGLYCAN; UNDECAPRENYL DIPHOSPHATE (N ACETYLGLUCOSAMINYL)(1 4) N ACETYLMURAMOYL PENTAPEPTIDE; UNDECAPRENYL DIPHOSPHATE-(N-ACETYLGLUCOSAMINYL)(1-4)-N-ACETYLMURAMOYL PENTAPEPTIDE;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BINDING AFFINITY; DRUG MECHANISM; MEMBRANE PERMEABILITY; MICROCOCCUS; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL WALL; DOSE RESPONSE; DRUG EFFECT; METABOLISM; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL WALL; DOSE-RESPONSE RELATIONSHIP, DRUG; MEMBRANE LIPIDS; MICROBIAL SENSITIVITY TESTS; MICROCOCCUS; MOLECULAR SEQUENCE DATA; NISIN; PEPTIDES; PEPTIDOGLYCAN; POLYISOPRENYL PHOSPHATE OLIGOSACCHARIDES; VANCOMYCIN;

EID: 0033579207     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.286.5448.2361     Document Type: Article

References (24)

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24. Supported by the Netherlands Foundations of Chemical Sciences and Applied Sciences with financial aid from the Netherlands Foundation for Scientific Research (E.B.) and by the Deutsche Forschungsgemeinschaft (DFG) (project Sa 292/8-1) and the research program of the Medical Faculty, University of Bonn (BONFOR) (I.W.).