메뉴 건너뛰기




Volumn 26, Issue 2, 2015, Pages 229-239

IFN-β and multiple sclerosis: Cross-talking of immune cells and integration of immunoregulatory networks

Author keywords

Bystander immune regulation; IFN therapy; Immune cell subsets; Multiple sclerosis

Indexed keywords

B CELL ACTIVATING FACTOR; BETA INTERFERON; BETA1A INTERFERON; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR5; FINGOLIMOD; FUMARIC ACID DIMETHYL ESTER; GLATIRAMER; INTERFERON BETA SERINE; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 27; MITOXANTRONE; MYELIN BASIC PROTEIN; NATALIZUMAB; OLIGOCLONAL BAND; PEGINTERFERON BETA1A; PROTEOLIPID PROTEIN; TERIFLUNOMIDE; TOLL LIKE RECEPTOR 7; ANTIVIRUS AGENT;

EID: 84926513526     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2014.11.005     Document Type: Short Survey
Times cited : (28)

References (113)
  • 1
    • 84884550190 scopus 로고    scopus 로고
    • Current and future therapies for multiple sclerosis
    • Minagar A. Current and future therapies for multiple sclerosis. Scientifica (Cairo) 2013, 2013:249101.
    • (2013) Scientifica (Cairo) , vol.2013 , pp. 249101
    • Minagar, A.1
  • 2
    • 79958108785 scopus 로고    scopus 로고
    • The mechanism of action of interferon-beta in relapsing multiple sclerosis
    • Kieseier B.C. The mechanism of action of interferon-beta in relapsing multiple sclerosis. CNS Drugs 2011, 25:491-502.
    • (2011) CNS Drugs , vol.25 , pp. 491-502
    • Kieseier, B.C.1
  • 4
    • 2542420686 scopus 로고    scopus 로고
    • Characterization of the type I interferon locus and identification of novel genes
    • Hardy M.P., Owczarek C.M., Jermiin L.S., Ejdeback M., Hertzog P.J. Characterization of the type I interferon locus and identification of novel genes. Genomics 2004, 84:331-345.
    • (2004) Genomics , vol.84 , pp. 331-345
    • Hardy, M.P.1    Owczarek, C.M.2    Jermiin, L.S.3    Ejdeback, M.4    Hertzog, P.J.5
  • 5
    • 38449122497 scopus 로고    scopus 로고
    • TLR-mediated activation of type I IFN during antiviral immune responses: fighting the battle to win the war
    • Severa M., Fitzgerald K.A. TLR-mediated activation of type I IFN during antiviral immune responses: fighting the battle to win the war. Curr Top Microbiol Immunol 2007, 316:167-192.
    • (2007) Curr Top Microbiol Immunol , vol.316 , pp. 167-192
    • Severa, M.1    Fitzgerald, K.A.2
  • 7
    • 33748475531 scopus 로고    scopus 로고
    • Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors
    • Honda K., Takaoka A., Taniguchi T. Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity 2006, 25:349-360.
    • (2006) Immunity , vol.25 , pp. 349-360
    • Honda, K.1    Takaoka, A.2    Taniguchi, T.3
  • 9
    • 33750433585 scopus 로고    scopus 로고
    • Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses
    • Hiscott J., Nguyen T.L., Arguello M., Nakhaei P., Paz S. Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses. Oncogene 2006, 25:6844-6867.
    • (2006) Oncogene , vol.25 , pp. 6844-6867
    • Hiscott, J.1    Nguyen, T.L.2    Arguello, M.3    Nakhaei, P.4    Paz, S.5
  • 12
    • 0034977353 scopus 로고    scopus 로고
    • Functional classification of interferon-stimulated genes identified using microarrays
    • de Veer M.J., Holko M., Frevel M., Walker E., Der S., Paranjape J.M., et al. Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol 2001, 69:912-920.
    • (2001) J Leukoc Biol , vol.69 , pp. 912-920
    • de Veer, M.J.1    Holko, M.2    Frevel, M.3    Walker, E.4    Der, S.5    Paranjape, J.M.6
  • 13
    • 84859717206 scopus 로고    scopus 로고
    • Innate immunity in the central nervous system
    • Ransohoff R.M., Brown M.A. Innate immunity in the central nervous system. J Clin Invest 2012, 122:1164-1171.
    • (2012) J Clin Invest , vol.122 , pp. 1164-1171
    • Ransohoff, R.M.1    Brown, M.A.2
  • 14
  • 15
    • 0031816173 scopus 로고    scopus 로고
    • In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis
    • Rudick R.A., Ransohoff R.M., Lee J.C., Peppler R., Yu M., Mathisen P.M., et al. In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis. Neurology 1998, 50:1294-1300.
    • (1998) Neurology , vol.50 , pp. 1294-1300
    • Rudick, R.A.1    Ransohoff, R.M.2    Lee, J.C.3    Peppler, R.4    Yu, M.5    Mathisen, P.M.6
  • 17
    • 22144466188 scopus 로고    scopus 로고
    • Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment
    • Avolio C., Filippi M., Tortorella C., Rocca M.A., Ruggieri M., Agosta F., et al. Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment. Mult Scler 2005, 11:441-446.
    • (2005) Mult Scler , vol.11 , pp. 441-446
    • Avolio, C.1    Filippi, M.2    Tortorella, C.3    Rocca, M.A.4    Ruggieri, M.5    Agosta, F.6
  • 18
    • 0034908543 scopus 로고    scopus 로고
    • In vitro modulation of adhesion molecules, adhesion phenomena, and fluid phase endocytosis on human umbilical vein endothelial cells and brain-derived microvascular endothelium by IFN-beta 1a
    • Defazio G., Gelati M., Corsini E., Nico B., Dufour A., Massa G., et al. In vitro modulation of adhesion molecules, adhesion phenomena, and fluid phase endocytosis on human umbilical vein endothelial cells and brain-derived microvascular endothelium by IFN-beta 1a. J Interferon Cytokine Res 2001, 21:267-272.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 267-272
    • Defazio, G.1    Gelati, M.2    Corsini, E.3    Nico, B.4    Dufour, A.5    Massa, G.6
  • 19
    • 0030498666 scopus 로고    scopus 로고
    • Interferon beta-1b decreases the migration of T lymphocytes in vitro: effects on matrix metalloproteinase-9
    • Stuve O., Dooley N.P., Uhm J.H., Antel J.P., Francis G.S., Williams G., et al. Interferon beta-1b decreases the migration of T lymphocytes in vitro: effects on matrix metalloproteinase-9. Ann Neurol 1996, 40:853-863.
    • (1996) Ann Neurol , vol.40 , pp. 853-863
    • Stuve, O.1    Dooley, N.P.2    Uhm, J.H.3    Antel, J.P.4    Francis, G.S.5    Williams, G.6
  • 20
    • 35448988886 scopus 로고    scopus 로고
    • Interferon-beta is neuroprotective against the toxicity induced by activated microglia
    • Jin S., Kawanokuchi J., Mizuno T., Wang J., Sonobe Y., Takeuchi H., et al. Interferon-beta is neuroprotective against the toxicity induced by activated microglia. Brain Res 2007, 1179:140-146.
    • (2007) Brain Res , vol.1179 , pp. 140-146
    • Jin, S.1    Kawanokuchi, J.2    Mizuno, T.3    Wang, J.4    Sonobe, Y.5    Takeuchi, H.6
  • 21
    • 16844385713 scopus 로고    scopus 로고
    • Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis
    • Biernacki K., Antel J.P., Blain M., Narayanan S., Arnold D.L., Prat A. Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis. Arch Neurol 2005, 62:563-568.
    • (2005) Arch Neurol , vol.62 , pp. 563-568
    • Biernacki, K.1    Antel, J.P.2    Blain, M.3    Narayanan, S.4    Arnold, D.L.5    Prat, A.6
  • 22
    • 34247590137 scopus 로고    scopus 로고
    • Environmental risk factors for multiple sclerosis. Part I: The role of infection
    • Ascherio A., Munger K.L. Environmental risk factors for multiple sclerosis. Part I: The role of infection. Ann Neurol 2007, 61:288-299.
    • (2007) Ann Neurol , vol.61 , pp. 288-299
    • Ascherio, A.1    Munger, K.L.2
  • 23
    • 66549109540 scopus 로고    scopus 로고
    • EBV in MS: guilty by association
    • Lunemann J.D., Munz C. EBV in MS: guilty by association. Trends Immunol 2009, 30:243-248.
    • (2009) Trends Immunol , vol.30 , pp. 243-248
    • Lunemann, J.D.1    Munz, C.2
  • 25
    • 77954725231 scopus 로고    scopus 로고
    • Epstein-Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation
    • Serafini B., Severa M., Columba-Cabezas S., Rosicarelli B., Veroni C., Chiappetta G., et al. Epstein-Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation. J Neuropathol Exp Neurol 2010, 69:677-693.
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 677-693
    • Serafini, B.1    Severa, M.2    Columba-Cabezas, S.3    Rosicarelli, B.4    Veroni, C.5    Chiappetta, G.6
  • 26
    • 0028926223 scopus 로고
    • Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein
    • Wucherpfennig K.W., Strominger J.L. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 1995, 80:695-705.
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Strominger, J.L.2
  • 28
    • 0242270822 scopus 로고    scopus 로고
    • Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases
    • Pender M.P. Infection of autoreactive B lymphocytes with EBV, causing chronic autoimmune diseases. Trends Immunol 2003, 24:584-588.
    • (2003) Trends Immunol , vol.24 , pp. 584-588
    • Pender, M.P.1
  • 29
    • 0034091461 scopus 로고    scopus 로고
    • Particle-associated retroviral RNA and tandem RGH/HERV-W copies on human chromosome 7q: possible components of a 'chain-reaction' triggered by infectious agents in multiple sclerosis?
    • Perron H., Perin J.P., Rieger F., Alliel P.M. Particle-associated retroviral RNA and tandem RGH/HERV-W copies on human chromosome 7q: possible components of a 'chain-reaction' triggered by infectious agents in multiple sclerosis?. J Neurovirol 2000, 6(Suppl. 2):S67-S75.
    • (2000) J Neurovirol , vol.6 , pp. S67-S75
    • Perron, H.1    Perin, J.P.2    Rieger, F.3    Alliel, P.M.4
  • 30
    • 33746930636 scopus 로고    scopus 로고
    • Cutting edge: Epstein-Barr virus transactivates the HERV-K18 superantigen by docking to the human complement receptor 2 (CD21) on primary B cells
    • Hsiao F.C., Lin M., Tai A., Chen G., Huber B.T. Cutting edge: Epstein-Barr virus transactivates the HERV-K18 superantigen by docking to the human complement receptor 2 (CD21) on primary B cells. J Immunol 2006, 177:2056-2060.
    • (2006) J Immunol , vol.177 , pp. 2056-2060
    • Hsiao, F.C.1    Lin, M.2    Tai, A.3    Chen, G.4    Huber, B.T.5
  • 31
    • 84858233979 scopus 로고    scopus 로고
    • Autoimmune disease: a role for new anti-viral therapies
    • Dreyfus D.H. Autoimmune disease: a role for new anti-viral therapies. Autoimmun Rev 2011, 11:88-97.
    • (2011) Autoimmun Rev , vol.11 , pp. 88-97
    • Dreyfus, D.H.1
  • 32
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M., Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005, 23:683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 33
    • 0025155486 scopus 로고
    • Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors
    • Pette M., Fujita K., Wilkinson D., Altmann D.M., Trowsdale J., Giegerich G., et al. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc Natl Acad Sci U S A 1990, 87:7968-7972.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 7968-7972
    • Pette, M.1    Fujita, K.2    Wilkinson, D.3    Altmann, D.M.4    Trowsdale, J.5    Giegerich, G.6
  • 34
    • 0034610973 scopus 로고    scopus 로고
    • High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire
    • Anderson A.C., Nicholson L.B., Legge K.L., Turchin V., Zaghouani H., Kuchroo V.K. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J Exp Med 2000, 191:761-770.
    • (2000) J Exp Med , vol.191 , pp. 761-770
    • Anderson, A.C.1    Nicholson, L.B.2    Legge, K.L.3    Turchin, V.4    Zaghouani, H.5    Kuchroo, V.K.6
  • 35
    • 35448961570 scopus 로고    scopus 로고
    • Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients
    • Imam S.A., Guyton M.K., Haque A., Vandenbark A., Tyor W.R., Ray S.K., et al. Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients. J Neuroimmunol 2007, 190:139-145.
    • (2007) J Neuroimmunol , vol.190 , pp. 139-145
    • Imam, S.A.1    Guyton, M.K.2    Haque, A.3    Vandenbark, A.4    Tyor, W.R.5    Ray, S.K.6
  • 36
    • 0034232036 scopus 로고    scopus 로고
    • Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge
    • O'Shea J.J., Visconti R. Type 1 IFNs and regulation of TH1 responses: enigmas both resolved and emerge. Nat Immunol 2000, 1:17-19.
    • (2000) Nat Immunol , vol.1 , pp. 17-19
    • O'Shea, J.J.1    Visconti, R.2
  • 37
    • 0034618094 scopus 로고    scopus 로고
    • Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    • Babbe H., Roers A., Waisman A., Lassmann H., Goebels N., Hohlfeld R., et al. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med 2000, 192:393-404.
    • (2000) J Exp Med , vol.192 , pp. 393-404
    • Babbe, H.1    Roers, A.2    Waisman, A.3    Lassmann, H.4    Goebels, N.5    Hohlfeld, R.6
  • 38
    • 84917740296 scopus 로고    scopus 로고
    • High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8(+) T cells
    • Lossius A., Johansen J.N., Vartdal F., Robins H., Jurate Saltyte B., Holmoy T., et al. High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8(+) T cells. Er J Immunol 2014, 44:3439-3452.
    • (2014) Er J Immunol , vol.44 , pp. 3439-3452
    • Lossius, A.1    Johansen, J.N.2    Vartdal, F.3    Robins, H.4    Jurate Saltyte, B.5    Holmoy, T.6
  • 40
    • 84876832178 scopus 로고    scopus 로고
    • Increased CD8+ T cell response to Epstein-Barr virus lytic antigens in the active phase of multiple sclerosis
    • Angelini D.F., Serafini B., Piras E., Severa M., Coccia E.M., Rosicarelli B., et al. Increased CD8+ T cell response to Epstein-Barr virus lytic antigens in the active phase of multiple sclerosis. PLoS Pathog 2013, 9:e1003220.
    • (2013) PLoS Pathog , vol.9 , pp. e1003220
    • Angelini, D.F.1    Serafini, B.2    Piras, E.3    Severa, M.4    Coccia, E.M.5    Rosicarelli, B.6
  • 41
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003, 421:744-748.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6
  • 43
    • 51249090471 scopus 로고    scopus 로고
    • T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
    • Hedegaard C.J., Krakauer M., Bendtzen K., Lund H., Sellebjerg F., Nielsen C.H. T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. Immunology 2008, 125:161-169.
    • (2008) Immunology , vol.125 , pp. 161-169
    • Hedegaard, C.J.1    Krakauer, M.2    Bendtzen, K.3    Lund, H.4    Sellebjerg, F.5    Nielsen, C.H.6
  • 45
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C., Hermans G., Pedotti R., Brendolan A., Schadt E., Garren H., et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 2002, 8:500-508.
    • (2002) Nat Med , vol.8 , pp. 500-508
    • Lock, C.1    Hermans, G.2    Pedotti, R.3    Brendolan, A.4    Schadt, E.5    Garren, H.6
  • 46
    • 0344389016 scopus 로고    scopus 로고
    • Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
    • Matusevicius D., Kivisakk P., He B., Kostulas N., Ozenci V., Fredrikson S., et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 1999, 5:101-104.
    • (1999) Mult Scler , vol.5 , pp. 101-104
    • Matusevicius, D.1    Kivisakk, P.2    He, B.3    Kostulas, N.4    Ozenci, V.5    Fredrikson, S.6
  • 47
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff R.M., Kivisakk P., Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol 2003, 3:569-581.
    • (2003) Nat Rev Immunol , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 48
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos J.S., Friese M.A., Craner M.J., Palace J., Newcombe J., Esiri M.M., et al. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 2008, 172:146-155.
    • (2008) Am J Pathol , vol.172 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6
  • 49
    • 34948909646 scopus 로고    scopus 로고
    • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    • Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R., Bernard M., et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 2007, 13:1173-1175.
    • (2007) Nat Med , vol.13 , pp. 1173-1175
    • Kebir, H.1    Kreymborg, K.2    Ifergan, I.3    Dodelet-Devillers, A.4    Cayrol, R.5    Bernard, M.6
  • 50
    • 84872542057 scopus 로고    scopus 로고
    • Serum levels of IL-17A in patients with relapsing-remitting multiple sclerosis treated with interferon-beta
    • Balasa R., Bajko Z., Hutanu A. Serum levels of IL-17A in patients with relapsing-remitting multiple sclerosis treated with interferon-beta. Mult Scler 2013, 19:885-890.
    • (2013) Mult Scler , vol.19 , pp. 885-890
    • Balasa, R.1    Bajko, Z.2    Hutanu, A.3
  • 51
    • 84872914335 scopus 로고    scopus 로고
    • Longitudinal interferon-beta effects in multiple sclerosis: differential regulation of IL-10 and IL-17A, while no sustained effects on IFN-gamma, IL-4 or IL-13
    • Kvarnstrom M., Ydrefors J., Ekerfelt C., Vrethem M., Ernerudh J. Longitudinal interferon-beta effects in multiple sclerosis: differential regulation of IL-10 and IL-17A, while no sustained effects on IFN-gamma, IL-4 or IL-13. J Neurol Sci 2013, 325:79-85.
    • (2013) J Neurol Sci , vol.325 , pp. 79-85
    • Kvarnstrom, M.1    Ydrefors, J.2    Ekerfelt, C.3    Vrethem, M.4    Ernerudh, J.5
  • 52
    • 46849101948 scopus 로고    scopus 로고
    • Increased IL-10 mRNA and IL-23 mRNA expression in multiple sclerosis: interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression
    • Krakauer M., Sorensen P., Khademi M., Olsson T., Sellebjerg F. Increased IL-10 mRNA and IL-23 mRNA expression in multiple sclerosis: interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression. Mult Scler 2008, 14:622-630.
    • (2008) Mult Scler , vol.14 , pp. 622-630
    • Krakauer, M.1    Sorensen, P.2    Khademi, M.3    Olsson, T.4    Sellebjerg, F.5
  • 53
    • 65449177629 scopus 로고    scopus 로고
    • IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation
    • Zhang X., Jin J., Tang Y., Speer D., Sujkowska D., Markovic-Plese S. IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation. J Immunol 2009, 182:3928-3936.
    • (2009) J Immunol , vol.182 , pp. 3928-3936
    • Zhang, X.1    Jin, J.2    Tang, Y.3    Speer, D.4    Sujkowska, D.5    Markovic-Plese, S.6
  • 55
    • 41849116363 scopus 로고    scopus 로고
    • Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial
    • Bar-Or A., Calabresi P.A., Arnold D., Markowitz C., Shafer S., Kasper L.H., et al. Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial. Ann Neurol 2008, 63:395-400.
    • (2008) Ann Neurol , vol.63 , pp. 395-400
    • Bar-Or, A.1    Calabresi, P.A.2    Arnold, D.3    Markowitz, C.4    Shafer, S.5    Kasper, L.H.6
  • 56
    • 60549116884 scopus 로고    scopus 로고
    • Long-term B-lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis
    • Stuve O., Leussink V.I., Frohlich R., Hemmer B., Hartung H.P., Menge T., et al. Long-term B-lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis. Arch Neurol 2009, 66:259-261.
    • (2009) Arch Neurol , vol.66 , pp. 259-261
    • Stuve, O.1    Leussink, V.I.2    Frohlich, R.3    Hemmer, B.4    Hartung, H.P.5    Menge, T.6
  • 57
    • 0026013693 scopus 로고
    • Blood-brain barrier damage in acute multiple sclerosis plaques. An immunocytological study
    • Gay D., Esiri M. Blood-brain barrier damage in acute multiple sclerosis plaques. An immunocytological study. Brain 1991, 114(Pt 1B):557-572.
    • (1991) Brain , vol.114 , pp. 557-572
    • Gay, D.1    Esiri, M.2
  • 58
    • 67650082863 scopus 로고    scopus 로고
    • Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid
    • Owens G.P., Bennett J.L., Lassmann H., O'Connor K.C., Ritchie A.M., Shearer A., et al. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann Neurol 2009, 65:639-649.
    • (2009) Ann Neurol , vol.65 , pp. 639-649
    • Owens, G.P.1    Bennett, J.L.2    Lassmann, H.3    O'Connor, K.C.4    Ritchie, A.M.5    Shearer, A.6
  • 59
    • 79953306014 scopus 로고    scopus 로고
    • Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin
    • Obermeier B., Lovato L., Mentele R., Bruck W., Forne I., Imhof A., et al. Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. J Neuroimmunol 2011, 233:245-248.
    • (2011) J Neuroimmunol , vol.233 , pp. 245-248
    • Obermeier, B.1    Lovato, L.2    Mentele, R.3    Bruck, W.4    Forne, I.5    Imhof, A.6
  • 60
    • 30344446249 scopus 로고    scopus 로고
    • Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment
    • Krumbholz M., Theil D., Cepok S., Hemmer B., Kivisakk P., Ransohoff R.M., et al. Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 2006, 129:200-211.
    • (2006) Brain , vol.129 , pp. 200-211
    • Krumbholz, M.1    Theil, D.2    Cepok, S.3    Hemmer, B.4    Kivisakk, P.5    Ransohoff, R.M.6
  • 62
    • 78649857216 scopus 로고    scopus 로고
    • Detection of Epstein-Barr virus and B-cell follicles in the multiple sclerosis brain: what you find depends on how and where you look
    • Aloisi F., Serafini B., Magliozzi R., Howell O.W., Reynolds R. Detection of Epstein-Barr virus and B-cell follicles in the multiple sclerosis brain: what you find depends on how and where you look. Brain 2010, 133:e157.
    • (2010) Brain , vol.133 , pp. e157
    • Aloisi, F.1    Serafini, B.2    Magliozzi, R.3    Howell, O.W.4    Reynolds, R.5
  • 63
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi R., Howell O., Vora A., Serafini B., Nicholas R., Puopolo M., et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007, 130:1089-1104.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3    Serafini, B.4    Nicholas, R.5    Puopolo, M.6
  • 64
    • 4944266319 scopus 로고    scopus 로고
    • Epstein-Barr virus: 40 years on
    • Young L.S., Rickinson A.B. Epstein-Barr virus: 40 years on. Nat Rev Cancer 2004, 4:757-768.
    • (2004) Nat Rev Cancer , vol.4 , pp. 757-768
    • Young, L.S.1    Rickinson, A.B.2
  • 66
    • 43149122203 scopus 로고    scopus 로고
    • Rituximab in a patient with multiple sclerosis - effect on B cells, plasma cells and intrathecal IgG synthesis
    • Petereit H.F., Moeller-Hartmann W., Reske D., Rubbert A. Rituximab in a patient with multiple sclerosis - effect on B cells, plasma cells and intrathecal IgG synthesis. Acta Neurol Scand 2008, 117:399-403.
    • (2008) Acta Neurol Scand , vol.117 , pp. 399-403
    • Petereit, H.F.1    Moeller-Hartmann, W.2    Reske, D.3    Rubbert, A.4
  • 67
    • 1542514778 scopus 로고    scopus 로고
    • Distinct profiles of human B cell effector cytokines: a role in immune regulation
    • Duddy M.E., Alter A., Bar-Or A. Distinct profiles of human B cell effector cytokines: a role in immune regulation. J Immunol 2004, 172:3422-3427.
    • (2004) J Immunol , vol.172 , pp. 3422-3427
    • Duddy, M.E.1    Alter, A.2    Bar-Or, A.3
  • 68
    • 16544381960 scopus 로고    scopus 로고
    • Regulatory roles for cytokine-producing B cells in infection and autoimmune disease
    • Lund F.E., Garvy B.A., Randall T.D., Harris D.P. Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. Curr Dir Autoimmun 2005, 8:25-54.
    • (2005) Curr Dir Autoimmun , vol.8 , pp. 25-54
    • Lund, F.E.1    Garvy, B.A.2    Randall, T.D.3    Harris, D.P.4
  • 70
    • 0037450740 scopus 로고    scopus 로고
    • Prevention of arthritis by interleukin 10-producing B cells
    • Mauri C., Gray D., Mushtaq N., Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003, 197:489-501.
    • (2003) J Exp Med , vol.197 , pp. 489-501
    • Mauri, C.1    Gray, D.2    Mushtaq, N.3    Londei, M.4
  • 71
    • 77951757865 scopus 로고    scopus 로고
    • Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS
    • Bar-Or A., Fawaz L., Fan B., Darlington P.J., Rieger A., Ghorayeb C., et al. Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS. Ann Neurol 2010, 67:452-461.
    • (2010) Ann Neurol , vol.67 , pp. 452-461
    • Bar-Or, A.1    Fawaz, L.2    Fan, B.3    Darlington, P.J.4    Rieger, A.5    Ghorayeb, C.6
  • 72
    • 0028981875 scopus 로고
    • Interferon beta-1b reduces interferon gamma-induced antigen-presenting capacity of human glial and B cells
    • Jiang H., Milo R., Swoveland P., Johnson K.P., Panitch H., Dhib-Jalbut S. Interferon beta-1b reduces interferon gamma-induced antigen-presenting capacity of human glial and B cells. J Neuroimmunol 1995, 61:17-25.
    • (1995) J Neuroimmunol , vol.61 , pp. 17-25
    • Jiang, H.1    Milo, R.2    Swoveland, P.3    Johnson, K.P.4    Panitch, H.5    Dhib-Jalbut, S.6
  • 73
    • 79954997896 scopus 로고    scopus 로고
    • B cells as a therapeutic target for IFN-beta in relapsing-remitting multiple sclerosis
    • Ramgolam V.S., Sha Y., Marcus K.L., Choudhary N., Troiani L., Chopra M., et al. B cells as a therapeutic target for IFN-beta in relapsing-remitting multiple sclerosis. J Immunol 2011, 186:4518-4526.
    • (2011) J Immunol , vol.186 , pp. 4518-4526
    • Ramgolam, V.S.1    Sha, Y.2    Marcus, K.L.3    Choudhary, N.4    Troiani, L.5    Chopra, M.6
  • 74
    • 84880022571 scopus 로고    scopus 로고
    • IFN-beta therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients
    • Giacomini E., Severa M., Rizzo F., Mechelli R., Annibali V., Ristori G., et al. IFN-beta therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients. Eur J Immunol 2013, 43:1963-1972.
    • (2013) Eur J Immunol , vol.43 , pp. 1963-1972
    • Giacomini, E.1    Severa, M.2    Rizzo, F.3    Mechelli, R.4    Annibali, V.5    Ristori, G.6
  • 75
    • 44949253997 scopus 로고    scopus 로고
    • Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity
    • Krumbholz M., Faber H., Steinmeyer F., Hoffmann L.A., Kumpfel T., Pellkofer H., et al. Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 2008, 131:1455-1463.
    • (2008) Brain , vol.131 , pp. 1455-1463
    • Krumbholz, M.1    Faber, H.2    Steinmeyer, F.3    Hoffmann, L.A.4    Kumpfel, T.5    Pellkofer, H.6
  • 77
    • 0021055656 scopus 로고
    • Ia-expressing cells and T lymphocytes of different subsets in peripheral nerve tissue during experimental allergic neuritis in Lewis rats
    • Olsson T., Holmdahl R., Klareskog L., Forsum U. Ia-expressing cells and T lymphocytes of different subsets in peripheral nerve tissue during experimental allergic neuritis in Lewis rats. Scand J Immunol 1983, 18:339-343.
    • (1983) Scand J Immunol , vol.18 , pp. 339-343
    • Olsson, T.1    Holmdahl, R.2    Klareskog, L.3    Forsum, U.4
  • 78
    • 0010592446 scopus 로고
    • Induction of immune responses in vivo with small numbers of veiled (dendritic) cells
    • Knight S.C., Mertin J., Stackpoole A., Clark J. Induction of immune responses in vivo with small numbers of veiled (dendritic) cells. Proc Natl Acad Sci U S A 1983, 80:6032-6035.
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 6032-6035
    • Knight, S.C.1    Mertin, J.2    Stackpoole, A.3    Clark, J.4
  • 79
    • 43249104826 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in multiple sclerosis: intracerebral recruitment and impaired maturation in response to interferon-beta
    • Lande R., Gafa V., Serafini B., Giacomini E., Visconti A., Remoli M.E., et al. Plasmacytoid dendritic cells in multiple sclerosis: intracerebral recruitment and impaired maturation in response to interferon-beta. J Neuropathol Exp Neurol 2008, 67:388-401.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 388-401
    • Lande, R.1    Gafa, V.2    Serafini, B.3    Giacomini, E.4    Visconti, A.5    Remoli, M.E.6
  • 80
    • 33645022328 scopus 로고    scopus 로고
    • Dendritic cells in multiple sclerosis lesions: maturation stage, myelin uptake, and interaction with proliferating T cells
    • Serafini B., Rosicarelli B., Magliozzi R., Stigliano E., Capello E., Mancardi G.L., et al. Dendritic cells in multiple sclerosis lesions: maturation stage, myelin uptake, and interaction with proliferating T cells. J Neuropathol Exp Neurol 2006, 65:124-141.
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 124-141
    • Serafini, B.1    Rosicarelli, B.2    Magliozzi, R.3    Stigliano, E.4    Capello, E.5    Mancardi, G.L.6
  • 81
    • 84872495039 scopus 로고    scopus 로고
    • EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: implications for viral immune escape
    • Severa M., Giacomini E., Gafa V., Anastasiadou E., Rizzo F., Corazzari M., et al. EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: implications for viral immune escape. Eur J Immunol 2013, 43:147-158.
    • (2013) Eur J Immunol , vol.43 , pp. 147-158
    • Severa, M.1    Giacomini, E.2    Gafa, V.3    Anastasiadou, E.4    Rizzo, F.5    Corazzari, M.6
  • 83
    • 78650940727 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
    • Longhini A.L., von Glehn F., Brandao C.O., de Paula R.F., Pradella F., Moraes A.S., et al. Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse. J Neuroinflammation 2011, 8:2.
    • (2011) J Neuroinflammation , vol.8 , pp. 2
    • Longhini, A.L.1    von Glehn, F.2    Brandao, C.O.3    de Paula, R.F.4    Pradella, F.5    Moraes, A.S.6
  • 84
    • 33748510173 scopus 로고    scopus 로고
    • Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response
    • Karni A., Abraham M., Monsonego A., Cai G., Freeman G.J., Hafler D., et al. Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. J Immunol 2006, 177:4196-4202.
    • (2006) J Immunol , vol.177 , pp. 4196-4202
    • Karni, A.1    Abraham, M.2    Monsonego, A.3    Cai, G.4    Freeman, G.J.5    Hafler, D.6
  • 85
    • 33646816017 scopus 로고    scopus 로고
    • Altered maturation of circulating dendritic cells in primary progressive MS patients
    • Lopez C., Comabella M., Al-zayat H., Tintore M., Montalban X. Altered maturation of circulating dendritic cells in primary progressive MS patients. J Neuroimmunol 2006, 175:183-191.
    • (2006) J Neuroimmunol , vol.175 , pp. 183-191
    • Lopez, C.1    Comabella, M.2    Al-zayat, H.3    Tintore, M.4    Montalban, X.5
  • 86
    • 41949084341 scopus 로고    scopus 로고
    • Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis
    • Vaknin-Dembinsky A., Murugaiyan G., Hafler D.A., Astier A.L., Weiner H.L. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J Neuroimmunol 2008, 195:140-145.
    • (2008) J Neuroimmunol , vol.195 , pp. 140-145
    • Vaknin-Dembinsky, A.1    Murugaiyan, G.2    Hafler, D.A.3    Astier, A.L.4    Weiner, H.L.5
  • 87
    • 33646233989 scopus 로고    scopus 로고
    • Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis
    • Stasiolek M., Bayas A., Kruse N., Wieczarkowiecz A., Toyka K.V., Gold R., et al. Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis. Brain 2006, 129:1293-1305.
    • (2006) Brain , vol.129 , pp. 1293-1305
    • Stasiolek, M.1    Bayas, A.2    Kruse, N.3    Wieczarkowiecz, A.4    Toyka, K.V.5    Gold, R.6
  • 88
    • 77954521172 scopus 로고    scopus 로고
    • An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in multiple sclerosis
    • Schwab N., Zozulya A.L., Kieseier B.C., Toyka K.V., Wiendl H. An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in multiple sclerosis. J Immunol 2010, 184:5368-5374.
    • (2010) J Immunol , vol.184 , pp. 5368-5374
    • Schwab, N.1    Zozulya, A.L.2    Kieseier, B.C.3    Toyka, K.V.4    Wiendl, H.5
  • 89
    • 67651204895 scopus 로고    scopus 로고
    • Altered innate immune response of plasmacytoid dendritic cells in multiple sclerosis
    • Bayas A., Stasiolek M., Kruse N., Toyka K.V., Selmaj K., Gold R. Altered innate immune response of plasmacytoid dendritic cells in multiple sclerosis. Clin Exp Immunol 2009, 157:332-342.
    • (2009) Clin Exp Immunol , vol.157 , pp. 332-342
    • Bayas, A.1    Stasiolek, M.2    Kruse, N.3    Toyka, K.V.4    Selmaj, K.5    Gold, R.6
  • 90
    • 84859750682 scopus 로고    scopus 로고
    • Decreased interferon-alpha production in response to CpG DNA dysregulates cytokine responses in patients with multiple sclerosis
    • Hirotani M., Niino M., Fukazawa T., Yaguchi H., Nakamura M., Kikuchi S., et al. Decreased interferon-alpha production in response to CpG DNA dysregulates cytokine responses in patients with multiple sclerosis. Clin Immunol 2012, 143:145-151.
    • (2012) Clin Immunol , vol.143 , pp. 145-151
    • Hirotani, M.1    Niino, M.2    Fukazawa, T.3    Yaguchi, H.4    Nakamura, M.5    Kikuchi, S.6
  • 91
    • 67649873307 scopus 로고    scopus 로고
    • Clinical response to interferon-beta-1a may be linked to low baseline circulating BDCA1 myeloid dendritic cells Differential role of circulating dendritic cells and CD4+ regulatory T-cells in relapsing-remitting multiple sclerosis: a 1-year longitudinal study
    • de Andres C., Aristimuno C., Bartolome M., de Las Heras V., Martinez-Gines M.L., Arroyo R., et al. Clinical response to interferon-beta-1a may be linked to low baseline circulating BDCA1 myeloid dendritic cells Differential role of circulating dendritic cells and CD4+ regulatory T-cells in relapsing-remitting multiple sclerosis: a 1-year longitudinal study. J Neuroimmunol 2009, 212:112-120.
    • (2009) J Neuroimmunol , vol.212 , pp. 112-120
    • de Andres, C.1    Aristimuno, C.2    Bartolome, M.3    de Las Heras, V.4    Martinez-Gines, M.L.5    Arroyo, R.6
  • 92
    • 0034951606 scopus 로고    scopus 로고
    • Altered phenotype and function of blood dendritic cells in multiple sclerosis are modulated by IFN-beta and IL-10
    • Huang Y.M., Stoyanova N., Jin Y.P., Teleshova N., Hussien Y., Xiao B.G., et al. Altered phenotype and function of blood dendritic cells in multiple sclerosis are modulated by IFN-beta and IL-10. Clin Exp Immunol 2001, 124:306-314.
    • (2001) Clin Exp Immunol , vol.124 , pp. 306-314
    • Huang, Y.M.1    Stoyanova, N.2    Jin, Y.P.3    Teleshova, N.4    Hussien, Y.5    Xiao, B.G.6
  • 93
    • 77956339214 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in multiple sclerosis: chemokine and chemokine receptor modulation by interferon-beta
    • Aung L.L., Fitzgerald-Bocarsly P., Dhib-Jalbut S., Balashov K. Plasmacytoid dendritic cells in multiple sclerosis: chemokine and chemokine receptor modulation by interferon-beta. J Neuroimmunol 2010, 226:158-164.
    • (2010) J Neuroimmunol , vol.226 , pp. 158-164
    • Aung, L.L.1    Fitzgerald-Bocarsly, P.2    Dhib-Jalbut, S.3    Balashov, K.4
  • 95
    • 84864851464 scopus 로고    scopus 로고
    • Multiple sclerosis-linked and interferon-beta-regulated gene expression in plasmacytoid dendritic cells
    • Aung L.L., Brooks A., Greenberg S.A., Rosenberg M.L., Dhib-Jalbut S., Balashov K.E. Multiple sclerosis-linked and interferon-beta-regulated gene expression in plasmacytoid dendritic cells. J Neuroimmunol 2012, 250:99-105.
    • (2012) J Neuroimmunol , vol.250 , pp. 99-105
    • Aung, L.L.1    Brooks, A.2    Greenberg, S.A.3    Rosenberg, M.L.4    Dhib-Jalbut, S.5    Balashov, K.E.6
  • 96
    • 80355146868 scopus 로고    scopus 로고
    • Monocyte recruitment during infection and inflammation
    • Shi C., Pamer E.G. Monocyte recruitment during infection and inflammation. Nat Rev Immunol 2011, 11:762-774.
    • (2011) Nat Rev Immunol , vol.11 , pp. 762-774
    • Shi, C.1    Pamer, E.G.2
  • 97
    • 84905116959 scopus 로고    scopus 로고
    • Differential roles of microglia and monocytes in the inflamed central nervous system
    • Yamasaki R., Lu H., Butovsky O., Ohno N., Rietsch A.M., Cialic R., et al. Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med 2014, 211:1533-1549.
    • (2014) J Exp Med , vol.211 , pp. 1533-1549
    • Yamasaki, R.1    Lu, H.2    Butovsky, O.3    Ohno, N.4    Rietsch, A.M.5    Cialic, R.6
  • 98
    • 48349089936 scopus 로고    scopus 로고
    • CCR5 expression on macrophages/microglia is associated with early remyelination in multiple sclerosis lesions
    • Trebst C., Konig F., Ransohoff R., Bruck W., Stangel M. CCR5 expression on macrophages/microglia is associated with early remyelination in multiple sclerosis lesions. Mult Scler 2008, 14:728-733.
    • (2008) Mult Scler , vol.14 , pp. 728-733
    • Trebst, C.1    Konig, F.2    Ransohoff, R.3    Bruck, W.4    Stangel, M.5
  • 99
    • 80052858860 scopus 로고    scopus 로고
    • Cytokines regulate neuronal gene expression: differential effects of Th1, Th2 and monocyte/macrophage cytokines
    • Lisak R.P., Nedelkoska L., Studzinski D., Bealmear B., Xu W., Benjamins J.A. Cytokines regulate neuronal gene expression: differential effects of Th1, Th2 and monocyte/macrophage cytokines. J Neuroimmunol 2011, 238:19-33.
    • (2011) J Neuroimmunol , vol.238 , pp. 19-33
    • Lisak, R.P.1    Nedelkoska, L.2    Studzinski, D.3    Bealmear, B.4    Xu, W.5    Benjamins, J.A.6
  • 100
    • 39749173780 scopus 로고    scopus 로고
    • The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells
    • Ifergan I., Kebir H., Bernard M., Wosik K., Dodelet-Devillers A., Cayrol R., et al. The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain 2008, 131:785-799.
    • (2008) Brain , vol.131 , pp. 785-799
    • Ifergan, I.1    Kebir, H.2    Bernard, M.3    Wosik, K.4    Dodelet-Devillers, A.5    Cayrol, R.6
  • 102
    • 71049186072 scopus 로고    scopus 로고
    • B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity
    • Brudek T., Christensen T., Aagaard L., Petersen T., Hansen H.J., Moller-Larsen A. B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity. Retrovirology 2009, 6:104.
    • (2009) Retrovirology , vol.6 , pp. 104
    • Brudek, T.1    Christensen, T.2    Aagaard, L.3    Petersen, T.4    Hansen, H.J.5    Moller-Larsen, A.6
  • 103
    • 0034790862 scopus 로고    scopus 로고
    • Monocyte activation and differentiation augment human endogenous retrovirus expression: implications for inflammatory brain diseases
    • Johnston J.B., Silva C., Holden J., Warren K.G., Clark A.W., Power C. Monocyte activation and differentiation augment human endogenous retrovirus expression: implications for inflammatory brain diseases. Ann Neurol 2001, 50:434-442.
    • (2001) Ann Neurol , vol.50 , pp. 434-442
    • Johnston, J.B.1    Silva, C.2    Holden, J.3    Warren, K.G.4    Clark, A.W.5    Power, C.6
  • 106
    • 84896114532 scopus 로고    scopus 로고
    • Deficient phosphorylation of Stat1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta
    • Gavasso S., Mosleth E.F., Maroy T., Jorgensen K., Nakkestad H.L., Gjertsen B.T., et al. Deficient phosphorylation of Stat1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta. PLOS ONE 2014, 9:e88632.
    • (2014) PLOS ONE , vol.9 , pp. e88632
    • Gavasso, S.1    Mosleth, E.F.2    Maroy, T.3    Jorgensen, K.4    Nakkestad, H.L.5    Gjertsen, B.T.6
  • 108
    • 72649106903 scopus 로고    scopus 로고
    • A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis
    • Comabella M., Lunemann J.D., Rio J., Sanchez A., Lopez C., Julia E., et al. A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis. Brain 2009, 132:3353-3365.
    • (2009) Brain , vol.132 , pp. 3353-3365
    • Comabella, M.1    Lunemann, J.D.2    Rio, J.3    Sanchez, A.4    Lopez, C.5    Julia, E.6
  • 109
    • 84876330741 scopus 로고    scopus 로고
    • Baseline gene expression signatures in monocytes from multiple sclerosis patients treated with interferon-beta
    • Bustamante M.F., Nurtdinov R.N., Rio J., Montalban X., Comabella M. Baseline gene expression signatures in monocytes from multiple sclerosis patients treated with interferon-beta. PLOS ONE 2013, 8:e60994.
    • (2013) PLOS ONE , vol.8 , pp. e60994
    • Bustamante, M.F.1    Nurtdinov, R.N.2    Rio, J.3    Montalban, X.4    Comabella, M.5
  • 111
    • 43049177588 scopus 로고    scopus 로고
    • Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    • Prinz M., Schmidt H., Mildner A., Knobeloch K.P., Hanisch U.K., Raasch J., et al. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 2008, 28:675-686.
    • (2008) Immunity , vol.28 , pp. 675-686
    • Prinz, M.1    Schmidt, H.2    Mildner, A.3    Knobeloch, K.P.4    Hanisch, U.K.5    Raasch, J.6
  • 112
    • 70349741303 scopus 로고    scopus 로고
    • Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis
    • Vandenbark A.A., Huan J., Agotsch M., La Tocha D., Goelz S., Offner H., et al. Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis. J Neuroimmunol 2009, 215:125-128.
    • (2009) J Neuroimmunol , vol.215 , pp. 125-128
    • Vandenbark, A.A.1    Huan, J.2    Agotsch, M.3    La Tocha, D.4    Goelz, S.5    Offner, H.6
  • 113
    • 0041429619 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    • Jego G., Palucka A.K., Blanck J.P., Chalouni C., Pascual V., Banchereau J. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 2003, 19:225-234.
    • (2003) Immunity , vol.19 , pp. 225-234
    • Jego, G.1    Palucka, A.K.2    Blanck, J.P.3    Chalouni, C.4    Pascual, V.5    Banchereau, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.