메뉴 건너뛰기




Volumn 43, Issue 7, 2013, Pages 1963-1972

IFN-β therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients

Author keywords

B cell; IFN ; Monocyte; Multiple sclerosis; TLR

Indexed keywords

B CELL ACTIVATING FACTOR; BETA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 6; MESSENGER RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9;

EID: 84880022571     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201243212     Document Type: Article
Times cited : (22)

References (56)
  • 2
    • 84868525833 scopus 로고    scopus 로고
    • B cells and antibodies in multiple sclerosis pathogenesis and therapy
    • Krumbholz, M., Derfuss, T., Hohlfeld, R. and Meinl, E., B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat. Rev. Neurol. 2012. 8: 613-623.
    • (2012) Nat. Rev. Neurol. , vol.8 , pp. 613-623
    • Krumbholz, M.1    Derfuss, T.2    Hohlfeld, R.3    Meinl, E.4
  • 3
    • 0021811854 scopus 로고
    • Immunoglobulin G, A, and M-clonal restriction in multiple sclerosis cerebrospinal fluid and serum-analysis by two-dimensional electrophoresis
    • Walsh, M. J., Tourtellotte, W. W., Roman, J. and Dreyer, W., Immunoglobulin G, A, and M-clonal restriction in multiple sclerosis cerebrospinal fluid and serum-analysis by two-dimensional electrophoresis. Clin. Immunol. Immunopathol. 1985. 35: 313-327.
    • (1985) Clin. Immunol. Immunopathol. , vol.35 , pp. 313-327
    • Walsh, M.J.1    Tourtellotte, W.W.2    Roman, J.3    Dreyer, W.4
  • 4
    • 0032950794 scopus 로고    scopus 로고
    • Identification of autoantibodies associated with myelin damage in multiple sclerosis
    • Genain, C. P., Cannella, B., Hauser, S. L. and Raine, C. S., Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 1999. 5: 170-175.
    • (1999) Nat. Med. , vol.5 , pp. 170-175
    • Genain, C.P.1    Cannella, B.2    Hauser, S.L.3    Raine, C.S.4
  • 5
    • 22544453860 scopus 로고    scopus 로고
    • Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein
    • O'Connor, K. C., Appel, H., Bregoli, L., Call, M. E., Catz, I., Chan, J. A., Moore, N. H. et al., Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J. Immunol. 2005. 175: 1974-1982.
    • (2005) J. Immunol. , vol.175 , pp. 1974-1982
    • O'Connor, K.C.1    Appel, H.2    Bregoli, L.3    Call, M.E.4    Catz, I.5    Chan, J.A.6    Moore, N.H.7
  • 6
    • 0042809490 scopus 로고    scopus 로고
    • Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis
    • Qin, Y., Duquette, P., Zhang, Y., Olek, M., Da, R. R., Richardson, J., Antel, J. P. et al., Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosis. Lab. Invest. 2003. 83: 1081-1088.
    • (2003) Lab. Invest. , vol.83 , pp. 1081-1088
    • Qin, Y.1    Duquette, P.2    Zhang, Y.3    Olek, M.4    Da, R.R.5    Richardson, J.6    Antel, J.P.7
  • 7
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi, R., Howell, O., Vora, A., Serafini, B., Nicholas, R., Puopolo, M., Reynolds, R. et al., Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007. 130: 1089-1104.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3    Serafini, B.4    Nicholas, R.5    Puopolo, M.6    Reynolds, R.7
  • 8
    • 2442708947 scopus 로고    scopus 로고
    • Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    • Serafini, B., Rosicarelli, B., Magliozzi, R., Stigliano, E. and Aloisi, F., Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol. 2004. 14: 164-174.
    • (2004) Brain Pathol. , vol.14 , pp. 164-174
    • Serafini, B.1    Rosicarelli, B.2    Magliozzi, R.3    Stigliano, E.4    Aloisi, F.5
  • 11
    • 60549116884 scopus 로고    scopus 로고
    • Long-term B-lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis
    • Stuve, O., Leussink, V. I., Frohlich, R., Hemmer, B., Hartung, H. P., Menge, T. and Kieseier, B. C., Long-term B-lymphocyte depletion with rituximab in patients with relapsing-remitting multiple sclerosis. Arch. Neurol. 2009. 66: 259-261.
    • (2009) Arch. Neurol. , vol.66 , pp. 259-261
    • Stuve, O.1    Leussink, V.I.2    Frohlich, R.3    Hemmer, B.4    Hartung, H.P.5    Menge, T.6    Kieseier, B.C.7
  • 12
    • 84858233979 scopus 로고    scopus 로고
    • Autoimmune disease: a role for new anti-viral therapies?
    • Dreyfus, D. H., Autoimmune disease: a role for new anti-viral therapies? Autoimmun. Rev. 2011. 11: 88-97.
    • (2011) Autoimmun. Rev. , vol.11 , pp. 88-97
    • Dreyfus, D.H.1
  • 13
    • 34247622766 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity in B-cell activation and antibody responses
    • Lanzavecchia, A. and Sallusto, F., Toll-like receptors and innate immunity in B-cell activation and antibody responses. Curr. Opin. Immunol. 2007. 19: 268-274.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 268-274
    • Lanzavecchia, A.1    Sallusto, F.2
  • 14
    • 84863191875 scopus 로고    scopus 로고
    • Regulation of B-cell responses by Toll-like receptors
    • Browne, E. P., Regulation of B-cell responses by Toll-like receptors. Immunology 2012. 136: 370-379.
    • (2012) Immunology , vol.136 , pp. 370-379
    • Browne, E.P.1
  • 16
    • 0034631779 scopus 로고    scopus 로고
    • The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes
    • Tomai, M. A., Imbertson, L. M., Stanczak, T. L., Tygrett, L. T. and Waldschmidt, T. J., The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes. Cell Immunol. 2000. 203: 55-65.
    • (2000) Cell Immunol. , vol.203 , pp. 55-65
    • Tomai, M.A.1    Imbertson, L.M.2    Stanczak, T.L.3    Tygrett, L.T.4    Waldschmidt, T.J.5
  • 19
    • 0033979858 scopus 로고    scopus 로고
    • Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists
    • Kavanaugh, A., Tomar, R., Reveille, J., Solomon, D. H. and Homburger, H. A., Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of Pathologists. Arch. Pathol. Lab. Med. 2000. 124: 71-81.
    • (2000) Arch. Pathol. Lab. Med. , vol.124 , pp. 71-81
    • Kavanaugh, A.1    Tomar, R.2    Reveille, J.3    Solomon, D.H.4    Homburger, H.A.5
  • 20
    • 37549011741 scopus 로고    scopus 로고
    • IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression
    • Remoli, M. E., Gafa, V., Giacomini, E., Severa, M., Lande, R. and Coccia, E. M., IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression. Eur. J. Immunol. 2007. 37: 3499-3508.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3499-3508
    • Remoli, M.E.1    Gafa, V.2    Giacomini, E.3    Severa, M.4    Lande, R.5    Coccia, E.M.6
  • 23
    • 0035869281 scopus 로고    scopus 로고
    • Interleukin-6 is a growth factor for nonmalignant human plasmablasts
    • Jego, G., Bataille, R. and Pellat-Deceunynck, C., Interleukin-6 is a growth factor for nonmalignant human plasmablasts. Blood 2001. 97: 1817-1822.
    • (2001) Blood , vol.97 , pp. 1817-1822
    • Jego, G.1    Bataille, R.2    Pellat-Deceunynck, C.3
  • 24
    • 44949253997 scopus 로고    scopus 로고
    • Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity
    • Krumbholz, M., Faber, H., Steinmeyer, F., Hoffmann, L. A., Kumpfel, T., Pellkofer, H., Derfuss, T. et al., Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 2008. 131: 1455-1463.
    • (2008) Brain , vol.131 , pp. 1455-1463
    • Krumbholz, M.1    Faber, H.2    Steinmeyer, F.3    Hoffmann, L.A.4    Kumpfel, T.5    Pellkofer, H.6    Derfuss, T.7
  • 25
    • 0023818749 scopus 로고
    • Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)
    • Tosato, G., Seamon, K. B., Goldman, N. D., Sehgal, P. B., May, L. T., Washington, G. C., Jones, K. D. et al., Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6). Science 1988. 239: 502-504.
    • (1988) Science , vol.239 , pp. 502-504
    • Tosato, G.1    Seamon, K.B.2    Goldman, N.D.3    Sehgal, P.B.4    May, L.T.5    Washington, G.C.6    Jones, K.D.7
  • 26
    • 0023808199 scopus 로고
    • Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages
    • Bauer, J., Ganter, U., Geiger, T., Jacobshagen, U., Hirano, T., Matsuda, T., Kishimoto, T. et al., Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages. Blood 1988. 72: 1134-1140.
    • (1988) Blood , vol.72 , pp. 1134-1140
    • Bauer, J.1    Ganter, U.2    Geiger, T.3    Jacobshagen, U.4    Hirano, T.5    Matsuda, T.6    Kishimoto, T.7
  • 27
    • 0033371496 scopus 로고    scopus 로고
    • Characterization of a new member of the TNF family expressed on antigen presenting cells
    • Tribouley, C., Wallroth, M., Chan, V., Paliard, X., Fang, E., Lamson, G., Pot, D. et al., Characterization of a new member of the TNF family expressed on antigen presenting cells. Biol. Chem. 1999. 380: 1443-1447.
    • (1999) Biol. Chem. , vol.380 , pp. 1443-1447
    • Tribouley, C.1    Wallroth, M.2    Chan, V.3    Paliard, X.4    Fang, E.5    Lamson, G.6    Pot, D.7
  • 28
    • 0028981875 scopus 로고
    • Interferon beta-1b reduces interferon gamma-induced antigen-presenting capacity of human glial and B cells
    • Jiang, H., Milo, R., Swoveland, P., Johnson, K. P., Panitch, H. and Dhib-Jalbut, S., Interferon beta-1b reduces interferon gamma-induced antigen-presenting capacity of human glial and B cells. J. Neuroimmunol. 1995. 61: 17-25.
    • (1995) J. Neuroimmunol. , vol.61 , pp. 17-25
    • Jiang, H.1    Milo, R.2    Swoveland, P.3    Johnson, K.P.4    Panitch, H.5    Dhib-Jalbut, S.6
  • 30
    • 33645956556 scopus 로고    scopus 로고
    • Toll-like receptor stimulation as a third signal required for activation of human naive B cells
    • Ruprecht, C. R. and Lanzavecchia, A., Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur. J. Immunol. 2006. 36: 810-816.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 810-816
    • Ruprecht, C.R.1    Lanzavecchia, A.2
  • 31
    • 0037073930 scopus 로고    scopus 로고
    • Maintenance of serological memory by polyclonal activation of human memory B cells
    • Bernasconi, N. L., Traggiai, E. and Lanzavecchia, A., Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002. 298: 2199-2202.
    • (2002) Science , vol.298 , pp. 2199-2202
    • Bernasconi, N.L.1    Traggiai, E.2    Lanzavecchia, A.3
  • 32
    • 0037438633 scopus 로고    scopus 로고
    • Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses
    • Tangye, S. G., Avery, D. T., Deenick, E. K. and Hodgkin, P. D., Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses. J. Immunol. 2003. 170: 686-694.
    • (2003) J. Immunol. , vol.170 , pp. 686-694
    • Tangye, S.G.1    Avery, D.T.2    Deenick, E.K.3    Hodgkin, P.D.4
  • 35
    • 61449146075 scopus 로고    scopus 로고
    • Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cells
    • Douagi, I., Gujer, C., Sundling, C., Adams, W. C., Smed-Sorensen, A., Seder, R. A., Karlsson Hedestam, G. B. et al., Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cells. J. Immunol. 2009. 182: 1991-2001.
    • (2009) J. Immunol. , vol.182 , pp. 1991-2001
    • Douagi, I.1    Gujer, C.2    Sundling, C.3    Adams, W.C.4    Smed-Sorensen, A.5    Seder, R.A.6    Karlsson Hedestam, G.B.7
  • 36
    • 0041429619 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    • Jego, G., Palucka, A. K., Blanck, J. P., Chalouni, C., Pascual, V. and Banchereau, J., Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 2003. 19: 225-234.
    • (2003) Immunity , vol.19 , pp. 225-234
    • Jego, G.1    Palucka, A.K.2    Blanck, J.P.3    Chalouni, C.4    Pascual, V.5    Banchereau, J.6
  • 37
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
    • Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S. et al., Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986. 324: 73-76.
    • (1986) Nature , vol.324 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3    Taga, T.4    Watanabe, Y.5    Matsuda, T.6    Kashiwamura, S.7
  • 38
    • 0026602470 scopus 로고
    • VLA-4-fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobulin secretion
    • Roldan, E., Garcia-Pardo, A. and Brieva, J. A., VLA-4-fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobulin secretion. J. Exp. Med. 1992. 175: 1739-1747.
    • (1992) J. Exp. Med. , vol.175 , pp. 1739-1747
    • Roldan, E.1    Garcia-Pardo, A.2    Brieva, J.A.3
  • 39
    • 34247574625 scopus 로고    scopus 로고
    • B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling
    • Mackay, F., Silveira, P. A. and Brink, R., B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling. Curr. Opin. Immunol. 2007. 19: 327-336.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 327-336
    • Mackay, F.1    Silveira, P.A.2    Brink, R.3
  • 40
    • 77954725231 scopus 로고    scopus 로고
    • Epstein-Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation
    • Serafini, B., Severa, M., Columba-Cabezas, S., Rosicarelli, B., Veroni, C., Chiappetta, G., Magliozzi, R. et al., Epstein-Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation. J. Neuropathol. Exp. Neurol. 2010. 69: 677-693.
    • (2010) J. Neuropathol. Exp. Neurol. , vol.69 , pp. 677-693
    • Serafini, B.1    Severa, M.2    Columba-Cabezas, S.3    Rosicarelli, B.4    Veroni, C.5    Chiappetta, G.6    Magliozzi, R.7
  • 41
    • 1642370060 scopus 로고    scopus 로고
    • Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells
    • Coccia, E. M., Severa, M., Giacomini, E., Monneron, D., Remoli, M. E., Julkunen, I., Cella, M. et al., Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells. Eur. J. Immunol. 2004. 34: 796-805.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 796-805
    • Coccia, E.M.1    Severa, M.2    Giacomini, E.3    Monneron, D.4    Remoli, M.E.5    Julkunen, I.6    Cella, M.7
  • 42
    • 84869140690 scopus 로고    scopus 로고
    • Interferon-beta induces hepatocyte growth factor in monocytes of multiple sclerosis patients
    • Molnarfi, N., Benkhoucha, M., Bjarnadottir, K., Juillard, C. and Lalive, P. H., Interferon-beta induces hepatocyte growth factor in monocytes of multiple sclerosis patients. PLoS One 2013. 7: e49882.
    • (2013) PLoS One , vol.7
    • Molnarfi, N.1    Benkhoucha, M.2    Bjarnadottir, K.3    Juillard, C.4    Lalive, P.H.5
  • 43
    • 72649106903 scopus 로고    scopus 로고
    • A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis
    • Comabella, M., Lunemann, J. D., Rio, J., Sanchez, A., Lopez, C., Julia, E., Fernandez, M. et al., A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis. Brain 2009. 132: 3353-3365.
    • (2009) Brain , vol.132 , pp. 3353-3365
    • Comabella, M.1    Lunemann, J.D.2    Rio, J.3    Sanchez, A.4    Lopez, C.5    Julia, E.6    Fernandez, M.7
  • 44
    • 43049177588 scopus 로고    scopus 로고
    • Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    • Prinz, M., Schmidt, H., Mildner, A., Knobeloch, K. P., Hanisch, U. K., Raasch, J., Merkler, D. et al., Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 2008. 28: 675-686.
    • (2008) Immunity , vol.28 , pp. 675-686
    • Prinz, M.1    Schmidt, H.2    Mildner, A.3    Knobeloch, K.P.4    Hanisch, U.K.5    Raasch, J.6    Merkler, D.7
  • 45
    • 84864818532 scopus 로고    scopus 로고
    • Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms
    • Poovassery, J. S. and Bishop, G. A., Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms. J. Immunol. 2012. 189: 1757-1764.
    • (2012) J. Immunol. , vol.189 , pp. 1757-1764
    • Poovassery, J.S.1    Bishop, G.A.2
  • 47
    • 84866782855 scopus 로고    scopus 로고
    • Naturally occurring antibodies as therapeutics for neurologic disease: can human monoclonal IgMs replace the limited resource IVIG?
    • Warrington, A. E., Van Keulen, V., Pease, L. R. and Rodriguez, M., Naturally occurring antibodies as therapeutics for neurologic disease: can human monoclonal IgMs replace the limited resource IVIG? Adv. Exp. Med. Biol. 2012. 750: 44-55.
    • (2012) Adv. Exp. Med. Biol. , vol.750 , pp. 44-55
    • Warrington, A.E.1    Van Keulen, V.2    Pease, L.R.3    Rodriguez, M.4
  • 48
    • 0036237054 scopus 로고    scopus 로고
    • Prospective study on the relationship between infections and multiple sclerosis exacerbations
    • Buljevac, D., Flach, H. Z., Hop, W. C., Hijdra, D., Laman, J. D., Savelkoul, H. F., van Der Meche, F. G. et al., Prospective study on the relationship between infections and multiple sclerosis exacerbations. Brain 2002. 125: 952-960.
    • (2002) Brain , vol.125 , pp. 952-960
    • Buljevac, D.1    Flach, H.Z.2    Hop, W.C.3    Hijdra, D.4    Laman, J.D.5    Savelkoul, H.F.6    van Der Meche, F.G.7
  • 49
    • 33747705430 scopus 로고    scopus 로고
    • The risk of relapses in multiple sclerosis during systemic infections
    • Correale, J., Fiol, M. and Gilmore, W., The risk of relapses in multiple sclerosis during systemic infections. Neurology 2006. 67: 652-659.
    • (2006) Neurology , vol.67 , pp. 652-659
    • Correale, J.1    Fiol, M.2    Gilmore, W.3
  • 50
    • 0032528551 scopus 로고    scopus 로고
    • Effects of influenza vaccination and influenza illness on exacerbations in multiple sclerosis
    • De Keyser, J., Zwanikken, C. and Boon, M., Effects of influenza vaccination and influenza illness on exacerbations in multiple sclerosis. J. Neurol. Sci. 1998. 159: 51-53.
    • (1998) J. Neurol. Sci. , vol.159 , pp. 51-53
    • De Keyser, J.1    Zwanikken, C.2    Boon, M.3
  • 51
    • 0034489937 scopus 로고    scopus 로고
    • Prognostic factors in multiple sclerosis: role of intercurrent infections and vaccinations against influenza and hepatitis B
    • Merelli, E. and Casoni, F., Prognostic factors in multiple sclerosis: role of intercurrent infections and vaccinations against influenza and hepatitis B. Neurol. Sci. 2000. 21: S853-S856.
    • (2000) Neurol. Sci. , vol.21
    • Merelli, E.1    Casoni, F.2
  • 53
    • 78249235626 scopus 로고    scopus 로고
    • Modulation of toll-like receptor function has therapeutic potential in autoimmune disease
    • Clanchy, F. I. and Sacre, S. M., Modulation of toll-like receptor function has therapeutic potential in autoimmune disease. Expert. Opin. Biol. Ther. 2010. 10: 1703-1716.
    • (2010) Expert. Opin. Biol. Ther. , vol.10 , pp. 1703-1716
    • Clanchy, F.I.1    Sacre, S.M.2
  • 54
    • 77955164022 scopus 로고    scopus 로고
    • Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients
    • Enevold, C., Oturai, A. B., Sorensen, P. S., Ryder, L. P., Koch-Henriksen, N. and Bendtzen, K., Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients. Mult. Scler. 2010. 16: 942-949.
    • (2010) Mult. Scler. , vol.16 , pp. 942-949
    • Enevold, C.1    Oturai, A.B.2    Sorensen, P.S.3    Ryder, L.P.4    Koch-Henriksen, N.5    Bendtzen, K.6
  • 55
    • 79952461669 scopus 로고    scopus 로고
    • TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study
    • doi:10.1186/ar3277
    • Kawasaki, A., Furukawa, H., Kondo, Y., Ito, S., Hayashi, T., Kusaoi, M., Matsumoto, I. et al., TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study. Arthritis Res. Ther. 2011. 13: R41. doi:10.1186/ar3277.
    • (2011) Arthritis Res. Ther. , vol.13
    • Kawasaki, A.1    Furukawa, H.2    Kondo, Y.3    Ito, S.4    Hayashi, T.5    Kusaoi, M.6    Matsumoto, I.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.