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Volumn 11, Issue 3, 2015, Pages 1-33

Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CD63 ANTIGEN; CD9 ANTIGEN; CYCLIN A1; HEAT SHOCK COGNATE PROTEIN 70; LIPOCORTIN 1; MICRORNA; MICRORNA 143 3P; MICRORNA 17 5P; MICRORNA 186 5P; MICRORNA 20A 5P; MICRORNA 21 5P; MICRORNA 23A 3P; MICRORNA 23B 3P; MICRORNA 27B 3P; MICRORNA 378A 3P; MICRORNA 378F; MICRORNA 423 3P; MICRORNA 629 5P; MICRORNA 7 5P; MICRORNA 92A 3P; PEPTIDES AND PROTEINS; PROTEIN E6; PROTEIN E7; PROTEIN LET 7D 5P; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; ONCOPROTEIN; REPRESSOR PROTEIN;

EID: 84926506268     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004712     Document Type: Article
Times cited : (206)

References (134)
  • 1
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: from basic studies to clinical application
    • zur Hausen H, (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2: 342–350. 12044010
    • (2002) Nat Rev Cancer , vol.2 , pp. 342-350
    • zur Hausen, H.1
  • 2
    • 0023809597 scopus 로고
    • Correlation of modified human papilloma virus early gene expression with altered growth properties in C4–1 cervical carcinoma cells
    • von Knebel Doeberitz M, Oltersdorf T, Schwarz E, Gissmann L, (1988) Correlation of modified human papilloma virus early gene expression with altered growth properties in C4–1 cervical carcinoma cells. Cancer Res 48: 3780–3786. 2837324
    • (1988) Cancer Res , vol.48 , pp. 3780-3786
    • von Knebel Doeberitz, M.1    Oltersdorf, T.2    Schwarz, E.3    Gissmann, L.4
  • 3
    • 68949194550 scopus 로고    scopus 로고
    • Oncogenic activities of human papillomaviruses
    • McLaughlin-Drubin ME, Munger K, (2009) Oncogenic activities of human papillomaviruses. Virus Res 143: 195–208. doi: 10.1016/j.virusres.2009.06.008 19540281
    • (2009) Virus Res , vol.143 , pp. 195-208
    • McLaughlin-Drubin, M.E.1    Munger, K.2
  • 4
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM, (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129–1136. 2175676
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 5
    • 0030008177 scopus 로고    scopus 로고
    • Telomerase activation by the E6 gene product of human papillomavirus type 16
    • Klingelhutz AJ, Foster SA, McDougall JK, (1996) Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380: 79–82. 8598912
    • (1996) Nature , vol.380 , pp. 79-82
    • Klingelhutz, A.J.1    Foster, S.A.2    McDougall, J.K.3
  • 6
    • 59549098296 scopus 로고    scopus 로고
    • The human papillomavirus E7 oncoprotein
    • McLaughlin-Drubin ME, Munger K, (2009) The human papillomavirus E7 oncoprotein. Virology 384: 335–344. doi: 10.1016/j.virol.2008.10.006 19007963
    • (2009) Virology , vol.384 , pp. 335-344
    • McLaughlin-Drubin, M.E.1    Munger, K.2
  • 7
    • 0034612296 scopus 로고    scopus 로고
    • Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
    • Butz K, Denk C, Ullmann A, Scheffner M, Hoppe-Seyler F, (2000) Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein. Proc Natl Acad Sci U S A 97: 6693–6697. 10829072
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6693-6697
    • Butz, K.1    Denk, C.2    Ullmann, A.3    Scheffner, M.4    Hoppe-Seyler, F.5
  • 8
    • 0141730323 scopus 로고    scopus 로고
    • siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells
    • Butz K, Ristriani T, Hengstermann A, Denk C, Scheffner M, et al. (2003) siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells. Oncogene 22: 5938–5945. 12955072
    • (2003) Oncogene , vol.22 , pp. 5938-5945
    • Butz, K.1    Ristriani, T.2    Hengstermann, A.3    Denk, C.4    Scheffner, M.5
  • 9
    • 28944438180 scopus 로고    scopus 로고
    • Inhibition of papillomavirus protein function in cervical cancer cells by intrabody targeting
    • Griffin H, Elston R, Jackson D, Ansell K, Coleman M, et al. (2006) Inhibition of papillomavirus protein function in cervical cancer cells by intrabody targeting. J Mol Biol 355: 360–378. 16324714
    • (2006) J Mol Biol , vol.355 , pp. 360-378
    • Griffin, H.1    Elston, R.2    Jackson, D.3    Ansell, K.4    Coleman, M.5
  • 10
    • 39049171519 scopus 로고    scopus 로고
    • New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer
    • Yamato K, Yamada T, Kizaki M, Ui-Tei K, Natori Y, et al. (2008) New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer. Cancer Gene Ther 15: 140–153. 18157144
    • (2008) Cancer Gene Ther , vol.15 , pp. 140-153
    • Yamato, K.1    Yamada, T.2    Kizaki, M.3    Ui-Tei, K.4    Natori, Y.5
  • 11
    • 34547528566 scopus 로고    scopus 로고
    • Intracellular scFvs against the viral E6 oncoprotein provoke apoptosis in human papillomavirus-positive cancer cells
    • Lagrange M, Boulade-Ladame C, Mailly L, Weiss E, Orfanoudakis G, et al. (2007) Intracellular scFvs against the viral E6 oncoprotein provoke apoptosis in human papillomavirus-positive cancer cells. Biochem Biophys Res Commun 361: 487–492. 17658466
    • (2007) Biochem Biophys Res Commun , vol.361 , pp. 487-492
    • Lagrange, M.1    Boulade-Ladame, C.2    Mailly, L.3    Weiss, E.4    Orfanoudakis, G.5
  • 12
  • 13
    • 0034331178 scopus 로고    scopus 로고
    • Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways
    • Wells SI, Francis DA, Karpova AY, Dowhanick JJ, Benson JD, et al. (2000) Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways. EMBO J 19: 5762–5771. 11060027
    • (2000) EMBO J , vol.19 , pp. 5762-5771
    • Wells, S.I.1    Francis, D.A.2    Karpova, A.Y.3    Dowhanick, J.J.4    Benson, J.D.5
  • 14
    • 0038032792 scopus 로고    scopus 로고
    • RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells
    • Hall AH, Alexander KA, (2003) RNA interference of human papillomavirus type 18 E6 and E7 induces senescence in HeLa cells. J Virol 77: 6066–6069. 12719599
    • (2003) J Virol , vol.77 , pp. 6066-6069
    • Hall, A.H.1    Alexander, K.A.2
  • 15
    • 84860324470 scopus 로고    scopus 로고
    • Roles for microRNAs in conferring robustness to biological processes
    • Ebert MS, Sharp PA, (2012) Roles for microRNAs in conferring robustness to biological processes. Cell 149: 515–524. doi: 10.1016/j.cell.2012.04.005 22541426
    • (2012) Cell , vol.149 , pp. 515-524
    • Ebert, M.S.1    Sharp, P.A.2
  • 16
    • 36548999250 scopus 로고    scopus 로고
    • MicroRNAs and cancer
    • Cowland JB, Hother C, Gronbaek K, (2007) MicroRNAs and cancer. APMIS 115: 1090–1106. 18042145
    • (2007) APMIS , vol.115 , pp. 1090-1106
    • Cowland, J.B.1    Hother, C.2    Gronbaek, K.3
  • 17
    • 84858126071 scopus 로고    scopus 로고
    • MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
    • Iorio MV, Croce CM, (2012) MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 4: 143–159. doi: 10.1002/emmm.201100209 22351564
    • (2012) EMBO Mol Med , vol.4 , pp. 143-159
    • Iorio, M.V.1    Croce, C.M.2
  • 18
    • 84875795070 scopus 로고    scopus 로고
    • mir-17–92: a polycistronic oncomir with pleiotropic functions
    • Olive V, Li Q, He L, (2013) mir-17–92: a polycistronic oncomir with pleiotropic functions. Immunol Rev 253: 158–166. doi: 10.1111/imr.12054 23550645
    • (2013) Immunol Rev , vol.253 , pp. 158-166
    • Olive, V.1    Li, Q.2    He, L.3
  • 19
    • 84926467900 scopus 로고    scopus 로고
    • Aging, Cellular Senescence, and Cancer
    • Campisi J, (2012) Aging, Cellular Senescence, and Cancer. Annu Rev Physiol.
    • (2012) Annu Rev Physiol
    • Campisi, J.1
  • 21
    • 84872021739 scopus 로고    scopus 로고
    • Virus-encoded microRNAs: an overview and a look to the future
    • Kincaid RP, Sullivan CS, (2012) Virus-encoded microRNAs: an overview and a look to the future. PLoS Pathog 8: e1003018. doi: 10.1371/journal.ppat.1003018 23308061
    • (2012) PLoS Pathog , vol.8 , pp. 1003018
    • Kincaid, R.P.1    Sullivan, C.S.2
  • 22
    • 84896528671 scopus 로고    scopus 로고
    • microRNAs are biomarkers of oncogenic human papillomavirus infections
    • Wang X, Wang HK, Li Y, Hafner M, Banerjee NS, et al. (2014) microRNAs are biomarkers of oncogenic human papillomavirus infections. Proc Natl Acad Sci U S A 111: 4262–4267. doi: 10.1073/pnas.1401430111 24591631
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 4262-4267
    • Wang, X.1    Wang, H.K.2    Li, Y.3    Hafner, M.4    Banerjee, N.S.5
  • 24
    • 84894097845 scopus 로고    scopus 로고
    • Roles of MiR-101 and its target gene Cox-2 in early diagnosis of cervical cancer in Uygur women
    • Lin C, Huang F, Zhang YJ, Tuokan T, Kuerban G, (2014) Roles of MiR-101 and its target gene Cox-2 in early diagnosis of cervical cancer in Uygur women. Asian Pac J Cancer Prev 15: 45–48. 24528073
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 45-48
    • Lin, C.1    Huang, F.2    Zhang, Y.J.3    Tuokan, T.4    Kuerban, G.5
  • 25
    • 84870734858 scopus 로고    scopus 로고
    • Profiling of microRNA-mRNA reveals roles of microRNAs in cervical cancer
    • Ma D, Zhang YY, Guo YL, Li ZJ, Geng L, (2012) Profiling of microRNA-mRNA reveals roles of microRNAs in cervical cancer. Chin Med J (Engl) 125: 4270–4276. 23217399
    • (2012) Chin Med J (Engl) , vol.125 , pp. 4270-4276
    • Ma, D.1    Zhang, Y.Y.2    Guo, Y.L.3    Li, Z.J.4    Geng, L.5
  • 26
    • 84864568344 scopus 로고    scopus 로고
    • Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm
    • Cheung TH, Man KN, Yu MY, Yim SF, Siu NS, et al. (2012) Dysregulated microRNAs in the pathogenesis and progression of cervical neoplasm. Cell Cycle 11: 2876–2884. doi: 10.4161/cc.21278 22801550
    • (2012) Cell Cycle , vol.11 , pp. 2876-2884
    • Cheung, T.H.1    Man, K.N.2    Yu, M.Y.3    Yim, S.F.4    Siu, N.S.5
  • 27
    • 84860229754 scopus 로고    scopus 로고
    • The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer
    • Lajer CB, Garnaes E, Friis-Hansen L, Norrild B, Therkildsen MH, et al. (2012) The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer. Br J Cancer 106: 1526–1534. doi: 10.1038/bjc.2012.109 22472886
    • (2012) Br J Cancer , vol.106 , pp. 1526-1534
    • Lajer, C.B.1    Garnaes, E.2    Friis-Hansen, L.3    Norrild, B.4    Therkildsen, M.H.5
  • 28
    • 84871945452 scopus 로고    scopus 로고
    • Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis
    • Wilting SM, Snijders PJ, Verlaat W, Jaspers A, van de Wiel MA, et al. (2013) Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis. Oncogene 32: 106–116. doi: 10.1038/onc.2012.20 22330141
    • (2013) Oncogene , vol.32 , pp. 106-116
    • Wilting, S.M.1    Snijders, P.J.2    Verlaat, W.3    Jaspers, A.4    van de Wiel, M.A.5
  • 29
    • 84863011861 scopus 로고    scopus 로고
    • miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2
    • Liu L, Yu X, Guo X, Tian Z, Su M, et al. (2012) miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2. Mol Med Rep 5: 753–760. doi: 10.3892/mmr.2011.696 22160209
    • (2012) Mol Med Rep , vol.5 , pp. 753-760
    • Liu, L.1    Yu, X.2    Guo, X.3    Tian, Z.4    Su, M.5
  • 30
    • 79959975720 scopus 로고    scopus 로고
    • Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29
    • Li Y, Wang F, Xu J, Ye F, Shen Y, et al. (2011) Progressive miRNA expression profiles in cervical carcinogenesis and identification of HPV-related target genes for miR-29. J Pathol 224: 484–495. doi: 10.1002/path.2873 21503900
    • (2011) J Pathol , vol.224 , pp. 484-495
    • Li, Y.1    Wang, F.2    Xu, J.3    Ye, F.4    Shen, Y.5
  • 31
    • 84866287777 scopus 로고    scopus 로고
    • Aberrant microRNA expression in human cervical carcinomas
    • Rao Q, Shen Q, Zhou H, Peng Y, Li J, et al. (2012) Aberrant microRNA expression in human cervical carcinomas. Med Oncol 29: 1242–1248. doi: 10.1007/s12032-011-9830-2 21264530
    • (2012) Med Oncol , vol.29 , pp. 1242-1248
    • Rao, Q.1    Shen, Q.2    Zhou, H.3    Peng, Y.4    Li, J.5
  • 32
    • 78649909329 scopus 로고    scopus 로고
    • MicroRNA miR-886–5p inhibits apoptosis by down-regulating Bax expression in human cervical carcinoma cells
    • Li JH, Xiao X, Zhang YN, Wang YM, Feng LM, et al. (2011) MicroRNA miR-886–5p inhibits apoptosis by down-regulating Bax expression in human cervical carcinoma cells. Gynecol Oncol 120: 145–151. doi: 10.1016/j.ygyno.2010.09.009 20947150
    • (2011) Gynecol Oncol , vol.120 , pp. 145-151
    • Li, J.H.1    Xiao, X.2    Zhang, Y.N.3    Wang, Y.M.4    Feng, L.M.5
  • 33
    • 77955615260 scopus 로고    scopus 로고
    • MicroRNA expression variability in human cervical tissues
    • Pereira PM, Marques JP, Soares AR, Carreto L, Santos MA, (2010) MicroRNA expression variability in human cervical tissues. PLoS One 5: e11780. doi: 10.1371/journal.pone.0011780 20668671
    • (2010) PLoS One , vol.5 , pp. 11780
    • Pereira, P.M.1    Marques, J.P.2    Soares, A.R.3    Carreto, L.4    Santos, M.A.5
  • 34
    • 49749107841 scopus 로고    scopus 로고
    • Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth
    • Wang X, Tang S, Le SY, Lu R, Rader JS, et al. (2008) Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 3: e2557. doi: 10.1371/journal.pone.0002557 18596939
    • (2008) PLoS One , vol.3 , pp. 2557
    • Wang, X.1    Tang, S.2    Le, S.Y.3    Lu, R.4    Rader, J.S.5
  • 35
    • 52049097315 scopus 로고    scopus 로고
    • Altered MicroRNA expression in cervical carcinomas
    • Lee JW, Choi CH, Choi JJ, Park YA, Kim SJ, et al. (2008) Altered MicroRNA expression in cervical carcinomas. Clin Cancer Res 14: 2535–2542. doi: 10.1158/1078-0432.CCR-07-1231 18451214
    • (2008) Clin Cancer Res , vol.14 , pp. 2535-2542
    • Lee, J.W.1    Choi, C.H.2    Choi, J.J.3    Park, Y.A.4    Kim, S.J.5
  • 36
    • 77951953494 scopus 로고    scopus 로고
    • Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls
    • Witten D, Tibshirani R, Gu SG, Fire A, Lui WO, (2010) Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. BMC Biol 8: 58. doi: 10.1186/1741-7007-8-58 20459774
    • (2010) BMC Biol , vol.8 , pp. 58
    • Witten, D.1    Tibshirani, R.2    Gu, S.G.3    Fire, A.4    Lui, W.O.5
  • 37
    • 84920722785 scopus 로고    scopus 로고
    • Dysregulated microRNA expression in adenocarcinoma of the uterine cervix: Clinical impact of miR-363–3p
    • Park H, Lee MJ, Jeong JY, Choi MC, Jung SG, et al. (2014) Dysregulated microRNA expression in adenocarcinoma of the uterine cervix: Clinical impact of miR-363–3p. Gynecol Oncol 135: 565–572. doi: 10.1016/j.ygyno.2014.09.010 25230213
    • (2014) Gynecol Oncol , vol.135 , pp. 565-572
    • Park, H.1    Lee, M.J.2    Jeong, J.Y.3    Choi, M.C.4    Jung, S.G.5
  • 38
    • 84911020701 scopus 로고    scopus 로고
    • Microarray analysis revealed markedly differential miRNA expression profiles in cervical intraepithelial neoplasias and invasive squamous cell carcinoma
    • Liang S, Tian T, Liu X, Shi H, Tang C, et al. (2014) Microarray analysis revealed markedly differential miRNA expression profiles in cervical intraepithelial neoplasias and invasive squamous cell carcinoma. Future Oncol 10: 2023–2032. doi: 10.2217/fon.14.38 24559408
    • (2014) Future Oncol , vol.10 , pp. 2023-2032
    • Liang, S.1    Tian, T.2    Liu, X.3    Shi, H.4    Tang, C.5
  • 39
    • 84875434021 scopus 로고    scopus 로고
    • MicroRNA-182 plays an onco-miRNA role in cervical cancer
    • Tang T, Wong HK, Gu W, Yu MY, To KF, et al. (2013) MicroRNA-182 plays an onco-miRNA role in cervical cancer. Gynecol Oncol 129: 199–208. doi: 10.1016/j.ygyno.2012.12.043 23313739
    • (2013) Gynecol Oncol , vol.129 , pp. 199-208
    • Tang, T.1    Wong, H.K.2    Gu, W.3    Yu, M.Y.4    To, K.F.5
  • 40
    • 34447134869 scopus 로고    scopus 로고
    • Patterns of known and novel small RNAs in human cervical cancer
    • Lui WO, Pourmand N, Patterson BK, Fire A, (2007) Patterns of known and novel small RNAs in human cervical cancer. Cancer Res 67: 6031–6043. 17616659
    • (2007) Cancer Res , vol.67 , pp. 6031-6043
    • Lui, W.O.1    Pourmand, N.2    Patterson, B.K.3    Fire, A.4
  • 41
    • 42249105032 scopus 로고    scopus 로고
    • Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells
    • Martinez I, Gardiner AS, Board KF, Monzon FA, Edwards RP, et al. (2008) Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene 27: 2575–2582. 17998940
    • (2008) Oncogene , vol.27 , pp. 2575-2582
    • Martinez, I.1    Gardiner, A.S.2    Board, K.F.3    Monzon, F.A.4    Edwards, R.P.5
  • 42
    • 80051786033 scopus 로고    scopus 로고
    • Differential expression of cellular microRNAs in HPV 11, -16, and-45 transfected cells
    • Dreher A, Rossing M, Kaczkowski B, Andersen DK, Larsen TJ, et al. (2011) Differential expression of cellular microRNAs in HPV 11, -16, and-45 transfected cells. Biochem Biophys Res Commun 412: 20–25. doi: 10.1016/j.bbrc.2011.07.011 21782796
    • (2011) Biochem Biophys Res Commun , vol.412 , pp. 20-25
    • Dreher, A.1    Rossing, M.2    Kaczkowski, B.3    Andersen, D.K.4    Larsen, T.J.5
  • 43
    • 84877355736 scopus 로고    scopus 로고
    • Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification
    • Gunasekharan V, Laimins LA, (2013) Human papillomaviruses modulate microRNA 145 expression to directly control genome amplification. J Virol 87: 6037–6043. doi: 10.1128/JVI.00153-13 23468503
    • (2013) J Virol , vol.87 , pp. 6037-6043
    • Gunasekharan, V.1    Laimins, L.A.2
  • 44
    • 84885874679 scopus 로고    scopus 로고
    • Identification of miRNAs Dysregulated in Human Foreskin Keratinocytes (HFKs) Expressing the Human Papillomavirus (HPV) Type 16 E6 and E7 Oncoproteins
    • Yablonska S, Hoskins EE, Wells SI, Khan SA, (2013) Identification of miRNAs Dysregulated in Human Foreskin Keratinocytes (HFKs) Expressing the Human Papillomavirus (HPV) Type 16 E6 and E7 Oncoproteins. Microrna 2: 2–13. 25070710
    • (2013) Microrna , vol.2 , pp. 2-13
    • Yablonska, S.1    Hoskins, E.E.2    Wells, S.I.3    Khan, S.A.4
  • 45
    • 62549156668 scopus 로고    scopus 로고
    • Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6
    • Wang X, Wang HK, McCoy JP, Banerjee NS, Rader JS, et al. (2009) Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6. RNA 15: 637–647. doi: 10.1261/rna.1442309 19258450
    • (2009) RNA , vol.15 , pp. 637-647
    • Wang, X.1    Wang, H.K.2    McCoy, J.P.3    Banerjee, N.S.4    Rader, J.S.5
  • 46
    • 77957195647 scopus 로고    scopus 로고
    • MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6
    • McKenna DJ, McDade SS, Patel D, McCance DJ, (2010) MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6. J Virol 84: 10644–10652. doi: 10.1128/JVI.00703-10 20702634
    • (2010) J Virol , vol.84 , pp. 10644-10652
    • McKenna, D.J.1    McDade, S.S.2    Patel, D.3    McCance, D.J.4
  • 47
    • 84904657288 scopus 로고    scopus 로고
    • Biogenesis and secretion of exosomes
    • Kowal J, Tkach M, Thery C, (2014) Biogenesis and secretion of exosomes. Curr Opin Cell Biol 29C: 116–125.
    • (2014) Curr Opin Cell Biol , vol.29C , pp. 116-125
    • Kowal, J.1    Tkach, M.2    Thery, C.3
  • 48
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, et al. (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9: 654–659. 17486113
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5
  • 49
    • 84879535955 scopus 로고    scopus 로고
    • Extracellular vesicles—biomarkers and effectors of the cellular interactome in cancer
    • Rak J, (2013) Extracellular vesicles—biomarkers and effectors of the cellular interactome in cancer. Front Pharmacol 4: 21. doi: 10.3389/fphar.2013.00021 23508692
    • (2013) Front Pharmacol , vol.4 , pp. 21
    • Rak, J.1
  • 50
    • 84871960964 scopus 로고    scopus 로고
    • Tumor-cell-derived microvesicles as carriers of molecular information in cancer
    • Martins VR, Dias MS, Hainaut P, (2013) Tumor-cell-derived microvesicles as carriers of molecular information in cancer. Curr Opin Oncol 25: 66–75. doi: 10.1097/CCO.0b013e32835b7c81 23165142
    • (2013) Curr Opin Oncol , vol.25 , pp. 66-75
    • Martins, V.R.1    Dias, M.S.2    Hainaut, P.3
  • 52
    • 80053309537 scopus 로고    scopus 로고
    • Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth
    • Kogure T, Lin WL, Yan IK, Braconi C, Patel T, (2011) Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology 54: 1237–1248. doi: 10.1002/hep.24504 21721029
    • (2011) Hepatology , vol.54 , pp. 1237-1248
    • Kogure, T.1    Lin, W.L.2    Yan, I.K.3    Braconi, C.4    Patel, T.5
  • 53
    • 84862908547 scopus 로고    scopus 로고
    • Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
    • Montecalvo A, Larregina AT, Shufesky WJ, Stolz DB, Sullivan ML, et al. (2012) Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 119: 756–766. doi: 10.1182/blood-2011-02-338004 22031862
    • (2012) Blood , vol.119 , pp. 756-766
    • Montecalvo, A.1    Larregina, A.T.2    Shufesky, W.J.3    Stolz, D.B.4    Sullivan, M.L.5
  • 54
    • 84874637012 scopus 로고    scopus 로고
    • Exosomal tumor microRNA modulates premetastatic organ cells
    • Rana S, Malinowska K, Zoller M, (2013) Exosomal tumor microRNA modulates premetastatic organ cells. Neoplasia 15: 281–295. 23479506
    • (2013) Neoplasia , vol.15 , pp. 281-295
    • Rana, S.1    Malinowska, K.2    Zoller, M.3
  • 55
    • 84879419464 scopus 로고    scopus 로고
    • Leukemia cell to endothelial cell communication via exosomal miRNAs
    • Umezu T, Ohyashiki K, Kuroda M, Ohyashiki JH, (2013) Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 32: 2747–2755. doi: 10.1038/onc.2012.295 22797057
    • (2013) Oncogene , vol.32 , pp. 2747-2755
    • Umezu, T.1    Ohyashiki, K.2    Kuroda, M.3    Ohyashiki, J.H.4
  • 56
    • 78650553841 scopus 로고    scopus 로고
    • Human tumor virus utilizes exosomes for intercellular communication
    • Meckes DG, Jr.Shair KH, Marquitz AR, Kung CP, Edwards RH, et al. (2010) Human tumor virus utilizes exosomes for intercellular communication. Proc Natl Acad Sci U S A 107: 20370–20375. doi: 10.1073/pnas.1014194107 21059916
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 20370-20375
    • Meckes, D.G.1    Shair, K.H.2    Marquitz, A.R.3    Kung, C.P.4    Edwards, R.H.5
  • 57
    • 80655147035 scopus 로고    scopus 로고
    • Viral miRNAs exploiting the endosomal-exosomal pathway for intercellular cross-talk and immune evasion
    • Pegtel DM, van de Garde MD, Middeldorp JM, (2011) Viral miRNAs exploiting the endosomal-exosomal pathway for intercellular cross-talk and immune evasion. Biochim Biophys Acta 1809: 715–721. doi: 10.1016/j.bbagrm.2011.08.002 21855666
    • (2011) Biochim Biophys Acta , vol.1809 , pp. 715-721
    • Pegtel, D.M.1    van de Garde, M.D.2    Middeldorp, J.M.3
  • 58
    • 84884765359 scopus 로고    scopus 로고
    • Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies
    • Chugh PE, Sin SH, Ozgur S, Henry DH, Menezes P, et al. (2013) Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies. PLoS Pathog 9: e1003484. doi: 10.1371/journal.ppat.1003484 23874201
    • (2013) PLoS Pathog , vol.9 , pp. 1003484
    • Chugh, P.E.1    Sin, S.H.2    Ozgur, S.3    Henry, D.H.4    Menezes, P.5
  • 59
    • 84862618600 scopus 로고    scopus 로고
    • Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers
    • D’Souza-Schorey C, Clancy JW, (2012) Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev 26: 1287–1299. doi: 10.1101/gad.192351.112 22713869
    • (2012) Genes Dev , vol.26 , pp. 1287-1299
    • D’Souza-Schorey, C.1    Clancy, J.W.2
  • 60
    • 84884585784 scopus 로고    scopus 로고
    • Exosomes: the future of biomarkers in medicine
    • Properzi F, Logozzi M, Fais S, (2013) Exosomes: the future of biomarkers in medicine. Biomark Med 7: 769–778. doi: 10.2217/bmm.13.63 24044569
    • (2013) Biomark Med , vol.7 , pp. 769-778
    • Properzi, F.1    Logozzi, M.2    Fais, S.3
  • 61
    • 84883548848 scopus 로고    scopus 로고
    • The origin, function, and diagnostic potential of RNA within extracellular vesicles present in human biological fluids
    • Taylor DD, Gercel-Taylor C, (2013) The origin, function, and diagnostic potential of RNA within extracellular vesicles present in human biological fluids. Front Genet 4: 142. doi: 10.3389/fgene.2013.00142 23908664
    • (2013) Front Genet , vol.4 , pp. 142
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 63
    • 84864448111 scopus 로고    scopus 로고
    • High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries
    • Mullokandov G, Baccarini A, Ruzo A, Jayaprakash AD, Tung N, et al. (2012) High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries. Nat Methods 9: 840–846. doi: 10.1038/nmeth.2078 22751203
    • (2012) Nat Methods , vol.9 , pp. 840-846
    • Mullokandov, G.1    Baccarini, A.2    Ruzo, A.3    Jayaprakash, A.D.4    Tung, N.5
  • 64
    • 84866423871 scopus 로고    scopus 로고
    • MicroRNAs in the p53 network: micromanagement of tumour suppression
    • Hermeking H, (2012) MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer 12: 613–626. doi: 10.1038/nrc3318 22898542
    • (2012) Nat Rev Cancer , vol.12 , pp. 613-626
    • Hermeking, H.1
  • 65
    • 21644448222 scopus 로고    scopus 로고
    • Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53
    • Hengstermann A, D’Silva M A, Kuballa P, Butz K, Hoppe-Seyler F, et al. (2005) Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53. J Virol 79: 9296–9300. 15994823
    • (2005) J Virol , vol.79 , pp. 9296-9300
    • Hengstermann, A.1    D’Silva, M.A.2    Kuballa, P.3    Butz, K.4    Hoppe-Seyler, F.5
  • 66
    • 48249098902 scopus 로고    scopus 로고
    • Antagomir-17–5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM
    • Fontana L, Fiori ME, Albini S, Cifaldi L, Giovinazzi S, et al. (2008) Antagomir-17–5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS One 3: e2236. doi: 10.1371/journal.pone.0002236 18493594
    • (2008) PLoS One , vol.3 , pp. 2236
    • Fontana, L.1    Fiori, M.E.2    Albini, S.3    Cifaldi, L.4    Giovinazzi, S.5
  • 67
    • 77951092028 scopus 로고    scopus 로고
    • Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region
    • Wu S, Huang S, Ding J, Zhao Y, Liang L, et al. (2010) Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3′ untranslated region. Oncogene 29: 2302–2308. doi: 10.1038/onc.2010.34 20190813
    • (2010) Oncogene , vol.29 , pp. 2302-2308
    • Wu, S.1    Huang, S.2    Ding, J.3    Zhao, Y.4    Liang, L.5
  • 68
    • 0037229178 scopus 로고    scopus 로고
    • Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells
    • DeFilippis RA, Goodwin EC, Wu L, DiMaio D, (2003) Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells. J Virol 77: 1551–1563. 12502868
    • (2003) J Virol , vol.77 , pp. 1551-1563
    • DeFilippis, R.A.1    Goodwin, E.C.2    Wu, L.3    DiMaio, D.4
  • 69
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Unit 3 22
    • Thery C, Amigorena S, Raposo G, Clayton A, (2006) Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol Chapter 3: Unit 3 22.
    • (2006) Curr Protoc Cell Biol Chapter , vol.3
    • Thery, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 70
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • Taylor DD, Gercel-Taylor C, (2008) MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 110: 13–21. doi: 10.1016/j.ygyno.2008.04.033 18589210
    • (2008) Gynecol Oncol , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 71
    • 84870599244 scopus 로고    scopus 로고
    • Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells
    • Bellingham SA, Coleman BM, Hill AF, (2012) Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells. Nucleic Acids Res.
    • (2012) Nucleic Acids Res
    • Bellingham, S.A.1    Coleman, B.M.2    Hill, A.F.3
  • 72
    • 84924845177 scopus 로고    scopus 로고
    • Analyzing the circulating microRNAs in exosomes/extracellular vesicles from serum or plasma by qRT-PCR
    • Moldovan L, Batte K, Wang Y, Wisler J, Piper M, (2013) Analyzing the circulating microRNAs in exosomes/extracellular vesicles from serum or plasma by qRT-PCR. Methods Mol Biol 1024: 129–145. doi: 10.1007/978-1-62703-453-1_10 23719947
    • (2013) Methods Mol Biol , vol.1024 , pp. 129-145
    • Moldovan, L.1    Batte, K.2    Wang, Y.3    Wisler, J.4    Piper, M.5
  • 73
    • 0033740178 scopus 로고    scopus 로고
    • Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways
    • Goodwin EC, DiMaio D, (2000) Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc Natl Acad Sci U S A 97: 12513–12518. 11070078
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 12513-12518
    • Goodwin, E.C.1    DiMaio, D.2
  • 74
    • 82355175140 scopus 로고    scopus 로고
    • Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation
    • Magaldi TG, Almstead LL, Bellone S, Prevatt EG, Santin AD, et al. (2012) Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation. Virology 422: 114–124. doi: 10.1016/j.virol.2011.10.012 22056390
    • (2012) Virology , vol.422 , pp. 114-124
    • Magaldi, T.G.1    Almstead, L.L.2    Bellone, S.3    Prevatt, E.G.4    Santin, A.D.5
  • 75
    • 0027158747 scopus 로고
    • Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
    • Hwang ES, Riese DJ, 2ndSettleman J, Nilson LA, Honig J, et al. (1993) Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. J Virol 67: 3720–3729. 8389903
    • (1993) J Virol , vol.67 , pp. 3720-3729
    • Hwang, E.S.1    Riese, D.J.2    Settleman, J.3    Nilson, L.A.4    Honig, J.5
  • 76
    • 0028824891 scopus 로고
    • Suppression of cellular proliferation by the papillomavirus E2 protein
    • Dowhanick JJ, McBride AA, Howley PM, (1995) Suppression of cellular proliferation by the papillomavirus E2 protein. J Virol 69: 7791–7799. 7494290
    • (1995) J Virol , vol.69 , pp. 7791-7799
    • Dowhanick, J.J.1    McBride, A.A.2    Howley, P.M.3
  • 77
    • 84880295341 scopus 로고    scopus 로고
    • Silencing of human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells
    • Honegger A, Leitz J, Bulkescher J, Hoppe-Seyler K, Hoppe-Seyler F, (2013) Silencing of human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells. Int J Cancer.
    • (2013) Int J Cancer
    • Honegger, A.1    Leitz, J.2    Bulkescher, J.3    Hoppe-Seyler, K.4    Hoppe-Seyler, F.5
  • 78
    • 0024784328 scopus 로고
    • Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene
    • Durst M, Gallahan D, Jay G, Rhim JS, (1989) Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene. Virology 173: 767–771. 2556855
    • (1989) Virology , vol.173 , pp. 767-771
    • Durst, M.1    Gallahan, D.2    Jay, G.3    Rhim, J.S.4
  • 79
    • 35448940511 scopus 로고    scopus 로고
    • Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses
    • Kuner R, Vogt M, Sultmann H, Buness A, Dymalla S, et al. (2007) Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses. J Mol Med (Berl) 85: 1253–1262. 17589817
    • (2007) J Mol Med (Berl) , vol.85 , pp. 1253-1262
    • Kuner, R.1    Vogt, M.2    Sultmann, H.3    Buness, A.4    Dymalla, S.5
  • 80
    • 65949124668 scopus 로고    scopus 로고
    • Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling
    • Buitrago-Perez A, Garaulet G, Vazquez-Carballo A, Paramio JM, Garcia-Escudero R, (2009) Molecular Signature of HPV-Induced Carcinogenesis: pRb, p53 and Gene Expression Profiling. Curr Genomics 10: 26–34. doi: 10.2174/138920209787581235 19721808
    • (2009) Curr Genomics , vol.10 , pp. 26-34
    • Buitrago-Perez, A.1    Garaulet, G.2    Vazquez-Carballo, A.3    Paramio, J.M.4    Garcia-Escudero, R.5
  • 81
    • 67749143728 scopus 로고    scopus 로고
    • Modulation of microRNA processing by p53
    • Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, et al. (2009) Modulation of microRNA processing by p53. Nature 460: 529–533. doi: 10.1038/nature08199 19626115
    • (2009) Nature , vol.460 , pp. 529-533
    • Suzuki, H.I.1    Yamagata, K.2    Sugimoto, K.3    Iwamoto, T.4    Kato, S.5
  • 82
    • 84896908234 scopus 로고    scopus 로고
    • Characterization of the microRNA expression profile of cervical squamous cell carcinoma metastases
    • Ding H, Wu YL, Wang YX, Zhu FF, (2014) Characterization of the microRNA expression profile of cervical squamous cell carcinoma metastases. Asian Pac J Cancer Prev 15: 1675–1679. 24641388
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 1675-1679
    • Ding, H.1    Wu, Y.L.2    Wang, Y.X.3    Zhu, F.F.4
  • 83
    • 78449268612 scopus 로고    scopus 로고
    • EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF
    • Chou YT, Lin HH, Lien YC, Wang YH, Hong CF, et al. (2010) EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF. Cancer Res 70: 8822–8831. doi: 10.1158/0008-5472.CAN-10-0638 20978205
    • (2010) Cancer Res , vol.70 , pp. 8822-8831
    • Chou, Y.T.1    Lin, H.H.2    Lien, Y.C.3    Wang, Y.H.4    Hong, C.F.5
  • 84
    • 51349103144 scopus 로고    scopus 로고
    • Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer
    • Foekens JA, Sieuwerts AM, Smid M, Look MP, de Weerd V, et al. (2008) Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer. Proc Natl Acad Sci U S A 105: 13021–13026. doi: 10.1073/pnas.0803304105 18755890
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13021-13026
    • Foekens, J.A.1    Sieuwerts, A.M.2    Smid, M.3    Look, M.P.4    de Weerd, V.5
  • 85
    • 83255162659 scopus 로고    scopus 로고
    • An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis
    • Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, et al. (2011) An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147: 1233–1247. doi: 10.1016/j.cell.2011.10.043 22153071
    • (2011) Cell , vol.147 , pp. 1233-1247
    • Hatziapostolou, M.1    Polytarchou, C.2    Aggelidou, E.3    Drakaki, A.4    Poultsides, G.A.5
  • 86
    • 84863070560 scopus 로고    scopus 로고
    • A functional polymorphism at microRNA-629-binding site in the 3′-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population
    • Yang L, Li Y, Cheng M, Huang D, Zheng J, et al. (2012) A functional polymorphism at microRNA-629-binding site in the 3′-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population. Carcinogenesis 33: 338–347. doi: 10.1093/carcin/bgr272 22114071
    • (2012) Carcinogenesis , vol.33 , pp. 338-347
    • Yang, L.1    Li, Y.2    Cheng, M.3    Huang, D.4    Zheng, J.5
  • 87
    • 79957558166 scopus 로고    scopus 로고
    • Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence
    • Dhahbi JM, Atamna H, Boffelli D, Magis W, Spindler SR, et al. (2011) Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence. PLoS One 6: e20509. doi: 10.1371/journal.pone.0020509 21637828
    • (2011) PLoS One , vol.6 , pp. 20509
    • Dhahbi, J.M.1    Atamna, H.2    Boffelli, D.3    Magis, W.4    Spindler, S.R.5
  • 88
    • 38049103266 scopus 로고    scopus 로고
    • MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression
    • Lee DY, Deng Z, Wang CH, Yang BB, (2007) MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression. Proc Natl Acad Sci U S A 104: 20350–20355. 18077375
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20350-20355
    • Lee, D.Y.1    Deng, Z.2    Wang, C.H.3    Yang, B.B.4
  • 89
    • 78649743127 scopus 로고    scopus 로고
    • Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
    • Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, et al. (2010) Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Blood 116: e118–127. doi: 10.1182/blood-2010-05-285403 20733160
    • (2010) Blood , vol.116 , pp. 118-127
    • Jima, D.D.1    Zhang, J.2    Jacobs, C.3    Richards, K.L.4    Dunphy, C.H.5
  • 91
    • 80052964176 scopus 로고    scopus 로고
    • The PKB/FOXO switch in aging and cancer
    • Kloet DE, Burgering BM, (2011) The PKB/FOXO switch in aging and cancer. Biochim Biophys Acta 1813: 1926–1937. doi: 10.1016/j.bbamcr.2011.04.003 21539865
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1926-1937
    • Kloet, D.E.1    Burgering, B.M.2
  • 92
    • 77956475436 scopus 로고    scopus 로고
    • Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24–2 cluster and its implication in human diseases
    • Chhabra R, Dubey R, Saini N, (2010) Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24–2 cluster and its implication in human diseases. Mol Cancer 9: 232. doi: 10.1186/1476-4598-9-232 20815877
    • (2010) Mol Cancer , vol.9 , pp. 232
    • Chhabra, R.1    Dubey, R.2    Saini, N.3
  • 93
    • 84877798880 scopus 로고    scopus 로고
    • High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan
    • Dellago H, Preschitz-Kammerhofer B, Terlecki-Zaniewicz L, Schreiner C, Fortschegger K, et al. (2013) High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan. Aging Cell 12: 446–458. doi: 10.1111/acel.12069 23496142
    • (2013) Aging Cell , vol.12 , pp. 446-458
    • Dellago, H.1    Preschitz-Kammerhofer, B.2    Terlecki-Zaniewicz, L.3    Schreiner, C.4    Fortschegger, K.5
  • 94
    • 78651359790 scopus 로고    scopus 로고
    • Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging
    • Lee S, Jung JW, Park SB, Roh K, Lee SY, et al. (2011) Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging. Cell Mol Life Sci 68: 325–336. doi: 10.1007/s00018-010-0457-9 20652617
    • (2011) Cell Mol Life Sci , vol.68 , pp. 325-336
    • Lee, S.1    Jung, J.W.2    Park, S.B.3    Roh, K.4    Lee, S.Y.5
  • 95
    • 84907546537 scopus 로고    scopus 로고
    • The microRNA-23b/27b/24–1 cluster is a disease progression marker and tumor suppressor in prostate cancer
    • Goto Y, Kojima S, Nishikawa R, Enokida H, Chiyomaru T, et al. (2014) The microRNA-23b/27b/24–1 cluster is a disease progression marker and tumor suppressor in prostate cancer. Oncotarget.
    • (2014) Oncotarget
    • Goto, Y.1    Kojima, S.2    Nishikawa, R.3    Enokida, H.4    Chiyomaru, T.5
  • 96
    • 84871222985 scopus 로고    scopus 로고
    • miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer
    • Majid S, Dar AA, Saini S, Arora S, Shahryari V, et al. (2012) miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer. Cancer Res 72: 6435–6446. doi: 10.1158/0008-5472.CAN-12-2181 23074286
    • (2012) Cancer Res , vol.72 , pp. 6435-6446
    • Majid, S.1    Dar, A.A.2    Saini, S.3    Arora, S.4    Shahryari, V.5
  • 97
    • 77958517467 scopus 로고    scopus 로고
    • MiRNA profile associated with replicative senescence, extended cell culture, and ectopic telomerase expression in human foreskin fibroblasts
    • Bonifacio LN, Jarstfer MB, (2010) MiRNA profile associated with replicative senescence, extended cell culture, and ectopic telomerase expression in human foreskin fibroblasts. PLoS One 5.
    • (2010) PLoS One , vol.5
    • Bonifacio, L.N.1    Jarstfer, M.B.2
  • 98
    • 64749116346 scopus 로고    scopus 로고
    • c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
    • Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, et al. (2009) c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 458: 762–765. doi: 10.1038/nature07823 19219026
    • (2009) Nature , vol.458 , pp. 762-765
    • Gao, P.1    Tchernyshyov, I.2    Chang, T.C.3    Lee, Y.S.4    Kita, K.5
  • 99
    • 84862812020 scopus 로고    scopus 로고
    • A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
    • Jiang S, Zhang LF, Zhang HW, Hu S, Lu MH, et al. (2012) A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. EMBO J 31: 1985–1998. doi: 10.1038/emboj.2012.45 22354042
    • (2012) EMBO J , vol.31 , pp. 1985-1998
    • Jiang, S.1    Zhang, L.F.2    Zhang, H.W.3    Hu, S.4    Lu, M.H.5
  • 100
    • 84903903537 scopus 로고    scopus 로고
    • Genus Beta Human Papillomavirus E6 Proteins Vary in Their Effects on the Transactivation of p53 Target Genes
    • White EA, Walther J, Javanbakht H, Howley PM, (2014) Genus Beta Human Papillomavirus E6 Proteins Vary in Their Effects on the Transactivation of p53 Target Genes. J Virol 88: 8201–8212. doi: 10.1128/JVI.01197-14 24850740
    • (2014) J Virol , vol.88 , pp. 8201-8212
    • White, E.A.1    Walther, J.2    Javanbakht, H.3    Howley, P.M.4
  • 101
    • 0030827303 scopus 로고    scopus 로고
    • Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
    • Funk JO, Waga S, Harry JB, Espling E, Stillman B, et al. (1997) Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. Genes Dev 11: 2090–2100. 9284048
    • (1997) Genes Dev , vol.11 , pp. 2090-2100
    • Funk, J.O.1    Waga, S.2    Harry, J.B.3    Espling, E.4    Stillman, B.5
  • 102
    • 0030756473 scopus 로고    scopus 로고
    • The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2
    • Jones DL, Alani RM, Munger K, (1997) The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev 11: 2101–2111. 9284049
    • (1997) Genes Dev , vol.11 , pp. 2101-2111
    • Jones, D.L.1    Alani, R.M.2    Munger, K.3
  • 103
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, et al. (2005) MicroRNA expression profiles classify human cancers. Nature 435: 834–838. 15944708
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3    Alvarez-Saavedra, E.4    Lamb, J.5
  • 104
    • 33644819964 scopus 로고    scopus 로고
    • Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    • Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, et al. (2006) Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9: 189–198. 16530703
    • (2006) Cancer Cell , vol.9 , pp. 189-198
    • Yanaihara, N.1    Caplen, N.2    Bowman, E.3    Seike, M.4    Kumamoto, K.5
  • 105
    • 84890907806 scopus 로고    scopus 로고
    • Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
    • Villarroya-Beltri C, Gutierrez-Vazquez C, Sanchez-Cabo F, Perez-Hernandez D, Vazquez J, et al. (2013) Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun 4: 2980. doi: 10.1038/ncomms3980 24356509
    • (2013) Nat Commun , vol.4 , pp. 2980
    • Villarroya-Beltri, C.1    Gutierrez-Vazquez, C.2    Sanchez-Cabo, F.3    Perez-Hernandez, D.4    Vazquez, J.5
  • 107
    • 84866974959 scopus 로고    scopus 로고
    • Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples
    • Nuovo GJ, Garofalo M, Valeri N, Roulstone V, Volinia S, et al. (2012) Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples. Mod Pathol 25: 1333–1344. doi: 10.1038/modpathol.2012.95 22699519
    • (2012) Mod Pathol , vol.25 , pp. 1333-1344
    • Nuovo, G.J.1    Garofalo, M.2    Valeri, N.3    Roulstone, V.4    Volinia, S.5
  • 108
    • 84857399748 scopus 로고    scopus 로고
    • Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA
    • Volinia S, Galasso M, Sana ME, Wise TF, Palatini J, et al. (2012) Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA. Proc Natl Acad Sci U S A 109: 3024–3029. doi: 10.1073/pnas.1200010109 22315424
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3024-3029
    • Volinia, S.1    Galasso, M.2    Sana, M.E.3    Wise, T.F.4    Palatini, J.5
  • 109
    • 78449293102 scopus 로고    scopus 로고
    • The miR-17–92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence
    • Hong L, Lai M, Chen M, Xie C, Liao R, et al. (2010) The miR-17–92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res 70: 8547–8557. doi: 10.1158/0008-5472.CAN-10-1938 20851997
    • (2010) Cancer Res , vol.70 , pp. 8547-8557
    • Hong, L.1    Lai, M.2    Chen, M.3    Xie, C.4    Liao, R.5
  • 110
    • 84896495128 scopus 로고    scopus 로고
    • miR-92a family and their target genes in tumorigenesis and metastasis
    • Li M, Guan X, Sun Y, Shu X, Li C, (2014) miR-92a family and their target genes in tumorigenesis and metastasis. Exp Cell Res.
    • (2014) Exp Cell Res
    • Li, M.1    Guan, X.2    Sun, Y.3    Shu, X.4    Li, C.5
  • 111
    • 84907485172 scopus 로고    scopus 로고
    • MicroRNAs in cancer
    • Di Leva G, Garofalo M, Croce CM, (2014) MicroRNAs in cancer. Annu Rev Pathol 9: 287–314. doi: 10.1146/annurev-pathol-012513-104715 24079833
    • (2014) Annu Rev Pathol , vol.9 , pp. 287-314
    • Di Leva, G.1    Garofalo, M.2    Croce, C.M.3
  • 112
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • Raposo G, Stoorvogel W, (2013) Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 200: 373–383. doi: 10.1083/jcb.201211138 23420871
    • (2013) J Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 113
    • 81055157988 scopus 로고    scopus 로고
    • Exosome secretion: molecular mechanisms and roles in immune responses
    • Bobrie A, Colombo M, Raposo G, Thery C, (2011) Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12: 1659–1668. doi: 10.1111/j.1600-0854.2011.01225.x 21645191
    • (2011) Traffic , vol.12 , pp. 1659-1668
    • Bobrie, A.1    Colombo, M.2    Raposo, G.3    Thery, C.4
  • 114
    • 80052381608 scopus 로고    scopus 로고
    • Characterization of extracellular circulating microRNA
    • Turchinovich A, Weiz L, Langheinz A, Burwinkel B, (2011) Characterization of extracellular circulating microRNA. Nucleic Acids Res 39: 7223–7233. doi: 10.1093/nar/gkr254 21609964
    • (2011) Nucleic Acids Res , vol.39 , pp. 7223-7233
    • Turchinovich, A.1    Weiz, L.2    Langheinz, A.3    Burwinkel, B.4
  • 115
    • 84875033024 scopus 로고    scopus 로고
    • Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations
    • Williams Z, Ben-Dov IZ, Elias R, Mihailovic A, Brown M, et al. (2013) Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations. Proc Natl Acad Sci U S A 110: 4255–4260. doi: 10.1073/pnas.1214046110 23440203
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 4255-4260
    • Williams, Z.1    Ben-Dov, I.Z.2    Elias, R.3    Mihailovic, A.4    Brown, M.5
  • 116
    • 84926430567 scopus 로고    scopus 로고
    • MicroRNAs as Cancer Biomarkers
    • Nouraee N, Calin GA, (2013) MicroRNAs as Cancer Biomarkers. Microrna 2: 102–117. 25070780
    • (2013) Microrna , vol.2 , pp. 102-117
    • Nouraee, N.1    Calin, G.A.2
  • 117
    • 84905122848 scopus 로고    scopus 로고
    • MicroRNAs in cancer: biomarkers, functions and therapy
    • Hayes J, Peruzzi PP, Lawler S, (2014) MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med 20: 460–469. doi: 10.1016/j.molmed.2014.06.005 25027972
    • (2014) Trends Mol Med , vol.20 , pp. 460-469
    • Hayes, J.1    Peruzzi, P.P.2    Lawler, S.3
  • 118
    • 84857968441 scopus 로고    scopus 로고
    • The majority of microRNAs detectable in serum and saliva is concentrated in exosomes
    • Gallo A, Tandon M, Alevizos I, Illei GG, (2012) The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS One 7: e30679. doi: 10.1371/journal.pone.0030679 22427800
    • (2012) PLoS One , vol.7 , pp. 30679
    • Gallo, A.1    Tandon, M.2    Alevizos, I.3    Illei, G.G.4
  • 119
    • 84871346487 scopus 로고    scopus 로고
    • Clinical applications for microRNAs in cancer
    • Nana-Sinkam SP, Croce CM, (2013) Clinical applications for microRNAs in cancer. Clin Pharmacol Ther 93: 98–104. doi: 10.1038/clpt.2012.192 23212103
    • (2013) Clin Pharmacol Ther , vol.93 , pp. 98-104
    • Nana-Sinkam, S.P.1    Croce, C.M.2
  • 120
    • 77954056447 scopus 로고    scopus 로고
    • A direct phenotypic comparison of siRNA pools and multiple individual duplexes in a functional assay
    • Parsons BD, Schindler A, Evans DH, Foley E, (2009) A direct phenotypic comparison of siRNA pools and multiple individual duplexes in a functional assay. PLoS One 4: e8471. doi: 10.1371/journal.pone.0008471 20041186
    • (2009) PLoS One , vol.4 , pp. 8471
    • Parsons, B.D.1    Schindler, A.2    Evans, D.H.3    Foley, E.4
  • 121
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • Jackson AL, Linsley PS, (2010) Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov 9: 57–67. doi: 10.1038/nrd3010 20043028
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 122
    • 0023392945 scopus 로고
    • High-efficiency transformation of mammalian cells by plasmid DNA
    • Chen C, Okayama H, (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7: 2745–2752. 3670292
    • (1987) Mol Cell Biol , vol.7 , pp. 2745-2752
    • Chen, C.1    Okayama, H.2
  • 124
    • 0019032544 scopus 로고
    • A model for the computer analysis of synchronous DNA distributions obtained by flow cytometry
    • Fox MH, (1980) A model for the computer analysis of synchronous DNA distributions obtained by flow cytometry. Cytometry 1: 71–77. 7023881
    • (1980) Cytometry , vol.1 , pp. 71-77
    • Fox, M.H.1
  • 125
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri GP, Lee X, Basile G, Acosta M, Scott G, et al. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92: 9363–9367. 7568133
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3    Acosta, M.4    Scott, G.5
  • 126
    • 0032514283 scopus 로고    scopus 로고
    • Uncoupling of p21WAF1/CIP1/SDI1 mRNA and protein expression upon genotoxic stress
    • Butz K, Geisen C, Ullmann A, Zentgraf H, Hoppe-Seyler F, (1998) Uncoupling of p21WAF1/CIP1/SDI1 mRNA and protein expression upon genotoxic stress. Oncogene 17: 781–787. 9715280
    • (1998) Oncogene , vol.17 , pp. 781-787
    • Butz, K.1    Geisen, C.2    Ullmann, A.3    Zentgraf, H.4    Hoppe-Seyler, F.5
  • 127
    • 33344474696 scopus 로고    scopus 로고
    • Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells
    • Crnkovic-Mertens I, Semzow J, Hoppe-Seyler F, Butz K, (2006) Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells. J Mol Med (Berl) 84: 232–240. 16437214
    • (2006) J Mol Med (Berl) , vol.84 , pp. 232-240
    • Crnkovic-Mertens, I.1    Semzow, J.2    Hoppe-Seyler, F.3    Butz, K.4
  • 128
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402–408. 11846609
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 129
    • 84855293838 scopus 로고    scopus 로고
    • miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
    • Friedlander MR, Mackowiak SD, Li N, Chen W, Rajewsky N, (2012) miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res 40: 37–52. doi: 10.1093/nar/gkr688 21911355
    • (2012) Nucleic Acids Res , vol.40 , pp. 37-52
    • Friedlander, M.R.1    Mackowiak, S.D.2    Li, N.3    Chen, W.4    Rajewsky, N.5
  • 130
    • 84873607610 scopus 로고    scopus 로고
    • Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer
    • Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, et al. (2013) Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell 23: 159–170. doi: 10.1016/j.ccr.2013.01.002 23410972
    • (2013) Cancer Cell , vol.23 , pp. 159-170
    • Weischenfeldt, J.1    Simon, R.2    Feuerbach, L.3    Schlangen, K.4    Weichenhan, D.5
  • 131
    • 0347755643 scopus 로고    scopus 로고
    • The microRNA Registry
    • Griffiths-Jones S, (2004) The microRNA Registry. Nucleic Acids Res 32: D109–111. 14681370
    • (2004) Nucleic Acids Res , vol.32 , pp. 109-111
    • Griffiths-Jones, S.1
  • 134
    • 78651293534 scopus 로고    scopus 로고
    • miRBase: integrating microRNA annotation and deep-sequencing data
    • Kozomara A, Griffiths-Jones S, (2011) miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res 39: D152–157. doi: 10.1093/nar/gkq1027 21037258
    • (2011) Nucleic Acids Res , vol.39 , pp. 152-157
    • Kozomara, A.1    Griffiths-Jones, S.2


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