mir-17-92: A polycistronic oncomir with pleiotropic functions

Immunological Reviews

Volumn 253, Issue 1, 2013, Pages 158-166

  Olive, Virginie ^a   Li, Qijing ^b   He, Lin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cancer; miR17 92; miRNAs

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; JANUS KINASE 1; JANUS KINASE 2; MICRORNA; MICRORNA 17; MICRORNA 92; MIR 19; MYC PROTEIN; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; RAS PROTEIN; STAT5 PROTEIN; TENSIN; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ANGIOGENESIS; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; BURKITT LYMPHOMA; CARCINOGENESIS; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; COLON CANCER; ERYTHROLEUKEMIA; FIBROBLAST; FOLLICULAR LYMPHOMA; GENE AMPLIFICATION; GENE STRUCTURE; GENOME; HUMAN; IMMUNE SYSTEM; LIVER CANCER; LUNG CANCER; LUNG HYPOPLASIA; MALIGNANT TRANSFORMATION; MANTLE CELL LYMPHOMA; METASTASIS; MOLECULAR DYNAMICS; NEOPLASM; NONHUMAN; ONCOGENE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINOBLASTOMA; SOLID TUMOR; STEM CELL; TRANSCRIPTION REGULATION; TRANSGENE; TUMOR CELL; TUMOR GROWTH;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLULAR MICROENVIRONMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEOPLASMS; ONCOGENES; ORGAN SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875795070     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12054     Document Type: Article

References (59)

1. Ambros V. The functions of animal microRNAs. Nature 2004;431:350-355.
2. Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science 2005;309:1519-1524.
3. Kim VN, Han J, Siomi MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 2009;10:126-139.
4. Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nature reviews. Genetics 2008;9:102-114.
5. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009;136:215-233.
6. Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD. Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell 2012;151:1055-1067.
7. Guo H, Ingolia NT, Weissman JS, Bartel DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010;466:835-840.
8. Bagga S, et al. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 2005;122:553-563.
9. Bazzini A, Lee MT, Giraldez AJ. Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish. Science 2012;336:233-237.
10. Djuranovic S, Nahvi A, Green R. miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science 2012;336:237-240.
11. Megraw M, Sethupathy P, Corda B, Hatzigeorgiou AG. miRGen: a database for the study of animal microRNA genomic organization and function. Nucleic Acids Res 2007;35:D149-D155.
12. Cheloufi S, Dos Santos CO, Chong MMW, Hannon GJ. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 2010;465:584-589.
13. Cifuentes D, et al. A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science 2010;328:1694-1698.
14. Blumenthal T. Operons in eukaryotes. Brief Funct Genomics Proteomics 2004;3:199-211.
15. Ota A, et al. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res 2004;64:3087-3095.
16. Tagawa H, Seto M. A microRNA cluster as a target of genomic amplification in malignant lymphoma. Leukemia 2005;19:2013-2016.
17. Hayashita Y, et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 2005;65:9628-9632.
18. Takakura S, et al. Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells. Cancer Sci 2008;99:1147-1154.
19. Lu J, et al. MicroRNA expression profiles classify human cancers. Nature 2005;435:834-838.
20. Tanzer A, Stadler PF. Molecular evolution of a microRNA cluster. J Mol Biol 2004;339:327-335.
21. Mendell JT. miRiad roles for the miR-17-92 cluster in development and disease. Cell 2008;133:217-222.
22. Ventura A, et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 2008;132:875-886.
23. Xiao C, et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 2008;9:405-414.
24. Oeztuerk-Winder F, Guinot A, Ochalek A, Ventura J-J. Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis. EMBO J 2012;31:3431-3441.
25. Lu Y, Thomson JM, Wong HYF, Hammond SM, Hogan BLM. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol 2007;310:442-453.
26. Jiang S, et al. Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood 2011;118:5487-5497.
27. Wu T, et al. Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation. Proc Natl Acad Sci USA 2012;109:9965-9970.
28. Calin GA, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004;101:2999-3004.
29. He L, et al. A microRNA component of the p53 tumour suppressor network. Nature 2007;447:1130-1134.
30. Adams JM, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985;318:533-538.
31. He L, et al. A microRNA polycistron as a potential human oncogene. Nature 2005;435:828-833.
32. Uziel T, et al. The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci USA 2009;106:2812-2817.
33. Wong P, et al. The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res 2010;70:3833-3842.
34. Conkrite K, et al. miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma. Genes Dev 2011;25:1734-1745.
35. Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004;432:307-315.
36. Olive V, et al. miR-19 is a key oncogenic component of mir-17-92. Genes Dev 2009;23:2839-2849.
37. Mu P, et al. Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev 2009;23:2806-2811.
38. Mavrakis KJ, et al. Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia. Nat Cell Biol 2010;12:372-379.
39. Hong L, et al. The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res 2010;70:8547-8557.
40. Nittner D, et al. Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. Nat Cell Biol 2012;14:958-965.
41. Seoane J, Le HV, Massagué J. Cell culture Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 2002;419:729-734.
42. Tsuchida A, et al. miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer. Cancer Sci 2011;102:2264-2271.
43. Li Y, et al. The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice. Blood 2012;119:4486-4498.
44. Shan SW, et al. MicroRNA MiR-17 retards tissue growth and represses fibronectin expression. Nat Cell Biol 2009;11:1031-1038.
45. Hossain A, Kuo MT, Saunders GF. Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol 2006;26:8191-8201.
46. Zhang L, et al. microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acac Sci USA 2006;103:9136-9141.
47. Dews M, et al. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet 2006;38:1060-1065.
48. Doebele C, et al. Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood 2010;115:4944-4950.
49. Donnell KAO, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005;435:839-843.
50. Mestdagh P, et al. The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma. Mol Cell 2010;40:762-773.
51. Woods K, Thomson JM, Hammond SM. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem 2007;282:2130-2134.
52. Kayali S, Giraud G, Morlé F, Guyot B. Spi-1, Fli-1 and Fli-3 (miR-17-92) oncogenes contribute to a single oncogenic network controlling cell proliferation in friend erythroleukemia. PLoS One 2012;7:e46799.
53. Mi S, et al. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci USA 2010;107:3710-3715.
54. Pospisil V, et al. Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation. EMBO J 2011;30:4450-4464.
55. Fassina A, et al. The miR-17-92 microRNA cluster: a novel diagnostic tool in large B-cell malignancies. Lab Invest 2012;92:1574-1582.
56. Gao X, et al. MiR-15a, miR-16-1 and miR-17-92 cluster expression are linked to poor prognosis in multiple myeloma. Leukemia Res 2012;36:1505-1509.
57. Chaulk SG, et al. Role of pri-miRNA tertiary structure in miR-17~92 miRNA biogenesis. RNA Biol 2011;8:1105-1114.
58. Guil S, Cáceres JF. The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nat Struct Mol Biol 2007;14:591-596.
59. Heo I, et al. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 2009;138:696-708.