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Volumn , Issue , 2013, Pages 217-233

Exploring systemic functions of lysosomal proteases: The perspective of genetically modified mouse models

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EID: 84926498939     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-7091-0885-7_6     Document Type: Chapter
Times cited : (3)

References (88)
  • 2
    • 78149471570 scopus 로고    scopus 로고
    • Autophagy in neurodegenerative disorders: Pathogenic roles and therapeutic implications
    • Banerjee R, Beal MF, Thomas B (2010) Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications. Trends Neurosci 33:541-549
    • (2010) Trends Neurosci , vol.33 , pp. 541-549
    • Banerjee, R.1    Beal, M.F.2    Thomas, B.3
  • 3
    • 77956063541 scopus 로고    scopus 로고
    • Pathophysiology of neuropathic lysosomal storage disorders
    • Bellettato CM, Scarpa M (2010) Pathophysiology of neuropathic lysosomal storage disorders. J Inherit Metab Dis 33:347-362
    • (2010) J Inherit Metab Dis , vol.33 , pp. 347-362
    • Bellettato, C.M.1    Scarpa, M.2
  • 6
    • 0036968842 scopus 로고    scopus 로고
    • Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation
    • Benavides F, Starost MF, Flores M, Gimenez-Conti IB, Guenet JL, Conti CJ (2002) Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation. Am J Pathol 161:693-703
    • (2002) Am J Pathol , vol.161 , pp. 693-703
    • Benavides, F.1    Starost, M.F.2    Flores, M.3    Gimenez-Conti, I.B.4    Guenet, J.L.5    Conti, C.J.6
  • 7
    • 84858150882 scopus 로고    scopus 로고
    • SM, Kusewitt DF, Digiovanni J, Conti CJ (2012) Protective role of cathepsin L in mouse skin carcinogenesis
    • Fischer
    • Benavides F, Perez C, Blando J, Contreras O, Shen J, Coussens LM, Fischer SM, Kusewitt DF, Digiovanni J, Conti CJ (2012) Protective role of cathepsin L in mouse skin carcinogenesis. Mol Carcinog 51:352-361
    • Mol Carcinog , vol.51 , pp. 352-361
    • Benavides, F.1    Perez, C.2    Blando, J.3    Contreras, O.4    Shen, J.5    Coussens, L.M.6
  • 8
    • 0037379365 scopus 로고    scopus 로고
    • Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called stratum corneum thiol protease as cathepsin l2
    • Bernard D, Mehul B, Thomas-Collignon A, Simonetti L, Remy V, Bernard MA, Schmidt R (2003) Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called 'stratum corneum thiol protease' as cathepsin l2. J Invest Dermatol 120:592-600
    • (2003) J Invest Dermatol , vol.120 , pp. 592-600
    • Bernard, D.1    Mehul, B.2    Thomas-Collignon, A.3    Simonetti, L.4    Remy, V.5    Bernard, M.A.6    Schmidt, R.7
  • 9
    • 38649111363 scopus 로고    scopus 로고
    • Cysteine cathepsins: Cellular roadmap to different functions
    • Brix K, Dunkhorst A, Mayer K, Jordans S (2008) Cysteine cathepsins: cellular roadmap to different functions. Biochimie 90:194-207
    • (2008) Biochimie , vol.90 , pp. 194-207
    • Brix, K.1    Dunkhorst, A.2    Mayer, K.3    Jordans, S.4
  • 12
    • 19544371373 scopus 로고    scopus 로고
    • Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century
    • Capecchi MR (2005) Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet 6:507-512
    • (2005) Nat Rev Genet , vol.6 , pp. 507-512
    • Capecchi, M.R.1
  • 13
    • 33744915019 scopus 로고    scopus 로고
    • Cystatin M/E is a high affinity inhibitor of cathepsin v and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification
    • Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL (2006) Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem 281: 15893-15899
    • (2006) J Biol Chem , vol.281 , pp. 15893-15899
    • Cheng, T.1    Hitomi, K.2    Van Vlijmen-Willems, I.M.3    De Jongh, G.J.4    Yamamoto, K.5    Nishi, K.6    Watts, C.7    Reinheckel, T.8    Schalkwijk, J.9    Zeeuwen, P.L.10
  • 19
    • 0021879684 scopus 로고
    • Expression of a microinjected porcine class i major histocompatibility complex gene in transgenic mice
    • Frels WI, Bluestone JA, Hodes RJ, Capecchi MR, Singer DS (1985) Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Science 228: 577-580
    • (1985) Science , vol.228 , pp. 577-580
    • Frels, W.I.1    Bluestone, J.A.2    Hodes, R.J.3    Capecchi, M.R.4    Singer, D.S.5
  • 22
    • 68349145078 scopus 로고    scopus 로고
    • Next-generation gene targeting in the mouse for functional genomics
    • Gondo Y, Fukumura R, Murata T, Makino S (2009) Next-generation gene targeting in the mouse for functional genomics. BMB Rep 42:315-323
    • (2009) BMB Rep , vol.42 , pp. 315-323
    • Gondo, Y.1    Fukumura, R.2    Murata, T.3    Makino, S.4
  • 23
    • 0000701072 scopus 로고
    • The genetics of a new hair deficiency, furless, in the house mouse
    • Green EL (1954) The genetics of a new hair deficiency, furless, in the house mouse. J Hered 45: 115-118
    • (1954) J Hered , vol.45 , pp. 115-118
    • Green, E.L.1
  • 28
    • 0043011297 scopus 로고    scopus 로고
    • Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)
    • Houseweart MK, Pennacchio LA, Vilaythong A, Peters C, Noebels JL, Myers RM (2003) Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J Neurobiol 56:315-327
    • (2003) J Neurobiol , vol.56 , pp. 315-327
    • Houseweart, M.K.1    Pennacchio, L.A.2    Vilaythong, A.3    Peters, C.4    Noebels, J.L.5    Myers, R.M.6
  • 29
    • 26244445000 scopus 로고    scopus 로고
    • The lysosomal cysteine proteases in MHC class II antigen presentation
    • Hsing LC, Rudensky AY (2005) The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol Rev 207:229-241
    • (2005) Immunol Rev , vol.207 , pp. 229-241
    • Hsing, L.C.1    Rudensky, A.Y.2
  • 35
    • 77950487987 scopus 로고    scopus 로고
    • Mechanisms of cross-Talk between the ubiquitin-proteasome and autophagy-lysosome systems
    • Korolchuk VI, Menzies FM, Rubinsztein DC (2010) Mechanisms of cross-Talk between the ubiquitin-proteasome and autophagy-lysosome systems. FEBS Lett 584:1393-1398
    • (2010) FEBS Lett , vol.584 , pp. 1393-1398
    • Korolchuk, V.I.1    Menzies, F.M.2    Rubinsztein, D.C.3
  • 37
    • 0035446403 scopus 로고    scopus 로고
    • Cystatin B-deficient mice have increased expression of apoptosis and glial activation genes
    • Lieuallen K, Pennacchio LA, Park M, Myers RM, Lennon GG (2001) Cystatin B-deficient mice have increased expression of apoptosis and glial activation genes. Hum Mol Genet 10: 1867-1871
    • (2001) Hum Mol Genet , vol.10 , pp. 1867-1871
    • Lieuallen, K.1    Pennacchio, L.A.2    Park, M.3    Myers, R.M.4    Lennon, G.G.5
  • 38
  • 40
    • 79953163995 scopus 로고    scopus 로고
    • Proteolytic networks in cancer
    • Mason SD, Joyce JA (2011) Proteolytic networks in cancer. Trends Cell Biol 21:228-237
    • (2011) Trends Cell Biol , vol.21 , pp. 228-237
    • Mason, S.D.1    Joyce, J.A.2
  • 41
    • 33749017931 scopus 로고    scopus 로고
    • Cysteine cathepsins: Multifunctional enzymes in cancer
    • Mohamed MM, Sloane BF (2006) Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6:764-775
    • (2006) Nat Rev Cancer , vol.6 , pp. 764-775
    • Mohamed, M.M.1    Sloane, B.F.2
  • 43
    • 0025826050 scopus 로고
    • Lysosomal storage diseases
    • Neufeld EF (1991) Lysosomal storage diseases. Annu Rev Biochem 60:257-280
    • (1991) Annu Rev Biochem , vol.60 , pp. 257-280
    • Neufeld, E.F.1
  • 44
    • 12844286997 scopus 로고    scopus 로고
    • Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture
    • Newby AC (2005) Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev 85:1-31
    • (2005) Physiol Rev , vol.85 , pp. 1-31
    • Newby, A.C.1
  • 46
    • 3042595457 scopus 로고    scopus 로고
    • Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity
    • Ondr JK, Pham CT (2004) Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity. J Biol Chem 279:27525-27533
    • (2004) J Biol Chem , vol.279 , pp. 27525-27533
    • Ondr, J.K.1    Pham, C.T.2
  • 50
    • 0033587689 scopus 로고    scopus 로고
    • Dipeptidyl peptidase i is required for the processing and activation of granzymes A and B in vivo
    • Pham CT, Ley TJ (1999) Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci U S A 96:8627-8632
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8627-8632
    • Pham, C.T.1    Ley, T.J.2
  • 52
    • 0034930528 scopus 로고    scopus 로고
    • Towards specific functions of lysosomal cysteine peptidases: Phenotypes of mice deficient for cathepsin B or cathepsin L
    • Reinheckel T, Deussing J, Roth W, Peters C (2001) Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. Biol Chem 382:735-741
    • (2001) Biol Chem , vol.382 , pp. 735-741
    • Reinheckel, T.1    Deussing, J.2    Roth, W.3    Peters, C.4
  • 54
    • 77957855881 scopus 로고    scopus 로고
    • Specialized roles for cysteine cathepsins in health and disease
    • Reiser J, Adair B, Reinheckel T (2010) Specialized roles for cysteine cathepsins in health and disease. J Clin Invest 120:3421-3431
    • (2010) J Clin Invest , vol.120 , pp. 3421-3431
    • Reiser, J.1    Adair, B.2    Reinheckel, T.3
  • 55
    • 27844547641 scopus 로고    scopus 로고
    • Molecular dissection of mesenchymal-epithelial interactions in the hair follicle
    • Rendl M, Lewis L, Fuchs E (2005) Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol 3:e331
    • (2005) PLoS Biol , vol.3 , pp. e331
    • Rendl, M.1    Lewis, L.2    Fuchs, E.3
  • 57
    • 0029083689 scopus 로고
    • Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
    • Saftig P, Hetman M, Schmahl W, Weber K, Heine L, Mossmann H, Koster A, Hess B, Evers M, von Figura K et al (1995) Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J 14:3599-3608
    • (1995) EMBO J , vol.14 , pp. 3599-3608
    • Saftig, P.1    Hetman, M.2    Schmahl, W.3    Weber, K.4    Heine, L.5    Mossmann, H.6    Koster, A.7    Hess, B.8    Evers, M.9    Von Figura, K.10
  • 59
    • 33746255613 scopus 로고    scopus 로고
    • Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice
    • Sevenich L, Pennacchio LA, Peters C, Reinheckel T (2006) Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol Chem 387: 885-891
    • (2006) Biol Chem , vol.387 , pp. 885-891
    • Sevenich, L.1    Pennacchio, L.A.2    Peters, C.3    Reinheckel, T.4
  • 67
    • 34447636403 scopus 로고    scopus 로고
    • Do cathepsins play a role in abdominal aortic aneurysm pathogenesis?
    • Sukhova GK, Shi GP (2006) Do cathepsins play a role in abdominal aortic aneurysm pathogenesis? Ann N Y Acad Sci 1085:161-169
    • (2006) Ann N y Acad Sci , vol.1085 , pp. 161-169
    • Sukhova, G.K.1    Shi, G.P.2
  • 68
    • 0032145836 scopus 로고    scopus 로고
    • Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
    • Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P (1998) Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 102:576-583
    • (1998) J Clin Invest , vol.102 , pp. 576-583
    • Sukhova, G.K.1    Shi, G.P.2    Simon, D.I.3    Chapman, H.A.4    Libby, P.5
  • 70
    • 14044271503 scopus 로고    scopus 로고
    • Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice
    • Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP (2005) Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res 96:368-375
    • (2005) Circ Res , vol.96 , pp. 368-375
    • Sukhova, G.K.1    Wang, B.2    Libby, P.3    Pan, J.H.4    Zhang, Y.5    Grubb, A.6    Fang, K.7    Chapman, H.A.8    Shi, G.P.9
  • 73
    • 33644758571 scopus 로고    scopus 로고
    • Murine cathepsin f deficiency causes neuronal lipofuscinosis and late-onset neurological disease
    • Tang CH, Lee JW, Galvez MG, Robillard L, Mole SE, Chapman HA (2006) Murine cathepsin f deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Mol Cell Biol 26:2309-2316
    • (2006) Mol Cell Biol , vol.26 , pp. 2309-2316
    • Tang, C.H.1    Lee, J.W.2    Galvez, M.G.3    Robillard, L.4    Mole, S.E.5    Chapman, H.A.6
  • 74
    • 60549104999 scopus 로고    scopus 로고
    • Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling
    • Tang Q, Cai J, Shen D, Bian Z, Yan L, Wang YX, Lan J, Zhuang GQ, Ma WZ, Wang W (2009) Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling. J Mol Med 87:249-260
    • (2009) J Mol Med , vol.87 , pp. 249-260
    • Tang, Q.1    Cai, J.2    Shen, D.3    Bian, Z.4    Yan, L.5    Wang, Y.X.6    Lan, J.7    Zhuang, G.Q.8    Ma, W.Z.9    Wang, W.10
  • 75
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryoderived stem cells
    • Thomas KR, Capecchi MR (1987) Site-directed mutagenesis by gene targeting in mouse embryoderived stem cells. Cell 51:503-512
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 76
    • 0036097449 scopus 로고    scopus 로고
    • The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling
    • Tobin DJ, Foitzik K, Reinheckel T, Mecklenburg L, Botchkarev VA, Peters C, Paus R (2002) The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol 160:1807-1821
    • (2002) Am J Pathol , vol.160 , pp. 1807-1821
    • Tobin, D.J.1    Foitzik, K.2    Reinheckel, T.3    Mecklenburg, L.4    Botchkarev, V.A.5    Peters, C.6    Paus, R.7
  • 78
    • 69249140641 scopus 로고    scopus 로고
    • Lysosomes as suicide bags in cell death myth or reality?
    • Turk B, Turk V (2009) Lysosomes as 'suicide bags' in cell death: myth or reality?. J Biol Chem 284:21783-21787
    • (2009) J Biol Chem , vol.284 , pp. 21783-21787
    • Turk, B.1    Turk, V.2
  • 79
    • 0034659833 scopus 로고    scopus 로고
    • A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration
    • Tyynela J, Sohar I, Sleat DE, Gin RM, Donnelly RJ, Baumann M, Haltia M, Lobel P (2000) A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration. EMBO J 19:2786-2792
    • (2000) EMBO J , vol.19 , pp. 2786-2792
    • Tyynela, J.1    Sohar, I.2    Sleat, D.E.3    Gin, R.M.4    Donnelly, R.J.5    Baumann, M.6    Haltia, M.7    Lobel, P.8
  • 81
    • 65949117636 scopus 로고    scopus 로고
    • Macrophages: Promising targets for the treatment of atherosclerosis
    • Wilson HM, Barker RN, Erwig LP (2009) Macrophages: promising targets for the treatment of atherosclerosis. Curr Vasc Pharmacol 7:234-243
    • (2009) Curr Vasc Pharmacol , vol.7 , pp. 234-243
    • Wilson, H.M.1    Barker, R.N.2    Erwig, L.P.3
  • 82
  • 84
    • 0036848352 scopus 로고    scopus 로고
    • A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification
    • Zeeuwen PL, van Vlijmen-Willems IM, Hendriks W, Merkx GF, Schalkwijk J (2002) A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification. Hum Mol Genet 11:2867-2875
    • (2002) Hum Mol Genet , vol.11 , pp. 2867-2875
    • Zeeuwen, P.L.1    Van Vlijmen-Willems, I.M.2    Hendriks, W.3    Merkx, G.F.4    Schalkwijk, J.5
  • 85
    • 33845740609 scopus 로고    scopus 로고
    • Colocalization of cystatin M/E and cathepsin v in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation
    • Zeeuwen PL, Ishida-Yamamoto A, van Vlijmen-Willems IM, Cheng T, Bergers M, Iizuka H, Schalkwijk J (2007) Colocalization of cystatin M/E and cathepsin V in lamellar granules and corneodesmosomes suggests a functional role in epidermal differentiation. J Invest Dermatol 127:120-128
    • (2007) J Invest Dermatol , vol.127 , pp. 120-128
    • Zeeuwen, P.L.1    Ishida-Yamamoto, A.2    Van Vlijmen-Willems, I.M.3    Cheng, T.4    Bergers, M.5    Iizuka, H.6    Schalkwijk, J.7
  • 86
    • 67349129706 scopus 로고    scopus 로고
    • The biology of cystatin M/E and its cognate target proteases
    • Zeeuwen PL, Cheng T, Schalkwijk J (2009) The biology of cystatin M/E and its cognate target proteases. J Invest Dermatol 129:1327-1338
    • (2009) J Invest Dermatol , vol.129 , pp. 1327-1338
    • Zeeuwen, P.L.1    Cheng, T.2    Schalkwijk, J.3


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