Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site: A novel clue for the role of cystatin M/E in epidermal cornification

Journal of Biological Chemistry

Volumn 281, Issue 23, 2006, Pages 15893-15899

  Cheng, Tsing ^a   Hitomi, Kiyotaka ^b   Van Vlijmen Willems, Ivonne M J J ^a   De Jongh, Gys J ^a   Yamamoto, Kanae ^b   Nishi, Koji ^b   Watts, Colin ^c   Reinheckel, Thomas ^d   Schalkwijk, Joost ^a   Zeeuwen, Patrick L J M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NAGOYA UNIVERSITY   (Japan)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME KINETICS; ENZYMES; KINETIC THEORY; MUTAGENESIS; SKIN;

CYSTEINE PROTEASES; HUMAN CATHEPSIN L; HUMAN CATHEPSIN V; LEGUMAIN;

ENZYME INHIBITION;

CATHEPSIN; CATHEPSIN L; CATHEPSIN V; CYSTATIN; CYSTATIN M E; CYSTEINE PROTEINASE; LEGUMAIN; PROTEINASE; TRANSGLUTAMINASE 3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; SKIN;

BASE SEQUENCE; BINDING SITES; CATHEPSINS; CYSTATINS; CYSTEINE ENDOPEPTIDASES; DNA PRIMERS; ENZYME ACTIVATION; EPIDERMIS; HUMANS; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED;

EID: 33744915019     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M600694200     Document Type: Article

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