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Volumn 11, Issue 3, 2015, Pages 1-25

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALANINE; ASPARTIC ACID; CARBOXYLIC ACID; GLUCOSE; PHOSPHOPYRUVATE CARBOXYLASE; PYRUVIC ACID; SUCCINIC ACID; GLYCEROL;

EID: 84926451743     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004689     Document Type: Article
Times cited : (98)

References (83)
  • 1
    • 73449135758 scopus 로고    scopus 로고
    • Human African trypanosomiasis
    • Brun R, Blum J, Chappuis F, Burri C, (2010) Human African trypanosomiasis. Lancet 375:148–159. doi: 10.1016/S0140-6736(09)60829-1 19833383
    • (2010) Lancet , vol.375 , pp. 148-159
    • Brun, R.1    Blum, J.2    Chappuis, F.3    Burri, C.4
  • 2
    • 78349310347 scopus 로고    scopus 로고
    • Potential new drugs for human African trypanosomiasis: some progress at last
    • Barrett MP, (2010) Potential new drugs for human African trypanosomiasis: some progress at last. Curr Opin Infect Dis 23:603–608. doi: 10.1097/QCO.0b013e32833f9fd0 20844428
    • (2010) Curr Opin Infect Dis , vol.23 , pp. 603-608
    • Barrett, M.P.1
  • 3
    • 15044362303 scopus 로고    scopus 로고
    • Energy generation in insect stages of Trypanosoma brucei: metabolism in flux
    • Besteiro S, Barrett MP, Rivière L, Bringaud F, (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends Parasitol 21:185–191. 15780841
    • (2005) Trends Parasitol , vol.21 , pp. 185-191
    • Besteiro, S.1    Barrett, M.P.2    Rivière, L.3    Bringaud, F.4
  • 4
    • 33745810581 scopus 로고    scopus 로고
    • Energy metabolism of trypanosomatids: adaptation to available carbon sources
    • Bringaud F, Rivière L, Coustou V, (2006) Energy metabolism of trypanosomatids: adaptation to available carbon sources. Mol Biochem Parasitol 149:1–9. 16682088
    • (2006) Mol Biochem Parasitol , vol.149 , pp. 1-9
    • Bringaud, F.1    Rivière, L.2    Coustou, V.3
  • 5
    • 0017366999 scopus 로고
    • Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome
    • Opperdoes FR, Borst P, (1977) Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome. FEBS Lett 80:360–364. 142663
    • (1977) FEBS Lett , vol.80 , pp. 360-364
    • Opperdoes, F.R.1    Borst, P.2
  • 6
    • 0001370373 scopus 로고
    • Aspects of the metabolism of amino acids in the tsetse fly, Glossina (Diptera)
    • Bursell E, (1963) Aspects of the metabolism of amino acids in the tsetse fly, Glossina (Diptera) J Insect Physiol 9:439–452.
    • (1963) J Insect Physiol , vol.9 , pp. 439-452
    • Bursell, E.1
  • 7
    • 15044345677 scopus 로고    scopus 로고
    • Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose
    • Lamour N, Rivière L, Coustou V, Coombs GH, Barrett MP, et al. (2005) Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. J Biol Chem 280:11902–11910. 15665328
    • (2005) J Biol Chem , vol.280 , pp. 11902-11910
    • Lamour, N.1    Rivière, L.2    Coustou, V.3    Coombs, G.H.4    Barrett, M.P.5
  • 8
    • 47749098363 scopus 로고    scopus 로고
    • Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei
    • Coustou V, Biran M, Breton M, Guegan F, Rivière L, et al. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. J Biol Chem 283:16342–16354. doi: 10.1074/jbc.M709592200 18430732
    • (2008) J Biol Chem , vol.283 , pp. 16342-16354
    • Coustou, V.1    Biran, M.2    Breton, M.3    Guegan, F.4    Rivière, L.5
  • 9
    • 0031021873 scopus 로고    scopus 로고
    • Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes
    • Bakker BM, Michels PA, Opperdoes FR, Westerhoff HV, (1997) Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes. J Biol Chem 272:3207–3215. 9013556
    • (1997) J Biol Chem , vol.272 , pp. 3207-3215
    • Bakker, B.M.1    Michels, P.A.2    Opperdoes, F.R.3    Westerhoff, H.V.4
  • 10
    • 84862312013 scopus 로고    scopus 로고
    • Proliferating bloodstream-form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes
    • Haanstra JR, van Tuijl A, van Dam J, van Winden W, Tielens AG, et al. (2012) Proliferating bloodstream-form Trypanosoma brucei use a negligible part of consumed glucose for anabolic processes. Int J Parasitol 42:667–673. doi: 10.1016/j.ijpara.2012.04.009 22580731
    • (2012) Int J Parasitol , vol.42 , pp. 667-673
    • Haanstra, J.R.1    van Tuijl, A.2    van Dam, J.3    van Winden, W.4    Tielens, A.G.5
  • 11
    • 0017399485 scopus 로고
    • Localization of glycerol-3-phosphate oxidase in the mitochondrion and particulate NAD+-linked glycerol-3-phosphate dehydrogenase in the microbodies of the bloodstream form to Trypanosoma brucei
    • Opperdoes FR, Borst P, Bakker S, Leene W, (1977) Localization of glycerol-3-phosphate oxidase in the mitochondrion and particulate NAD+-linked glycerol-3-phosphate dehydrogenase in the microbodies of the bloodstream form to Trypanosoma brucei. Eur J Biochem 76:29–39. 142010
    • (1977) Eur J Biochem , vol.76 , pp. 29-39
    • Opperdoes, F.R.1    Borst, P.2    Bakker, S.3    Leene, W.4
  • 12
    • 0001695264 scopus 로고
    • Studies on the metabolism of the protozoa. 9. Comparative metabolism of blood-stream and culture forms of Trypanosoma rhodesiense
    • Ryley JF, (1962) Studies on the metabolism of the protozoa. 9. Comparative metabolism of blood-stream and culture forms of Trypanosoma rhodesiense. Biochem J 85:211–223. 13983265
    • (1962) Biochem J , vol.85 , pp. 211-223
    • Ryley, J.F.1
  • 13
    • 0000753134 scopus 로고
    • The catabolism of glucose by strains of Trypanosoma rhodesiense
    • Grant PT, Fulton JD, (1957) The catabolism of glucose by strains of Trypanosoma rhodesiense. Biochem J 66:242–250. 13445679
    • (1957) Biochem J , vol.66 , pp. 242-250
    • Grant, P.T.1    Fulton, J.D.2
  • 14
    • 84856218111 scopus 로고
    • The glucose metabolism in vitro of Trypanosoma rhodesiense
    • Fulton JD, Stevens TS, (1945) The glucose metabolism in vitro of Trypanosoma rhodesiense. Biochem J 39:317–320. 16747912
    • (1945) Biochem J , vol.39 , pp. 317-320
    • Fulton, J.D.1    Stevens, T.S.2
  • 15
    • 84894722803 scopus 로고    scopus 로고
    • Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei
    • Rico E, Rojas F, Mony BM, Szoor B, Macgregor P, et al. (2013) Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei. Front Cell Infect Microbiol 3:78. doi: 10.3389/fcimb.2013.00078 24294594
    • (2013) Front Cell Infect Microbiol , vol.3 , pp. 78
    • Rico, E.1    Rojas, F.2    Mony, B.M.3    Szoor, B.4    Macgregor, P.5
  • 16
    • 0015268972 scopus 로고
    • Developmental changes in ultrastructure and physiology of Trypanosoma brucei
    • Brown RC, Evans DA, Vickerman K, (1972) Developmental changes in ultrastructure and physiology of Trypanosoma brucei. Trans R Soc Trop Med Hyg 66:336–337. 5048840
    • (1972) Trans R Soc Trop Med Hyg , vol.66 , pp. 336-337
    • Brown, R.C.1    Evans, D.A.2    Vickerman, K.3
  • 17
    • 0020066949 scopus 로고
    • Carbon-13 nuclear-magnetic-resonance studies of glucose catabolism by Trypanosoma brucei gambiense
    • Mackenzie NE, Hall JE, Seed JR, Scott AI, (1982) Carbon-13 nuclear-magnetic-resonance studies of glucose catabolism by Trypanosoma brucei gambiense. Eur J Biochem 121:657–661. 7056262
    • (1982) Eur J Biochem , vol.121 , pp. 657-661
    • Mackenzie, N.E.1    Hall, J.E.2    Seed, J.R.3    Scott, A.I.4
  • 18
    • 0023718006 scopus 로고
    • 13C-NMR analysis of alanine metabolism by isolated perfused livers from C3HeB/FeJ mice infected with African trypanosomes
    • Hall JE, Mackenzie NE, Mansfield JM, McCloskey DE, Scott AI, (1988) 13C-NMR analysis of alanine metabolism by isolated perfused livers from C3HeB/FeJ mice infected with African trypanosomes. Comp Biochem Physiol B 89:679–685. 3378406
    • (1988) Comp Biochem Physiol B , vol.89 , pp. 679-685
    • Hall, J.E.1    Mackenzie, N.E.2    Mansfield, J.M.3    McCloskey, D.E.4    Scott, A.I.5
  • 19
    • 70449720907 scopus 로고    scopus 로고
    • Alanine aminotransferase of Trypanosoma brucei—a key role in proline metabolism in procyclic life forms
    • Spitznagel D, Ebikeme C, Biran M, Nic a' Bháird N, Bringaud F, et al. (2009) Alanine aminotransferase of Trypanosoma brucei—a key role in proline metabolism in procyclic life forms. FEBS J 276:7187–7199. doi: 10.1111/j.1742-4658.2009.07432.x 19895576
    • (2009) FEBS J , vol.276 , pp. 7187-7199
    • Spitznagel, D.1    Ebikeme, C.2    Biran, M.3    Nic a' Bháird, N.4    Bringaud, F.5
  • 20
    • 0024497978 scopus 로고
    • The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodstream forms of Trypanosoma brucei
    • Cronín CN, Nolan DP, Voorheis HP, (1989) The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodstream forms of Trypanosoma brucei. FEBS Lett 244:26–30. 2924907
    • (1989) FEBS Lett , vol.244 , pp. 26-30
    • Cronín, C.N.1    Nolan, D.P.2    Voorheis, H.P.3
  • 21
    • 0027404204 scopus 로고
    • A 6-phosphogluconate dehydrogenase gene from Trypanosoma brucei
    • Barrett MP, Le Page RW, (1993) A 6-phosphogluconate dehydrogenase gene from Trypanosoma brucei. Mol Biochem Parasitol 57:89–99. 8426618
    • (1993) Mol Biochem Parasitol , vol.57 , pp. 89-99
    • Barrett, M.P.1    Le Page, R.W.2
  • 22
    • 84892684614 scopus 로고    scopus 로고
    • Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei
    • Kerkhoven EJ, Achcar F, Alibu VP, Burchmore RJ, Gilbert IH, et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei. PLoS Comput Biol 9:e1003371. doi: 10.1371/journal.pcbi.1003371 24339766
    • (2013) PLoS Comput Biol , vol.9 , pp. 1003371
    • Kerkhoven, E.J.1    Achcar, F.2    Alibu, V.P.3    Burchmore, R.J.4    Gilbert, I.H.5
  • 23
    • 34547911022 scopus 로고    scopus 로고
    • Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major
    • Turnock DC, Ferguson MA, . (2007) Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Eukaryot Cell 6:1450–1463. 17557881
    • (2007) Eukaryot Cell , vol.6 , pp. 1450-1463
    • Turnock, D.C.1    Ferguson, M.A.2
  • 24
    • 84859440745 scopus 로고    scopus 로고
    • The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei
    • Kuettel S, Wadum MC, Güther ML, Mariño K, Riemer C, et al. (2012) The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei. Mol Microbiol 84:340–351. doi: 10.1111/j.1365-2958.2012.08026.x 22375793
    • (2012) Mol Microbiol , vol.84 , pp. 340-351
    • Kuettel, S.1    Wadum, M.C.2    Güther, M.L.3    Mariño, K.4    Riemer, C.5
  • 25
    • 33745195679 scopus 로고    scopus 로고
    • The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol
    • Martin KL, Smith TK, (2006) The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol. Mol Microbiol 61:89–105. 16824097
    • (2006) Mol Microbiol , vol.61 , pp. 89-105
    • Martin, K.L.1    Smith, T.K.2
  • 26
    • 84859736494 scopus 로고    scopus 로고
    • myo-Inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei
    • Gonzalez-Salgado A, Steinmann ME, Greganova E, Rauch M, Mäser P, et al. (2012) myo-Inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei. J Biol Chem 287:13313–13323. doi: 10.1074/jbc.M112.344812 22351763
    • (2012) J Biol Chem , vol.287 , pp. 13313-13323
    • Gonzalez-Salgado, A.1    Steinmann, M.E.2    Greganova, E.3    Rauch, M.4    Mäser, P.5
  • 27
    • 84892737050 scopus 로고    scopus 로고
    • Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viability
    • Mazet M, Morand P, Biran M, Bouyssou G, Courtois P, et al. (2013) Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viability. PLoS Negl Trop Dis 7:e2587. doi: 10.1371/journal.pntd.0002587 24367711
    • (2013) PLoS Negl Trop Dis , vol.7 , pp. 2587
    • Mazet, M.1    Morand, P.2    Biran, M.3    Bouyssou, G.4    Courtois, P.5
  • 28
    • 16844370149 scopus 로고    scopus 로고
    • New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle
    • van Weelden SW, van Hellemond JJ, Opperdoes FR, Tielens AG, (2005) New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle. J Biol Chem 280:12451–12460. 15647263
    • (2005) J Biol Chem , vol.280 , pp. 12451-12460
    • van Weelden, S.W.1    van Hellemond, J.J.2    Opperdoes, F.R.3    Tielens, A.G.4
  • 29
    • 33748746561 scopus 로고    scopus 로고
    • Fumarate is an essential intermediary metabolite produced by the procyclic Trypanosoma brucei
    • Coustou V, Biran M, Besteiro S, Rivière L, Baltz T, et al.(2006) Fumarate is an essential intermediary metabolite produced by the procyclic Trypanosoma brucei. J Biol Chem 281:26832–26846. 16857679
    • (2006) J Biol Chem , vol.281 , pp. 26832-26846
    • Coustou, V.1    Biran, M.2    Besteiro, S.3    Rivière, L.4    Baltz, T.5
  • 30
    • 84861215880 scopus 로고    scopus 로고
    • ATP synthesis-coupled and-uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma
    • Millerioux Y, Morand P, Biran M, Mazet M, Moreau P, et al. (2012) ATP synthesis-coupled and-uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma. J Biol Chem 287:17186–17197. doi: 10.1074/jbc.M112.355404 22474284
    • (2012) J Biol Chem , vol.287 , pp. 17186-17197
    • Millerioux, Y.1    Morand, P.2    Biran, M.3    Mazet, M.4    Moreau, P.5
  • 31
    • 69149109724 scopus 로고    scopus 로고
    • Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes
    • Rivière L, Moreau P, Allmann S, Hahn M, Biran M, et al. (2009) Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes. Proc Natl Acad Sci U S A 106:12694–12699. doi: 10.1073/pnas.0903355106 19625628
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12694-12699
    • Rivière, L.1    Moreau, P.2    Allmann, S.3    Hahn, M.4    Biran, M.5
  • 33
    • 38349079839 scopus 로고    scopus 로고
    • New surveyor tools for charting microbial metabolic maps
    • Breitling R, Vitkup D, Barrett MP, (2008) New surveyor tools for charting microbial metabolic maps. Nat Rev Microbiol 6:156–161. 18026122
    • (2008) Nat Rev Microbiol , vol.6 , pp. 156-161
    • Breitling, R.1    Vitkup, D.2    Barrett, M.P.3
  • 35
    • 84869167609 scopus 로고    scopus 로고
    • Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii
    • MacRae JI, Sheiner L, Nahid A, Tonkin C, Striepen B, et al. (2012) Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host Microbe 12:682–692. doi: 10.1016/j.chom.2012.09.013 23159057
    • (2012) Cell Host Microbe , vol.12 , pp. 682-692
    • MacRae, J.I.1    Sheiner, L.2    Nahid, A.3    Tonkin, C.4    Striepen, B.5
  • 36
    • 84878818779 scopus 로고    scopus 로고
    • Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum
    • MacRae JI, Dixon MW, Dearnley MK, Chua HH, Chambers JM, et al. (2013) Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum. BMC Biol 11:67. doi: 10.1186/1741-7007-11-67 23763941
    • (2013) BMC Biol , vol.11 , pp. 67
    • MacRae, J.I.1    Dixon, M.W.2    Dearnley, M.K.3    Chua, H.H.4    Chambers, J.M.5
  • 37
    • 84893809802 scopus 로고    scopus 로고
    • Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism
    • Storm J, Sethia S, Blackburn GJ, Chokkathukalam A, Watson DG, et al. (2014) Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism. PLoS Pathog 10:e1003876. doi: 10.1371/journal.ppat.1003876 24453970
    • (2014) PLoS Pathog , vol.10 , pp. 1003876
    • Storm, J.1    Sethia, S.2    Blackburn, G.J.3    Chokkathukalam, A.4    Watson, D.G.5
  • 38
    • 84869425686 scopus 로고    scopus 로고
    • Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation
    • Creek DJ, Chokkathukalam A, Jankevics A, Burgess KE, Breitling R, et al. (2012) Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Anal Chem 84:8442–8447. doi: 10.1021/ac3018795 22946681
    • (2012) Anal Chem , vol.84 , pp. 8442-8447
    • Creek, D.J.1    Chokkathukalam, A.2    Jankevics, A.3    Burgess, K.E.4    Breitling, R.5
  • 39
    • 84872544333 scopus 로고    scopus 로고
    • mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data
    • Chokkathukalam A, Jankevics A, Creek DJ, Achcar F, Barrett MP, Breitling R, (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics. 29:281–283. doi: 10.1093/bioinformatics/bts674 23162054
    • (2013) Bioinformatics , vol.29 , pp. 281-283
    • Chokkathukalam, A.1    Jankevics, A.2    Creek, D.J.3    Achcar, F.4    Barrett, M.P.5    Breitling, R.6
  • 40
    • 84883399470 scopus 로고    scopus 로고
    • Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis
    • Achcar F, Barrett MP, Breitling R, (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS J 280:4640–4651. doi: 10.1111/febs.12436 23865459
    • (2013) FEBS J , vol.280 , pp. 4640-4651
    • Achcar, F.1    Barrett, M.P.2    Breitling, R.3
  • 41
    • 84859621949 scopus 로고    scopus 로고
    • Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei
    • Gualdron-López M, Vapola MH, Miinalainen IJ, Hiltunen JK, Michels PA, Antonenkov VD, (2012) Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei. PLoS One 7:e34530. doi: 10.1371/journal.pone.0034530 22506025
    • (2012) PLoS One , vol.7 , pp. 34530
    • Gualdron-López, M.1    Vapola, M.H.2    Miinalainen, I.J.3    Hiltunen, J.K.4    Michels, P.A.5    Antonenkov, V.D.6
  • 42
    • 58149170698 scopus 로고    scopus 로고
    • A comparative study of methylglyoxal metabolism in trypanosomatids
    • Greig N, Wyllie S, Patterson S, Fairlamb AH, (2009) A comparative study of methylglyoxal metabolism in trypanosomatids. FEBS J 276:376–386. doi: 10.1111/j.1742-4658.2008.06788.x 19076214
    • (2009) FEBS J , vol.276 , pp. 376-386
    • Greig, N.1    Wyllie, S.2    Patterson, S.3    Fairlamb, A.H.4
  • 43
    • 84961006890 scopus 로고
    • Metabolic studies on heart mitochondria. II. The inhibitory action of parapyruvate on the tricarboxylic acid cycle
    • Montgomery CM, Webb JL, (1956) Metabolic studies on heart mitochondria. II. The inhibitory action of parapyruvate on the tricarboxylic acid cycle. J Biol Chem 221:359–368. 13345825
    • (1956) J Biol Chem , vol.221 , pp. 359-368
    • Montgomery, C.M.1    Webb, J.L.2
  • 45
    • 0020490086 scopus 로고
    • Purine metabolism in the bloodstream forms of Trypanosoma gambiense and Trypanosoma rhodesiense
    • Fish WR, Looker DL, Marr JJ, Berens RL, (1982) Purine metabolism in the bloodstream forms of Trypanosoma gambiense and Trypanosoma rhodesiense. Biochim Biophys Acta 719:223–231. 6817814
    • (1982) Biochim Biophys Acta , vol.719 , pp. 223-231
    • Fish, W.R.1    Looker, D.L.2    Marr, J.J.3    Berens, R.L.4
  • 46
    • 84877863145 scopus 로고    scopus 로고
    • Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei
    • Creek DJ, Nijagal B, Kim DH, Rojas F, Matthews KR, et al. (2013) Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrob Agents Chemother 57:2768–2779. doi: 10.1128/AAC.00044-13 23571546
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2768-2779
    • Creek, D.J.1    Nijagal, B.2    Kim, D.H.3    Rojas, F.4    Matthews, K.R.5
  • 47
    • 0029808060 scopus 로고    scopus 로고
    • Purine-specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism
    • Parkin DW, (1996) Purine-specific nucleoside N-ribohydrolase from Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism. J Biol Chem 271:21713–21719. 8702965
    • (1996) J Biol Chem , vol.271 , pp. 21713-21719
    • Parkin, D.W.1
  • 48
    • 0021038831 scopus 로고
    • The enzymes of purine salvage in Trypanosoma cruzi, Trypanosoma brucei and Leishmania mexicana
    • Davies MJ, Ross AM, Gutteridge WE, (1983) The enzymes of purine salvage in Trypanosoma cruzi, Trypanosoma brucei and Leishmania mexicana. Parasitology 87:211–217. 6316234
    • (1983) Parasitology , vol.87 , pp. 211-217
    • Davies, M.J.1    Ross, A.M.2    Gutteridge, W.E.3
  • 49
    • 41949114922 scopus 로고    scopus 로고
    • Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei
    • Vodnala M, Fijolek A, Rofougaran R, Mosimann M, Mäser P, Hofer A, (2008) Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei J Biol Chem 283:5380–5388. doi: 10.1074/jbc.M705603200 18167353
    • (2008) J Biol Chem , vol.283 , pp. 5380-5388
    • Vodnala, M.1    Fijolek, A.2    Rofougaran, R.3    Mosimann, M.4    Mäser, P.5    Hofer, A.6
  • 50
    • 9244221583 scopus 로고    scopus 로고
    • Aromatic amino acid transamination and methionine recycling in trypanosomatids
    • Berger BJ, Dai WW, Wang H, Stark RE, Cerami A, (1996) Aromatic amino acid transamination and methionine recycling in trypanosomatids. Proc Natl Acad Sci USA 93: 4126–4130. 8633027
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4126-4130
    • Berger, B.J.1    Dai, W.W.2    Wang, H.3    Stark, R.E.4    Cerami, A.5
  • 51
    • 0034494342 scopus 로고    scopus 로고
    • Transport of methionine in Trypanosoma brucei brucei
    • Hasne MP, Barrett MP, (2000) Transport of methionine in Trypanosoma brucei brucei. Mol Biochem Parasitol 111:299–307. 11163438
    • (2000) Mol Biochem Parasitol , vol.111 , pp. 299-307
    • Hasne, M.P.1    Barrett, M.P.2
  • 52
    • 0026074688 scopus 로고
    • Alterations in Krebs cycle enzyme activities and carbohydrate catabolism in two strains of Trypanosoma brucei during in vitro differentiation of their bloodstream to procyclic stages
    • Durieux PO, Schütz P, Brun R, Köhler P, (1991) Alterations in Krebs cycle enzyme activities and carbohydrate catabolism in two strains of Trypanosoma brucei during in vitro differentiation of their bloodstream to procyclic stages. Mol Biochem Parasitol 45:19–27. 1904988
    • (1991) Mol Biochem Parasitol , vol.45 , pp. 19-27
    • Durieux, P.O.1    Schütz, P.2    Brun, R.3    Köhler, P.4
  • 53
    • 0021179516 scopus 로고
    • A comparison of the glycosomes (microbodies) isolated from Trypanosoma brucei bloodstream form and cultured procyclic trypomastigotes
    • Hart DT, Misset O, Edwards SW, Opperdoes FR, (1984) A comparison of the glycosomes (microbodies) isolated from Trypanosoma brucei bloodstream form and cultured procyclic trypomastigotes. Mol Biochem Parasitol 12:25–35. 6749187
    • (1984) Mol Biochem Parasitol , vol.12 , pp. 25-35
    • Hart, D.T.1    Misset, O.2    Edwards, S.W.3    Opperdoes, F.R.4
  • 54
    • 84926497908 scopus 로고    scopus 로고
    • Hasne, MP (2001) Amino acid transporters in Trypanosoma brucei brucei. University of Glasgow PhD thesis.
  • 55
    • 33644858560 scopus 로고    scopus 로고
    • The malate dehydrogenase isoforms from Trypanosoma brucei: subcellular localization and differential expression in bloodstream and procyclic forms
    • Aranda A, Maugeri D, Uttaro AD, Opperdoes F, Cazzulo JJ, et al.(2006) The malate dehydrogenase isoforms from Trypanosoma brucei: subcellular localization and differential expression in bloodstream and procyclic forms. Int J Parasitol 36:295–307. 16321390
    • (2006) Int J Parasitol , vol.36 , pp. 295-307
    • Aranda, A.1    Maugeri, D.2    Uttaro, A.D.3    Opperdoes, F.4    Cazzulo, J.J.5
  • 56
    • 0017664528 scopus 로고
    • Particle-bound enzymes in the bloodstream form of Trypanosoma brucei
    • Opperdoes FR, Borst P, Spits H, (1977) Particle-bound enzymes in the bloodstream form of Trypanosoma brucei. Eur J Biochem 76:21–28. 195809
    • (1977) Eur J Biochem , vol.76 , pp. 21-28
    • Opperdoes, F.R.1    Borst, P.2    Spits, H.3
  • 57
    • 0017399485 scopus 로고
    • Localization of glycerol-3-phosphate oxidase in the mitochondrion and particulate NAD+-linked glycerol-3-phosphate dehydrogenase in the microbodies of the bloodstream form to Trypanosoma brucei
    • Opperdoes FR, Borst P, Bakker S, Leene W, (1977) Localization of glycerol-3-phosphate oxidase in the mitochondrion and particulate NAD+-linked glycerol-3-phosphate dehydrogenase in the microbodies of the bloodstream form to Trypanosoma brucei. Eur J Biochem 76:29–39. 142010
    • (1977) Eur J Biochem , vol.76 , pp. 29-39
    • Opperdoes, F.R.1    Borst, P.2    Bakker, S.3    Leene, W.4
  • 58
    • 84874729704 scopus 로고    scopus 로고
    • Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms
    • Ali JA, Tagoe DN, Munday JC, Donachie A, Morrison LJ, de Koning HP, (2013) Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms. PLoS One 8:e58034. doi: 10.1371/journal.pone.0058034 23505454
    • (2013) PLoS One , vol.8 , pp. 58034
    • Ali, J.A.1    Tagoe, D.N.2    Munday, J.C.3    Donachie, A.4    Morrison, L.J.5    de Koning, H.P.6
  • 59
    • 84872712111 scopus 로고    scopus 로고
    • Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines
    • Ali JA, Creek DJ, Burgess K, Allison HC, Field MC, et al. (2013) Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines. Mol Pharmacol 83:439–453. doi: 10.1124/mol.112.082321 23188714
    • (2013) Mol Pharmacol , vol.83 , pp. 439-453
    • Ali, J.A.1    Creek, D.J.2    Burgess, K.3    Allison, H.C.4    Field, M.C.5
  • 60
    • 79955602637 scopus 로고    scopus 로고
    • High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome
    • Alsford S, Turner DJ, Obado SO, Sanchez-Flores A, Glover L, et al. (2011) High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. Genome Res 21:915–924. doi: 10.1101/gr.115089.110 21363968
    • (2011) Genome Res , vol.21 , pp. 915-924
    • Alsford, S.1    Turner, D.J.2    Obado, S.O.3    Sanchez-Flores, A.4    Glover, L.5
  • 61
    • 20244378176 scopus 로고    scopus 로고
    • ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation
    • Coustou V, Besteiro S, Biran M, Diolez P, Bouchaud V, et al. (2003) ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation. J Biol Chem 278:49625–49635. 14506274
    • (2003) J Biol Chem , vol.278 , pp. 49625-49635
    • Coustou, V.1    Besteiro, S.2    Biran, M.3    Diolez, P.4    Bouchaud, V.5
  • 62
    • 0027285203 scopus 로고
    • The acquisition of lysophosphatidylcholine by African trypanosomes
    • Bowes AE, Samad AH, Jiang P, Weaver B, Mellors A, (1993) The acquisition of lysophosphatidylcholine by African trypanosomes. J Biol Chem 268:13885–13892. 8314756
    • (1993) J Biol Chem , vol.268 , pp. 13885-13892
    • Bowes, A.E.1    Samad, A.H.2    Jiang, P.3    Weaver, B.4    Mellors, A.5
  • 63
    • 33747154470 scopus 로고    scopus 로고
    • Fatty acid synthesis by elongases in trypanosomes
    • Lee SH, Stephens JL, Paul KS, Englund PT, (2006) Fatty acid synthesis by elongases in trypanosomes. Cell 126:691–699. 16923389
    • (2006) Cell , vol.126 , pp. 691-699
    • Lee, S.H.1    Stephens, J.L.2    Paul, K.S.3    Englund, P.T.4
  • 64
    • 78149321649 scopus 로고    scopus 로고
    • Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase
    • Mariño K, Güther ML, Wernimont AK, Amani M, Hui R, et al. (2010) Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase. Glycobiology 20:1619–1630. doi: 10.1093/glycob/cwq115 20724435
    • (2010) Glycobiology , vol.20 , pp. 1619-1630
    • Mariño, K.1    Güther, M.L.2    Wernimont, A.K.3    Amani, M.4    Hui, R.5
  • 65
    • 79960978737 scopus 로고    scopus 로고
    • Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth
    • Saunders EC, Ng WW, Chambers JM, Ng M, Naderer T, et al. (2011) Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth. J Biol Chem 286:27706–27717. doi: 10.1074/jbc.M110.213553 21636575
    • (2011) J Biol Chem , vol.286 , pp. 27706-27717
    • Saunders, E.C.1    Ng, W.W.2    Chambers, J.M.3    Ng, M.4    Naderer, T.5
  • 66
    • 84857469186 scopus 로고    scopus 로고
    • Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism
    • Achcar F, Kerkhoven EJ, Bakker BM, Barrett MP, SilicoTryp Consortium, et al.(2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Comput Biol 8:e1002352. doi: 10.1371/journal.pcbi.1002352 22379410
    • (2012) PLoS Comput Biol , vol.8 , pp. 1002352
    • Achcar, F.1    Kerkhoven, E.J.2    Bakker, B.M.3    Barrett, M.P.4
  • 68
    • 70450253253 scopus 로고    scopus 로고
    • Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei
    • Jensen BC, Sivam D, Kifer CT, Myler PJ, Parsons M, (2009) Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei. BMC Genomics 10:482. doi: 10.1186/1471-2164-10-482 19840382
    • (2009) BMC Genomics , vol.10 , pp. 482
    • Jensen, B.C.1    Sivam, D.2    Kifer, C.T.3    Myler, P.J.4    Parsons, M.5
  • 69
    • 84867423957 scopus 로고    scopus 로고
    • Proteome remodelling during development from blood to insect-form Trypanosoma brucei quantified by SILAC and mass spectrometry
    • Gunasekera K, Wüthrich D, Braga-Lagache S, Heller M, Ochsenreiter T, (2012) Proteome remodelling during development from blood to insect-form Trypanosoma brucei quantified by SILAC and mass spectrometry. BMC Genomics 13:556. doi: 10.1186/1471-2164-13-556 23067041
    • (2012) BMC Genomics , vol.13 , pp. 556
    • Gunasekera, K.1    Wüthrich, D.2    Braga-Lagache, S.3    Heller, M.4    Ochsenreiter, T.5
  • 70
    • 70049114411 scopus 로고    scopus 로고
    • The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness
    • Nett IR, Martin DM, Miranda-Saavedra D, Lamont D, Barber JD, et al. (2009) The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness. Mol Cell Proteomics 8:1527–1538. doi: 10.1074/mcp.M800556-MCP200 19346560
    • (2009) Mol Cell Proteomics , vol.8 , pp. 1527-1538
    • Nett, I.R.1    Martin, D.M.2    Miranda-Saavedra, D.3    Lamont, D.4    Barber, J.D.5
  • 71
    • 84884702027 scopus 로고    scopus 로고
    • The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control
    • Millerioux Y, Ebikeme C, Biran M, Morand P, Bouyssou G, et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Mol Microbiol 90:114–29. doi: 10.1111/mmi.12351 23899193
    • (2013) Mol Microbiol , vol.90 , pp. 114-129
    • Millerioux, Y.1    Ebikeme, C.2    Biran, M.3    Morand, P.4    Bouyssou, G.5
  • 73
    • 0024948840 scopus 로고
    • Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers
    • Hirumi H, Hirumi K, (1989) Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J Parasitol 75:985–989. 2614608
    • (1989) J Parasitol , vol.75 , pp. 985-989
    • Hirumi, H.1    Hirumi, K.2
  • 74
    • 78049351897 scopus 로고    scopus 로고
    • Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis
    • t’Kindt R, Jankevics A, Scheltema R, Zheng L, Watson DG, (2010). Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis. Anal Bioanal Chem 398:2059–2069. doi: 10.1007/s00216-010-4139-0 20824428
    • (2010) Anal Bioanal Chem , vol.398 , pp. 2059-2069
    • t’Kindt, R.1    Jankevics, A.2    Scheltema, R.3    Zheng, L.4    Watson, D.G.5
  • 75
    • 60649089559 scopus 로고    scopus 로고
    • Highly sensitive feature detection for high resolution LC/MS
    • Tautenhahn R, Bottcher C, Neumann S, (2008). Highly sensitive feature detection for high resolution LC/MS. BMC Bioinformatics 9:504. doi: 10.1186/1471-2105-9-504 19040729
    • (2008) BMC Bioinformatics , vol.9 , pp. 504
    • Tautenhahn, R.1    Bottcher, C.2    Neumann, S.3
  • 76
    • 79953267955 scopus 로고    scopus 로고
    • PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis
    • Scheltema RA, Jankevics A, Jansen RC, Swertz MA, Breitling R, (2011) PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis. Anal Chem 83:2786–2793. doi: 10.1021/ac2000994 21401061
    • (2011) Anal Chem , vol.83 , pp. 2786-2793
    • Scheltema, R.A.1    Jankevics, A.2    Jansen, R.C.3    Swertz, M.A.4    Breitling, R.5
  • 77
    • 84859223223 scopus 로고    scopus 로고
    • IDEOM: An Excel interface for analysis of LC-MS based metabolomics data
    • Creek DJ, Jankevics A, Burgess KEV, Breitling R, Barrett MP, (2012) IDEOM: An Excel interface for analysis of LC-MS based metabolomics data. Bioinformatics 28:1048–1049. doi: 10.1093/bioinformatics/bts069 22308147
    • (2012) Bioinformatics , vol.28 , pp. 1048-1049
    • Creek, D.J.1    Jankevics, A.2    Burgess, K.E.V.3    Breitling, R.4    Barrett, M.P.5
  • 78
    • 81255144050 scopus 로고    scopus 로고
    • Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography—Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction
    • Creek DJ, Jankevics A, Breitling R, Watson DG, Barrett MP, et al. (2011) Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid Chromatography—Mass Spectrometry: Improved Metabolite Identification by Retention Time Prediction. Anal Chem 83:8703–8710. doi: 10.1021/ac2021823 21928819
    • (2011) Anal Chem , vol.83 , pp. 8703-8710
    • Creek, D.J.1    Jankevics, A.2    Breitling, R.3    Watson, D.G.4    Barrett, M.P.5
  • 79
    • 0033169005 scopus 로고    scopus 로고
    • Concentration Measurement by Proton NMR Using the ERETIC Method
    • Akoka S, Barantin L, Trierweiler M, (1999) Concentration Measurement by Proton NMR Using the ERETIC Method. Anal Chem 71:2554–2557. doi: 10.1021/ac981422i 21662801
    • (1999) Anal Chem , vol.71 , pp. 2554-2557
    • Akoka, S.1    Barantin, L.2    Trierweiler, M.3
  • 82
    • 0033555250 scopus 로고    scopus 로고
    • Affinity chromatography using trypanocidal arsenical drugs identifies a specific interaction between glycerol-3-phosphate dehydrogenase from Trypanosoma brucei and Cymelarsan
    • Denise H, Giroud C, Barrett MP, Baltz T, (1999) Affinity chromatography using trypanocidal arsenical drugs identifies a specific interaction between glycerol-3-phosphate dehydrogenase from Trypanosoma brucei and Cymelarsan. Eur J Biochem 259:339–346. 9914512
    • (1999) Eur J Biochem , vol.259 , pp. 339-346
    • Denise, H.1    Giroud, C.2    Barrett, M.P.3    Baltz, T.4
  • 83
    • 0029564258 scopus 로고
    • Molecular characterization of the mitochondrial heat shock protein 60 gene from Trypanosoma brucei
    • Bringaud F, Peyruchaud S, Baltz D, Giroud C, Simpson L, Baltz T, (1995) Molecular characterization of the mitochondrial heat shock protein 60 gene from Trypanosoma brucei. Mol Biochem Parasitol 74:119–123. 8719252
    • (1995) Mol Biochem Parasitol , vol.74 , pp. 119-123
    • Bringaud, F.1    Peyruchaud, S.2    Baltz, D.3    Giroud, C.4    Simpson, L.5    Baltz, T.6


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