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Volumn 84, Issue 2, 2012, Pages 340-351

The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GUANOSINE DIPHOSPHATE MANNOSE; MANNOSE; MANNOSE PHOSPHATE ISOMERASE;

EID: 84859440745     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2012.08026.x     Document Type: Article
Times cited : (19)

References (33)
  • 1
    • 0037101948 scopus 로고    scopus 로고
    • Developmentally regulated trafficking of the lysosomal membrane protein p67 in Trypanosoma brucei
    • Alexander, D.L., Schwartz, K.J., Balber, A.E., and Bangs, J.D. (2002) Developmentally regulated trafficking of the lysosomal membrane protein p67 in Trypanosoma brucei. J Cell Sci 115: 3253-3263.
    • (2002) J Cell Sci , vol.115 , pp. 3253-3263
    • Alexander, D.L.1    Schwartz, K.J.2    Balber, A.E.3    Bangs, J.D.4
  • 2
    • 17744411208 scopus 로고    scopus 로고
    • Oral ingestion of mannose elevates blood mannose levels: a first step toward a potential therapy for carbohydrate-deficient glycoprotein syndrome type I
    • Alton, G., Kjaergaard, S., Etchison, J.R., Skovby, F., and Freeze, H.H. (1997) Oral ingestion of mannose elevates blood mannose levels: a first step toward a potential therapy for carbohydrate-deficient glycoprotein syndrome type I. Biochem Mol Med 60: 127-133.
    • (1997) Biochem Mol Med , vol.60 , pp. 127-133
    • Alton, G.1    Kjaergaard, S.2    Etchison, J.R.3    Skovby, F.4    Freeze, H.H.5
  • 3
    • 33745060757 scopus 로고    scopus 로고
    • Comparative proteomics of glycosomes from bloodstream form and procyclic culture form Trypanosoma brucei brucei
    • Colasante, C., Ellis, M., Ruppert, T., and Voncken, F. (2006) Comparative proteomics of glycosomes from bloodstream form and procyclic culture form Trypanosoma brucei brucei. Proteomics 6: 3275-3293.
    • (2006) Proteomics , vol.6 , pp. 3275-3293
    • Colasante, C.1    Ellis, M.2    Ruppert, T.3    Voncken, F.4
  • 4
    • 1842425027 scopus 로고    scopus 로고
    • Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana
    • Davis, A.J., Perugini, M.A., Smith, B.J., Stewart, J.D., Ilg, T., Hodder, A.N., and Handman, E. (2004) Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana. J Biol Chem 279: 12462-12468.
    • (2004) J Biol Chem , vol.279 , pp. 12462-12468
    • Davis, A.J.1    Perugini, M.A.2    Smith, B.J.3    Stewart, J.D.4    Ilg, T.5    Hodder, A.N.6    Handman, E.7
  • 5
    • 74349118194 scopus 로고    scopus 로고
    • GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei
    • Denton, H., Fyffe, S., and Smith, T.K. (2010) GDP-mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei. Biochem J 425: 603-614.
    • (2010) Biochem J , vol.425 , pp. 603-614
    • Denton, H.1    Fyffe, S.2    Smith, T.K.3
  • 6
    • 21044443776 scopus 로고    scopus 로고
    • The membrane-bound histidine acid phosphatase TbMBAP1 is essential for endocytosis and membrane recycling in Trypanosoma brucei
    • Engstler, M., Weise, F., Bopp, K., Grunfelder, C.G., Gunzel, M., Heddergott, N., and Overath, P. (2005) The membrane-bound histidine acid phosphatase TbMBAP1 is essential for endocytosis and membrane recycling in Trypanosoma brucei. J Cell Sci 118: 2105-2118.
    • (2005) J Cell Sci , vol.118 , pp. 2105-2118
    • Engstler, M.1    Weise, F.2    Bopp, K.3    Grunfelder, C.G.4    Gunzel, M.5    Heddergott, N.6    Overath, P.7
  • 7
    • 0022635703 scopus 로고
    • Biosynthesis of Trypanosoma brucei variant surface glycoproteins. N-glycosylation and addition of a phosphatidylinositol membrane anchor
    • Ferguson, M.A., Duszenko, M., Lamont, G.S., Overath, P., and Cross, G.A. (1986) Biosynthesis of Trypanosoma brucei variant surface glycoproteins. N-glycosylation and addition of a phosphatidylinositol membrane anchor. J Biol Chem 261: 356-362.
    • (1986) J Biol Chem , vol.261 , pp. 356-362
    • Ferguson, M.A.1    Duszenko, M.2    Lamont, G.S.3    Overath, P.4    Cross, G.A.5
  • 8
    • 0035898610 scopus 로고    scopus 로고
    • Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability
    • Garami, A., and Ilg, T. (2001a) Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability. EMBO J 20: 3657-3666.
    • (2001) EMBO J , vol.20 , pp. 3657-3666
    • Garami, A.1    Ilg, T.2
  • 9
    • 0035794186 scopus 로고    scopus 로고
    • The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence
    • Garami, A., and Ilg, T. (2001b) The role of phosphomannose isomerase in Leishmania mexicana glycoconjugate synthesis and virulence. J Biol Chem 276: 6566-6575.
    • (2001) J Biol Chem , vol.276 , pp. 6566-6575
    • Garami, A.1    Ilg, T.2
  • 10
    • 58149170698 scopus 로고    scopus 로고
    • A comparative study of methylglyoxal metabolism in trypanosomatids
    • Greig, N., Wyllie, S., Patterson, S., and Fairlamb, A.H. (2009) A comparative study of methylglyoxal metabolism in trypanosomatids. FEBS J 276: 376-386.
    • (2009) FEBS J , vol.276 , pp. 376-386
    • Greig, N.1    Wyllie, S.2    Patterson, S.3    Fairlamb, A.H.4
  • 11
    • 0035801644 scopus 로고    scopus 로고
    • Purification, cloning and characterization of a GPI inositol deacylase from Trypanosoma brucei
    • Guther, M.L., Leal, S., Morrice, N.A., Cross, G.A., and Ferguson, M.A. (2001) Purification, cloning and characterization of a GPI inositol deacylase from Trypanosoma brucei. EMBO J 20: 4923-4934.
    • (2001) EMBO J , vol.20 , pp. 4923-4934
    • Guther, M.L.1    Leal, S.2    Morrice, N.A.3    Cross, G.A.4    Ferguson, M.A.5
  • 12
    • 0024948840 scopus 로고
    • Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers
    • Hirumi, H., and Hirumi, K. (1989) Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J Parasitol 75: 985-989.
    • (1989) J Parasitol , vol.75 , pp. 985-989
    • Hirumi, H.1    Hirumi, K.2
  • 13
    • 0026043234 scopus 로고
    • The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residues
    • Low, P., Dallner, G., Mayor, S., Cohen, S., Chait, B.T., and Menon, A.K. (1991) The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residues. J Biol Chem 266: 19250-19257.
    • (1991) J Biol Chem , vol.266 , pp. 19250-19257
    • Low, P.1    Dallner, G.2    Mayor, S.3    Cohen, S.4    Chait, B.T.5    Menon, A.K.6
  • 14
    • 33645902165 scopus 로고    scopus 로고
    • The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology
    • MacRae, J.I., Obado, S.O., Turnock, D.C., Roper, J.R., Kierans, M., Kelly, J.M., and Ferguson, M.A. (2006) The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology. Mol Biochem Parasitol 147: 126-136.
    • (2006) Mol Biochem Parasitol , vol.147 , pp. 126-136
    • MacRae, J.I.1    Obado, S.O.2    Turnock, D.C.3    Roper, J.R.4    Kierans, M.5    Kelly, J.M.6    Ferguson, M.A.7
  • 15
    • 42449115251 scopus 로고    scopus 로고
    • Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei
    • Manthri, S., Guther, M.L., Izquierdo, L., Acosta-Serrano, A., and Ferguson, M.A. (2008) Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei. Glycobiology 18: 367-383.
    • (2008) Glycobiology , vol.18 , pp. 367-383
    • Manthri, S.1    Guther, M.L.2    Izquierdo, L.3    Acosta-Serrano, A.4    Ferguson, M.A.5
  • 16
    • 79960126726 scopus 로고    scopus 로고
    • Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei
    • Marino, K., Guther, M.L., Wernimont, A.K., Qiu, W., Hui, R., and Ferguson, M.A. (2011) Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei. Eukaryot Cell 10: 985-997.
    • (2011) Eukaryot Cell , vol.10 , pp. 985-997
    • Marino, K.1    Guther, M.L.2    Wernimont, A.K.3    Qiu, W.4    Hui, R.5    Ferguson, M.A.6
  • 17
    • 0025895045 scopus 로고
    • Phenylmethanesulphonyl fluoride inhibits GPI anchor biosynthesis in the African trypanosome
    • Masterson, W.J., and Ferguson, M.A. (1991) Phenylmethanesulphonyl fluoride inhibits GPI anchor biosynthesis in the African trypanosome. EMBO J 10: 2041-2045.
    • (1991) EMBO J , vol.10 , pp. 2041-2045
    • Masterson, W.J.1    Ferguson, M.A.2
  • 18
    • 0032029271 scopus 로고    scopus 로고
    • The glycosylation of the variant surface glycoproteins and procyclic acidic repetitive proteins of Trypanosoma brucei
    • Mehlert, A., Zitzmann, N., Richardson, J.M., Treumann, A., and Ferguson, M.A. (1998) The glycosylation of the variant surface glycoproteins and procyclic acidic repetitive proteins of Trypanosoma brucei. Mol Biochem Parasitol 91: 145-152.
    • (1998) Mol Biochem Parasitol , vol.91 , pp. 145-152
    • Mehlert, A.1    Zitzmann, N.2    Richardson, J.M.3    Treumann, A.4    Ferguson, M.A.5
  • 19
    • 0023878448 scopus 로고
    • Candidate glycophospholipid precursor for the glycosylphosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoproteins
    • Menon, A.K., Mayor, S., Ferguson, M.A., Duszenko, M., and Cross, G.A. (1988) Candidate glycophospholipid precursor for the glycosylphosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoproteins. J Biol Chem 263: 1970-1977.
    • (1988) J Biol Chem , vol.263 , pp. 1970-1977
    • Menon, A.K.1    Mayor, S.2    Ferguson, M.A.3    Duszenko, M.4    Cross, G.A.5
  • 20
    • 47749148417 scopus 로고    scopus 로고
    • Role of hexosamine biosynthesis in Leishmania growth and virulence
    • Naderer, T., Wee, E., and McConville, M.J. (2008) Role of hexosamine biosynthesis in Leishmania growth and virulence. Mol Microbiol 69: 858-869.
    • (2008) Mol Microbiol , vol.69 , pp. 858-869
    • Naderer, T.1    Wee, E.2    McConville, M.J.3
  • 21
    • 33646074032 scopus 로고    scopus 로고
    • In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes
    • Opperdoes, F.R., and Szikora, J.P. (2006) In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes. Mol Biochem Parasitol 147: 193-206.
    • (2006) Mol Biochem Parasitol , vol.147 , pp. 193-206
    • Opperdoes, F.R.1    Szikora, J.P.2
  • 22
    • 42549120380 scopus 로고    scopus 로고
    • The LAMP-like protein p67 plays an essential role in the lysosome of African trypanosomes
    • Peck, R.F., Shiflett, A.M., Schwartz, K.J., McCann, A., Hajduk, S.L., and Bangs, J.D. (2008) The LAMP-like protein p67 plays an essential role in the lysosome of African trypanosomes. Mol Microbiol 68: 933-946.
    • (2008) Mol Microbiol , vol.68 , pp. 933-946
    • Peck, R.F.1    Shiflett, A.M.2    Schwartz, K.J.3    McCann, A.4    Hajduk, S.L.5    Bangs, J.D.6
  • 23
    • 0030612893 scopus 로고    scopus 로고
    • The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro
    • Raz, B., Iten, M., Grether-Buhler, Y., Kaminsky, R., and Brun, R. (1997) The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro. Acta Trop 68: 139-147.
    • (1997) Acta Trop , vol.68 , pp. 139-147
    • Raz, B.1    Iten, M.2    Grether-Buhler, Y.3    Kaminsky, R.4    Brun, R.5
  • 24
    • 0037197847 scopus 로고    scopus 로고
    • Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei
    • Roper, J.R., Guther, M.L., Milne, K.G., and Ferguson, M.A. (2002) Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei. Proc Natl Acad Sci USA 99: 5884-5889.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5884-5889
    • Roper, J.R.1    Guther, M.L.2    Milne, K.G.3    Ferguson, M.A.4
  • 25
    • 21244496004 scopus 로고    scopus 로고
    • The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number
    • Roper, J.R., Guther, M.L., Macrae, J.I., Prescott, A.R., Hallyburton, I., Acosta-Serrano, A., and Ferguson, M.A. (2005) The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number. J Biol Chem 280: 19728-19736.
    • (2005) J Biol Chem , vol.280 , pp. 19728-19736
    • Roper, J.R.1    Guther, M.L.2    Macrae, J.I.3    Prescott, A.R.4    Hallyburton, I.5    Acosta-Serrano, A.6    Ferguson, M.A.7
  • 26
    • 1642293193 scopus 로고    scopus 로고
    • A model for sedimentation in inhomogeneous media. I. Dynamic density gradients from sedimenting co-solutes
    • Schuck, P. (2004) A model for sedimentation in inhomogeneous media. I. Dynamic density gradients from sedimenting co-solutes. Biophys Chem 108: 187-200.
    • (2004) Biophys Chem , vol.108 , pp. 187-200
    • Schuck, P.1
  • 27
    • 0033990862 scopus 로고    scopus 로고
    • The transferrin receptor of Trypanosoma brucei
    • Steverding, D. (2000) The transferrin receptor of Trypanosoma brucei. Parasitol Int 48: 191-198.
    • (2000) Parasitol Int , vol.48 , pp. 191-198
    • Steverding, D.1
  • 28
    • 47049088391 scopus 로고    scopus 로고
    • The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form Trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation
    • Stokes, M.J., Guther, M.L., Turnock, D.C., Prescott, A.R., Martin, K.L., Alphey, M.S., and Ferguson, M.A. (2008) The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form Trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation. J Biol Chem 283: 16147-16161.
    • (2008) J Biol Chem , vol.283 , pp. 16147-16161
    • Stokes, M.J.1    Guther, M.L.2    Turnock, D.C.3    Prescott, A.R.4    Martin, K.L.5    Alphey, M.S.6    Ferguson, M.A.7
  • 29
    • 0018836491 scopus 로고
    • Trypanosoma brucei brucei: inhibition of glycosylation of the major variable surface coat glycoprotein by tunicamycin
    • Strickler, J.E., and Patton, C.L. (1980) Trypanosoma brucei brucei: inhibition of glycosylation of the major variable surface coat glycoprotein by tunicamycin. Proc Natl Acad Sci USA 77: 1529-1533.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 1529-1533
    • Strickler, J.E.1    Patton, C.L.2
  • 30
    • 34547911022 scopus 로고    scopus 로고
    • Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major
    • Turnock, D.C., and Ferguson, M.A. (2007) Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major. Eukaryot Cell 6: 1450-1463.
    • (2007) Eukaryot Cell , vol.6 , pp. 1450-1463
    • Turnock, D.C.1    Ferguson, M.A.2
  • 31
    • 35348963515 scopus 로고    scopus 로고
    • The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in Trypanosoma brucei
    • Turnock, D.C., Izquierdo, L., and Ferguson, M.A. (2007) The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in Trypanosoma brucei. J Biol Chem 282: 28853-28863.
    • (2007) J Biol Chem , vol.282 , pp. 28853-28863
    • Turnock, D.C.1    Izquierdo, L.2    Ferguson, M.A.3
  • 32
    • 33751186348 scopus 로고    scopus 로고
    • Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4′-epimerase conditional null mutant
    • Urbaniak, M.D., Turnock, D.C., and Ferguson, M.A. (2006) Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4′-epimerase conditional null mutant. Eukaryot Cell 5: 1906-1913.
    • (2006) Eukaryot Cell , vol.5 , pp. 1906-1913
    • Urbaniak, M.D.1    Turnock, D.C.2    Ferguson, M.A.3
  • 33
    • 0033525524 scopus 로고    scopus 로고
    • A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei
    • Wirtz, E., Leal, S., Ochatt, C., and Cross, G.A. (1999) A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol Biochem Parasitol 99: 89-101.
    • (1999) Mol Biochem Parasitol , vol.99 , pp. 89-101
    • Wirtz, E.1    Leal, S.2    Ochatt, C.3    Cross, G.A.4


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