Revisiting the Central Metabolism of the Bloodstream Forms of Trypanosoma brucei: Production of Acetate in the Mitochondrion Is Essential for Parasite Viability

PLoS Neglected Tropical Diseases

Volumn 7, Issue 12, 2013, Pages

  Mazet, Muriel ^a   Morand, Pauline ^a   Biran, Marc ^a   Bouyssou, Guillaume ^b   Courtois, Pierrette ^c   Daulouède, Sylvie ^c   Millerioux, Yoann ^a   Franconi, Jean Michel ^a   Vincendeau, Philippe ^c   Moreau, Patrick ^b   Bringaud, Frédéric ^a  

^a CNRS University Bordeaux Segalen   (France)

^b University Victor Segalen   (France)

^c CIRAD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ACETYL COENZYME A SYNTHETASE; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; THREONINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; BLOOD FLOW; ENZYME ASSAY; FEMALE; GENE EXPRESSION; GLUCOSE METABOLISM; IMMUNOFLUORESCENCE; LIPOGENESIS; MITOCHONDRION; MOUSE; NONHUMAN; PARASITE VIABILITY; PROTON NUCLEAR MAGNETIC RESONANCE; RNA INTERFERENCE; TRYPANOSOMA; TRYPANOSOMA BRUCEI; WESTERN BLOTTING;

ACETATES; ANIMALS; BLOOD; FEMALE; GLUCOSE; MAGNETIC RESONANCE SPECTROSCOPY; METABOLIC NETWORKS AND PATHWAYS; MICE, INBRED BALB C; MITOCHONDRIA; REVERSE GENETICS; SUCCINIC ACID; SURVIVAL ANALYSIS; THREONINE; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84892737050     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002587     Document Type: Article

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