Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 31, 2009, Pages 12694-12699

  Rivière, Loïc ^a   Moreau, Patrick ^b   Allmann, Stefan ^c   Hahn, Matthias ^c   Biran, Marc ^d   Plazolles, Nicolas ^a   Franconi, Jean Michel ^d   Boshart, Michael ^c   Bringaud, Frédéric ^a,d  

^a University Victor Segalen   (France)

^b University Victor Segalen   (France)

^c UNIVERSITY OF MUNICH   (Germany)

^d CNRS University Bordeaux Segalen   (France)

Author keywords

Acetyl CoA synthetase; Citrate malate shuttle; De novo lipid biosynthesis; Mitochondrial acetate

Indexed keywords

ACETIC ACID; ACETIC ACID DERIVATIVE; ACETYL COENZYME A; ACETYL COENZYME A SYNTHETASE; CARBON 14; CELL ENZYME; CELL SURFACE PROTEIN; CITRATE LYASE; GLUCOSE; UNCLASSIFIED DRUG; CITRATE (PRO 3S) LYASE; CITRATE (PRO-3S)-LYASE; CITRIC ACID; LIPID; LYASE; MALIC ACID; MALIC ACID DERIVATIVE; MULTIENZYME COMPLEX;

ARTICLE; CELL COMPARTMENTALIZATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; FATTY ACID SYNTHESIS; GENE DELETION; GENE INDUCTION; GENE REPRESSION; GENETIC CODE; ISOTOPE LABELING; LIFE CYCLE; LIPOGENESIS; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; REDUCTION; RNA INTERFERENCE; SHUTTLE VECTOR; TRYPANOSOMA BRUCEI; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; GENETICS; METABOLISM; PHYSIOLOGY;

EUKARYOTA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

ACETATE-COA LIGASE; ACETATES; ACETYL COENZYME A; ANIMALS; CITRIC ACID; LIPIDS; MALATES; MITOCHONDRIA; MULTIENZYME COMPLEXES; OXO-ACID-LYASES; RNA INTERFERENCE; TRYPANOSOMA BRUCEI BRUCEI;

EID: 69149109724     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903355106     Document Type: Article

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