Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages

Journal of Functional Foods

Volumn 14, Issue , 2015, Pages 779-790

  Cárdeno, Ana ^a   Aparicio Soto, Marina ^a   Montserrat de la Paz, Sergio ^a,b   Bermudez, Beatriz ^a,b   Muriana, Francisco J G ^b   Alarcón de la Lastra, Catalina ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b INSTITUTO DE LA GRASA   (Spain)

Author keywords

Inflammation; Macrophages; Monocytes; Neutrophils; Squalene

Indexed keywords

MURINAE;

EID: 84926322038     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.03.009     Document Type: Article

References (60)

1. Alexander S.P., Mathie A., Peters J.A. Guide to receptors and channels (GRAC), 5th edition. British Journal of Pharmacology 2011, 164(Suppl. 1):S1-S324.
2. Andreakos E., Sacre S.M., Smith C., Lundberg A., Kiriakidis S., Stonehouse T., Foxwell B.M. Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP. Blood 2004, 103:2229-2237.
3. Araujo J.A., Zhang M., Yin F. Heme oxygenase-1, oxidation, inflammation, and atherosclerosis. Frontiers in Pharmacology 2012, 3:119.
4. Bordet R., Gele P., Duriez P., Fruchart J.C. PPARs: A new target for neuroprotection. Journal of Neurology, Neurosurgery, and Psychiatry 2006, 77:285-287.
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976, 72:248-254.
6. Brune B., Dehne N., Grossmann N., Jung M., Namgaladze D., Schmid T., von Knethen A., Weigert A. Redox control of inflammation in macrophages. Antioxidants & Redox Signaling 2013, 19(6):595-637.
7. Cardeno A., Sanchez-Hidalgo M., Aparicio-Soto M., Alarcon-de-la-Lastra C. Unsaponifiable fraction from extra virgin olive oil inhibits the inflammatory response in LPS-activated murine macrophages. Food Chemistry 2014, 147:117-123.
8. Cardozo L.F., Pedruzzi L.M., Stenvinkel P., Stockler-Pinto M.B., Daleprane J.B., Leite M., Mafra D. Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2. Biochimie 2013, 95:1525-1533.
9. Chang J., Kim B.M., Chang C.H. Co-stimulation of TLR4 and Dectin-1 induces the production of inflammatory cytokines but not TGF-beta for Th17 cell differentiation. Immune network 2014, 14:30-37.
10. Chanput W., Mes J., Vreeburg R.A., Savelkoul H.F., Wichers H.J. Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: A tool to study inflammation modulating effects of food-derived compounds. Food & Function 2010, 1:254-261.
11. de Araujo T.H., Okada S.S., Ghosn E.E., Taniwaki N.N., Rodrigues M.R., de Almeida S.R., Albuquerque R.C. Intracellular localization of myeloperoxidase in murine peritoneal B-lymphocytes and macrophages. Cell Immunology 2013, 281:27-30.
12. Epelman S., Lavine K.J., Randolph G.J. Origin and functions of tissue macrophages. Immunity 2014, 41:21-35.
13. Gjyshi O., Bottero V., Veettil M.V., Dutta S., Singh V.V., Chikoti L., Chandran B. Kaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infection. PLoS Pathogens 2014, 10:e1004460.
14. Gordon S., Taylor P.R. Monocyte and macrophage heterogeneity. Nature Reviews. Immunology 2005, 5:953-964.
15. Granados-Principal S., Quiles J.L., Ramirez-Tortosa C.L., Ochoa-Herrera J., Perez-Lopez P., Pulido-Moran M., Ramirez-Tortosa M.C. Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages. Molecular Nutrition & Food Research 2012, 56:733-740.
16. Gurgis F.M., Ziaziaris W., Munoz L. Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27 phosphorylation, and cell cycle: Role and targeting. Molecular Pharmacology 2014, 85:345-356.
17. Helenius M., Kyrylenko S., Vehviläinen P., Salminen A. Characterization of aging-associated up-regulation of constitutive nuclear factor-kappa B binding activity. Antioxidants & Redox Signaling 2001, 3:147-156.
18. Jaiswal A.K. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radical Biology & Medicine 2004, 36:1199-1207.
19. Jeon Y., Jung Y., Kim M.C., Kwon H.C., Kang K.S., Kim Y.K., Kim S.N. Sargahydroquinoic acid inhibits TNFalpha-induced AP-1 and NF-kappaB signaling in HaCaT cells through PPARalpha activation. Biochemical and Biophysical Research Communications 2014, 450(4):1553-1559.
20. Jung C.H., Kim J.H., Park S., Kweon D.H., Kim S.H., Ko S.G. Inhibitory effect of Agrimonia pilosa Ledeb. on inflammation by suppression of iNOS and ROS production. Immunological Investigations 2010, 39:159-170.
21. Jung K.H., Hong S.W., Zheng H.M., Lee H.S., Lee H., Lee D.H., Hong S.S. Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats. Journal of Pineal Research 2010, 48:239-250.
22. Kabuto H., Yamanushi T.T., Janjua N., Takayama F., Mankura M. Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model. Journal of Oleo Science 2013, 62:21-28.
23. Kaminska B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochimica et Biophysica Acta 2005, 1754:253-262.
24. Kang I.S., Kim C. Taurine chloramine administered in vivo increases NRF2-regulated antioxidant enzyme expression in murine peritoneal macrophages. Advances in Experimental Medicine and Biology 2013, 775:259-267.
25. Kang J.W., Lee S.M. Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion. Journal of Pineal Research 2012, 53:67-76.
26. Khokha R., Murthy A., Weiss A. Metalloproteinases and their natural inhibitors in inflammation and immunity. Nature Reviews. Immunology 2013, 13:649-665.
27. Kim K.J., Yoon K.Y., Lee B.Y. Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in RAW264.7 cells. Fitoterapia 2012, 83:1628-1635.
28. Kim S.K., Karadeniz F. Biological importance and applications of squalene and squalane. Advances in Food and Nutrition Research 2012, 65:223-233.
29. Kwon D.J., Ju S.M., Youn G.S., Choi S.Y., Park J. Supression of iNOS and COX-2 expression by flavokawain A via blockade of NF-kB and AP-1 activation in RAW 264.7 macrophages. Food and Chemical Toxicology 2013, 58:479-486.
30. Kyriakis J.M., Avruch J. Mammalian MAPK signal transduction pathways activated by stress and inflammation: A 10-year update. Physiological Reviews 2012, 92:689-737.
31. Lai W.C., Zhou M., Shankavaram U., Peng G., Wahl L.M. Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. Journal of Immunology 2003, 170:6244-6249.
32. Lee H.N., Surh Y.J. Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders. Biochemical Pharmacology 2012, 84:1340-1350.
33. Li D.Y., Xue M.Y., Geng Z.R., Chen P.Y. The suppressive effects of Bursopentine (BP5) on oxidative stress and NF-κB activation in lipopolysaccharide-activated murine peritoneal macrophages. Cellular Physiology and Biochemistry 2012, 29:9-20.
34. Liu M., Boussetta T., Makni-Maalej K., Fay M., Driss F., El-Benna J., Lagarde M., Guichardant M. Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities. Lipids 2014, 49:49-57.
35. Liu Y., Xu X., Bi D., Wang X., Zhang X., Dai H., Chen S., Zhang W. Influence of squalene feeding on plasma leptin, testosterone & blood pressure in rats. The Indian Journal of Medical Research 2009, 129:150-153.
36. Lou-Bonafonte J.M., Arnal C., Navarro M.A., Osada J. Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development. Molecular Nutrition & Food Research 2012, 56:1043-1057.
37. Moorcroft M.J., Davis J., Compton R.G. Detection and determination of nitrate and nitrite: A review. Talanta 2001, 54:785-803.
38. Murad S. Toll-like receptor 4 in inflammation and angiogenesis: A double-edged sword. Frontiers in Immunology 2014, 5:313.
39. Nathan C. Neutrophils and immunity: Challenges and opportunities. Nature Reviews. Immunology 2006, 6:173-182.
40. Nissinen L., Kahari V.M. Matrix metalloproteinases in inflammation. Biochimica et Biophysica Acta 2014, 1840:2571-2580.
41. Nussbaum C., Klinke A., Adam M., Baldus S., Sperandio M. Myeloperoxidase: A leukocyte-derived protagonist of inflammation and cardiovascular disease. Antioxidants & Redox Signaling 2013, 18:692-713.
42. O'Connor P.M., Lapointe T.K., Beck P.L., Buret A.G. Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease. Inflammatory Bowel Diseases 2010, 16:1411-1420.
43. Ostlund R.E., Racette S.B., Stenson W.F. Effects of trace components of dietary fat on cholesterol metabolism: Phytosterols, oxysterols, and squalene. Nutrition Reviews 2002, 60:349-359.
44. Radnai B., Tucsek Z., Bognar Z., Antus C., Mark L., Berente Z., Veres B. Ferulaldehyde, a water-soluble degradation product of polyphenols, inhibits the lipopolysaccharide-induced inflammatory response in mice. The Journal of Nutrition 2009, 139:291-297.
45. Reddy L.H., Couvreur P. Squalene: A natural triterpene for use in disease management and therapy. Advanced Drug Delivery Reviews 2009, 61:1412-1426.
46. Renga B., Mencarelli A., Migliorati M., Cipriani S., D'Amore C., Distrutti E., Fiorucci S. SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-gamma by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts. Inflammation Research: Official Journal of the European Histamine Research Society 2011, 60:577-587.
47. Sabeena Farvin K.H., Anandan R., Kumar S.H., Shiny K.S., Sankar T.V., Thankappan T.K. Effect of squalene on tissue defense system in isoproterenol-induced myocardial infarction in rats. Pharmacological Research 2004, 50:231-236.
48. Sanchez Miranda E., Perez Ramos J., Fresan Orozco C., Zavala Sanchez M.A., Perez Gutierrez S. Anti-inflammatory effects of hyptis albida chloroform extract on lipopolysaccharide-stimulated peritoneal macrophages. ISRN Pharmacology 2013, 2013:713060.
49. Sanchez-Fidalgo S., Cardeno A., Sanchez-Hidalgo M., Aparicio-Soto M., Villegas I., Rosillo M.A., de la Lastra C.A. Dietary unsaponifiable fraction from extra virgin olive oil supplementation attenuates acute ulcerative colitis in mice. European Journal of Pharmaceutical Sciences 2012, 48:572-581.
50. Sanchez-Hidalgo M., Martin A.R., Villegas I., Alarcon De La Lastra C. Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces chronic colonic inflammation in rats. Biochemical Pharmacology 2005, 69:1733-1744.
51. Scolastici C., Ong T.P., Moreno F.S. Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model. Nutrition and Cancer 2004, 50:101-109.
52. Shi C., Pamer E.G. Monocyte recruitment during infection and inflammation. Nature Reviews. Immunology 2011, 11:762-774.
53. Skehan P., Storeng R., Scudiero D., Monks A., McMahon J., Vistica D., Boyd M.R. New colorimetric cytotoxicity assay for anticancer-drug screening. Journal of the National Cancer Institute 1990, 82:1107-1112.
54. Soehnlein O., Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nature Reviews. Immunology 2010, 10:427-439.
55. Steenport M., Khan K.M., Du B., Barnhard S.E., Dannenberg A.J., Falcone D.J. Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: Evidence for the role of TNF-alpha and cyclooxygenase-2. Journal of Immunology 2009, 183:8119-8127.
56. Tak P.P., Firestein G.S. NF-kappaB: A key role in inflammatory diseases. The Journal of Clinical Investigation 2001, 107:7-11.
57. Takahashi T., Kozaki K., Yatabe Y., Achiwa H., Hida T. Increased expression of COX-2 in the development of human lung cancers. Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer 2002, 21:177-181.
58. Varela L.M., Ortega A., Bermudez B., Lopez S., Pacheco Y.M., Villar J., Abia R., Muriana F.J. A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes. The American Journal of Clinical Nutrition 2011, 93:918-925.
59. Wang W.M., Chen H., Zhong F., Lu Y., Han L., Chen N. Inhibitory effects of rosiglitazone on lipopolysaccharide-induced inflammation in a murine model and HK-2 cells. American Journal of Nephrology 2011, 34:152-162.
60. Zhang Z., Yeung W.K., Huang Y., Chen Z.Y. Effect of squalene and shark liver oil on serum cholesterol level in hamsters. International Journal of Food Sciences and Nutrition 2002, 53(5):411-418.