SHP-dependent and -independent induction of peroxisome proliferator- activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts

Inflammation Research

Volumn 60, Issue 6, 2011, Pages 577-587

  Renga, Barbara ^a   Mencarelli, Andrea ^a   Migliorati, Marco ^a   Cipriani, Sabrina ^a   D'Amore, Claudio ^a   Distrutti, Eleonora ^b   Fiorucci, Stefano ^a,b  

^a UNIVERSITY OF PERUGIA   (Italy)

^b Hospital Saint Mary of Mercy   (Italy)

Author keywords

Farnesoid X receptor; Hepatic stellate cells; HSC T6 cells; Liver inflammation; Peroxisome proliferator activated receptor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CELL NUCLEUS RECEPTOR; COLLAGEN TYPE 1; FARNESOID X RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMALL HETERODIMER PARTNER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STIMULATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; INVERTED REPEAT; LIVER FIBROSIS; LIVER INJURY; MALE; MOLECULAR INTERACTION; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CARBON TETRACHLORIDE; CELL LINE; CHENODEOXYCHOLIC ACID; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION REGULATION; HEK293 CELLS; HEPATIC STELLATE CELLS; HUMANS; INTERLEUKIN-1BETA; MALE; MYOFIBROBLASTS; PHENOTYPE; PPAR GAMMA; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79956197013     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-010-0306-1     Document Type: Article

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