Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages

Food and Chemical Toxicology

Volumn 58, Issue , 2013, Pages 479-486

  Kwon, Dong Joo ^a   Ju, Sung Mi ^a   Youn, Gi Soo ^a   Choi, Soo Young ^a   Park, Jinseu ^a  

^a Hallym University   (South Korea)

Author keywords

COX 2; Flavokawain A; Inflammation; INOS; LPS; Macrophages

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; FLAVOKAWAIN A; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN C FOS; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLOOXYGENASE 2 GENE; CYTOKINE PRODUCTION; CYTOTOXICITY TEST; DRUG EFFECT; DRUG IDENTIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; INTRACELLULAR SIGNALING; MACROPHAGE; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

3-[4,5-DIMETHYLTHIAZOL-2-YL]-2,5-DIPHENYLTETRAZOLIUM BROMIDE; ACTIVATOR PROTEIN-1; AP-1; COX-2; CYCLOOXYGENASE; DMEM; DULBECCO'S MODIFIED EAGLE MEDIUM; ELISA; ENZYME LINKED IMMUNE SORBENT ASSAY; FBS; FETAL BOVINE SERUM; FLAVOKAWAIN A; HORSERADISH PEROXIDASE; HRP; IΚBΑ; INDUCIBLE NO SYNTHASE; INFLAMMATION; INHIBITOR OF KAPPA B ALPHA; INOS; LIPOPOLYSACCHARIDES; LPS; MACROPHAGES; MTT; NF-ΚB; NITRIC OXIDE; NO; NUCLEAR FACTOR-ΚB; PCR; PGE(2); POLYMERASE CHAIN REACTION; PROSTAGLANDIN E(2); SDS; SODIUM DODECYL SULPHATE; TLR4; TOLL-LIKE RECEPTOR 4;

ANIMALS; BASE SEQUENCE; CELL LINE; CHALCONE; CYCLOOXYGENASE 2; CYTOKINES; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTOR AP-1;

MURINAE; PIPER METHYSTICUM;

EID: 84879293715     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.05.031     Document Type: Article

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