Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, reduces chronic colonic inflammation in rats

Biochemical Pharmacology

Volumn 69, Issue 12, 2005, Pages 1733-1744

  Sanchez Hidalgo M ^a   Martin A R ^a   Villegas, I ^a   Alarcon De La Lastra C ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Apoptosis; Colitis; COX 2; NF B; PPAR ; Prostaglandins

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOPEROXIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN D2; PROSTAGLANDIN E2; ROSIGLITAZONE; SYNAPTOTAGMIN; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CELL FUNCTION; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ASSAY; ENZYME BLOOD LEVEL; FEEDING; FEMALE; HISTOPATHOLOGY; INTESTINE ULCER; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; ULCERATIVE COLITIS; UPREGULATION;

ANIMALS; APOPTOSIS; CHRONIC DISEASE; COLITIS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; PPAR GAMMA; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; THIAZOLIDINEDIONES;

EID: 20344363144     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.03.024     Document Type: Article

References (54)

1. G. Van Assche, and P. Rutgeerts Antiadhesion molecule therapy in inflammatory bowel disease Inflamm Bowel Dis 8 2002 291 300
2. W.J. Sandborn, and T.A. Yednock Novel approaches to treating inflammatory bowel disease: targeting alpha-4 integrin Am J Gastroenterol 98 2003 2372 2382
3. L.J. Crofford COX-1 and COX-2 expression: Implications and predictions J Rheumatol 24 1997 15 19
4. T.D. Warner, and J.A. Mitchell Cyclooxygenases: new forms, new inhibitors, and lesson from the clinic Faseb J 18 2004 790 804
5. A.R. Martín, I. Villegas, C. La Casa, and C. Alarcon De la Lastra The cyclo-oxygenase-2 inhibitor, rofecoxib, attenuates mucosal damage due to colitis induced by trinitrobenzene sulphonic acid in rats Eur J Pharmacol 481 2003 281 291
6. A.R. Martín, I. Villegas, C. La Casa, and C. Alarcon De La Lastra Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats Biochem Pharmacol 67 2004 1399 1410
7. I. Villegas, C. Alarcon De la Lastra, A. Orjales, and C. La Casa A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice Int Immunopharmacol 3 2003 1731 1741
8. I. Villegas, and C. Alarcon De la Lastra A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice Int Immunopharmacol 24 2003 209 218
9. R.N. Fedorak, L.R. Empey, C. MacArthur, and L.D. Jewell Misoprostol provides a colonic mucosal protective effect during acetic acid-induced colitis in rats Gastroenterology 98 1990 615 625
10. T.G. Tessner, S Schloemann, S.M. Cohn, and W.F. Stenson Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice Gastroenterology 115 1998 874 882
11. D.W. Gilroy, P.R. Colville-Nash, D. Willis, J. Chivers, M.J. Paul-Clark, and D.A. Willoughby Inducible cyclooxygenase may have anti-inflammatory properties Nat Med 5 1999 698 701
12. M.N. Ajuebor, A. Singh, and J.L. Wallace Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis Am J Physiol Gastrointest Liver Physiol 279 2000 G238 G244
13. B. Berenguer, C. Alarcón de la Lastra, F.J. Moreno, and Ma.J. Martín Chronic gastric ulcer healing in rats subjected to selective and non-selective cyclooxygenase-2 inhibitors Eur J Pharmacol 3 2002 125 135
14. A. Cabrero, J.C. Laguna, and M. Vazquez Peroxisome proliferator-activated receptors and the control of inflammation Curr Drug Targets Inflamm Allergy 3 2002 243 248
15. H.K. Na, and Y.J. Surh Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands as bifunctional regulators of cell proliferation Biochem Pharmacol 66 2003 1381 1391
16. C. Alarcón de la Lastra, S. Sánchez-Fidalgo, I. Villegas, and V. Motilva New pharmacological perspectives and therapeutic potential of PPARγ agonists Curr Pharm Design 10 28 2004 3505 3524
17. H.A. Pershadsingh Peroxisome proliferator-activated receptor-gamma: therapeutic target for diseases beyond diabetes: quo vadis? Expert Opin Investig Drugs 13 2004 215 228
18. L. Dubuquoy, S. Dharancy, S. Nutten, S. Pettersson, J. Auwerx, and P. Desreumaux Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases Lancet 2 2002 1410 1418
19. M. Dubois, M.C. Vantyghem, K. Schoonjans, and F. Pattou Thiazolidinediones in type 2 diabetes Role of peroxisome proliferator-activated receptor gamma (PPARgamma)] Ann Endocrinol 63 2002 511 523
20. D.J. Adamson, D. Frew, R. Tatoud, C.R. Wolf, and C.N. Palmer Diclofenac antagonizes peroxisome proliferator-activated receptor-gamma signaling Mol Pharmacol 61 2002 7 12
21. P. Desreumaux, L. Dubuquoy, S. Nutten, M. Peuchmauer, W. Englaro, and K. Schoonjans Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor γ (PPARγ) heterodimer: a basis for new therapeutic strategies J Exp Med 193 2001 827 838
22. M. Lefebvre, B. Paulweber, L. Fajas, J. Woods, C. McCrary, and J.F. Colombel Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells J Endocrinol 162 1999 331 340
23. K. Katayama, K. Wada, A. Nakajima, H. Mizuguchi, T. Hayakawa, and S. Nakagawa A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model Gastroenterology 124 2003 1315 1324
24. L. Dubuquoy, E.A. Jansson, S. Deeb, S. Rakotobe, M. Karoui, and J.F. Colombel Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis Gastroenterology 124 2003 1265 1276
25. S. Cuzzocrea, A. Ianaro, N.S. Wayman, E. Mazzon, B. Pisano, and L. Dugo The cyclopentenone prostaglandin 15-deoxy-delta(12,14)-PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat Br J Pharmacol 8 2003 8 88
26. C.G. Su, X. Wen, S.T. Bailey, W. Jiang, S.M. Rangwala, and S.A. Keilbaugh A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response J Clin Invest 104 1999 383 389
27. T. Takagi, Y. Naito, N. Tomatsuri, O. Handa, H. Ichikawa, and N. Yoshida Pioglitazone, a PPAR-gamma ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade Redox Rep 7 2002 283 289
28. L.J. Saubermann, A. Nakajima, K. Wada, S. Zhao, Y. Terauchi, and T. Kadowaki Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis Inflamm Bowel Dis 8 2002 330 339
29. H. Kohno, S. Yoshitani, S. Takashima, A. Okumura, M. Hosokawa, and N. Yamaguchi a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats Jpn J Cancer Res 92 2001 396 403
30. G.P. Morris, P.L. Beck, M.S. Herridge, W.T. Depew, M.R. Szewczuk, and J.L. Wallace Hapten-induced model of chronic inflammation and ulceration in the rat colon Gastroenterology 96 3 1989 795 803
31. C. Bobin-Dubigeon, X. Collin, N. Grimaud, J.M. Robert, G. Le Baut, and J.Y. Petit Effects of tumour necrosis factor-α synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis Eur J Pharmacol 421 2001 103 110
32. M.B. Grisham, J.N. Beniot, and D.N. Granger Assessment of leukocyte involvement during ischemia and reperfusion of intestine Methods Enzymol 186 1990 729 742
33. M. Helenius, M. Hanninen, S.K. Lehtinek, and A. Salminen Changes associate with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB Biochem J 318 1996 603 608
34. C. Alarcón de la Lastra, M.J. Martín, and V. Motilva Antiulcer and gastroprotective effect of quercetin: a gross and histologic study Pharmacology 48 1994 56 62
35. M.I. Torres, M. García-Martín, M.I. Fernández, N. Nieto, A. Gil, and A. Ríos Experimental colitis induced by trinitrobenzenesulfonic acid. An ultrastructural and histochemical study Dig Dis Sci 44 1999 2523 2529
36. I.C. Lawrance, F. Wu, A.Z. Leite, J. Willis, G.A. West, and C. Fiocchi A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B Gastroenterology 125 2003 1750 1761
37. C. Jobin, and R.B. Sartor NF-kappaB signaling proteins as therapeutic targets for inflammatory bowel diseases Inflamm Bowel Dis 6 2000 206 213
38. S.W. Chung, B.Y. Kang, S.H. Kim, Y.K. Pak, D. Cho, and G. Trinchieri Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-γ and nuclear factor-κ B J Biol Chem 275 2000 32681 32687
39. A. Rossi, P. Kapahi, G. Natoli, T. Takahashi, Y. Chen, and M. Karin Anti-inflammatory cyclopentene prostaglandins are direct inhibitors of IκB kinase Nature 403 2000 103 108
40. 2 in activated murine macrophages Mol Cell Biol 20 2000 1692 1698
41. L. Nagy, H.Y. Lao, D. Chakravarti, R.J. Lin, C.A. Hassig, and D.E. Ayer Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase Cell 89 1997 373 380
42. 2 before and after induction of colitis with trinitrobenzenesulfonic acid in rats decreases inflammation Gastroenterology 96 1989 1290 1300
43. K. Kabashima, T. Saji, T. Murata, M. Nagamachi, T. Matsuoka, and E. Segui The prostaglandin receptor EP4 supresses colitis, mucosal damage and CD4 cell activation in the gut J Invest 109 2002 883 893
44. S.R. Zamuner, N. Warrier, A.G. Bureo, W.K. MacNaughton, and J.L. Wallace Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction Gut 52 2003 1714 1720
45. N.A. Callejas, A. Catrillo, L. Bosca, and P.J. Martín-Sanz Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators Pharmacol Exp Ther 288 1999 1235 1241
46. H. Inoue, T. Tanabe, and K. Umeson Feedback control of cyclooxygenase-2 expression through PPARγ J Biol Chem 275 2000 28028 28032
47. K. Subbaramaiah, D.T. Lin, J.C. Hart, and A.J. Dannenberg Peroxisome proliferator-activated receptor γ ligands suppress the transcriptional activation of cyclooxygenase-2: evidence for involvement of activator protein-1 and CREB-binding protein/p300 J Biol Chem 276 2001 12440 12448
48. D. Tardieu, J.P. Jaeg, A. Deloly, D.E. Corpet, J. Cadet, and C.R. Petit The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy- deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats Carcinogenesis 21 2000 973 976
49. G. Yue, P.S. Lai, K. Yin, F.F. Sun, R.G. Nagele, and X. Liu Colon epithelial cell death in 2,4 6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production J Pharmacol Exp Ther 297 2001 915 925
50. Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production J Pharmacol Exp Ther 21 2001 973 976
51. G. Chinetti, S. Griglio, M. Antonucci, I.P. Torra, P. Delerive, and Z. Majd Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages J Biol Chem 273 1998 25573 25580
52. W.L. Yang, and H. Frucht Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells Carcinogenesis 22 2001 1379 1383
53. G.G. Chen, J.F. Lee, S.H. Wang, U.P. Chan, P.C. Ip, and W.Y. Au Apoptosis induced by activation of peroxisome-proliferator activated receptor-gamma is associated with Bcl-2 and NF-kappaB in human colon cancer Life Sci 70 2002 2631 2646
54. M.Y. Li, H. Deng, J.M. Zhao, D. Dai, and X.Y. Tan PPARgamma pathway activation results in apoptosis and COX-2 inhibition in HepG2 cells World J Gastroenterol 9 2003 1220 1226