A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes

American Journal of Clinical Nutrition

Volumn 93, Issue 5, 2011, Pages 918-925

  Varela, Lourdes M ^a   Ortega, Almudena ^a   Bermudez, Beatriz ^a   Lopez, Sergio ^a   Pacheco, Yolanda M ^a   Villar, Jose ^b   Abia, Rocio ^a   Muriana, Francisco J G ^a  

^a INSTITUTO DE LA GRASA   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B100; APOLIPOPROTEIN B48; APOLIPOPROTEIN B48 RECEPTOR; CHOLESTEROL; FATTY ACID; INSULIN; MESSENGER RNA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; DIET RESTRICTION; HUMAN; HUMAN EXPERIMENT; LIPID DIET; LIPID STORAGE; MACROPHAGE; MALE; MONOCYTE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; POSTPRANDIAL STATE; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ADULT; CROSS-OVER STUDIES; DIETARY FATS; HUMANS; HYPERTRIGLYCERIDEMIA; KINETICS; LIPID METABOLISM; LIPIDS; MALE; MONOCYTES; RECEPTORS, LIPOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SINGLE-BLIND METHOD; TRANSCRIPTIONAL ACTIVATION; YOUNG ADULT;

EID: 79955388920     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.110.007765     Document Type: Article

References (15)

1. Zilversmit DB. Atherogenic nature of triglycerides, postprandial lipidemia, and triglyceride-rich remnant lipoproteins. Clin Chem 1995; 41:153-8.
2. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischaemic heart disease, and death in men and women. JAMA 2007;298:299-308. (Pubitemid 47080484)
3. Gianturco SH, Ramprasad MP, Song R, Li R, Brown ML, Bradley WA. Apolipoprotein B-48 or its apolipoprotein B-100 equivalent mediates the binding of triglyceride-rich lipoproteins to their unique human monocyte-macrophage receptor. Arterioscler Thromb Vase Biol 1998; 18:968-76. (Pubitemid 28272593)
4. Proctor SD, Vine DF, Mamo JC. Arterial retention of apolipoprotein B (48)-and B(100)-containing lipoproteins in atherogenesis. Curr Opin Lipidol 2002;13:461-70. (Pubitemid 35231925)
5. Brown ML, Ramprasad MP, Umeda PK, et al. A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis. Proc Natl Acad Sci USA 2000;97:7488-93. (Pubitemid 30431490)
6. Brown ML, Yui K, Smith JD, et al. The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor. J Lipid Res 2002;43:1181-91. (Pubitemid 34988166)
7. Nordestgaard BG, Wootton R, Lewis B. Selective retention of VLDL, IDL, and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo: molecular size as a determinant of fractional loss from the intima-inner media. Arterioscler Thromb Vase Biol 1995;15:534-42.
8. Alipour A, van Oostrom AJ, Izraeljan A, et al. Leukocyte activation by triglyceride-rich lipoproteins. Arterioscler Thromb Vase Biol 2008;28:792-7. (Pubitemid 351651339)
9. Pacheco YM, Bermudez B, Lopez S, Abia R, Villar J, Muriana FJG. Ratio of oleic to palmitic acid is a dietary determinant of thrombogenic and fibrinolytic factors during the postprandial state in men. Am J Clin Nutr 2006;84:342-9. (Pubitemid 44699143)
10. Pacheco YM, Abia R, Olivera A, Spiegel S, Ruiz-Gutierrez V, Muriana FJG. Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins. Cell Mol Life Sci 2003;60:2757-66. (Pubitemid 38041375)
11. Lopez S, Bermudez B, Pacheco YM, Villar J, Abia R, Muriana FJG. Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids. Am J Clin Nutr 2008;88:638-44.
12. den Hartigh LJ, Connolly-Rohrbach JE, Fore S, Huser TR, Rutledge JC. Fatty acids from very low-density lipoprotein lipolysis products induce lipid droplet accumulation in human monocytes. J Immunol 2010;184:3927-36.
13. Mosig S, Rennert K, Büttner P, et al. Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism. BMC Med Genomics 2008;1:60.
14. Woollard KJ, Geissmann F. Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol 2010;7:77-86.
15. Bozza PT, Magalhães KG, Weller PF. Leukocyte lipid bodies - biogenesis and functions in inflammation. Biochim Biophys Acta 2009;1791:540-51.