Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in RAW264.7 cells

Fitoterapia

Volumn 83, Issue 8, 2012, Pages 1628-1635

  Kim, Kui Jin ^a   Yoon, Kye Yoon ^b   Lee, Boo Yong ^b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CHA University   (South Korea)

Author keywords

Inflammation; Low molecular weight fucoidan; MAPK; Oxidative stress; ROS

Indexed keywords

CYCLOOXYGENASE 2; FUCOIDIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE; LOW MOLECULAR WEIGHT FUCOIDAN; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BROWN ALGA; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME INHIBITION; IN VITRO STUDY; INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UNDARIA PINNATIFIDA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARBOHYDRATE CONFORMATION; CELL SURVIVAL; CYTOKINES; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OXIDATIVE STRESS; POLYSACCHARIDES; UNDARIA;

UNDARIA PINNATIFIDA;

EID: 84870773196     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2012.09.014     Document Type: Article

References (46)

1. T. Hanada, and A. Yoshimura Regulation of cytokine signaling and inflammation Cytokine Growth Factor Rev 13 2002 413 421
2. H. Kleinert, A. Pautz, K. Linker, and P.M. Schwarz Regulation of the expression of inducible nitric oxide synthase Eur J Pharmacol 500 2004 255 266
3. N.A. Chartrain, D.A. Geller, P.P. Koty, N.F. Sitrin, A.K. Nussler, and E.P. Hoffman Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene J Biol Chem 269 1994 6765 6772
4. C.J. Lowenstein, and E. Padalko iNOS (NOS2) at a glance J Cell Sci 117 2004 2865 2867
5. H. Liu, R. Colavitti, I.I. Rovira, and T. Finkel Redox-dependent transcriptional regulation Circ Res 97 2005 967 974
6. J. Macdonald, H.F. Galley, and N.R. Webster Oxidative stress and gene expression in sepsis Br J Anaesth 90 2003 221 232
7. C.S. Yang, D.S. Lee, C.H. Song, S.J. An, S. Li, and J.M. Kim Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock J Exp Med 204 2007 583 594
8. M. Torres, and H.J. Forman Redox signaling and the MAP kinase pathways Biofactors 17 2003 287 296
9. F.L. Chiu, and J.K. Lin Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages FEBS Lett 582 2008 2407 2412
10. A. Beress, O. Wassermann, S. Tahhan, T. Bruhn, L. Beress, and E.N. Kraiselburd A new procedure for the isolation of anti-HIV compounds (polysaccharides and polyphenols) from the marine alga Fucus vesiculosus J Nat Prod 56 1993 478 488
11. M.S. Pereira, B. Mulloy, and P.A. Mourao Structure and anticoagulant activity of sulfated fucans. Comparison between the regular, repetitive, and linear fucans from echinoderms with the more heterogeneous and branched polymers from brown algae J Biol Chem 274 1999 7656 7667
12. S. Koyanagi, N. Tanigawa, H. Nakagawa, S. Soeda, and H. Shimeno Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities Biochem Pharmacol 65 2003 173 179
13. S. Preeprame, K. Hayashi, J.B. Lee, U. Sankawa, and T. Hayashi A novel antivirally active fucan sulfate derived from an edible brown alga, Sargassum horneri Chem Pharm Bull (Tokyo) 49 2001 484 485
14. V.N. Bochkov, V.A. Tkachuk, M.P. Philippova, D.V. Stambolsky, F.R. Buhler, and T.J. Resink Ligand selectivity of 105 kDa and 130 kDa lipoprotein-binding proteins in vascular-smooth-muscle-cell membranes is unique Biochem J 317 Pt 1 1996 297 304
15. K.J. Kim, O.H. Lee, and B.Y. Lee Low-molecular-weight fucoidan regulates myogenic differentiation through the mitogen-activated protein kinase pathway in C2C12 cells Br J Nutr 2011 1 9
16. K.J. Kim, O.H. Lee, and B.Y. Lee Fucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes Life Sci 86 2010 791 797
17. K.J. Kim, O.H. Lee, and B.Y. Lee Genotoxicity studies on fucoidan from sporophyll of Undaria pinnatifida Food Chem Toxicol 48 2010 1101 1104
18. K.J. Kim, O.H. Lee, H.H. Lee, and B.Y. Lee A 4-week repeated oral dose toxicity study of fucoidan from the sporophyll of Undaria pinnatifida in Sprague-Dawley rats Toxicology 267 2010 154 158
19. B. Li, F. Lu, X. Wei, and R. Zhao Fucoidan: structure and bioactivity Molecules 13 2008 1671 1695
20. M.L. Cho, B.Y. Lee, and S.G. You Relationship between oversulfation and conformation of low and high molecular weight fucoidans and evaluation of their in vitro anticancer activity Molecules 16 2010 291 297
21. S. You, C. Yang, H. Lee, and B.-Y. Lee Molecular characteristics of partially hydrolyzed fucoidans from sporophyll of Undaria pinnatifida and their in vitro anticancer activity Food Chem 119 2010 554 559
22. J.W. Yang, S.Y. Yoon, S.J. Oh, S.K. Kim, and K.W. Kang Bifunctional effects of fucoidan on the expression of inducible nitric oxide synthase Biochem Biophys Res Commun 346 2006 345 350
23. H. Do, N.S. Kang, S. Pyo, T.R. Billiar, and E.H. Sohn Differential regulation by fucoidan of IFN-gamma-induced NO production in glial cells and macrophages J Cell Biochem 111 2010 1337 1345
24. M.N. Khan, J.Y. Cho, M.C. Lee, J.Y. Kang, N.G. Park, and H. Fujii Isolation of two anti-inflammatory and one pro-inflammatory polyunsaturated fatty acids from the brown seaweed Undaria pinnatifida J Agric Food Chem 55 2007 6984 6988
25. H.Y. Park, M.H. Han, C. Park, C.Y. Jin, G.Y. Kim, and I.W. Choi Anti-inflammatory effects of fucoidan through inhibition of NF-kappaB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells Food Chem Toxicol 49 2011 1745 1752
26. C. Yang, D. Chung, I.S. Shin, H. Lee, J. Kim, and Y. Lee Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida Int J Biol Macromol 43 2008 433 437
27. A. Nardella, F. Chaubet, C. Boisson-Vidal, C. Blondin, P. Durand, and J. Jozefonvicz Anticoagulant low molecular weight fucans produced by radical process and ion exchange chromatography of high molecular weight fucans extracted from the brown seaweed Ascophyllum nodosum Carbohydr Res 289 1996 201 208
28. N.W. Roehm, G.H. Rodgers, S.M. Hatfield, and A.L. Glasebrook An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT J Immunol Methods 142 1991 257 265
29. S. Furukawa, T. Fujita, M. Shimabukuro, M. Iwaki, Y. Yamada, and Y. Nakajima Increased oxidative stress in obesity and its impact on metabolic syndrome J Clin Invest 114 2004 1752 1761
30. D. Yen, J. Cheung, H. Scheerens, F. Poulet, T. McClanahan, and B. McKenzie IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6 J Clin Invest 116 2006 1310 1316
31. C. Szabo, J.A. Mitchell, C. Thiemermann, and J.R. Vane Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock Br J Pharmacol 108 1993 786 792
32. R.L. Baehner, L.A. Boxer, and J. Davis The biochemical basis of nitroblue tetrazolium reduction in normal human and chronic granulomatous disease polymorphonuclear leukocytes Blood 48 1976 309 313
33. B. Veres, F. Gallyas Jr., G. Varbiro, Z. Berente, E. Osz, and G. Szekeres Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock Biochem Pharmacol 65 2003 1373 1382
34. Q. Zhao, X. Wang, L.D. Nelin, Y. Yao, R. Matta, and M.E. Manson MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock J Exp Med 203 2006 131 140
35. S. Hashimoto, K. Morohoshi, T. Suzuki, and K. Matsushima Lipopolysaccharide-inducible gene expression profile in human monocytes Scand J Infect Dis 35 2003 619 627
36. S.J. Klebanoff, M.A. Vadas, J.M. Harlan, L.H. Sparks, J.R. Gamble, and J.M. Agosti Stimulation of neutrophils by tumor necrosis factor J Immunol 136 1986 4220 4225
37. J.R. Vane, J.A. Mitchell, I. Appleton, A. Tomlinson, D. Bishop-Bailey, and J. Croxtall Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation Proc Natl Acad Sci U S A 91 1994 2046 2050
38. C. Stevens, G. Walz, C. Singaram, M.L. Lipman, B. Zanker, and A. Muggia Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease Dig Dis Sci 37 1992 818 826
39. M. Feldmann, F.M. Brennan, and R. Maini Cytokines in autoimmune disorders Int Rev Immunol 17 1998 217 228
40. G.H. Wong, and D.V. Goeddel Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism Science 242 1988 941 944
41. A. Masuda, D.L. Longo, Y. Kobayashi, E. Appella, J.J. Oppenheim, and K. Matsushima Induction of mitochondrial manganese superoxide dismutase by interleukin 1 FASEB J 2 1988 3087 3091
42. J.S. Luoma, P. Stralin, S.L. Marklund, T.P. Hiltunen, T. Sarkioja, and S. Yla-Herttuala Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins Arterioscler Thromb Vasc Biol 18 1998 157 167
43. J.J. Haddad, and S.C. Land Redox/ROS regulation of lipopolysaccharide- induced mitogen-activated protein kinase (MAPK) activation and MAPK-mediated TNF-alpha biosynthesis Br J Pharmacol 135 2002 520 536
44. J. Saldeen, and N. Welsh p38 MAPK inhibits JNK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-KB translocation in insulin-producing cells Eur Cytokine Netw 15 2004 47 52
45. E.D. Chan, B.W. Winston, S.T. Uh, M.W. Wynes, D.M. Rose, and D.W. Riches Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages J Immunol 162 1999 415 422
46. W.A.J.P. Wijesinghe, and Y.-J. Jeon Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: a review Carbohydr Polym 88 2012 13 20