Celastrol induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-and kappa;B signaling pathway

Pharmacology

Volumn 93, Issue 1-2, 2014, Pages 39-46

  Sha, Min ^a   Ye, Jun ^a   Zhang, Li Xin ^a   Luan, Zheng Yun ^a   Chen, Ya Bao ^a   Huang, Jun Xing ^b  

^a Institutes of Clinical Medicine   (China)

^b NANTONG UNIVERSITY   (China)

Author keywords

Apoptosis; Celastrol; Gastric cancer; miR 21 inhibitor; PI3K Akt NF B signaling pathway

Indexed keywords

ANTINEOPLASTIC AGENT; CELASTROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA 21; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH CANCER; UPREGULATION; WESTERN BLOTTING; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENE REPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; MICRORNAS; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TRITERPENES;

EID: 84892417914     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000357683     Document Type: Article

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