The effects of MAPK inhibitors on a proteasome inhibitor, MG132-induced HeLa cell death in relation to reactive oxygen species and glutathione

Toxicology Letters

Volumn 192, Issue 2, 2010, Pages 134-140

  Han, Yong Hwan ^a   Park, Woo Hyun ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Apoptosis; GSH; MAPK inhibitor; MG132; ROS

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL;

APOPTOSIS; CELL PROLIFERATION; DRUG INTERACTIONS; GLUTATHIONE; GROWTH INHIBITORS; HELA CELLS; HUMANS; LEUPEPTINS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES;

EID: 74149085251     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.10.015     Document Type: Article

References (30)

1. Blenis J. Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 5889-5892
2. Chen T.J., Jeng J.Y., Lin C.W., Wu C.Y., and Chen Y.C. Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells. Toxicology 223 (2006) 113-126
3. Dasmahapatra G., Rahmani M., Dent P., and Grant S. The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism. Blood 107 (2006) 232-240
4. Emanuele S., Calvaruso G., Lauricella M., Giuliano M., Bellavia G., D'Anneo A., Vento R., and Tesoriere G. Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-XS and activation of caspase-3. Int. J. Oncol. 21 (2002) 857-865
5. Estrela J.M., Ortega A., and Obrador E. Glutathione in cancer biology and therapy. Crit. Rev. Clin. Lab. Sci. 43 (2006) 143-181
6. Genestra M. Oxyl radicals, redox-sensitive signalling cascades and antioxidants. Cell. Signal. 19 (2007) 1807-1819
7. Gomez-Lazaro M., Galindo M.F., Melero-Fernandez de Mera R.M., Fernandez-Gomez F.J., Concannon C.G., Segura M.F., Comella J.X., Prehn J.H., and Jordan J. Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate. Mol. Pharmacol. 71 (2007) 736-743
8. 2. Role in cell survival following oxidant injury. J. Biol. Chem. 271 (1996) 4138-4142
9. Han Y.H., and Park W.H. The effects of MAPK inhibitors on antimycin A-treated Calu-6 lung cancer cells in relation to cell growth, reactive oxygen species, and glutathione. Mol. Cell. Biochem. (2009)
10. Han Y.H., Kim S.Z., Kim S.H., and Park W.H. Arsenic trioxide inhibits growth of As4.1 juxtaglomerular cells via cell cycle arrest and caspase-independent apoptosis. Am. J. Physiol. 293 (2007) F511-520
11. Han Y.H., Kim S.Z., Kim S.H., and Park W.H. Pyrogallol as a glutathione depletor induces apoptosis in HeLa cells. Int. J. Mol. Med. 21 (2008) 721-730
12. Han Y.H., Kim S.Z., Kim S.H., and Park W.H. Pyrogallol inhibits the growth of human lung cancer Calu-6 cells via arresting the cell cycle arrest. Toxicol. In Vitro 22 (2008) 1605-1609
13. Han Y.H., Moon H.J., You B.R., Kim S.Z., Kim S.H., and Park W.H. JNK and p38 inhibitors increase and decrease apoptosis, respectively, in pyrogallol-treated calf pulmonary arterial endothelial cells. Int. J. Mol. Med. 24 (2009) 717-722
14. Han Y.H., Moon H.J., You B.R., and Park W.H. The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH. Oncol. Rep. 22 (2009) 215-221
15. Henson E.S., and Gibson S.B. Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy. Cell. Signal. 18 (2006) 2089-2097
16. Higuchi Y. Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J. Cell. Mol. Med. 8 (2004) 455-464
17. Hsin Y.H., Chen C.F., Huang S., Shih T.S., Lai P.S., and Chueh P.J. The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicol. Lett. 179 (2008) 130-139
18. Jahngen-Hodge J., Obin M.S., Gong X., Shang F., Nowell Jr. T.R., Gong J., Abasi H., Blumberg J., and Taylor A. Regulation of ubiquitin-conjugating enzymes by glutathione following oxidative stress. J. Biol. Chem. 272 (1997) 28218-28226
19. Kusuhara M., Takahashi E., Peterson T.E., Abe J., Ishida M., Han J., Ulevitch R., and Berk B.C. p38 kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2. Circ. Res. 83 (1998) 824-831
20. Lee D.H., and Goldberg A.L. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol. 8 (1998) 397-403
21. Ling Y.H., Liebes L., Zou Y., and Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J. Biol. Chem. 278 (2003) 33714-33723
22. Mao X., Yu C.R., Li W.H., and Li W.X. Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells. Cell Res. 18 (2008) 879-888
23. Marshall N.J., Goodwin C.J., and Holt S.J. A critical assessment of the use of microculture tetrazolium assays to measure cell growth and function. Growth Regul. 5 (1995) 69-84
24. Orlowski R.Z. The role of the ubiquitin-proteasome pathway in apoptosis. Cell Death Differ. 6 (1999) 303-313
25. Park W.H., Han Y.W., Kim S.H., and Kim S.Z. A superoxide anion generator, pyrogallol induces apoptosis in As4.1 cells through the depletion of intracellular GSH content. Mutat. Res. 619 (2007) 81-92
26. Perez-Galan P., Roue G., Villamor N., Montserrat E., Campo E., and Colomer D. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 107 (2006) 257-264
27. Qiu J.H., Asai A., Chi S., Saito N., Hamada H., and Kirino T. Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons. J. Neurosci. 20 (2000) 259-265
28. Rygiel T.P., Mertens A.E., Strumane K., van der Kammen R., and Collard J.G. The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation. J. Cell Sci. 121 (2008) 1183-1192
29. Voges D., Zwickl P., and Baumeister W. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu. Rev. Biochem. 68 (1999) 1015-1068
30. Wu H.M., Chi K.H., and Lin W.W. Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production. FEBS Lett. 526 (2002) 101-105