CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor κB: Implications for bidirectional tumor-stromal interactions

Journal of Biological Chemistry

Volumn 287, Issue 46, 2012, Pages 39115-39124

  Singh, Ajay P ^a   Arora, Sumit ^a   Bhardwaj, Arun ^a   Srivastava, Sanjeev K ^a   Kadakia, Madhavi P ^b   Wang, Bin ^a   Grizzle, William E ^c   Owen, Laurie B ^a   Singh, Seema ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b WRIGHT STATE UNIVERSITY   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SIGNALING; CHEMICAL ACTIVATION; CYTOLOGY; DISEASES; ENZYMES; TUMORS;

CHROMATIN IMMUNOPRECIPITATION ASSAY; EXTRACELLULAR-REGULATED KINASE; INHIBITORY PROTEINS; NUCLEAR ACCUMULATION; NUCLEAR FACTOR KAPPAB; PANCREATIC TUMOR CELLS; SIGNALING PATHWAYS; THERAPEUTIC OUTCOMES;

CELLS;

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SONIC HEDGEHOG PROTEIN;

ARTICLE; BIOACCUMULATION; CANCER CELL CULTURE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84869068038     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.409581     Document Type: Article

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