Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 4, 2015, Pages 936-945.e4

  Ming, Mei ^a   Zhao, Baozhong ^a   Shea, Christopher R ^a   Shah, Palak ^a   Qiang, Lei ^a   White, Steven R ^a   Sims, Diane M ^a   He, Yu Ying ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

filaggrin; Sirtuin 1 (SIRT1); skin barrier

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; FILAGGRIN; IMMUNOGLOBULIN E; MESSENGER RNA; OVALBUMIN; SIRTUIN 1; ALLERGEN; INTERMEDIATE FILAMENT PROTEIN; PROTEIN KINASE B;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE SILENCING; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BARRIER INTEGRITY; SKIN DEFECT; SKIN FUNCTION; SKIN HISTOLOGY; SKIN SENSITIZATION; SKIN WATER LOSS; WILD TYPE MOUSE; ANIMAL; DISEASE MODEL; EPIDERMIS; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MAST CELL; METABOLISM; PATHOLOGY; SKIN; ULTRASTRUCTURE;

ALLERGENS; ANIMALS; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; EPIDERMIS; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN E; INTERMEDIATE FILAMENT PROTEINS; KERATINOCYTES; MAST CELLS; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ARYL HYDROCARBON; SIRTUIN 1; SKIN;

EID: 84926250440     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.09.035     Document Type: Article

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