Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

Journal of Allergy and Clinical Immunology

Volumn 124, Issue 3, 2009, Pages

  Scharschmidt, Tiffany C ^a   Man, Mao Qiang ^a   Hatano, Yutaka ^a   Crumrine, Debra ^a   Gunathilake, Roshan ^a   Sundberg, John P ^b   Silva, Kathleen A ^b   Mauro, Theodora M ^a   Hupe, Melanie ^a   Cho, Soyun ^c   Wu, Yan ^d   Celli, Anna ^a   Schmuth, Matthias ^a   Feingold, Kenneth R ^a   Elias, Peter M ^a  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b JACKSON LABORATORY   (United States)

^c Seoul National University College of Medicine   (South Korea)

^d PEKING UNIVERSITY   (China)

Author keywords

Atopic dermatitis; barrier function; contact dermatitis; filaggrin; flaky tail mouse; lamellar body

Indexed keywords

BETA DEFENSIN 3; FILAGGRIN; HAPTEN; IMMUNOGLOBULIN E; IRRITANT AGENT; PROFILAGGRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; FRAMESHIFT MUTATION; LAMELLAR BODY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ALLERGY; SKIN INFLAMMATION; STRATUM CORNEUM;

EID: 69349087273     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2009.06.046     Document Type: Article

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