메뉴 건너뛰기




Volumn 35, Issue 5, 2015, Pages 1756-1763

Nuclear SMAD2 restrains proliferation of glioblastoma

Author keywords

Cancer cell growth; Glioblastoma multiforme (GBM); p21; SMAD2; SMAD3; Transforming growth factor (TGF )

Indexed keywords

PROTEIN P27; SHORT HAIRPIN RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; RECOMBINANT PROTEIN; SMAD2 PROTEIN, HUMAN; SMALL INTERFERING RNA;

EID: 84926163715     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373987     Document Type: Article
Times cited : (13)

References (49)
  • 1
    • 84884991530 scopus 로고    scopus 로고
    • Genomics informs glioblastoma biology
    • Schonberg DL, Bao S, Rich JN: Genomics informs glioblastoma biology. Nat Genet 2013;45:1105-1107.
    • (2013) Nat Genet , vol.45 , pp. 1105-1107
    • Schonberg, D.L.1    Bao, S.2    Rich, J.N.3
  • 2
    • 84904979333 scopus 로고    scopus 로고
    • Inhibition of foxo1 nuclear exclusion prevents metastasis of glioblastoma
    • Chen J, Huang Q, Wang F: Inhibition of foxo1 nuclear exclusion prevents metastasis of glioblastoma. Tumour Biol 2014;35:7195-7200.
    • (2014) Tumour Biol , vol.35 , pp. 7195-7200
    • Chen, J.1    Huang, Q.2    Wang, F.3
  • 3
    • 84925283004 scopus 로고    scopus 로고
    • Interplay of vegfa and mmp2 regulates invasion of glioblastoma
    • Gong J, Zhu S, Zhang Y, Wang J: Interplay of vegfa and mmp2 regulates invasion of glioblastoma. Tumour Biol 2014;35:11879-11885.
    • (2014) Tumour Biol , vol.35 , pp. 11879-11885
    • Gong, J.1    Zhu, S.2    Zhang, Y.3    Wang, J.4
  • 4
    • 84904754114 scopus 로고    scopus 로고
    • Egfr signaling-dependent inhibition of glioblastoma growth by ginsenoside rh2
    • Li S, Gao Y, Ma W, Guo W, Zhou G, Cheng T, Liu Y: Egfr signaling-dependent inhibition of glioblastoma growth by ginsenoside rh2. Tumour Biol 2014;35:5593-5598.
    • (2014) Tumour Biol , vol.35 , pp. 5593-5598
    • Li, S.1    Gao, Y.2    Ma, W.3    Guo, W.4    Zhou, G.5    Cheng, T.6    Liu, Y.7
  • 5
    • 84919847649 scopus 로고    scopus 로고
    • Mirna-181c inhibits egfr-signaling-dependent mmp9 activation via suppressing akt phosphorylation in glioblastoma
    • Wang F, Xiao W, Sun J, Han D, Zhu Y: Mirna-181c inhibits egfr-signaling-dependent mmp9 activation via suppressing akt phosphorylation in glioblastoma. Tumour Biol 2014;35:8653-8658.
    • (2014) Tumour Biol , vol.35 , pp. 8653-8658
    • Wang, F.1    Xiao, W.2    Sun, J.3    Han, D.4    Zhu, Y.5
  • 6
    • 47549090432 scopus 로고    scopus 로고
    • Tgfbeta in cancer
    • Massague J: Tgfbeta in cancer. Cell 2008;134:215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 7
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of tgf-beta signaling from cell membrane to the nucleus
    • Shi Y, Massague J: Mechanisms of tgf-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 8
    • 0031911356 scopus 로고    scopus 로고
    • Smads: Mediators and regulators of tgf-beta signaling
    • Kretzschmar M, Massague J: Smads: Mediators and regulators of tgf-beta signaling. Curr Opin Genet Dev 1998;8:103-111.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 103-111
    • Kretzschmar, M.1    Massague, J.2
  • 9
    • 0034654497 scopus 로고    scopus 로고
    • Controlling tgf-beta signaling
    • Massague J, Chen YG: Controlling tgf-beta signaling. Genes Dev 2000;14:627-644.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 10
    • 84866742560 scopus 로고    scopus 로고
    • Tgfbeta signalling in context
    • Massague J: Tgfbeta signalling in context. Nat Rev Mol Cell Biol 2012;13:616-630.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 616-630
    • Massague, J.1
  • 11
    • 84875479006 scopus 로고    scopus 로고
    • Tgfbeta receptor signaling is essential for inflammation-induced but not beta-cell workload-induced beta-cell proliferation
    • Xiao X, Wiersch J, El-Gohary Y, Guo P, Prasadan K, Paredes J, Welsh C, Shiota C, Gittes GK: Tgfbeta receptor signaling is essential for inflammation-induced but not beta-cell workload-induced beta-cell proliferation. Diabetes 2013;62:1217-1226.
    • (2013) Diabetes , vol.62 , pp. 1217-1226
    • Xiao, X.1    Wiersch, J.2    El-Gohary, Y.3    Guo, P.4    Prasadan, K.5    Paredes, J.6    Welsh, C.7    Shiota, C.8    Gittes, G.K.9
  • 13
    • 79952554055 scopus 로고    scopus 로고
    • Pmepa1 promotes androgen receptor-negative prostate cell proliferation through suppressing the smad3/4-c-myc-p21 cip1 signaling pathway
    • Liu R, Zhou Z, Huang J, Chen C: Pmepa1 promotes androgen receptor-negative prostate cell proliferation through suppressing the smad3/4-c-myc-p21 cip1 signaling pathway. J Pathol 2011;223:683-694.
    • (2011) J Pathol , vol.223 , pp. 683-694
    • Liu, R.1    Zhou, Z.2    Huang, J.3    Chen, C.4
  • 14
    • 36849000409 scopus 로고    scopus 로고
    • Sp1 and smad3 are required for high glucoseinduced p21(waf1) gene transcription in llc-pk1 cells
    • Chuang TD, Guh JY, Chiou SJ, Chen HC, Hung WC, Chuang LY: Sp1 and smad3 are required for high glucoseinduced p21(waf1) gene transcription in llc-pk1 cells. J Cell Biochem 2007;102:1190-1201.
    • (2007) J Cell Biochem , vol.102 , pp. 1190-1201
    • Chuang, T.D.1    Guh, J.Y.2    Chiou, S.J.3    Chen, H.C.4    Hung, W.C.5    Chuang, L.Y.6
  • 15
    • 28544450380 scopus 로고    scopus 로고
    • Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of smad2 and smad3 and regulates fibroblast responses via p21-activated kinase-2
    • Wilkes MC, Mitchell H, Penheiter SG, Dore JJ, Suzuki K, Edens M, Sharma DK, Pagano RE, Leof EB: Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of smad2 and smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res 2005;65:10431-10440.
    • (2005) Cancer Res , vol.65 , pp. 10431-10440
    • Wilkes, M.C.1    Mitchell, H.2    Penheiter, S.G.3    Dore, J.J.4    Suzuki, K.5    Edens, M.6    Sharma, D.K.7    Pagano, R.E.8    Leof, E.B.9
  • 16
    • 30344460672 scopus 로고    scopus 로고
    • Transcriptional activation of p21 by tranilast is mediated via transforming growth factor beta signal pathway
    • Charng MJ, Wu CH: Transcriptional activation of p21 by tranilast is mediated via transforming growth factor beta signal pathway. Br J Pharmacol 2006;147:117-124.
    • (2006) Br J Pharmacol , vol.147 , pp. 117-124
    • Charng, M.J.1    Wu, C.H.2
  • 17
    • 20144379460 scopus 로고    scopus 로고
    • Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(waf1/cip1)
    • Pardali K, Kowanetz M, Heldin CH, Moustakas A: Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(waf1/cip1). J Cell Physiol 2005;204:260-272.
    • (2005) J Cell Physiol , vol.204 , pp. 260-272
    • Pardali, K.1    Kowanetz, M.2    Heldin, C.H.3    Moustakas, A.4
  • 18
    • 0034703083 scopus 로고    scopus 로고
    • Role of smad proteins and transcription factor sp1 in p21(waf1/cip1) regulation by transforming growth factor-beta
    • Pardali K, Kurisaki A, Moren A, ten Dijke P, Kardassis D, Moustakas A: Role of smad proteins and transcription factor sp1 in p21(waf1/cip1) regulation by transforming growth factor-beta. J Biol Chem 2000;275:29244-29256.
    • (2000) J Biol Chem , vol.275 , pp. 29244-29256
    • Pardali, K.1    Kurisaki, A.2    Moren, A.3    Ten Dijke, P.4    Kardassis, D.5    Moustakas, A.6
  • 19
    • 84864286794 scopus 로고    scopus 로고
    • Increased tgf-beta1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with smad2/3 signaling
    • Miles FL, Tung NS, Aguiar AA, Kurtoglu S, Sikes RA: Increased tgf-beta1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with smad2/3 signaling. Prostate 2012;72:1339-1350.
    • (2012) Prostate , vol.72 , pp. 1339-1350
    • Miles, F.L.1    Tung, N.S.2    Aguiar, A.A.3    Kurtoglu, S.4    Sikes, R.A.5
  • 20
    • 62449215107 scopus 로고    scopus 로고
    • Tgfbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest
    • Lecanda J, Ganapathy V, D'Aquino-Ardalan C, Evans B, Cadacio C, Ayala A, Gold LI: Tgfbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest. Cell Cycle 2009;8:742-756.
    • (2009) Cell Cycle , vol.8 , pp. 742-756
    • Lecanda, J.1    Ganapathy, V.2    D'Aquino-Ardalan, C.3    Evans, B.4    Cadacio, C.5    Ayala, A.6    Gold, L.I.7
  • 21
    • 61449197711 scopus 로고    scopus 로고
    • Cdk2 phosphorylation of smad2 disrupts tgf-beta transcriptional regulation in resistant primary bone marrow myeloma cells
    • Baughn LB, Di Liberto M, Niesvizky R, Cho HJ, Jayabalan D, Lane J, Liu F, Chen-Kiang S: Cdk2 phosphorylation of smad2 disrupts tgf-beta transcriptional regulation in resistant primary bone marrow myeloma cells. J Immunol 2009;182:1810-1817.
    • (2009) J Immunol , vol.182 , pp. 1810-1817
    • Baughn, L.B.1    Di Liberto, M.2    Niesvizky, R.3    Cho, H.J.4    Jayabalan, D.5    Lane, J.6    Liu, F.7    Chen-Kiang, S.8
  • 24
    • 50649086810 scopus 로고    scopus 로고
    • Expression and putative functions of gdf-15, a member of the tgf-beta superfamily, in human glioma and glioblastoma cell lines
    • Strelau J, Schmeer C, Peterziel H, Sackmann T, Herold-Mende C, Steiner H, Weller M, Unsicker K: Expression and putative functions of gdf-15, a member of the tgf-beta superfamily, in human glioma and glioblastoma cell lines. Cancer Lett 2008;270:30-39.
    • (2008) Cancer Lett , vol.270 , pp. 30-39
    • Strelau, J.1    Schmeer, C.2    Peterziel, H.3    Sackmann, T.4    Herold-Mende, C.5    Steiner, H.6    Weller, M.7    Unsicker, K.8
  • 25
    • 79952749189 scopus 로고    scopus 로고
    • Map kinaseinteracting kinase 1 regulates smad2-dependent tgf-beta signaling pathway in human glioblastoma
    • Grzmil M, Morin P, Jr., Lino MM, Merlo A, Frank S, Wang Y, Moncayo G, Hemmings BA: Map kinaseinteracting kinase 1 regulates smad2-dependent tgf-beta signaling pathway in human glioblastoma. Cancer Res 2011;71:2392-2402.
    • (2011) Cancer Res , vol.71 , pp. 2392-2402
    • Grzmil, M.1    Morin, P.2    Lino, M.M.3    Merlo, A.4    Frank, S.5    Wang, Y.6    Moncayo, G.7    Hemmings, B.A.8
  • 27
    • 0032943080 scopus 로고    scopus 로고
    • Expression of transforming-growth-factor (tgf)-beta receptors and smad proteins in glioblastoma cell lines with distinct responses to tgf-beta1
    • Piek E, Westermark U, Kastemar M, Heldin CH, van Zoelen EJ, Nister M, Ten Dijke P: Expression of transforming-growth-factor (tgf)-beta receptors and smad proteins in glioblastoma cell lines with distinct responses to tgf-beta1. Int J Cancer 1999;80:756-763.
    • (1999) Int J Cancer , vol.80 , pp. 756-763
    • Piek, E.1    Westermark, U.2    Kastemar, M.3    Heldin, C.H.4    Van Zoelen, E.J.5    Nister, M.6    Ten Dijke, P.7
  • 29
    • 84924980270 scopus 로고    scopus 로고
    • Differential regulation of tgf-beta-induced, alk-5-mediated vegf release by smad2/3 versus smad1/5/8 signaling in glioblastoma
    • Seystahl K, Tritschler I, Szabo E, Tabatabai G, Weller M: Differential regulation of tgf-beta-induced, alk-5-mediated vegf release by smad2/3 versus smad1/5/8 signaling in glioblastoma. Neuro Oncol 2015;17:254-265.
    • (2015) Neuro Oncol , vol.17 , pp. 254-265
    • Seystahl, K.1    Tritschler, I.2    Szabo, E.3    Tabatabai, G.4    Weller, M.5
  • 30
    • 24644439547 scopus 로고    scopus 로고
    • Tgf-beta, neuronal stem cells and glioblastoma
    • Golestaneh N, Mishra B: Tgf-beta, neuronal stem cells and glioblastoma. Oncogene 2005;24:5722-5730.
    • (2005) Oncogene , vol.24 , pp. 5722-5730
    • Golestaneh, N.1    Mishra, B.2
  • 31
    • 56649117546 scopus 로고    scopus 로고
    • Glioblastoma-secreted factors induce igfbp7 and angiogenesis by modulating smad-2-dependent tgf-beta signaling
    • Pen A, Moreno MJ, Durocher Y, Deb-Rinker P, Stanimirovic DB: Glioblastoma-secreted factors induce igfbp7 and angiogenesis by modulating smad-2-dependent tgf-beta signaling. Oncogene 2008;27:6834-6844.
    • (2008) Oncogene , vol.27 , pp. 6834-6844
    • Pen, A.1    Moreno, M.J.2    Durocher, Y.3    Deb-Rinker, P.4    Stanimirovic, D.B.5
  • 34
    • 84896838291 scopus 로고    scopus 로고
    • Next generation sequencing analysis of mirnas: Mir-127-3p inhibits glioblastoma proliferation and activates tgf-beta signaling by targeting ski
    • Jiang H, Jin C, Liu J, Hua D, Zhou F, Lou X, Zhao N, Lan Q, Huang Q, Yoon JG, Zheng S, Lin B: Next generation sequencing analysis of mirnas: Mir-127-3p inhibits glioblastoma proliferation and activates tgf-beta signaling by targeting ski. OMICS 2014;18:196-206.
    • (2014) OMICS , vol.18 , pp. 196-206
    • Jiang, H.1    Jin, C.2    Liu, J.3    Hua, D.4    Zhou, F.5    Lou, X.6    Zhao, N.7    Lan, Q.8    Huang, Q.9    Yoon, J.G.10    Zheng, S.11    Lin, B.12
  • 35
    • 38949165993 scopus 로고    scopus 로고
    • Microglia-derived tgf-beta as an important regulator of glioblastoma invasion-an inhibition of tgf-beta-dependent effects by shrna against human tgf-beta type ii receptor
    • Wesolowska A, Kwiatkowska A, Slomnicki L, Dembinski M, Master A, Sliwa M, Franciszkiewicz K, Chouaib S, Kaminska B: Microglia-derived tgf-beta as an important regulator of glioblastoma invasion-an inhibition of tgf-beta-dependent effects by shrna against human tgf-beta type ii receptor. Oncogene 2008;27:918-930.
    • (2008) Oncogene , vol.27 , pp. 918-930
    • Wesolowska, A.1    Kwiatkowska, A.2    Slomnicki, L.3    Dembinski, M.4    Master, A.5    Sliwa, M.6    Franciszkiewicz, K.7    Chouaib, S.8    Kaminska, B.9
  • 37
    • 0035877007 scopus 로고    scopus 로고
    • Processing of immunosuppressive pro-tgf-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases
    • Leitlein J, Aulwurm S, Waltereit R, Naumann U, Wagenknecht B, Garten W, Weller M, Platten M: Processing of immunosuppressive pro-tgf-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases. J Immunol 2001;166:7238-7243.
    • (2001) J Immunol , vol.166 , pp. 7238-7243
    • Leitlein, J.1    Aulwurm, S.2    Waltereit, R.3    Naumann, U.4    Wagenknecht, B.5    Garten, W.6    Weller, M.7    Platten, M.8
  • 38
    • 0028210003 scopus 로고
    • Retroviral-mediated transduction of p53 gene increases tgf-beta expression in a human glioblastoma cell line
    • Fujiwara T, Mukhopadhyay T, Cai DW, Morris DK, Roth JA, Grimm EA: Retroviral-mediated transduction of p53 gene increases tgf-beta expression in a human glioblastoma cell line. Int J Cancer 1994;56:834-839.
    • (1994) Int J Cancer , vol.56 , pp. 834-839
    • Fujiwara, T.1    Mukhopadhyay, T.2    Cai, D.W.3    Morris, D.K.4    Roth, J.A.5    Grimm, E.A.6
  • 41
    • 84868694684 scopus 로고    scopus 로고
    • On the ontology based representation of cell lines
    • Ganzinger M, He S, Breuhahn K, Knaup P: On the ontology based representation of cell lines. PLoS One 2012;7:e48584.
    • (2012) PLoS One , vol.7 , pp. e48584
    • Ganzinger, M.1    He, S.2    Breuhahn, K.3    Knaup, P.4
  • 43
    • 0036085920 scopus 로고    scopus 로고
    • Sb-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type i activin receptor-like kinase (alk) receptors alk4, alk5, and alk7
    • Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS: Sb-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type i activin receptor-like kinase (alk) receptors alk4, alk5, and alk7. Mol Pharmacol 2002;62:65-74.
    • (2002) Mol Pharmacol , vol.62 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3    Harling, J.D.4    Gaster, L.M.5    Reith, A.D.6    Laping, N.J.7    Hill, C.S.8
  • 45
    • 84905049417 scopus 로고    scopus 로고
    • Pttg1 inhibits smad3 in prostate cancer cells to promote their proliferation
    • Huang S, Liao Q, Li L, Xin D: Pttg1 inhibits smad3 in prostate cancer cells to promote their proliferation. Tumour Biol 2014;35:6265-6270.
    • (2014) Tumour Biol , vol.35 , pp. 6265-6270
    • Huang, S.1    Liao, Q.2    Li, L.3    Xin, D.4
  • 46
    • 84928938678 scopus 로고    scopus 로고
    • Androgen receptor signaling regulates growth of glioblastoma multiforme in men
    • Yu X, Jiang Y, Wei W, Cong P, Ding Y, Xiang L, Wu K: Androgen receptor signaling regulates growth of glioblastoma multiforme in men. Tumour Biol 2014.
    • (2014) Tumour Biol
    • Yu, X.1    Jiang, Y.2    Wei, W.3    Cong, P.4    Ding, Y.5    Xiang, L.6    Wu, K.7
  • 47
    • 24344491428 scopus 로고    scopus 로고
    • Pathway-and expression level-dependent effects of oncogenic n-ras: P27(kip1) mislocalization by the ral-gef pathway and erk-mediated interference with smad signaling
    • Kfir S, Ehrlich M, Goldshmid A, Liu X, Kloog Y, Henis YI: Pathway-and expression level-dependent effects of oncogenic n-ras: P27(kip1) mislocalization by the ral-gef pathway and erk-mediated interference with smad signaling. Mol Cell Biol 2005;25:8239-8250.
    • (2005) Mol Cell Biol , vol.25 , pp. 8239-8250
    • Kfir, S.1    Ehrlich, M.2    Goldshmid, A.3    Liu, X.4    Kloog, Y.5    Henis, Y.I.6
  • 49
    • 0034735895 scopus 로고    scopus 로고
    • Disruption of tgf-beta growth inhibition by oncogenic ras is linked to p27kip1 mislocalization
    • Liu X, Sun Y, Ehrlich M, Lu T, Kloog Y, Weinberg RA, Lodish HF, Henis YI: Disruption of tgf-beta growth inhibition by oncogenic ras is linked to p27kip1 mislocalization. Oncogene 2000;19:5926-5935.
    • (2000) Oncogene , vol.19 , pp. 5926-5935
    • Liu, X.1    Sun, Y.2    Ehrlich, M.3    Lu, T.4    Kloog, Y.5    Weinberg, R.A.6    Lodish, H.F.7    Henis, Y.I.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.