PTTG1 inhibits SMAD3 in prostate cancer cells to promote their proliferation

Tumor Biology

Volumn 35, Issue 7, 2014, Pages 6265-6270

  Huang, Shengquan ^a   Liao, Qianjin ^b   Li, Longkun ^a   Xin, Dianqi ^c  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Xinqiao Community Health Service Center of Shapingba District   (China)

^c PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Pituitary tumor transforming gene 1; Prostate cancer; SMAD3

Indexed keywords

SECURIN; SHORT HAIRPIN RNA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SISTER CHROMATID; TRANSGENE;

CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MOLECULAR TARGETED THERAPY; PROSTATIC NEOPLASMS; SECURIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84905049417     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-1818-z     Document Type: Article

References (21)

1. Zhang X et al. Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Mol Endocrinol. 1999;13(1):156-66. (Pubitemid 29022288)
2. Yu R et al. Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: evidence from live cell imaging. Mol Endocrinol. 2000;14(8):1137-46. (Pubitemid 32260476)
3. Panguluri SK, Yeakel C, Kakar SS. PTTG: an important target gene for ovarian cancer therapy. J Ovarian Res. 2008;1(1):6.
4. El-Naggar SM, Malik MT, Kakar SS. Small interfering RNA against PTTG: a novel therapy for ovarian cancer. Int J Oncol. 2007;31(1):137-43.
5. Chen G et al. Inhibitory effects of anti-sense PTTG on malignant phenotype of human ovarian carcinoma cell line SK-OV-3. J Huazhong Univ Sci Technolog Med Sci. 2004;24(4):369-72. (Pubitemid 41559599)
6. Zhang J. et al. Overexpression of pituitary tumor transforming gene (PTTG) is associated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma. Acta Histochem 2013
7. Yan S et al. PTTG overexpression promotes lymph node metastasis in human esophageal squamous cell carcinoma. Cancer Res. 2009;69(8):3283-90.
8. Zhou C et al. Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin /TCF pathway in human esophageal squamous cell carcinoma. Int J Cancer. 2005;113(6):891-8. (Pubitemid 40096868)
9. Shibata Y et al. Expression of PTTG (pituitary tumor transforming gene) in esophageal cancer. Jpn J Clin Oncol. 2002;32(7):233-7. (Pubitemid 43102805)
10. Zhang ML, Lu S, Zheng SS. Epigenetic changes of pituitary tumor-derived transforming gene 1 in pancreatic cancer. Hepatobiliary Pancreat Dis Int. 2008;7(3):313-7. (Pubitemid 351895394)
11. Ai J et al. Identification of over-expressed genes in human renal cell carcinoma by combining suppression subtractive hybridization and cDNA library array. Sci China C Life Sci. 2004;47(2):148-57.
12. Dominguez A et al. hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. Oncogene. 1998;17(17):2187-93. (Pubitemid 28515372)
13. Zhou C et al. PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility. Oncogene. 2014;33(7):851-61.
14. Kim DS et al. Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity. Carcinogenesis. 2007;28(3):749-59. (Pubitemid 46523373)
15. Huang SQ et al. RNAi-mediated knockdown of pituitary tumor-transforming gene-1 (PTTG1) suppresses the proliferation and invasive potential of PC3 human prostate cancer cells. Braz J Med Biol Res. 2012;45(11):995-1001.
16. Massague J. TGFbeta in cancer. Cell. 2008;134(2):215-30.
17. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113(6):685-700. (Pubitemid 36724933)
18. Kretzschmar M, Massague J. SMADs: mediators and regulators of TGF-beta signaling. Curr Opin Genet Dev. 1998;8(1):103-11. (Pubitemid 28122148)
19. Massague J, Chen YG. Controlling TGF-beta signaling. Genes Dev. 2000;14(6):627-44.
20. Massague J. TGFbeta signalling in context. Nat Rev Mol Cell Biol. 2012;13(10):616-30.
21. Pavese J, Ogden IM, Bergan RC. An orthotopic murine model of human prostate cancer metastasis. J Vis Exp. 2013;79:e50873.